Postprocedural PAI-1 activity is a risk marker of subsequent clinical restenosis in patients both with and without stent implantation after elective balloon PTCA.

abstract：:Severe bleeding took place in a patient when abdominal aneurysm was removed by operation. Bleeding continued after infusion of heparin, antithrombin III (ATIII), fresh platelets and fresh blood. Infusion of tranexamic acid resulted in an immediate cessation of bleeding and improvement of his general condition. Sometim...

journal_title：Thrombosis research

authors： Takada A,Takada Y,Mori T,Sakaguchi S

更新日期：1990-04-15 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a lipid mediator generated by activated platelets and having various effects on numerous cell types. We investigated some effects of 1-oleyl LPA on vascular smooth muscle cells cultured from adult human normal arteries. At micromolar concentrations, LPA induced a mitogenic effect ([3H]-t...

journal_title：Thrombosis research

authors： Gennero I,Xuereb JM,Simon MF,Girolami JP,Bascands JL,Chap H,Boneu B,Sié P

更新日期：1999-06-01 00:00:00

abstract：:ZK-807834 (also known as CI-1031) is a small molecule that potently and selectively inhibits Factor Xa. Studies in animals have shown that ZK-807834 attenuates thrombosis and thrombus progression after fibrinolysis and exhibits an increased antithrombotic-to-bleeding risk ratio compared with conventional agents. The p...

journal_title：Thrombosis research

authors： Post JM,Sullivan ME,Abendschein D,Ewing J,Hinchman JW,Light DR

更新日期：2002-02-15 00:00:00

abstract：:Patients with protamine allergy present a difficult dilemma when reversal of heparin is required for excessive bleeding. Premedication with steroids and antihistamines has not been shown to effectively prevent anaphylactic reactions in patients with hypersensitivity to protamine. Other heparin antagonists are either n...

journal_title：Thrombosis research

authors： Sloand EM,Kessler CM,McIntosh CL,Klein HG

更新日期：1989-06-15 00:00:00

abstract：:The extrinsic pathway of coagulation is initiated when zymogen factor VII binds to its cell surface receptor tissue factor. Recently recombinant human tissue factor has become available and therefore in this study the direct binding of human factor VII in plasma to recombinant tissue factor was explored. Factor VII bi...

journal_title：Thrombosis research

authors： Sridhara S,Clarke BJ,Ofosu FA,High KA,Blajchman MA

更新日期：1993-05-15 00:00:00

abstract：:Acutely ill medical patients are at moderate to high risk of venous thromboembolism (VTE): approximately 10-30% of general medical patients may develop deep-vein thrombosis or pulmonary embolism, and the latter is a leading contributor to deaths in hospital. Medical conditions associated with a high risk of VTE includ...

journal_title：Thrombosis research

authors： Cohen AT,Nandini B,Wills JO,Ota S

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:Long-term dual antiplatelet therapy (DAPT) has substantially reduced the risk of post-percutaneous coronary intervention (PCI) myocardial infarction and stent thrombosis at the expense of major bleeding. We hypothesized that a short-term DAPT followed by extended P2Y12 inhibitor monotherapy might be approp...

journal_title：Thrombosis research

authors： Jin Y,Huang H,Shu X,Chen S,Lu L,Gao X,Wu Z

更新日期：2020-12-07 00:00:00

abstract：:Lipoprotein-associated coagulation inhibitor (LACI) is a plasma-derived protein that inhibits the tissue factor/factor VIIa/calcium/phospholipid complex in a factor Xa-dependent manner. Recombinant LACI (rLACI) added exogenously to plasma prolonged the activated partial thromboplastin time (APTT) and prothrombin time ...

journal_title：Thrombosis research

authors： Welsch DJ,Novotny WF,Wun TC

更新日期：1991-10-15 00:00:00

abstract：INTRODUCTION:Fibrin structure and cellular composition of thrombi profoundly affect the clinical outcomes in ischemic coronary and peripheral artery disease. Our study addressed the interrelations of structural features of thrombi and routinely measured laboratory parameters. MATERIALS AND METHODS:Thrombi removed by t...

journal_title：Thrombosis research

authors： Kovács A,Sótonyi P,Nagy AI,Tenekedjiev K,Wohner N,Komorowicz E,Kovács E,Nikolova N,Szabó L,Kovalszky I,Machovich R,Szelid Z,Becker D,Merkely B,Kolev K

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Systemic thrombolysis rapidly improves right ventricular (RV) dysfunction in patients with acute pulmonary embolism (PE) but is associated with major bleeding complications in up to 20%. The efficacy of low-dose, catheter-directed ultrasound-accelerated thrombolysis (USAT) on the reversal of RV dysfunction i...

