当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Rivaroxaban for the treatment of venous thromboembolism. A "real-life" perspective in 103 patients.

Rivaroxaban for the treatment of venous thromboembolism. A "real-life" perspective in 103 patients.

Abstract：

INTRODUCTION:Randomized clinical trials have demonstrated non-inferiority of rivaroxaban compared with vitamin K antagonists (VKAs) in the treatment of venous thromboembolism (VTE). Our objective was to analyze in real life, tolerance, recurrence, bleeding and adverse events of rivaroxaban in patients with acute symptomatic VTE. MATERIAL AND METHODS:Open follow-up study of a cohort of patients aged 18 and over diagnosed with deep vein thrombosis (DVT) and/or pulmonary embolism (PE) treated with rivaroxaban from December 2011 to January 2014. RESULTS:The total number of patients treated with rivaroxaban was 103. The mean age was 58+/-17 years. The most frequent co-morbidities were: hypertension (30.0%), dyslipidemia (23.3%) and respiratory disease (25.2%). The type of thromboembolic event treated was: DVT (64.1%), PE (18.4%), DVT+PE (17.5%). Of the rivaroxaban-treated patients, 30% did so from the initial anticoagulant therapy and the other 70% in long-term or extended anticoagulant therapy. The median time of treatment with rivaroxaban was 6 months [corrected]. There was one recurrence and no deaths occurred. Six patients had bleeding, one of which was severe. CONCLUSIONS:Rivaroxaban provides a therapeutic alternative in a group of patients with VTE with advantages over VKAs, because of the convenience in dosing, lack of requirements for periodic monitoring and limited interaction with other drugs.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Jara-Palomares L,Sanchez-Oro-Gomez R,Elias-Hernandez T,Morillo-Guerrero R,Ferrer-Galvan M,Asensio-Cruz MI,Barrot-Cortes E,Otero-Candelera R

doi

10.1016/j.thromres.2014.06.032

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

617-21

issue

3

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(14)00358-2

journal_volume

134

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • Murine models of vascular endothelial injury: Techniques and pathophysiology.

    abstract：:Vascular endothelial injury (VEI) triggers pathological processes in various cardiovascular diseases, such as coronary heart disease and hypertension. To further elucidate the in vivo pathological mechanisms of VEI, many animal models have been established. For the easiness of genetic manipulation and feeding, murine ...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2018.07.014

    authors： Wu Y,Su SA,Xie Y,Shen J,Zhu W,Xiang M

    更新日期：2018-09-01 00:00:00

  • The spectrum of thrombin in acute coronary syndromes.

    abstract：:The role of thrombin in vascular physiology and pathophysiology continues to impact our understanding of many cellular processes and systems including the function of platelets, endothelial cells, smooth muscle cells, leukocytes and the regulation of the coagulation cascade. Recent acute coronary syndrome clinical tri...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2015.02.013

    authors： Giri S,Jennings LK

    更新日期：2015-05-01 00:00:00

  • Fibrinogen and red blood cells in venous thrombosis.

    abstract：:Deep vein thrombosis and pulmonary embolism, collectively termed venous thromboembolism (VTE), affect over 1 million Americans each year. VTE is triggered by inflammation and blood stasis leading to the formation of thrombi rich in fibrin and red blood cells (RBCs). However, little is known about mechanisms regulating...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2014.03.017

    authors： Aleman MM,Walton BL,Byrnes JR,Wolberg AS

    更新日期：2014-05-01 00:00:00

  • Inhibition or acceleration of fibrin polymerization by monoclonal immunoglobulins and immunoglobulin fragments.

    abstract：:A prolongation of the thrombin clotting time by at least 25% was found in the presence of 8 of 26 IgG myeloma proteins, 2 of 5 IgA proteins and 1 of 10 macroglobulins, in a concentration of 10 mg/ml. Normal pooled immunoglobulin in concentrations up to 83 mg/ml were inactive. 2 IgG and 2 IgM monoclonal immunoglobulins...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(84)90315-3

    authors： Wisløff F,Michaelsen TE,Godal HC

    更新日期：1984-07-01 00:00:00

  • Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro.

    abstract：:Anticoagulant fucoidan fractions of different molecular weight and sulfate content were prepared and investigated for their effects on platelet function in vitro. The fucoidan fractions were incubated with human platelet rich plasma (PRP) at concentrations of 5, 10 and 50 micrograms/ml. Platelet activation was subsequ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(97)00037-6

    authors： Dürig J,Bruhn T,Zurborn KH,Gutensohn K,Bruhn HD,Béress L

    更新日期：1997-03-15 00:00:00

  • ATP-secretion occurs as an initial response in collagen induced platelet activation.

