Endogenous forms of fibrinogen in Hep G2 cells.

abstract：:To investigate the effects of new drugs on the prevention of venous thrombosis, the Wessler stasis model is extensively employed usually in the rabbit. In this model, a hypercoagulable state is achieved by the administration of either heterologous serum (often human serum) or an activated coagulation factor followed b...

journal_title：Thrombosis research

authors： Millet J,Vaillot M,Theveniaux J,Brown NL

更新日期：1996-02-15 00:00:00

abstract：INTRODUCTION:In contrast to unfractionated heparin (UFH), use of low-molecular weight heparin (LMWH) during pregnancy has not been reported to be associated with a significant decrease in bone mineral density (BMD). The aim of this study was to investigate whether long-term use of LMWH during pregnancy is associated wi...

journal_title：Thrombosis research

authors： Galambosi P,Hiilesmaa V,Ulander VM,Laitinen L,Tiitinen A,Kaaja R

更新日期：2016-07-01 00:00:00

abstract：:The extrinsic fibrinolytic system was assessed among 124 consecutive survivors of acute myocardial infarction below 70 years of age. In samples drawn 3 months after discharge from hospital, the PAI-1 levels were higher and the tPA activities were lower than among elderly healthy controls. In contrast, the AMI survivor...

journal_title：Thrombosis research

authors： Nilsson TK,Johnson O

更新日期：1987-12-15 00:00:00

abstract：:The zymogen form of circulating Factor VII activating protease (FSAP) is activated by histones that are released as a consequence of tissue damage or excessive inflammation. This is likely to have consequences in a number of disease conditions such as stroke, atherosclerosis, liver fibrosis, thrombosis and cancer. To ...

journal_title：Thrombosis research

authors： Rut W,Nielsen NV,Czarna J,Poreba M,Kanse SM,Drag M

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Diabetes mellitus is characterised by hyperglycaemia that plays an important role in the pathogenesis of diabetic complications including accumulation of methylglyoxal (MG), a highly reactive alpha-dicarbonyl metabolite of glucose degradation pathways and increased generation of advanced glycation end prod...

journal_title：Thrombosis research

authors： Gawlowski T,Stratmann B,Stirban AO,Negrean M,Tschoepe D

更新日期：2007-01-01 00:00:00

abstract：:The multiligand receptor, low density lipoprotein receptor-related protein (LRP), is implicated in processes such as atherosclerosis and fibrinolysis through its mediation of the catabolism of lipoproteins, proteases, and protease inhibitor complexes. The hepatoma cell line Hep G2 expresses LRP and has been used widel...

journal_title：Thrombosis research

authors： Grimsley PG,Quinn KA,Chesterman CN,Owensby DA

更新日期：1997-12-15 00:00:00

abstract：:Enzymatic treatment used for passaging of endothelial cells may induce release of von Willebrand factor (vWF). Decreased ability to replenish intracellular stores results in decreased secretion of vWF in later passages of cells. Since both trypsin and pancreatin complex have been used for passaging endothelial cells, ...

journal_title：Thrombosis research

authors： Lopes AA,Peranovich TM,Maeda NY,Bydlowski SP

更新日期：2001-02-15 00:00:00

abstract：:To characterize the putative biochemical modifications induced by the Ser 460 to Pro (Heerlen) mutation in protein S (PS), we expressed both wild-type (wt) and mutated recombinant PS in HEK cells. In SDS-polyacrylamide gels, r-PS Heerlen migrated at 71 kDa whereas r-wt PS migrated at 73 kDa, a difference abolished aft...

journal_title：Thrombosis research

authors： Morboeuf O,Borgel D,Aiach M,Kaabache T,Gandrille S,Gaussem P

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Impaired endothelial-dependent flow-mediated dilatation (FMD) has been used to demonstrate endothelial dysfunction in a wide variety of cardiovascular disease, but previous studies have excluded patients with atrial fibrillation(AF). We therefore hypothesised that endothelial dysfunction exists in AF and tha...

journal_title：Thrombosis research

authors： Freestone B,Chong AY,Nuttall S,Lip GY

更新日期：2008-01-01 00:00:00

abstract：:The anticoagulant properties of myxalin, a glycopeptide secreted by a Gram negative bacterium strain (Myxococcus xanthus) are studied and compared to those of heparin. This soluble material exhibits an anticoagulant activity which implies the inhibition of some serine proteases, thrombin and factor Xa. In the presence...

journal_title：Thrombosis research

authors： Akoum A,Josefonvicz J,Sigot M

更新日期：1990-10-01 00:00:00

abstract：:Platelet alpha adrenoceptor status was examined using the radioligands 3H-yohimbine (3H-YOH) and 3H-dihydroergocryptine (3H-DHE) in 14 patients with myeloproliferative disorder (MPD) and 10 normal controls. Platelets from normal controls and MPD patients sensitive to adrenaline induced aggregation exhibited approximat...