journal_title：Thrombosis research

authors： Engelhardt TC,Taylor AJ,Simprini LA,Kucher N

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:Whether clinical prediction rules for pulmonary embolism are accepted and used among general internal medicine residents remains uncertain. We therefore evaluated the frequency of use and acceptability of the Revised Geneva Score (RGS) and the Pulmonary Embolism Severity Index (PESI), and explored which fa...

journal_title：Thrombosis research

authors： Faller N,Stalder O,Limacher A,Bassetti S,Beer JH,Genné D,Battegay E,Hayoz D,Leuppi J,Mueller B,Perrier A,Waeber G,Rodondi N,Aujesky D

更新日期：2017-12-01 00:00:00

abstract：:Pharmacovigilance is an essential element of any drug treatment and considering the history of adverse events due to products used to treat inherited bleeding disorders, it should be an integral component of modern haemophilia treatment. Because inherited bleeding disorders and adverse events are rare, a multicentre, ...

journal_title：Thrombosis research

authors： Makris M,Calizzani G,Fischer K,Gilman EA,Hay CR,Lassila R,Lambert T,Ludlam CA,Mannucci PM

更新日期：2011-01-01 00:00:00

abstract：:We studied the stability of three markers of coagulation (prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin III complexes (TAT), and soluble fibrin (SF)) in stored frozen plasma, in addition to one marker of fibrinolysis (total fibrinogen degradation products and fibrin degradation products (TDP)). All marker...

journal_title：Thrombosis research

authors： Iversen LH,Thorlacius-Ussing O

更新日期：1996-01-15 00:00:00

abstract：INTRODUCTION:Antiphospholipid syndrome (APS) is a pro-thrombotic autoimmune disease that affects different vascular beds, with potential risk for recurrence. Systemic lupus erythematosus (SLE), specific autoantibodies profile and atherogenic disorders have been described as risk factors for the occurrence of first thro...

journal_title：Thrombosis research

authors： Saraiva Sda S,Custódio IF,Mazetto Bde M,Collela MP,de Paula EV,Appenzeller S,Annichino-Bizzachi J,Orsi FA

更新日期：2015-12-01 00:00:00

abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...

journal_title：Thrombosis research

authors： Wesemann W,Hoffmann D

更新日期：1985-09-15 00:00:00

abstract：:Resveratrol (3, 4', 5-trihydroxystilbene), a natural polyphenol, is found in some plants that are used in human nutrition. Grapes are a major source for resveratrol, and a significant amount can also be found in red wine. Several experimental studies have demonstrated biological properties of resveratrol, especially i...

journal_title：Thrombosis research

authors： Olas B,Wachowicz B,Saluk-Juszczak J,Zieliński T

更新日期：2002-08-15 00:00:00

abstract：:Protein C (PC) is the central protein in a major antithrombotic regulatory mechanism. Hereditary deficiencies of PC are associated with thrombosis. Therapeutic PC replacement may be an important treatment if pure functional human protein C is available in sufficient quantity. Human PC has been produced on a commercial...

journal_title：Thrombosis research

authors： Madden RM,Oppenheimer C,Wydro R,Marlar RA

更新日期：1990-02-01 00:00:00

abstract：INTRODUCTION:Data on efficacy and safety of using low molecular weight heparin in cancer patients with catheter-related upper extremity deep vein thrombosis is scarce and the risk of recurrent venous thromboembolism after discontinuation of anticoagulation is unknown. MATERIAL AND METHODS:We conducted a retrospective ...

journal_title：Thrombosis research

authors： Delluc A,Le Gal G,Scarvelis D,Carrier M

更新日期：2015-02-01 00:00:00

abstract：:It has been suggested that unstable angina at rest, like acute myocardial infarction, might be associated with a thrombotic process. In order to study the hypothesis that myocardial ischemia during exercise could also be associated with an activation of blood coagulation and/or fibrinolysis, we investigated the presen...

journal_title：Thrombosis research

authors： Bounameaux H,Righetti A,de Moerloose P,Bongard O,Reber G

更新日期：1992-01-01 00:00:00

abstract：:Highly purified bovine von Willebrand protein (vWP) has been studied with two complementary techniques. Light scattering measurements on different samples give weight average molecular weights in the range from 7 to 13 million, radius of gyration between 75 and 140 nm and diffusion coefficient near 4.15 X 10(-8) cm2/s...

