The effect of delayed analysis or freeze-thawing on the measurement of natural anticoagulants, resistance to activated protein C and markers of activation of the haemostatic system.

abstract：INTRODUCTION:To determine whether the HIT IgG class platelet factor 4 (PF4) enzyme immunoabsorbant assay (EIA) influenced the duration of parenteral direct thrombin inhibitor (pDTI) therapy or bleeding risk in patients started on pDTI for a presumed diagnosis of HIT. MATERIALS/METHODS:187 patients started on pDTI for ...

journal_title：Thrombosis research

authors： Reagan JL,Ingham RR 2nd,Dalia S,Butera JN,Sweeney JD

更新日期：2014-07-01 00:00:00

abstract：:beta-Factor XIIa (beta-XIIa, Mr approximately 30,000) was isolated from human plasma by a procedure which utilized, as an initial step, the adsorption of Factor XII to celite. Activation of Factor XII and subsequent release of beta-XIIa was brought about by the proteolytic action of co-adsorbed kallikrein. Two success...

journal_title：Thrombosis research

authors： Tankersley DL,Alving BM,Finlayson JS

更新日期：1982-02-15 00:00:00

abstract：BACKGROUND:In patients who are receiving warfarin therapy and require cataract surgery, it may be possible to continue warfarin in the perioperative period but the safety of this management strategy has not been systematically evaluated. METHODS:We performed a systematic review of the literature to assess the safety (...

journal_title：Thrombosis research

authors： Jamula E,Anderson J,Douketis JD

更新日期：2009-07-01 00:00:00

abstract：INTRODUCTION:The Cilostazol Stroke Prevention Study found that cilostazol, a phosphodiesterase 3 inhibitor, can reduce the risk of subsequent stroke in Japanese patients with cerebral infarction. Here, we measured the effects of cilostazol in vitro on shear-induced platelet aggregation, an important mechanism of thromb...

journal_title：Thrombosis research

authors： Nakamura T,Uchiyama S,Yamazaki M,Iwata M

更新日期：2007-01-01 00:00:00

abstract：:Two types of LMW heparin were prepared by gel filtration of standard heparin (LMW fraction) and by degradation of heparin by nitrous acid (LMW fragment), respectively. The effects on factor Xa inhibition (XaI), APTT, platelet aggregation and AT III level of these preparations were studied after subcutaneous administra...

journal_title：Thrombosis research

authors： Bergqvist D,Hedner U,Sjörin E,Holmer E

更新日期：1983-11-15 00:00:00

abstract：:The cerebral vascular supply is constructed to protect the cerebral hemispheres and brainstem from the consequences of blood flow cessation. Reversal of blood flow around local obstructions is a feature of the microvascular beds of the striatum and cerebral cortex. Cerebral capillaries of these beds consist of endothe...

journal_title：Thrombosis research

authors： del Zoppo GJ,Hallenbeck JM

更新日期：2000-05-01 00:00:00

abstract：INTRODUCTION:Although the procoagulant reactivity of monocytes largely depends on expression and cell surface presentation of tissue factor (TF), little is known about the impact of tissue factor pathway inhibitor (TFPI) on regulation of TF function on the monocyte surface. MATERIALS AND METHODS:Peripheral blood monon...

journal_title：Thrombosis research

authors： Basavaraj MG,Gruber FX,Sovershaev M,Appelbom HI,Osterud B,Petersen LC,Hansen JB

更新日期：2010-11-01 00:00:00

abstract：:Using the standard turbidimetric method of platelet aggregation and quantitation of platelet secretion with 14C-Serotonin, we have examined the responsiveness of the platelets of mongrel dogs to arachidonic acid (AA), and the thromboxane agonist U46619 in the presence and absence of a subthreshold concentration of epi...

journal_title：Thrombosis research

authors： McGoff MA,Allen BT,Der T,Sicard GA,Santoro SA

更新日期：1989-09-15 00:00:00

abstract：:We investigated the intracellular processes of the shape change in human megakaryoblastic leukemic cells, MEG-01, by platelet agonists. Thrombin induced the formation of many pseudopods. This shape change was also induced by phorbol 12-myristate 13 acetate (TPA) and weakly by Ca2+ ionophore, A23187, but not by ADP, co...

journal_title：Thrombosis research

authors： Goto S,Kobayashi M,Murate T,Hotta T,Hagiwara M,Hoshino T,Hidaka H,Saito H

更新日期：1992-10-01 00:00:00

abstract：:Enzymatic treatment used for passaging of endothelial cells may induce release of von Willebrand factor (vWF). Decreased ability to replenish intracellular stores results in decreased secretion of vWF in later passages of cells. Since both trypsin and pancreatin complex have been used for passaging endothelial cells, ...