journal_title：Thrombosis research

authors： Swart SS,Wood JK,Barnett DB

更新日期：1985-12-01 00:00:00

abstract：:To compare Canola a terrestrial (n-3) oil with fish oil (n-3) and common vegetable oil (n-6) in decreasing serum lipids and platelet aggregation, various oils were included in Chow-based diets and fed to rats in an eight-weeks feeding trial. The Chow diet contained 2% cholesterol along with either Canola, menhaden, sa...

journal_title：Thrombosis research

authors： Watkins T,Lenz P,Bierenbaum M

更新日期：1990-08-01 00:00:00

abstract：INTRODUCTION:Randomized clinical trials have demonstrated non-inferiority of rivaroxaban compared with vitamin K antagonists (VKAs) in the treatment of venous thromboembolism (VTE). Our objective was to analyze in real life, tolerance, recurrence, bleeding and adverse events of rivaroxaban in patients with acute sympto...

journal_title：Thrombosis research

authors： Jara-Palomares L,Sanchez-Oro-Gomez R,Elias-Hernandez T,Morillo-Guerrero R,Ferrer-Galvan M,Asensio-Cruz MI,Barrot-Cortes E,Otero-Candelera R

更新日期：2014-09-01 00:00:00

abstract：:Plasma homocysteine levels result from the effect of genetic and environmental factors. We investigated the hypothesis of familial association between folates, methylenetetrahydrofolate reductase (MTHFR) and hyperhomocysteinemia with acute events, studying three families through pedigree analysis and log-linear graphi...

journal_title：Thrombosis research

authors： Assanelli D,Grassi M,Bonanome A,Salvadori G,Bonetti P,Boldini A,Archetti S,Ruggeri G,Pezzini A,Pagnan A

更新日期：2002-01-15 00:00:00

abstract：INTRODUCTION:Genetic and autoimmune risk factors contribute to the development of thrombotic thrombocytopenic purpura (TTP) but triggers are needed to bring about acute disease. The aim of the study was to investigate the association of neutrophil activation with acute TTP, to assess whether neutrophil activation chang...

journal_title：Thrombosis research

authors： Mikes B,Sinkovits G,Farkas P,Csuka D,Schlammadinger A,Rázsó K,Demeter J,Domján G,Réti M,Prohászka Z

更新日期：2014-04-01 00:00:00

abstract：:Annexin V is a human phospholipid binding protein (M(r) 36,000) that binds with high affinity to activated platelets in vitro. We studied the biodistribution and thrombus binding of annexin V in rabbit and swine models of fully occlusive arterial thrombi formed 1-2 h prior to injection of annexin V. Iodinated annexin ...

journal_title：Thrombosis research

authors： Tait JF,Cerqueira MD,Dewhurst TA,Fujikawa K,Ritchie JL,Stratton JR

更新日期：1994-09-01 00:00:00

abstract：INTRODUCTION:The TF-FVIIa complex is the primary activator of coagulation. Elevated levels of microvesicle (MV) bearing tissue factor (TF)-dependent procoagulant activity are detectable in patients with an increased risk of thrombosis. Several methods have been described to measure MV TF activity but they are hampered ...

journal_title：Thrombosis research

authors： Vallier L,Bouriche T,Bonifay A,Judicone C,Bez J,Franco C,Guervilly C,Hisada Y,Mackman N,Houston R,Poncelet P,Dignat-George F,Lacroix R

更新日期：2019-10-01 00:00:00

abstract：:Generation of active Factor XII (FXIIa) triggers blood clotting on artificial surfaces and may also enhance intravascular thrombosis. We developed a patterned kaolin (0 to 0.3 pg/μm(2))/type 1 collagen fibril surface for controlled microfluidic clotting assays. Perfusion of whole blood (treated only with a low level o...

journal_title：Thrombosis research

authors： Zhu S,Diamond SL

更新日期：2014-12-01 00:00:00

abstract：:The in vitro and in vivo pharmacological properties of two oversulfated dermatan sulfate (DS) derivatives, S-DS1 and S-DS2, containing 2 and 3.7 sulfate groups/disaccharide unit respectively were compared to those of the parent DS (1 sulfate group/disaccharide unit). In a purified system the ability of S-DS1 and of S-...

journal_title：Thrombosis research

authors： Dol F,Caranobe C,Dupouy D,Petitou M,Lormeau JC,Choay J,Sié P,Boneu B

更新日期：1988-10-15 00:00:00

abstract：:PAF (1 ug/kg) injected intravenously (i.v.) into anesthetized rabbits resulted in marked loss of circulating platelets and leukocytes. Administration of FR-900452 1-methyl-3-(1-(5-methylthiomethyl-6-oxo-3-(2-oxo-3-cyclopenten-1-y lidene)- 2-piperazinyl) ethyl)-2-indolinone, a specific PAF inhibitor, at a dose of 10 mg...