    abstract：:The time course and degree of collagen induced platelet shape change, aggregation and ATP-secretion in citrated human platelet rich plasma was monitored with a lumi-aggregometer. Onset of ATP-secretion was measurable within seconds after collagen challenge and always distinctly before onset of shape change. In absence...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(86)90089-7

    authors： Malmgren R

    更新日期：1986-08-15 00:00:00

  • The effect of dabigatran on thrombin generation and coagulation assays in rabbit and human plasma.

    abstract：OBJECTIVES:Dabigatran etexilate is widely used for stroke prevention in the patients with atrial fibrillation. The anticoagulation activity of dabigatran is not necessary monitored in routine clinical practice. We aimed to study the effect of dabigatran on thrombin generation (TG) and coagulation assays in rabbit and h...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.03.012

    authors： Zhang C,Zhang P,Li H,Han L,Zhang L,Zhang L,Yang X

    更新日期：2018-05-01 00:00:00

  • Different effects of enoxaparin and unfractionated heparin on some thrombogenesis markers during hemodialysis: a cross-over study.

    abstract：BACKGROUND:Unfractionated heparin (UFH) and low molecular weight heparin constitute fundamental anticoagulants during hemodialysis (HD). We aimed to investigate the effect of UFH and enoxaparin on plasma levels of prothrombin fragment 1+2 (PF 1+2) and thrombin/antithrombin complex (TAT) as markers of intravascular thro...

    journal_title：Thrombosis research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.thromres.2007.12.014

    authors： Naumnik B,Pawlak K,Myśliwiec M

    更新日期：2009-02-01 00:00:00

  • Platelet and clotting activities after cold stress in diabetic patients.

    abstract：:Platelet and clotting abnormalities have been described in diabetes, but little is known about their relationship to daily stresses. In order to evaluate whether states of abnormal carbohydrate metabolism modify the hemostatic response to stress, 12 subjects with type I diabetes mellitus, 9 with type II, 7 with impair...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(88)90348-9

    authors： Maiello M,Boeri D,Bonadonna R,Odetti P,Saccarello A,Adezati L

    更新日期：1988-06-15 00:00:00

  • Cilostazol inhibits HMGB1 release in LPS-activated RAW 264.7 cells and increases the survival of septic mice.

    abstract：INTRODUCTION:Inflammation and coagulation play important roles in the pathogenesis of sepsis. Anticoagulants with anti-inflammatory action draw attention as therapeutic agent in sepsis. OBJECTIVE:Whether cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2-(1H)-quinolinone), anticoagulant, protects m...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2015.06.017

    authors： Chang KC

    更新日期：2015-08-01 00:00:00

  • Hemorrhagic and thrombotic complications in bone marrow transplant recipients.

    abstract：:Hemostatic challenges occur throughout the period of stem cell transplantation (SCT). Endothelial cells injury due to chemotherapy, growth factors, intravenous catheter, and graft-versus-host disease and profound thrombocytopenia are the major components involved in the hemostatic complications. Diffuse alveolar hemor...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/S0049-3848(07)70136-6

    authors： Nadir Y,Brenner B

    更新日期：2007-01-01 00:00:00

  • Outpatient management of pulmonary embolism.

    abstract：:Despite clear potential benefits of outpatient care, most patients suffering from pulmonary embolism (PE) are currently hospitalized due to the fear of possible adverse events. Nevertheless, some teams have increased or envisage to increase outpatient treatment or early discharge. We performed a narrative systematic r...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2017.05.001

    authors： Roy PM,Moumneh T,Penaloza A,Sanchez O

    更新日期：2017-07-01 00:00:00

  • Blood group AB and factor V Leiden as risk factors for pre-eclampsia: a population-based nested case-control study.

    abstract：INTRODUCTION:Pre-eclampsia is an important cause of maternal morbidity and mortality. Its etiology is still unknown. Clinical symptoms correlate with activation of coagulation and inherited thrombophilia has been associated with pre-eclampsia. ABO blood group has been associated with thrombotic disorders and pre-eclamp...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.11.012

    authors： Hiltunen LM,Laivuori H,Rautanen A,Kaaja R,Kere J,Krusius T,Paunio M,Rasi V

    更新日期：2009-06-01 00:00:00

  • Inhibition of red blood cell-induced platelet aggregation in whole blood by a nonionic surfactant, poloxamer 188 (RheothRx injection).

