Preparation of beta-XIIa (Hageman factor fragment) from human plasma.

abstract：:The abnormal Antithrombin-III (AT-III) Toyama has no ability to interact with heparin in the mast cells or heparin-like glycosaminoglycans on the surface of vascular endothelial cells, so that it has low heparin cofactor activity. In the present study, we have measured the binding capacity of 125I-labeled AT-III to cu...

journal_title：Thrombosis research

authors： Saito S,Takahashi K,Sakuragawa N

更新日期：1988-04-01 00:00:00

abstract：:This study comprised 50 patients subjected to major abdominal surgery, of which 13 developed deep vein thrombosis (DVT) according to the 125I-fibrinogen test. Plasma was sampled preoperatively, for the specific analysis of tissue plasminogen activator (t-PA) before and during venous occlusion. The recently described f...

journal_title：Thrombosis research

authors： Mellbring G,Dahlgren S,Wiman B,Sunnegårdh O

更新日期：1985-07-15 00:00:00

abstract：:An extensive study of the pharmacokinetics and the pharmacokinetics of the profibrinolytic activity of Defibrotide (D) in the rabbit has been made. a two compartment model was used to describe D's pharmacokinetics. The parameters of drug disposition and the rate constant of release from tissues to central compartment ...

journal_title：Thrombosis research

authors： Pescador R,Mantovani M,Prino G,Madonna M

更新日期：1983-04-01 00:00:00

abstract：:Patients with protamine allergy present a difficult dilemma when reversal of heparin is required for excessive bleeding. Premedication with steroids and antihistamines has not been shown to effectively prevent anaphylactic reactions in patients with hypersensitivity to protamine. Other heparin antagonists are either n...

journal_title：Thrombosis research

authors： Sloand EM,Kessler CM,McIntosh CL,Klein HG

更新日期：1989-06-15 00:00:00

abstract：:Optimal conditions for a method to simultaneously measure aggregation in 96 samples using a microplate reader were developed. The temperature of the assay was set at 25 degrees C, the optimal platelet concentration range was determined to be from 1-3 x 10(8) per mL, the assay volume was determined to be best at 100 mi...

journal_title：Thrombosis research

authors： Bednar B,Condra C,Gould RJ,Connolly TM

更新日期：1995-03-01 00:00:00

abstract：:In the present study a new clotting assay for the detection of an increased resistance of coagulation factor V against degradation by activated protein C (Factor V Leiden mutation, FVLM) was evaluated. The Factor V (Leiden) Test (Gradipore, North Ryde NSW, Australia) is based on the dilute Russell Viper Venom Time (DR...

journal_title：Thrombosis research

authors： Quehenberger P,Handler S,Mannhalter C,Kyrle PA,Speiser W

更新日期：1999-10-15 00:00:00

abstract：INTRODUCTION:We showed previously that the prothrombotic effect of one hour aldosterone (ALDO) infusion in rats was only partially mediated by the mineralocorticoid receptor (MR). Bearing in mind that ALDO potentiates the effects of angiotensin II (Ang II), in the present study we investigated the role of Ang II recept...

journal_title：Thrombosis research

authors： Gromotowicz-Poplawska A,Stankiewicz A,Kramkowski K,Gradzka A,Wojewodzka-Zelezniakowicz M,Dzieciol J,Szemraj J,Chabielska E

更新日期：2016-02-01 00:00:00

abstract：INTRODUCTION:Tissue factor (TF) pathway inhibitor (TFPI) is the physiological inhibitor of TF induced blood coagulation and two isoforms exists, TFPIα and TFPIβ. In atherosclerotic plaques, TFPI may inhibit TF activity and thrombus formation, which is the main cause of ischemic stroke in carotid artery disease. We aime...

journal_title：Thrombosis research

authors： Stavik B,Holm S,Espada S,Iversen N,Sporsheim B,Bjerkeli V,Dahl TB,Sandset PM,Skjelland M,Espevik T,Skretting G,Halvorsen B

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. Atrial myocarditis has been detected recently in some patients with lone atrial fibrillation. Virchow's triad of low blood flow, hypercoagulability, and endothelial dysfunction, enhances thrombus f...

journal_title：Thrombosis research

authors： Nakamura Y,Nakamura K,Fukushima-Kusano K,Ohta K,Matsubara H,Hamuro T,Yutani C,Ohe T

更新日期：2003-01-01 00:00:00

abstract：:The prevention of venous thromboembolism (VTE) in women with cancer requires special consideration. The presence of cancer results in both non-surgical and surgical patients having increased risk of VTE. This usually leads to a modification of the recommended preventive therapy, affecting the type, dose and length of ...

