Abstract：
:The in vitro and in vivo pharmacological properties of two oversulfated dermatan sulfate (DS) derivatives, S-DS1 and S-DS2, containing 2 and 3.7 sulfate groups/disaccharide unit respectively were compared to those of the parent DS (1 sulfate group/disaccharide unit). In a purified system the ability of S-DS1 and of S-DS2 to catalyse thrombin inhibition by heparin cofactor II was increased by ten- and seventeen-fold respectively. These compounds also had more potent anticoagulant activities in the activated partial thromboplastin time and the thrombin clotting time assays. Plasma immunodepleted in antithrombin III, heparin cofactor II and both cofactors allowed it to be demonstrated that these enhanced anti-coagulant activities were partly (S-DS1) or totally (S-SD2) independent of any plasma cofactors. In spite of these enhanced anticoagulant activities in vitro the oversulfated derivatives did not exhibit an increased antithrombotic activity in a thromboplastin Wessler type model. Moreover, at the doses investigated, S-DS2 had no antithrombotic effect. The influence of oversulfation on the pharmacokinetic pattern of DS was also investigated. As reported for unfractionated heparin, the biological activities generated after IV injection of high doses of S-DS1 and S-DS2 disappeared according to a concave-convex pattern. This may result from the higher affinities of S-DS1 and of S-DS2 toward endothelial cells in comparison with that of DS.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Dol F,Caranobe C,Dupouy D,Petitou M,Lormeau JC,Choay J,Sié P,Boneu Bdoi
10.1016/0049-3848(88)90094-1subject
Has Abstractpub_date
1988-10-15 00:00:00pages
153-64issue
2eissn
0049-3848issn
1879-2472journal_volume
52pub_type
杂志文章abstract：:Full-length Tissue Factor (flTF) - the obligatory co-factor for the serine protease (factor) VII/VIIa - serves as the initiator of blood coagulation. The flTF/VIIa complex triggers a sequence of proteolytic events that lead to the formation of a hemostatic plug. Aside from hemostatic maintenance, flTF can contribute t...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2012.02.027
更新日期：2012-05-01 00:00:00
abstract：:The effects of sodium salicylate (SS) on ADP-induced platelet aggregation and on a metabolism of calcium in platelets were studied, using gel-filtrated platelets (GFP). SS inhibited dose-responsively ADP-induced aggregation in the presence of fibrinogen and Ca2+. It was found that extracellular 45Ca2+ was rapidly take...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90232-4
更新日期：1985-08-01 00:00:00
abstract：:Human gel-filtered platelets or platelet-rich plasma were stimulated by sodium arachidonate or by ADP in the presence of two compounds known to inhibit ADP mediated aggregation and secretion - ATP and N-ethylmaleimide. Using gel-filtered platelets and the lowest concentration of agonist necessary to elicit maximum agg...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(83)90105-6
更新日期：1983-09-01 00:00:00
abstract：:When a purified myeloma protein with the ability to inhibit fibrin polymerization was preincubated with sheep anti-human F(ab')2 antibodies, there was a marked reduction of the ability to prolong the thrombin clotting time, while anti-Fc antibodies had only a slight effect. A monoclonal immunoglobulin which shortens t...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90284-1
更新日期：1985-11-15 00:00:00
abstract：:1 g acetyl salicylic acid orally significantly enhanced the initial rate of platelet aggregation induced by 1 mumol/l and 2.5 mumol/l ADP. Sodium salicylate was without effects on the platelet aggregation and specifically it did not prevent acetylsalicylic acid from inhibiting the secondary aggregation. Sodium salicyl...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(85)90212-9
更新日期：1985-06-15 00:00:00
abstract：INTRODUCTION:We showed previously that the prothrombotic effect of one hour aldosterone (ALDO) infusion in rats was only partially mediated by the mineralocorticoid receptor (MR). Bearing in mind that ALDO potentiates the effects of angiotensin II (Ang II), in the present study we investigated the role of Ang II recept...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.12.008
更新日期：2016-02-01 00:00:00
abstract：:Defibrotide both "in vitro" and "ex vivo" decreases PMN adhesion to nylon columns. This activity is blunted by 8-phenyltheophylline, a known blocker of adenosine A1/A2 receptors, suggesting that Defibrotide acts on that kind of receptors. Indomethacin, a blocker of PGI2 synthesis, did not cancel DFT's activity, sugges...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(95)00178-t
更新日期：1995-11-15 00:00:00