    abstract：:RheothRx Injection, an aqueous solution of a nonionic block copolymer (poloxamer 188) formulated for intravenous administration, was investigated as an inhibitor of red blood cell (RBC)-induced platelet aggregation at plasma concentrations of 0.05-5mgmL-1. Platelet aggregation was determined by measuring the fall in s...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(95)00134-d

    authors： Armstrong JK,Meiselman HJ,Fisher TC

    更新日期：1995-09-15 00:00:00

  • Relationship between periodontal disease, Porphyromonas gingivalis, peripheral vascular resistance markers and coronary artery disease in Asian Indians.

    abstract：INTRODUCTION:A close association exists between oral health and cardiovascular disease. Periodontal disease induces early vascular changes while oral pathogens have been detected in sub gingival and atheromatous plaques. We examined the interrelationship between Periodontal disease, oral bacteria, surrogate sub-clinica...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.04.023

    authors： Shanker J,Setty P,Arvind P,Nair J,Bhasker D,Balakrishna G,Kakkar VV

    更新日期：2013-07-01 00:00:00

  • Chronic kidney disease is associated with increased risk of venous thromboembolism recurrence.

    abstract：INTRODUCTION:It is currently unclear whether chronic kidney disease (CKD) and the decrease in renal function can influence the risk of venous thromboembolism (VTE) recurrence. MATERIALS AND METHODS:We performed an ambispective observational study on 409 patients with a previous episode of VTE. All the patients were in...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2017.10.011

    authors： Rattazzi M,Villalta S,De Lucchi L,Sponchiado A,Galliazzo S,Faggin E,Pagliara V,Zilli C,Callegari E,Caberlotto L,Puato M,Pauletto P

    更新日期：2017-12-01 00:00:00

  • Nephelometric determination of plasminogen and plasmin inhibitors in human plasma using fibrin suspension as a substrate.

    abstract：:A nephelometric method is described for determination of plasminogen and two types of plasmin inhibitors in human plasma having different affinity toward plasmin. This method is based on the kinetic analysis of effects of whole plasma and plasmin inhibitor fraction obtained from plasma on the activity of exogenously a...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90395-x

    authors： Saito Y,Takabayashi K,Tsukada T,Inada Y

    更新日期：1983-04-01 00:00:00

  • Real-world incidence of cancer following a first unprovoked venous thrombosis: Results from the EPIGETBO study.

    abstract：BACKGROUND:Venous thromboembolism (VTE) can be the first manifestation of cancer; however, the current incidence of malignancy in unselected patients with first unprovoked VTE needs to be confirmed. MATERIAL AND METHODS:Between March 1st, 2013 and February 28th, 2015 we included and followed-up all patients living in ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.02.151

    authors： Delluc A,Ianotto JC,Tromeur C,De Moreuil C,Couturaud F,Lacut K,Le Moigne E,Louis P,Thereaux J,Metges JP,Mottier D

    更新日期：2018-04-01 00:00:00

  • B cell biology, apoptosis, and autoantibodies to phospholipids.

    abstract：:Systemic autoimmune diseases are characterised by the development of a relatively narrow spectrum of autoantibodies. These are of considerable diagnostic value. In addition, in some diseases, including anti-phospholipid syndrome, these autoantibodies can be directly pathogenic. Understanding how these autoantibodies a...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2004.06.037

    authors： Cook MC

    更新日期：2004-01-01 00:00:00

  • Arterial thrombosis and cancer.

    abstract：:Cancer-associated arterial thrombotic events (ATEs) are increasingly recognized in specific malignancies and in association with the expanding armamentarium of novel chemotherapeutic agents. The improved cancer survival led to cardiovascular complications becoming clinically relevant many years after cancer diagnosis....

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2018.01.003

    authors： Aronson D,Brenner B

    更新日期：2018-04-01 00:00:00

  • Poor fibrinolytic response to venous occlusion by different criteria in patients with deep vein thrombosis.

    abstract：:Five criteria for poor response to a 20 min venous occlusion test were applied to 58 patients 3 months or more after acute deep vein thrombosis (DVT). The criteria were arbitrarily defined as the last 5 percentiles of response distributions in an age- and sex-matched healthy control group of 51 subjects. The criteria ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(91)90345-w

    authors： Stegnar M,Peternel P,Keber D,Vene N

    更新日期：1991-11-15 00:00:00

  • Symptomatic and asymptomatic deep vein thrombosis after total hip replacement. Differences in phlebographic pattern, described by a scoring of the thrombotic burden.

    abstract：:The aim was to describe the phlebographic pattern of asymptomatic and symptomatic deep vein thrombosis (DVT) after total hip replacement by the use of a scoring system in 102 consecutive patients (54 asymptomatic, 48 symptomatic). The DVTs were scored from 1 to 3, and registered in a scoring system dividing the deep v...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(00)00274-7

    authors： Björgell O,Nilsson PE,Benoni G,Bergqvist D

    更新日期：2000-09-01 00:00:00

  • Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody.

