Abstract：
INTRODUCTION:Portal vein thrombosis (PVT) is a well-known complication in patients with liver cirrhosis (LC). The aim of this study is to investigate the outcomes of cirrhotic patients with PVT treated with low-molecular-weight heparin (LMWH). METHOD:Ninety-one LC patients with PVT were treated with dalteparin or enoxaparin for six months. Patients with major bleeding during the last three months, severe thrombocytopenia, or impaired renal function were excluded. RESULTS:The median age was 62.9 years, and 59 patients had hepatocellular carcinoma. The overall recanalization rate was 61.5%. Patients with a favorable Child-Pugh class and those recently diagnosed as having a thrombus showed significantly better responses. In those who responded to the anticoagulation therapy, the post-treatment bilirubin and platelet levels were improved compared to those in the pre-treatment state. The relapse rate for PVT was 56.6%, and the median time to relapse was 4.0 months. Bleeding was reported in 13 patients (14.4%), and two patients died due to fatal bleeding. A history of variceal bleeding and low serum albumin were risk factors for bleeding. CONCLUSION:LMWH therapy for PVT in LC is effective. Advanced LC and a delayed start of anticoagulation treatment decrease the effect of LMWH. Despite its effectiveness, there is a risk of hemorrhage, hence anticoagulation should be carefully considered, especially in patients with advanced LC and a history of variceal bleeding.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Kwon J,Koh Y,Yu SJ,Yoon JHdoi
10.1016/j.thromres.2018.01.032subject
Has Abstractpub_date
2018-03-01 00:00:00pages
71-76eissn
0049-3848issn
1879-2472pii
S0049-3848(18)30041-0journal_volume
163pub_type
杂志文章abstract：:The candidate-gene approach can be used to locate and identify genetic variations that are associated with a particular phenotype. This gene-centric approach assumes that there exists important genetic variation within genes that can influence health. Identifying known genes which are candidates for the phenotype of i...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/S0049-3848(09)70139-2
更新日期：2009-01-01 00:00:00
abstract：:The placenta is the highly specialised organ of pregnancy that supports the normal growth and development of the fetus. Growth and function of the placenta are precisely regulated and coordinated to ensure the exchange of nutrients and waste products between the maternal and fetal circulatory systems operates at maxim...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2004.06.038
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:Only sparse information exists on the use of direct oral anticoagulant (DOAC) testing and the impact on clinical management. Here, we evaluated the clinical impact of DOAC measurements in a real-life clinical setting. Moreover, number of tests performed in relation to number of DOAC-treated patients was ev...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2019.01.016
更新日期：2019-03-01 00:00:00
abstract：:The three polypeptide chains of fibrinogen, A alpha, B beta and gamma chain, are synthesized on separate polysomes. Fully formed fibrinogen is a six chain, disulfide-linked, dimeric molecule with a molecular weight of 340kDa. Previous pulse-chase studies with L-35 S methionine using the human hepatocellular carcinoma ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90290-8
更新日期：1987-04-15 00:00:00
abstract：INTRODUCTION:Unfractionated heparin (UFH) does not cross the placenta and has demonstrated utility in the prevention and treatment of thrombosis during pregnancy. Limited information is available to guide initiation and monitoring of therapeutic UFH targeting an anti-Xa concentration of 0.3-0.7 u/ml during pregnancy. T...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2009.07.014
更新日期：2010-05-01 00:00:00
abstract：:In this study we examined in 100 patients testing positive for Helicobacter pylori infection whether successful eradication therapy with pantoprazole, clarithromycin, and metronidazole alters fibrinogen and other acute phase response markers. Of 100 patients, only 11 showed a fibrinogen level above 300 mg/dL. Successf...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(99)00230-3
更新日期：2000-03-15 00:00:00
abstract：:Studies with animal models implicate the plasma proteases factor XIIa (FXIIa) and α-kallikrein in arterial and venous thrombosis. As congenital deficiencies of factor XII (FXII) or prekallikrein (PK), the zymogens of FXIIa and α-kallikrein respectively, do not cause bleeding disorders, inhibition of these enzymes may ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2016.02.020
更新日期：2016-04-01 00:00:00
abstract：INTRODUCTION:Sepsis is frequently complicated by disseminated intravascular coagulation (DIC), which promotes multiple organ dysfunctions and significantly increase the mortality of patients with sepsis. How bacteria cause DIC is not fully understood. Outer membrane vesicles (OMVs) are membrane-enclosed microvesicles r...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2019.03.019
更新日期：2019-06-01 00:00:00
abstract：:Heparin is known to exert its antithrombotic effects by accelerating the effect of antithrombin (AT) and by mobilizing tissue factor pathway inhibitor (TFPI) into the circulation from vascular endothelium. Heparin treatment has been reported to decrease FVIIa activity by 40%; this was suggested as a new antithrombotic...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(00)00343-1
更新日期：2000-12-01 00:00:00
abstract：:The reunification of Germany in 1990 brought with it major challenges in terms of unifying the care offered to haemophilia patients. At that time, most of the treatment centres belonged to the largest regional hospitals. The centre for paediatric haemophilia patients in Leipzig was at the University Hospital. In this ...