abstract：:Studies of the factors affecting the first recurrence of ischemic stroke have reported inconsistent findings. Types of initial stroke and the racial differences in study samples are among the explanations that may account for this inconsistency. The aims of this study were to estimate the cumulative recurrence rates o...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(99)00146-2
更新日期：2000-02-01 00:00:00
abstract：:A series of 8 analogues of platelet-activating factor (PAF) in which both the acetyl group and the polar head are changed, were tested for biological activities on human and rabbit platelets in plasma. Two of these compounds, 1-O-hexadecyl-2-O-ethyl-rac-glycero-3-phosphoric acid-5'-trimethylammoniumpentyl ester and 1-...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(88)90244-7
更新日期：1988-02-15 00:00:00
abstract：:A simple and reproducible method to induce an occlusive thrombus in rabbit carotid artery is reported. Rabbits were anesthetized and prepared to record arterial pressure, heart rate, and carotid blood flow. A critical stenosis of a damaged carotid artery was obtained using an external plastic cylinder. Complete occlus...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(91)90147-o
更新日期：1991-05-15 00:00:00
abstract：:The potent inhibitor of platelet cAMP phosphodiesterase (PDE) HL 725 (9,10-Dimethoxy-2-mesitylimino-3-methyl-3, 4,6,7-tetrahydro-2H-pyrimido(6,1-A)-isoquinoline-4-one-hydrochloride), was examined for its effects on human and rat platelet aggregation. Strong inhibitory effects are seen on collagen-induced platelet aggr...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90376-8
更新日期：1987-07-15 00:00:00
abstract：:Thrombin-activatable fibrinolysis inhibitor (TAFI), also known as procarboxypeptidase U or plasma procarboxypeptidase B, is a relatively recently described plasma glycoprotein synthesised in the liver. It can be activated into active enzyme TAFIa (carboxypeptidase U or plasma carboxypeptidase B) by a complex of thromb...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(02)00072-5
更新日期：2002-04-01 00:00:00
abstract：:125I-fibronectin is incorporated into fibrin when blood plasma is clotted with thrombin. This process is dependent upon fibronectin concentration, temperature, and the presence of calcium ions. Fibronectin appears to be a very strong inhibitor of fibrin formation and influences both the thrombin clotting time and fibr...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(82)90308-5
更新日期：1982-09-01 00:00:00
abstract：INTRODUCTION:Z4A5 is a novel peptide that inhibits platelet aggregation and formation of platelet thrombi, but the mechanism of its anti-platelet effects remains unknown. This study explores the anti-platelet effect and mechanism of Z4A5. METHODS:We investigated the anti-platelet activity of Z4A5 on platelet aggregati...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2012.02.047
更新日期：2012-05-01 00:00:00
abstract：INTRODUCTION:Many antithrombotic drugs may have a deleterious effect on normal haemostasis leading to bleeding complications. The aim of this study was to determine if sub-therapeutic (low) doses of antithrombotic agents, when administered in combination, have enhanced efficacy without augmentation of bleeding time. M...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2005.11.015
更新日期：2006-01-01 00:00:00
abstract：:Selective serotonin reuptake inhibitors (SSRIs) have been reported to reduce platelet aggregation induced by ADP. ADP induces platelet aggregation through two purinergic receptors P2Y1 and P2Y12. We characterized the inhibitory properties of SSRIs on ADP-induced platelet aggregation and investigated the effects of SSR...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2013.02.007
更新日期：2013-04-01 00:00:00
abstract：:VKORC1 and VKORC1L1 are enzymes that both catalyze the reduction of vitamin K2,3-epoxide via vitamin K quinone to vitamin K hydroquinone. VKORC1 is the key enzyme of the classical vitamin K cycle by which vitamin K-dependent (VKD) proteins are γ-carboxylated by the hepatic γ-glutamyl carboxylase (GGCX). In contrast, t...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.01.025
更新日期：2015-05-01 00:00:00
abstract：:The incidence of thrombotic events is higher in neonates compared to children of other age groups. Perinatal and maternal risk factors, as well as the developing neonatal hemostatic system, are contributing factors in the higher rate of thrombosis in this pediatric population. This review summarizes the available lite...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2010.10.009
更新日期：2010-12-01 00:00:00
abstract：INTRODUCTION:After major liver surgery, there are risks of both postoperative bleeding and thrombosis. Routine coagulation monitoring is indicated, but may not provide adequate clinical guidance. Thus, we described the clotting status in a pilot study using broader coagulation testing. We analysed the temporal pattern ...