journal_title：Thrombosis research

authors： Lopes AA,Peranovich TM,Maeda NY,Bydlowski SP

更新日期：2001-02-15 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is a transient hypercoagulability state initiated, paradoxically, by the anticoagulant, heparin. It is characterized by antibody-induced activation of platelets, leading to thrombin generation. Many patients with HIT develop thrombosis; even when heparin is stopped because of "is...

journal_title：Thrombosis research

authors： Warkentin TE

更新日期：2003-05-01 00:00:00

abstract：:The role of free radical generation and its scavenging enzymes in circulating mice polymorphonuclear leukocytes (PMNLs) has been studied following pulmonary thromboembolism. Levels of malonaldehyde (MDA), 02- radical generation, activity of superoxide dismutase (SOD), catalase (CAT), lactate dehydrogenase (LDH), myelo...

journal_title：Thrombosis research

authors： Dikshit M,Kumari R,Srimal RC

更新日期：1992-05-01 00:00:00

abstract：:We studied a Japanese family with type I antithrombin (AT) deficiency and identified a novel in-frame deletion mutation (-ATG at nucleotide position of 2771-2773) in the AT gene, which predicted loss of a methionine (Met) at amino acid number of 103. In addition, we found a single base replacement of G to A at nucleot...

journal_title：Thrombosis research

authors： Katayama K,Hashimoto N,Tanaka Y,Ozawa T,Emi Y,Ikeda T,Katayama M,Nomura S,Kitajima I,Nakano T,Imanaka T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The quality of treatment with warfarin is mainly assessed by the time in therapeutic range (TTR) in patients with mechanical heart valve prosthesis (MHV). Our aim was to evaluate if International Normalized Ratio (INR) variability predicted a combined endpoint of thromboembolism, major bleeding and death bet...

journal_title：Thrombosis research

authors： Labaf A,Själander A,Stagmo M,Svensson PJ

更新日期：2015-12-01 00:00:00

abstract：:A blinded randomized multicenter trial of two non-activated prothrombin complex concentrates was carried out to determine the clinical effectivity in the treatment of acute hemarthrosis in hemophiliac patients with inhibitors. The one product was prepared via DEAE Sephadex chromatography, while the second was fraction...

journal_title：Thrombosis research

authors： Gomperts ED,Fannon RB,Lee ML,Kingdon HS,Kantrowitz JL,Addiego JE Jr,Carney J,Corrigan JJ,Hathaway W,Hilgartner MW

更新日期：1986-06-15 00:00:00

abstract：:Ethanol (88-880 mmol/l) inhibited the formation of proaggregatory, vasoconstricting thromboxane A2 (TxA2) during whole blood clotting and during thrombin-induced aggregation of platelet rich plasma. This inhibition was counteracted by the addition of exogenous arachidonic acid, which suggested that ethanol suppressed ...

journal_title：Thrombosis research

authors： Toivanen J,Ylikorkala O,Viinikka L

更新日期：1984-01-01 00:00:00

abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...

journal_title：Thrombosis research

authors： Wesemann W,Hoffmann D

更新日期：1985-09-15 00:00:00

abstract：INTRODUCTION:Association between ADAMTS13 levels and cardiovascular events has been described recently. However, no genetic study of ADAMTS13 in coronary patients has been described. MATERIALS AND METHODS:Based on related populations frequencies and functional studies, we tested three ADAMTS13 polymorphisms: C1342G (Q...

journal_title：Thrombosis research

authors： Schettert IT,Pereira AC,Lopes NH,Hueb WA,Krieger JE

更新日期：2010-01-01 00:00:00

abstract：:This study examined the effect of exercise on plasma fibrinogen concentrations with simultaneous measurements of plasma volume changes. Eight moderately active males aged 26.6+/-3.6 years (mean +/- SD) completed maximal (VO2max) and submaximal (75% VO2max for 30 minutes) exercise trials separated by 7 days. Venous blo...

journal_title：Thrombosis research

authors： El-Sayed MS,Jones PG,Sale C

更新日期：1999-12-15 00:00:00

abstract：INTRODUCTION:Preterm infants often require assisted ventilation, however ventilation when applied to the immature lung can initiate ventilator-induced lung injury (VILI). The biotrauma which underscores VILI is largely undefined, and is likely to involve vascular injury responses, including hemostasis. We aimed to use ...

journal_title：Thrombosis research

authors： Schmid C,Ignjatovic V,Pang B,Nie S,Williamson NA,Tingay DG,Pereira-Fantini PM

