The role of prothrombotic mutations in patients with Buerger's disease.

abstract：:Excess platelets shorten most clotting tests for lupus anticoagulant (LA). Often it is not clear if a shortened, normal or slightly prolonged result in a test masks a weak LA in combination with activated platelets, which express procoagulant phospholipid (PPL). Our aim was to investigate a new LA-insensitive factor X...

journal_title：Thrombosis research

authors： Exner T,Low J

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Influencing factors for clopidogrel-mediated platelet inhibition have only been evaluated by one or two different test systems in the same population so far. Since previous studies revealed poor correlations between the various platelet function tests, the identification of influencing variables for clopidog...

journal_title：Thrombosis research

authors： Gremmel T,Steiner S,Seidinger D,Koppensteiner R,Panzer S,Kopp CW

更新日期：2011-10-01 00:00:00

abstract：:Coagulation is initiated by tissue factor (TF). Coagulant TF is constitutively expressed by extravascular cells, but there is increasing evidence that TF can also be present within the blood, in particular during pathological conditions. Such TF is exposed on circulating cell-derived vesicles, and its presence has bee...

journal_title：Thrombosis research

authors： Kleinjan A,Böing AN,Sturk A,Nieuwland R

更新日期：2012-10-01 00:00:00

abstract：:The soluble fibrin monomer complexes (SFMC) in 154 obstetric patients with possible disseminated intravascular coagulation (DIC) were evaluated in SDS polyacrylamide gel electrophoresis (PAGE) after precipitation with B-alanine. Other coagulation tests were performed on these patients. The patients were classified int...

journal_title：Thrombosis research

authors： Aznar J,Gilabert J,Estelles A,Fernandez MA,Villa P,Aznar JA

更新日期：1982-09-15 00:00:00

abstract：:Owing to the beneficial health effects on human cardiovascular system, soybeans and soy-related products have been a focus of intensive research. Soy isoflavones are known to be primarily responsible for the soy-related biological effects including anti-platelet activity but its in vivo relevancy has not been fully ve...

journal_title：Thrombosis research

authors： Kim K,Lim KM,Shin HJ,Seo DB,Noh JY,Kang S,Chung HY,Shin S,Chung JH,Bae ON

更新日期：2013-03-01 00:00:00

abstract：:Lupus anticoagulants (LA) are IgG or IgM antibodies which prolong phospholipid-dependent coagulation tests. For the detection and quantitation of such antibodies, we have developed an ELISA with cephalin as the coating antigen. The sensitivity of this assay was compared to the activated partial thromboplastin time (AP...

journal_title：Thrombosis research

authors： Sletnes KE,Keirung G,Wisløff F

更新日期：1990-01-15 00:00:00

abstract：:The role of protein kinase C (PKC) in platelet activation by thrombin was assessed using a PKC inhibitor Ro 31-7549/001 (R2) which, in vitro, shows more selectivity for PKC than other kinase inhibitors. During early (1.5 s) thrombin-induced platelet activation, when phosphorylation of 47 kDa protein (pleckstrin) and m...

journal_title：Thrombosis research

authors： Geanacopoulos M,Turner J,Bowling KE,Vandenberg SR,Gear AR

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The immediate administration of oral antiplatelet therapy in the form of aspirin plus a P2Y12 inhibitor is the universally recognised standard of care for patients who present with acute myocardial infarction. Despite strong recommendations for their use, there are a paucity of data describing their onset of...

journal_title：Thrombosis research

authors： Khan N,Cox AR,Cotton JM

更新日期：2016-07-01 00:00:00

abstract：:Von Willebrand disease (VWD) is classified into three primary subtypes; type 1 includes partial quantitative deficiency, type 2 (A, B, M and N) includes qualitative defects and type 3 includes virtually complete deficiency of von Willebrand factor (VWF). Type 2A includes variants with decreased platelet adhesion cause...

journal_title：Thrombosis research

authors： Lillicrap D

更新日期：2007-01-01 00:00:00

abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...

journal_title：Thrombosis research

authors： Wesemann W,Hoffmann D

更新日期：1985-09-15 00:00:00

abstract：:Heavy menstrual bleeding (HMB) is defined as excessive menstrual blood loss (MBL) >80 mL per cycle, that interferes with a woman's physical, emotional, social wellbeing and quality of life. Aetiology is due to underlying uterine pathologies, coagulopathy, ovulation dysfunction, or iatrogenic. Up to 20% of women with H...