journal_title：Thrombosis research

authors： Okamoto M,Yoshida K,Nishikawa M,Kohsaka M,Aoki H

更新日期：1986-06-01 00:00:00

abstract：:Previous studies indicated that human placental anticoagulant protein, a member of the lipocortin family, prolonged the clotting time of normal plasma when clotting was induced by brain thromboplastin or by kaolin in the presence of cephalin and calcium. Using a two-stage amidolytic assay to assess factor X activation...

journal_title：Thrombosis research

authors： Kondo S,Noguchi M,Funakoshi T,Fujikawa K,Kisiel W

更新日期：1987-11-15 00:00:00

abstract：:The susceptibility of von Willebrand factor /vWF/ to digestion by human neutrophil cathepsin G in highly purified FVIII/vWF concentrate /BHS/ and in cryoprecipitate has been studied. In contrast to human neutrophil elastase, cathepsin G inactivates and degrades vWF not only in BHS but also in cryoprecipitate. Fibrinog...

journal_title：Thrombosis research

authors： Jeleńska M,Kopeć M,Sopata I,Vigh Z,Scharrer I,Breddin K

更新日期：1991-02-15 00:00:00

abstract：INTRODUCTION:Monocyte- and microparticle (MP)-associated tissue factor (TF) is upregulated in diabetes. Lipopolysaccharide (LPS) induces expression of TF and alternatively spliced TF (asTF) and increases MP release from monocytes. Using LPS-stimulated TF-bearing human monocytes, we examined whether glibenclamide, a sul...

journal_title：Thrombosis research

authors： Henriksson CE,Hellum M,Haug KB,Aass HC,Joø GB,Øvstebø R,Trøseid AM,Klingenberg O,Kierulf P

更新日期：2011-11-01 00:00:00

abstract：:Concentration-response relationships of human platelet aggregation rates were analyzed for a variety of agonists and inhibitors. Their approximation by the Hill equation showed that the values of the Hill coefficient (h) were agonist-dependent and increased as follows: hADP = hL-EPINEPHRINE = hPAF = hPGH2 = hU46619 le...

journal_title：Thrombosis research

authors： Vrzheshch PV,Tatarintsev AV,Yershov DE,Varfolomeyev SD

更新日期：1992-06-01 00:00:00

abstract：:Collagen-induced platelet aggregation and secretion (ATP-release) in whole-blood and platelet-rich plasma was compared. Although the amount of ATP released was comparable in whole-blood and platelet-rich plasma, the maximum extent of aggregation was greater when platelets were studied in their natural milieu, i.e. who...

journal_title：Thrombosis research

authors： Joseph R,Welch KM,D'Andrea G,Riddle JM

更新日期：1989-03-01 00:00:00

abstract：:Indirect genetic diagnosis using polymorphic DNA markers can be useful in large-scale screening programs, which is technically simpler, more rapid and amenable. The main objective of this study was to test the informativeness of two common intragenic markers (TaqI and XmnI) in Iranian haemophilia B families to detect ...

journal_title：Thrombosis research

authors： Ghandil P,Ghadiri A,Farhud D,Zeinali S

更新日期：2004-01-01 00:00:00

abstract：:Activated platelets may adhere to leukocytes and form circulating mixed aggregates. The latter are considered a reliable marker of a prothrombotic state and are associated with several cardiovascular conditions. The molecular mechanisms responsible of this cellular interaction include a central role of platelet P-sele...

journal_title：Thrombosis research

authors： Cerletti C,Tamburrelli C,Izzi B,Gianfagna F,de Gaetano G

更新日期：2012-03-01 00:00:00

abstract：:Thrombus formation was electrically induced in the left common carotid artery of rats with preoccluded both vertebral and right carotid arteries. Following thrombus induction, animals became unresponsive and lost their righting reflex. The loss of righting reflex was observed when cortical tissular pO2 reached 55 +/- ...

journal_title：Thrombosis research

authors： Massad L,Plotkine M,Capdeville C,Boulu RG

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:The level of platelet reactivity (PR) inhibition obtained after P2Y12-ADP receptor antagonist loading dose (LD) is associated with the ischemic and bleeding risk following percutaneous coronary intervention (PCI) in acute coronary syndromes (ACS). OBJECTIVE:We aimed to evaluate the level of PR inhibition ac...

journal_title：Thrombosis research

authors： Laine M,Toesca R,Berbis J,Frere C,Barnay P,Pansieri M,Peyre JP,Michelet P,Bessereau J,Camilleri E,Helaf O,Camaleonte M,Paganelli F,Dignat-George F,Bonello L

更新日期：2013-07-01 00:00:00

abstract：INTRODUCTION:Warfarin is the most widely prescribed vitamin K antagonist and in the United States and Europe more than 10 million people are currently in long-term oral anticoagulant treatment. This study aims to retrospectively validate a dynamic statistical model providing dosage suggestions to patients in warfarin t...

journal_title：Thrombosis research

authors： Nielsen PB,Lundbye-Christensen S,Rasmussen LH,Larsen TB

更新日期：2014-03-01 00:00:00