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P2Y12 inhibitor monotherapy and dual antiplatelet therapy after percutaneous coronary intervention: An updated meta-analysis of randomized trials.

Abstract：

INTRODUCTION:Long-term dual antiplatelet therapy (DAPT) has substantially reduced the risk of post-percutaneous coronary intervention (PCI) myocardial infarction and stent thrombosis at the expense of major bleeding. We hypothesized that a short-term DAPT followed by extended P2Y12 inhibitor monotherapy might be appropriate for patients with both high ischemic and bleeding risks. MATERIALS AND METHODS:We searched the databases: Pubmed, EMBASE, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov to identify randomized trials assessing the antiplatelet strategies after PCI. The primary safety endpoint was Bleeding Academic Research Consortium (BARC) type 3 or 5 bleeding. The efficacy outcome was a composite of all-cause mortality/cardiovascular disease (CVD) death, myocardial infarction, or stroke. A random-effect model was used to calculate the pooled hazard ratios (HRs) with 95% confidence intervals (CIs). RESULTS:We identified 5 randomized trials comparing P2Y12 inhibitor monotherapy with standard DAPT (12 months) (16,057 versus 16,088). P2Y12 inhibitor monotherapy following short-term DAPT (1 to 3 months) significantly reduced the risk of BARC type 3 or 5 bleeding compared to standard DAPT (pooled HR: 0.63, 95%CI: 0.46-0.86). The difference between P2Y12 inhibitor monotherapy and standard DAPT in reducing the composite CVD outcomes was not statistically significant (HR: 0.88, 95%CI: 0.77-1.01). CONCLUSIONS:P2Y12 inhibitor monotherapy might be an effective strategy for lowering severe bleeding complications and simultaneously preserving the ischemic benefit in patients receiving PCI.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Jin Y,Huang H,Shu X,Chen S,Lu L,Gao X,Wu Z

doi

10.1016/j.thromres.2020.11.038

subject

Has Abstract

pub_date

2020-12-07 00:00:00

pages

115-121

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(20)30646-0

journal_volume

198

pub_type

杂志文章

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