journal_title：Thrombosis research

authors： Davies J,Kadir RA

更新日期：2017-03-01 00:00:00

abstract：:The coumarin derivative AD6 is known to inhibit platelet aggregation and release and it possesses vasodilatory properties on coronary arteries of laboratory animals. Furthermore, the inhibition of the production of TxB2 from endogenous substrates after stimulation of human platelets with collagen has been demonstrated...

journal_title：Thrombosis research

authors： Porcellati S,Costantini V,Prosdocimi M,Pistolesi R,Porrovecchio P,Nenci GG,Goracci G

更新日期：1987-07-01 00:00:00

abstract：INTRODUCTION:Electronic consultations (eConsults) are asynchronous, consultative electronic-based communications that are aimed to improve efficient and timely access to specialist advice. Our study aim was to evaluate the use and impact of the Canadian Champlain BASE™ (Building Access to Specialists through eConsultat...

journal_title：Thrombosis research

authors： Skeith L,Mohamed M,Karovitch A,Liddy C,Afkham A,Archibald D,Keely E

更新日期：2017-12-01 00:00:00

abstract：:Stent implantation after balloon dilation of coronary arteries has improved clinical prognosis in patients undergoing transluminal coronary angioplasty (PTCA), but late restenosis remains a relevant problem. A previous study has indicated that PAI-1 activity changes immediately after PTCA without stent implantation ar...

journal_title：Thrombosis research

authors： Prisco D,Fedi S,Antonucci E,Capanni M,Chiarugi L,Chioccioli M,Falai M,Giglioli C,Abbate R,Gensini GF

更新日期：2001-11-01 00:00:00

abstract：:Tissue factor pathway inhibitor is the major potent physiologic inhibitor of tissue factor-induced coagulation. Several potential binding sites for transcription factors have been described in the 750 bp of the 5' flanking region of the human tissue factor pathway inhibitor gene reported earlier. To identify elements ...

journal_title：Thrombosis research

authors： Petit L,Lesnik P,Dachet C,Hugou I,Moreau M,Chapman J,Rouis M

更新日期：1999-09-01 00:00:00

abstract：:A simple and discriminating assay for the determination of the fast-acting plasminogen activator inhibitor (PAI) activity in human plasma is described. The method is based on the inhibition of purified tissue plasminogen activator (tPA) by plasma diluted with a PAI-depleted plasma and the subsequent measurement of res...

journal_title：Thrombosis research

authors： Contant G,Martinoli JL

更新日期：1989-11-01 00:00:00

abstract：INTRODUCTION:Pelvic deep vein thrombosis (DVT) is difficult to diagnose during pregnancy. In a two-center trial, we evaluated the agreement between ultrasonography and magnetic resonance imaging (MRI) in diagnosing the extent of DVT into the pelvic veins during pregnancy. MATERIALS AND METHODS:Pregnant women with prox...

journal_title：Thrombosis research

authors： Torkzad MR,Bremme K,Hellgren M,Eriksson MJ,Hagman A,Jörgensen T,Lund K,Sandgren G,Blomqvist L,Kälebo P

更新日期：2010-08-01 00:00:00

abstract：:While the role of platelets in hemostasis is well characterized from a biological perspective, the biophysical interactions between platelets and their mechanical microenvironment are relatively unstudied. The field of cellular mechanics has developed a number of approaches to study the effects of extracellular matrix...

journal_title：Thrombosis research

authors： Ciciliano JC,Tran R,Sakurai Y,Lam WA

更新日期：2014-04-01 00:00:00

abstract：:Optimal conditions for a method to simultaneously measure aggregation in 96 samples using a microplate reader were developed. The temperature of the assay was set at 25 degrees C, the optimal platelet concentration range was determined to be from 1-3 x 10(8) per mL, the assay volume was determined to be best at 100 mi...

journal_title：Thrombosis research

authors： Bednar B,Condra C,Gould RJ,Connolly TM

更新日期：1995-03-01 00:00:00

abstract：:β(2)glycoprotein I (β(2)GPI) is the major antigen in the antiphospholipid syndrome. It has been shown that β(2)GPI can adapt to different conformations, a circular, a S-shaped and a J-shaped conformation. In literature anticoagulant properties of β(2)GPI have been indicated, though there is no consensus on how β(2)GPI...

journal_title：Thrombosis research

authors： Ninivaggi M,Kelchtermans H,Lindhout T,de Laat B

更新日期：2012-10-01 00:00:00

abstract：:The pharmacokinetics of a low molecular weight heparin (LMWH) with a mean mw of 4000-6000 D (KABI 2165, Fragmin) was studied in 6 healthy volunteers after intravenous (iv) and subcutaneous (sc) administration of 120 U (anti FXa)/kg. The half-life in plasma of the anti FXa activity after iv injection was 119 +/- 17 min...