    abstract：:Tissue factor, the cofactor for factor VIIa-catalyzed activation of factors IX and X, plays an important role in the initiation of hemostasis. However, the distribution of tissue factor in the body has not been defined until recently. In the present study frozen sections of non-malignant human tissues were immunostain...

    journal_title：Thrombosis research

    pub_type： 更正并重新发布的文章,杂志文章

    doi：10.1016/0049-3848(90)90148-6

    authors： Fleck RA,Rao LV,Rapaport SI,Varki N

    更新日期：1990-07-15 00:00:00

  • Disulfide bond exchanges in integrins αIIbβ3 and αvβ3 are required for activation and post-ligation signaling during clot retraction.

    abstract：BACKGROUND:Integrin αIIbβ3 mediates platelet adhesion, aggregation and fibrin clot retraction. These processes require activation of αIIbβ3 and post-ligation signaling. Disulfide bond exchanges are involved in αIIbβ3 and αvβ3 activation. METHODS:In order to investigate the role of integrin activation and disulfide bon...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.02.001

    authors： Mor-Cohen R,Rosenberg N,Averbukh Y,Seligsohn U,Lahav J

    更新日期：2014-05-01 00:00:00

  • Reactivity of heparin with the human plasma heparin-binding proteins thrombin, antithrombin III, and apolipoproteins E and B-100.

    abstract：:The heparin-binding properties of human plasma apolipoproteins B-100 and E (apoB-100 and E) of low density lipoproteins (LDL), thrombin, and antithrombin-III (AT-III) were investigated. A highly reactive heparin (HRH) to apoB-100 was isolated by chromatography of crude heparin on a column of LDL immobilized to Affi-Ge...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(84)90258-5

    authors： Cardin AD,Barnhart RL,Witt KR,Jackson RL

    更新日期：1984-06-15 00:00:00

  • Prior simvastatin treatment is associated with reduced thrombin generation and platelet activation in patients with acute ST-segment elevation myocardial infarction.

    abstract：BACKGROUND:It has been reported that statin therapy produces additional effects including impaired activation of blood coagulation. It is not clear whether statins can affect hemostasis in patients with acute coronary syndrome. The aim of this study was to investigate the effect of prior statin treatment on thrombin ge...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2009.06.021

    authors： Pastuszczak M,Kotlarz A,Mostowik M,Zalewski J,Zmudka K,Undas A

    更新日期：2010-05-01 00:00:00

  • Thromboembolic complications several days after a single-dose administration of aspirin.

    abstract：:The antithrombotic properties of acetyl salicylic acid (ASA) used at current doses are largely demonstrated. However, our previous study showed unexpected thrombotic potencies associated with the use of this drug. In this study we investigate the effect of aspirin on an experimental thrombosis induced by laser beams, ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(97)00302-2

    authors： Aguejouf O,Belougne-Malfatti E,Doutremepuich F,Belon P,Doutremepuich C

    更新日期：1998-02-01 00:00:00

  • Peripheral benzodiazepine ligands inhibit aggregation and thromboxane synthesis induced by arachidonic acid in rabbit platelets in vitro.

    abstract：:Seven compounds having varying affinities for peripheral benzodiazepine (p sites) were evaluated in vitro as inhibitors of arachidonic acid-induced rabbit platelet aggregation and thromboxane B2 (TXB2) synthesis. With the exception of flumazenil, all compounds inhibited both parameters with IC50 values ranging from 0....

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(95)00062-v

    authors： Choppin A,Berry CN

    更新日期：1995-05-15 00:00:00

  • Statin use and venous thromboembolism in cancer: A large, active comparator, propensity score matched cohort study.

    abstract：BACKGROUND:Statins have been shown to have a protective effect for venous thromboembolism (VTE) in the general population. This study sought to assess the association between statins and the risk for cancer-associated deep vein thrombosis (DVT) and pulmonary embolism (PE). METHODS:Patients with newly diagnosed cancer ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2017.08.001

    authors： El-Refai SM,Black EP,Adams VR,Talbert JC,Brown JD

    更新日期：2017-10-01 00:00:00

  • Accumulation and release of acridine derivatives by intact platelets.

    abstract：:A new approach to the investigation of accumulation of acridine derivatives and release by platelets is proposed. At high concentrations of acridine orange (AO) inside dense bodies, a two component fluorescence spectrum with maxima at 530 and 640 nm has been recorded. Computer deconvolution of spectra provided additio...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90102-2

    authors： Popov EG,Gabbasov ZA,Gavrilov IYu,Pozin EYa,Mejlumian AG

    更新日期：1987-09-15 00:00:00