journal_title：Thrombosis research

authors： Cohen AT,Wills JO,Bharathi N,Solis JV

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The recanalization rate in patients with deep venous thrombosis (DVT) of the legs treated with the direct oral anticoagulants (DOAC) is unknown. METHODS:In an Italian cohort, we investigated the rate of residual vein thrombosis (RVT) after three and/or six months in 352 patients with proximal DVT who had be...

journal_title：Thrombosis research

authors： Prandoni P,Ageno W,Mumoli N,Zanatta N,Imberti D,Visonà A,Ciammaichella M,Simioni L,Cappelli R,Bucherini E,Di Nisio M,Avruscio G,Camporese G,Parisi R,Cuppini S,Turatti G,Noventa F,Sarolo L

更新日期：2017-05-01 00:00:00

abstract：:Although effective therapies for haemophilia have been available for decades, the prevention and treatment of joint disease remain major clinical concerns for all haemophilia patients. Early identification of joint disease is vital to initiate or modify treatment, and prevent arthropathy. However, there remains a need...

journal_title：Thrombosis research

authors： Lambert T,Auerswald G,Benson G,Hedner U,Jiménez-Yuste V,Ljung R,Morfini M,Remor E,Santagostino E,Zupančić Šalek S

更新日期：2014-06-01 00:00:00

abstract：:The effect of red wine drinking was tested on fibrinolytic parameters and blood cells in nine healthy students at rest and after acute exercise. The subjects were randomly assigned in a crossover design to one of three treatment regimes: control situation, low-dose wine group, and high-dose wine group. Blood samples w...

journal_title：Thrombosis research

authors： Johansen KM,Skorpe S,Olsen JO,Osterud B

更新日期：1999-12-01 00:00:00

abstract：:Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large, polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone marrow, lining blood vessel walls where they release their platelet progeny into circulation. Although little is known about how MKs dif...

journal_title：Thrombosis research

authors： Couldwell G,Machlus KR

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Remote ischaemic conditioning (RIC) has been shown to prevent platelet activation during ablation for atrial fibrillation. RIC has also been associated with more postoperative transfusion in the off-pump coronary artery bypass graft surgery (OPCAB) patients. We evaluated the effects of RIC on coagulation f...

journal_title：Thrombosis research

authors： Kim TK,Nam K,Cho YJ,Choi S,Row HS,Jeon Y

更新日期：2020-03-01 00:00:00

abstract：:DMP 728 is a potent and specific platelet GPIIb/IIIa antagonist. Like all GPIIb/IIIa antagonists, DMP 728 has a steep dose-response relationship in inhibiting platelet aggregation. In this study the relationships between receptor occupancy, platelet aggregation and bleeding time was determined in anesthetized dogs aft...

journal_title：Thrombosis research

authors： Tsao PW,Bozarth JM,Jackson SA,Forsythe MS,Flint SK,Mousa SA

更新日期：1995-03-15 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long term complication of acute pulmonary embolism (PE). Untreated, CTEPH is associated with a very poor prognosis and high risk of mortality, although curation can be achieved by surgical removal of the obstructive endothelialised thromboemboli ...

journal_title：Thrombosis research

authors： Ende-Verhaar YM,Huisman MV,Klok FA

更新日期：2017-03-01 00:00:00

abstract：:Cardiovascular disease (CVD) includes a number of conditions such as myocardial infarction, coronary heart disease, stroke, and venous thromboembolism. CVD is a leading health problem worldwide and a major cause of mortality, morbidity, and disability; it is also associated with high healthcare costs. The incidence of...

journal_title：Thrombosis research

authors： Cohen AT,Imfeld S,Markham J,Granziera S

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:The purpose of the present study was to study the concept of aspirin resistance or non-responsiveness by investigating the response to long-term aspirin therapy in patients with a former acute myocardial infarction (AMI). MATERIALS AND METHODS:Patients with an AMI (n=202) randomly assigned to aspirin 160 ...

journal_title：Thrombosis research

authors： Andersen K,Hurlen M,Arnesen H,Seljeflot I

更新日期：2002-10-01 00:00:00

abstract：:Intimal proliferation of smooth muscle cells is an important characteristic of developing atherosclerotic lesions and late occlusion of venous bypass grafts. Platelet-derived growth factor, released from aggregating platelets at sites of endothelial injury, has been suggested as a main factor responsible for intimal h...