journal_title：Thrombosis research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.thromres.2013.10.018
更新日期：2014-11-01 00:00:00
abstract：INTRODUCTION:Dabigatran (Dabi) is not routinely monitored. However, in emergency cases quantitative assessment is required and laboratories must provide suitable tests at all hours. Little is known about Dabi effects on thrombin generation. MATERIALS AND METHODS:Patient samples (n=241) were analyzed for functional Dab...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.04.032
更新日期：2015-07-01 00:00:00
abstract：:This study compares selected properties of purified tryptic fragments of human von Willebrand (vW) protein in order to better understand how the M(r) 116,000 fragment retains activity in ristocetin-induced platelet agglutination. Wheat germ agglutinin (WGA) aggregation of platelet-rich plasma was potentiated by preinc...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(83)90408-5
更新日期：1983-08-01 00:00:00
abstract：BACKGROUND:Thrombosis and complement activation are pathogenic features of antiphospholipid syndrome (APS). Their molecular link is Plasma carboxypeptidase-B, also known as thrombin activatable fibrinolysis inhibitor (TAFIa), which plays a dual role: anti-fibrinolytic, by cleaving carboxyl-terminal lysine residues from...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2017.06.028
更新日期：2017-10-01 00:00:00
abstract：:It is known that a low-molecular-weight heparin (LMWH) is more effective than unfractionated heparin in unstable angina/non-Q-wave myocardial infarction (UA/NQMI) and the platelet GPIIb/IIIa receptors play an important role in acute myocardial infarction (AMI). Therefore, enoxaparin might have a similar advantage over...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(01)00242-0
更新日期：2001-05-01 00:00:00
abstract：:We purified the urinary procoagulant from frozen human urine by introducing phenyl-Sepharose hydrophobic chromatography. By this method, the apoprotein of the procoagulant and the lipid-like substance were separately recovered. Upon reassociation with the lipid-like substance or exogenous crude phospholipids, the apop...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(84)90114-2
更新日期：1984-03-15 00:00:00
abstract：BACKGROUND:Direct oral anticoagulants (DOACs) are high risk medications with short half-lives making adherence vitally important. Global measures for adherence have been described; however, there is a lack of patient-level data on adherence. METHODS:This prospective, single-center study in an interdisciplinary interna...