更新日期：2020-12-01 00:00:00

abstract：UNLABELLED:Disturbances of coagulation and fibrinolysis have been reported in patients with chronic uremia. Studies of different coagulation and fibrinolysis parameters in regularly dialyzed patients have yielded conflicting results. Global fibrinolytic capacity (GFC) examines the function of the entire fibrinolytic sy...

journal_title：Thrombosis research

authors： Agras PI,Baskin E,Cengiz N,Kirazli S,Saatci U,Ozbek N

更新日期：2005-01-01 00:00:00

abstract：:The influence of acute hypoxemia on blood fibrinolytic activity was investigated in 12 healthy males. Physiologically significant hypoxemia was produced by inspiration of 13% oxygen for 30 min. Six healthy males were exposed to hypoxemia at rest and 6 males to hypoxemia during exhaustive physical exercise on an ergocy...

journal_title：Thrombosis research

authors： Stegnar M,Peternel P,Chen JP

更新日期：1987-02-15 00:00:00

abstract：:Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), presents a large clinical burden. Prompt, effective and sustained anticoagulation is vital because of the risk of recurrent events, including life-threatening PE, and complications such as post-thrombotic syndrome and chro...

journal_title：Thrombosis research

authors： Prandoni P

更新日期：2014-08-01 00:00:00

abstract：:The effect of dalteparin, a low molecular weight heparin, on severely antithrombin III (ATIII)-decreased disseminated intravascular coagulation (DIC) model was compared with that of unfractionated heparin (heparin). The DIC model in rabbits was produced by continuous infusion of thrombin in combination with bolus inje...

journal_title：Thrombosis research

authors： Tazawa S,Ichikawa K,Misawa K,Fukuyama J,Hamano S,Miyata H,Sakuragawa N

更新日期：1995-12-01 00:00:00

abstract：:Human and bovine alpha-thrombins (greater than 90% alpha form) with high fibrinogen clotting activities (approximately 3,000 U.S. units/mg protein) exhibit similar Michaelis menten kinetics with the p-nitroanilide tripeptide substrates Tos-Gly-Pro-arg-pNA (Chromozym-TH) and D-Phe-Pip-Arg-pNA (S-2238). The kinetic para...

journal_title：Thrombosis research

authors： Lottenberg R,Hall JA,Fenton JW 2nd,Jackson CM

更新日期：1982-11-01 00:00:00

abstract：:Time response curves of the anti-thrombotic effects, bleeding enhancing effects, effects on APTT, anti-Xa activities, anti-thrombin activities and thrombin generation inhibitory activities of the low molecular weight heparinoid Org 10172 and heparin have been compared in rats. The time courses of these effects were si...

journal_title：Thrombosis research

authors： Hobbelen PM,Vogel GM,Meuleman DG

更新日期：1987-12-01 00:00:00

abstract：INTRODUCTION:Monocyte- and microparticle (MP)-associated tissue factor (TF) is upregulated in diabetes. Lipopolysaccharide (LPS) induces expression of TF and alternatively spliced TF (asTF) and increases MP release from monocytes. Using LPS-stimulated TF-bearing human monocytes, we examined whether glibenclamide, a sul...

journal_title：Thrombosis research

authors： Henriksson CE,Hellum M,Haug KB,Aass HC,Joø GB,Øvstebø R,Trøseid AM,Klingenberg O,Kierulf P

更新日期：2011-11-01 00:00:00

abstract：INTRODUCTION:A paradox seems to exist: exercising leads to clotting activation in conventional clotting tests, but exercising persons have a low risk of thrombosis. In this study we tried to evaluate the effect of exercise performance status on in vitro plasma thrombin generation, which represents an overall function t...

journal_title：Thrombosis research

authors： Cimenti C,Schlagenhauf A,Leschnik B,Schretter M,Tschakert G,Gröschl W,Seibert FJ,Hofmann P,Muntean WE

更新日期：2013-06-01 00:00:00

abstract：:Bovine myelin basic protein (BP) induced a shape change and endogenous phosphorylation of a 45,000 (45K) molecular weight protein of intact human platelets. This effect occurred rapidly over an effective concentration range of 5-100 microM BP. BP peptides encompassing residues 1-42, 43-88, and 89-169 from the BP molec...

journal_title：Thrombosis research

authors： Chiang TM,Whitaker JN,Kang AH,Beachey EH

更新日期：1982-03-15 00:00:00

abstract：INTRODUCTION:Fluid resuscitation after trauma often results in dilutional coagulopathy that may hinder control of bleeding and, once initial hemostasis has been secured, heighten risk of perioperative bleeding when further surgery is required. Since multiple coagulation factor deficiencies typically accompany fluid res...

journal_title：Thrombosis research

authors： Pragst I,Kaspereit F,Dörr B,Dickneite G

更新日期：2010-03-01 00:00:00