journal_title：Thrombosis research

authors： Binnie C,Wagner RH,Cooper H,Hermans J

更新日期：1985-11-15 00:00:00

abstract：:Hemorrhagic and thrombotic complications are common in the term and preterm infant. Limited information is currently available about neonatal platelet structure and function, and how these may predispose infants to bleeding problems. This study comparing platelet ultrastructure of 71 different term and preterm infants...

journal_title：Thrombosis research

authors： Saving KL,Jennings DE,Aldag JC,Caughey RC

更新日期：1994-03-15 00:00:00

abstract：:The thrombolytic efficacy of recombinant tissue-type plasminogen activator (tPA) in the presence and absence of a thromboxane synthase inhibitor was studied in a model of femoral artery thrombosis in the anesthetized rabbit. The thrombus was formed by injection of thrombin and whole blood into an isolated segment of t...

journal_title：Thrombosis research

authors： Shebuski RJ,Storer BL,Fujita T

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:The immediate administration of oral antiplatelet therapy in the form of aspirin plus a P2Y12 inhibitor is the universally recognised standard of care for patients who present with acute myocardial infarction. Despite strong recommendations for their use, there are a paucity of data describing their onset of...

journal_title：Thrombosis research

authors： Khan N,Cox AR,Cotton JM

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:This study aimed to determine the risk factors for subclinical umbilical catheter-related thrombosis (UCRT) and its association with clinical morbidities. MATERIALS AND METHODS:In infants without any symptoms associated with umbilical catheterization, the presence of thrombosis was monitored using abdomin...

journal_title：Thrombosis research

authors： Hwang JH,Chung ML,Lim YJ

更新日期：2020-10-01 00:00:00

abstract：:Atherothrombosis is the leading cause of morbidity and mortality in patients with diabetes mellitus. Several mechanisms contribute to the diabetic prothrombotic state, including endothelial dysfunction, coagulative activation and platelet hyper-reactivity. In particular, diabetic platelets are characterised by dysregu...

journal_title：Thrombosis research

authors： Vazzana N,Ranalli P,Cuccurullo C,Davì G

更新日期：2012-03-01 00:00:00

abstract：:Mild hyperhomocysteinemia is recognized as a risk factor for venous thromboembolism (VTE), though its role in the thrombogenic processes is not understood. Its possible association with impaired fibrinolysis was investigated in 157 patients (61 women, 96 men) below the age of 60 years (43+/-11, mean+/-SD) with a histo...

journal_title：Thrombosis research

authors： Bozic M,Stegnar M,Fermo I,Ritonja A,Peternel P,Stare J,D'Angelo A

更新日期：2000-11-15 00:00:00

abstract：:Thrombus formation was electrically induced in the left common carotid artery of rats with preoccluded both vertebral and right carotid arteries. Following thrombus induction, animals became unresponsive and lost their righting reflex. The loss of righting reflex was observed when cortical tissular pO2 reached 55 +/- ...

journal_title：Thrombosis research

authors： Massad L,Plotkine M,Capdeville C,Boulu RG

更新日期：1987-10-01 00:00:00

abstract：:Human platelets synthesize nitric oxide (NO) through an endothelial-type NO synthase (ecNOS) activated also by substances enhancing 3',5'-cyclic adenosine monophosphate (cAMP) concentrations, such as catecholamines, beta-adrenoceptor agonists and adenosine. To verify whether cAMP directly activates ecNOS through the c...

journal_title：Thrombosis research

authors： Russo I,Doronzo G,Mattiello L,De Salve A,Trovati M,Anfossi G

更新日期：2004-01-01 00:00:00

abstract：:Anticoagulant fucoidan fractions of different molecular weight and sulfate content were prepared and investigated for their effects on platelet function in vitro. The fucoidan fractions were incubated with human platelet rich plasma (PRP) at concentrations of 5, 10 and 50 micrograms/ml. Platelet activation was subsequ...

journal_title：Thrombosis research

authors： Dürig J,Bruhn T,Zurborn KH,Gutensohn K,Bruhn HD,Béress L

更新日期：1997-03-15 00:00:00

abstract：INTRODUCTION:Unicompartmental knee arthroplasty (UKA) has increased due to potential favourable complication rates when compared to total knee arthroplasty (TKA). Although venous thromboembolism (VTE) is a well-documented complication after TKA limited data is available after UKA and mostly presented as secondary findi...

journal_title：Thrombosis research

authors： Petersen PB,Jørgensen CC,Gromov K,Kehlet H,Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement Collaborative Group.

更新日期：2020-11-01 00:00:00