journal_title：Thrombosis research
pub_type： 信件
doi：10.1016/j.thromres.2019.04.021
更新日期：2019-07-01 00:00:00
abstract：:Previous studies have indicated that the skin bleeding time test does not accurately reflect visceral bleeding time (BT). The present study examines the predictive value of the skin bleeding time for brain bleeding tendency. Sixteen Sprague-Dawley rats were divided into equal groups. The first group (controls) underwe...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(94)90282-8
更新日期：1994-12-15 00:00:00
abstract：:Clot lysis induced by streptokinase has been studied and the influences of pH and the concentrations of plasminogen, fibrinogen and buffer composition investigated. Variations in the concentrations of plasminogen strongly effect the SK apparent activity, maxima being obtained at different plasminogen concentrations li...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(91)90071-4
更新日期：1991-12-15 00:00:00
abstract：INTRODUCTION:High RDW values are associated with adverse prognosis in many clinical conditions including short and medium term outcome of patients with ST Elevation Myocardial Infarction (STEMI). The aim of the present study was to evaluate the association between RDW and long term mortality in STEMI patients undergoin...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2014.08.016
更新日期：2014-11-01 00:00:00
abstract：:The antithrombotic effect of a synthetic symmetrical triglyceride having eicosapentaenoic acid (EPA) at positions 1 and 3, and gamma-linolenic acid (GLA) at position 2 was investigated. Administration of the triglyceride significantly increased thrombus formation time and thrombotic occlusion time induced by light irr...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(95)99610-k
更新日期：1995-06-01 00:00:00
abstract：:ZK-807834 (also known as CI-1031) is a small molecule that potently and selectively inhibits Factor Xa. Studies in animals have shown that ZK-807834 attenuates thrombosis and thrombus progression after fibrinolysis and exhibits an increased antithrombotic-to-bleeding risk ratio compared with conventional agents. The p...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(02)00024-5
更新日期：2002-02-15 00:00:00
abstract：BACKGROUND:The treatment of venous thromboembolism (VTE) in cancer patients remains controversial. PURPOSE:The Italian Society for Thrombosis and Haemostasis (SISET) commissioned a project to develop clinical practice guidelines for the therapy of VTE in patients with malignancies. METHODS:Key questions about the tre...
journal_title：Thrombosis research
pub_type： 杂志文章,实务指引
doi：10.1016/j.thromres.2009.08.006
更新日期：2009-11-01 00:00:00
abstract：INTRODUCTION:Inherited thrombophilia has been associated with unexplained recurrent pregnancy loss (RPL) and stillbirth. This thrombotic tendency can manifest as thrombotic lesions in the placenta, and may lead to abortion and stillbirth. The aim of our case-control study was to investigate the prevalence of FVL and FI...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2005.06.005
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Minimizing bleeding and transfusion is desirable given its cost, complexity and potential for adverse events. Concerns have been heightened by recent data demonstrating that bleeding events may predict worse outcomes and by warnings about the safety of erythropoietic stimulating agents. Prior small studies s...
journal_title：Thrombosis research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.thromres.2008.09.015
更新日期：2009-03-01 00:00:00
abstract：:The purpose of this study was to determine if the results obtained in platelet function tests and whole blood perfusions are associated with those in platelet function analyser (PFA)-100. We used collagen type I monomers and fibrils to analyse the distinct roles of glycoprotein (GP) Ia/IIa and other collagen receptors...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(01)00283-3
更新日期：2001-07-15 00:00:00
abstract：:Hemophilia patients with inhibitors against FVIII/FIX present with a major challenge in the clinical practice. In the 1970s such patients were treated in association with emergency situations and essential surgery using huge amounts of FVIII/FIX concentrates often preceded by extracorporal adsorption of antibodies aga...
journal_title：Thrombosis research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.thromres.2010.01.021
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND AND AIM:Recent studies have documented that elevation of C-reactive protein (CRP) levels after percutaneous coronary intervention (PCI) have been predictive of adverse outcome. This study was performed to test the hypothesis that preprocedural use of naproxen sodium is associated with a reduction in the exte...
journal_title：Thrombosis research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.thromres.2006.11.003
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND/AIMS:The plasminogen activator (PA)-plasmin system is primarily involved in fibrinolysis, but is also in the patho/physiological events in which breakdown of extracellular matrices is evoked topically. In this present study, we examined the expression of fibrinolytic factors, tissue-type PA (t-PA) and Type 1...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(01)00370-x
更新日期：2001-11-15 00:00:00
abstract：:Blood platelets have recently been shown to express PYK2, a nonreceptor tyrosine kinase belonging to the FAK gene family. In this study, we examined the involvement of protein kinase C (PKC) in PYK2-related responses in human platelets. While PYK2 tyrosine phosphorylation induced by thrombin was inhibited by preincuba...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(98)00188-1
更新日期：1999-03-15 00:00:00
abstract：:Use of low molecular weight heparins (LMWHs) is now generally accepted as an ideal method of prophylaxis against postoperative venous thromboembolism. However, the long-term effects on the development of postthrombotic deep vein insufficiency are not known. Every patient developing such complications consumes a vast a...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/0049-3848(95)00232-4
更新日期：1996-01-01 00:00:00