journal_title：Thrombosis research
pub_type： 临床试验,杂志文章
doi：10.1016/j.thromres.2015.05.023
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Minimizing bleeding and transfusion is desirable given its cost, complexity and potential for adverse events. Concerns have been heightened by recent data demonstrating that bleeding events may predict worse outcomes and by warnings about the safety of erythropoietic stimulating agents. Prior small studies s...
journal_title：Thrombosis research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.thromres.2008.09.015
更新日期：2009-03-01 00:00:00
abstract：:Bleeding events are a common adverse effect in oral anticoagulation that frequently depend on the duration and intensity of treatment. Major bleeding events, particularly intracerebral hemorrhages, are a serious complication in cases that require the rapid reversal of anticoagulation. Urgent correction of the coagulat...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/s0049-3848(99)00085-7
更新日期：1999-08-15 00:00:00
abstract：:RheothRx Injection, an aqueous solution of a nonionic block copolymer (poloxamer 188) formulated for intravenous administration, was investigated as an inhibitor of red blood cell (RBC)-induced platelet aggregation at plasma concentrations of 0.05-5mgmL-1. Platelet aggregation was determined by measuring the fall in s...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(95)00134-d
更新日期：1995-09-15 00:00:00
abstract：:Blackfoot disease is a unique endemic and chronic progressive arteriosclerotic vascular disease in southwest area of Taiwan. In this study, we determined the plasma levels of tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI), urokinase plasminogen activator (uPA), and von Willebrand factor (vWF...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(93)90188-t
更新日期：1993-11-01 00:00:00
abstract：:Collagen-induced platelet aggregation and secretion (ATP-release) in whole-blood and platelet-rich plasma was compared. Although the amount of ATP released was comparable in whole-blood and platelet-rich plasma, the maximum extent of aggregation was greater when platelets were studied in their natural milieu, i.e. who...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(89)90203-x
更新日期：1989-03-01 00:00:00
abstract：:Gastrointestinal bleeding due to colonic angiodysplasia is a well-recognised complication of von Willebrand disease (vWD), occurring almost exclusively in subtypes of the disease associated with a reduction in high-molecular-weight (HMW) multimers of von Willebrand factor (vWF). A deficiency of vWF HMW multimers also ...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2006.01.022
更新日期：2006-01-01 00:00:00
abstract：:Upon stimulation or apoptosis, eukaryotic cells shed membrane vesicles of submicron size. These so-called microparticles (MPs) are detected and characterized based on the exposure of antigens characteristic of their respective parental cells and on the increased distribution of negatively charged phospholipids to the ...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/S0049-3848(08)70019-7
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:In reconstructive head and neck cancer surgery, tissue flaps are transferred to the surgical defect and revascularized by anastomosis of small vessels. Cancer patients are in a hypercoagulable state with high risk of peri- and postoperative thrombotic events. Thrombosis to the tissue flap anastomoses or mi...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/S0049-3848(16)30195-5
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Arterial calcification is associated with increased risk of cardiovascular events. Osteoprotegerin (OPG) is a cytokine involved in the bone metabolism and vascular calcification. Recent data support a relationship between high serum levels of OPG and increased risk for cardiovascular disease in human. The ai...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2006.12.004
更新日期：2007-01-01 00:00:00
abstract：INTRODUCTION:Fluid resuscitation after trauma often results in dilutional coagulopathy that may hinder control of bleeding and, once initial hemostasis has been secured, heighten risk of perioperative bleeding when further surgery is required. Since multiple coagulation factor deficiencies typically accompany fluid res...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2009.10.011
更新日期：2010-03-01 00:00:00
abstract：INTRODUCTION:Increased levels of circulating tissue factor (TF)-positive microvesicles (MVs) may increase the risk of thrombosis. Indeed, TF-positive MVs are detected in plasma of patients with various types of diseases. In this study, we measured levels of MV TF activity in non-cancer severely ill patients and cancer ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2018.03.001
更新日期：2018-05-01 00:00:00