journal_title：Thrombosis research

authors： Nilsson J,Elgue G,Wallin M,Hamsten A,Blombck M

更新日期：1989-04-15 00:00:00

abstract：:Sandwich ELISA systems were developed to measure human von Willebrand factor (vWF). In one system the microtitre plates were coated with goat F(ab')2 to vWF. The F(ab')2 different molecular forms in the soluble phase. VWF antigen bound by the F(ab')2 antibody was subsequently determined by using horse-radish peroxidas...

journal_title：Thrombosis research

authors： Silveira AM,Yamamoto T,Adamson L,Hessel B,Blombäck B

更新日期：1986-07-01 00:00:00

abstract：INTRODUCTION:Conventional Vacutainer® Sodium Citrate blood collection tubes contain a relatively high concentration of contaminating magnesium ions, which may result in shortening of the prothrombin time (PT) and the International Normalized Ratio (INR). Recently the manufacturer of Vacutainer® Sodium Citrate tubes int...

journal_title：Thrombosis research

authors： van den Besselaar AM,van Vlodrop IJ,Berendes PB,Cobbaert CM

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Plasma viscosity (PV) constitutes an independent important predictor of initial and recurrent cardiac events and mortality. It has been suggested that there is a geographical variation in PV values related to coronary event rates. Little information exists regarding PV in Spain. Therefore, our objective wa...

journal_title：Thrombosis research

authors： Vayá A,Simó M,Santaolaria M,Carrasco P,Corella D

更新日期：2007-01-01 00:00:00

abstract：:An anticoagulant activity was identified and isolated from the leaves of a West African plant, Aspilia africana by gel filtration on Sephadex G-100. The anticoagulant factor had an apparent molecular weight of approximately 60,000 d. Upon incubation with plasma, it prolonged the partial thromboplastin time, prothrombi...

journal_title：Thrombosis research

authors： Hanna MM,Niemetz J

更新日期：1987-08-15 00:00:00

abstract：:Despite clear potential benefits of outpatient care, most patients suffering from pulmonary embolism (PE) are currently hospitalized due to the fear of possible adverse events. Nevertheless, some teams have increased or envisage to increase outpatient treatment or early discharge. We performed a narrative systematic r...

journal_title：Thrombosis research

authors： Roy PM,Moumneh T,Penaloza A,Sanchez O

更新日期：2017-07-01 00:00:00

abstract：:The effect of the combined oral administration of pentoxifylline (pof) and low dose acetylsalicylic acid (ASA) was evaluated with the help of the laser-induced thrombosis in rat mesenteric arterioles. Laser-induced thrombosis is inhibited in a dose-dependent way by both drugs. The administration of ASA, either simulta...

journal_title：Thrombosis research

authors： Seiffge D,Weithmann KU

更新日期：1987-04-15 00:00:00

abstract：BACKGROUND:Integrin αIIbβ3 mediates platelet adhesion, aggregation and fibrin clot retraction. These processes require activation of αIIbβ3 and post-ligation signaling. Disulfide bond exchanges are involved in αIIbβ3 and αvβ3 activation. METHODS:In order to investigate the role of integrin activation and disulfide bon...

journal_title：Thrombosis research

authors： Mor-Cohen R,Rosenberg N,Averbukh Y,Seligsohn U,Lahav J

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Atherosclerosis, the underlying disorder of coronary artery disease (CAD), is an inflammatory process involving multiple molecular pathways. Chemokine-mediated mechanisms are potent regulators of atherosclerosis. Genetic variations that alter such signaling pathways could affect susceptibility to CAD. We i...

journal_title：Thrombosis research

authors： Apostolakis S,Baritaki S,Kochiadakis GE,Igoumenidis NE,Panutsopulos D,Spandidos DA

更新日期：2007-01-01 00:00:00

abstract：:Thromboangiitis obliterans (TAO), or Buerger's disease, is a segmental occlusive inflammatory disorder of the arteries and veins, and etiopathogenesis is still obscure. In the present study we investigated the prevalence of prothrombin 20210 G-->A, factor V 1691 G-->A (Factor V Leiden), and factor V 4070 A-->G (His 12...

journal_title：Thrombosis research

authors： Avcu F,Akar E,Demirkiliç U,Yilmaz E,Akar N,Yalçin A

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:To characterize antithrombin (AT) levels in normal pregnancy. METHODS:We performed secondary analyses with data from 3 studies. Using a single measurement from each subject in the first analysis (cross-sectional), we correlated AT levels with gestational age from the middle of the second trimester throughout...

journal_title：Thrombosis research

authors： James AH,Rhee E,Thames B,Philipp CS

更新日期：2014-09-01 00:00:00