journal_title：Thrombosis research

authors： Bratt G,Törnebohm E,Widlund L,Lockner D

更新日期：1986-06-01 00:00:00

abstract：OBJECTIVES:Screening of patients with sepsis for disseminated intravascular coagulation (DIC) has been recommended in several guidelines. However, DIC screening is still not widely accepted as an essential component of sepsis management, partly because of a lack of evidence that DIC screening has an effect on mortality...

journal_title：Thrombosis research

authors： Umemura Y,Yamakawa K,Hayakawa M,Hamasaki T,Fujimi S,Japan Septic Disseminated Intravascular Coagulation (J-Septic DIC) study group.

更新日期：2018-01-01 00:00:00

abstract：:Patients with active cancer have a heightened risk of venous thromboembolism (VTE). This risk is further increased by the initiation of chemotherapy. Although previous studies have suggested that the use of parenteral thromboprophylaxis in all ambulatory cancer patients receiving chemotherapy significantly decreases t...

journal_title：Thrombosis research

authors： Kimpton M,Wells PS,Carrier M

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Clinical parameters, biomarkers and imaging-based risk stratification are widely accepted in pulmonary embolism(PE). The present study has investigated the prognostic role of simplified Pulmonary Embolism Severity Index (sPESI) score and the European Society of Cardiology (ESC) model. METHODS:This prospecti...

journal_title：Thrombosis research

authors： Ozsu S,Ozlu T,Sentürk A,Uçar EY,Kırkıl G,Kadıoğlu EE,Altınsoy B,Saylan B,Selimoğlu HŞ,Dabak G,Tutar N,Uysal A,TUPEG Study Investigators.

更新日期：2014-06-01 00:00:00

abstract：:Annexin V is a human phospholipid binding protein (M(r) 36,000) that binds with high affinity to activated platelets in vitro. We studied the biodistribution and thrombus binding of annexin V in rabbit and swine models of fully occlusive arterial thrombi formed 1-2 h prior to injection of annexin V. Iodinated annexin ...

journal_title：Thrombosis research

authors： Tait JF,Cerqueira MD,Dewhurst TA,Fujikawa K,Ritchie JL,Stratton JR

更新日期：1994-09-01 00:00:00

abstract：INTRODUCTION:Previous studies have suggested the used of off-label recombinant factor VII (rFVIIa) increases the risk of thromboembolic events, but the effect of the dose of rFVIIa is not well described in the literature. MATERIALS AND METHODS:All adult patients that received off-label rFVIIa from 2005-2012 were inclu...

journal_title：Thrombosis research

authors： Bucklin MH,Acquisto NM,Nelson C

更新日期：2014-05-01 00:00:00

abstract：:Studies of the factors affecting the first recurrence of ischemic stroke have reported inconsistent findings. Types of initial stroke and the racial differences in study samples are among the explanations that may account for this inconsistency. The aims of this study were to estimate the cumulative recurrence rates o...

journal_title：Thrombosis research

authors： Wu TH,Chen HH,Lee TK

更新日期：2000-02-01 00:00:00

abstract：:The need for anticoagulation in dialysis patients is common and the incidence of venous thromboembolism (VTE) and atrial fibrillation in this population is high. While direct data are lacking on the management of anticoagulation in dialysis patients, careful weighing of risks and benefits on the basis of evidence from...

journal_title：Thrombosis research

authors： Lo DS,Rabbat CG,Clase CM

更新日期：2006-01-01 00:00:00

abstract：:The prevention of venous thromboembolism (VTE) in women with cancer requires special consideration. The presence of cancer results in both non-surgical and surgical patients having increased risk of VTE. This usually leads to a modification of the recommended preventive therapy, affecting the type, dose and length of ...

journal_title：Thrombosis research

authors： Cohen AT,Wills JO,Bharathi N,Solis JV

更新日期：2011-02-01 00:00:00

abstract：:Heparin and other antithrombotic drugs besides their anticoagulant action could have a profibrinolytic effect. We have analyzed the effect of unfractionated heparin (UFH) and hirudin on PAI-1 gene expression in human umbilical vein endothelial cells (HUVEC). Cells were stimulated with UFH (1 and 10 IU/ml) and hirudin ...

journal_title：Thrombosis research

authors： Orbe J,Montes R,Zabalegui N,Pérez-Ruiz A,Páramo JA

更新日期：1999-05-01 00:00:00