Gastrointestinal bleeding in von Willebrand disease.

abstract：:G-proteins play a major role in cell signaling and specific abnormalities in these proteins have been implicated in some diseases. Although, two human G alpha q coding sequences are published, they differ at functionally important regions. We have sequenced the human G alpha q cDNA synthesized from normal platelet mRN...

journal_title：Thrombosis research

authors： Gabbeta J,Dhanasekaran N,Rao AK

更新日期：1998-07-01 00:00:00

abstract：INTRODUCTION:Unicompartmental knee arthroplasty (UKA) has increased due to potential favourable complication rates when compared to total knee arthroplasty (TKA). Although venous thromboembolism (VTE) is a well-documented complication after TKA limited data is available after UKA and mostly presented as secondary findi...

journal_title：Thrombosis research

authors： Petersen PB,Jørgensen CC,Gromov K,Kehlet H,Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement Collaborative Group.

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and inc...

journal_title：Thrombosis research

authors： Pike MM,Larson NB,Wassel CL,Cohoon KP,Tsai MY,Pankow JS,Hanson NQ,Decker PA,Berardi C,Alexander KS,Cushman M,Zakai NA,Bielinski SJ

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Ambient particulate matter (PM) is associated with cardiovascular morbidity and mortality. It has been proposed that PM induces a pro-thrombotic process, increasing the risk of cardiovascular events, with some support from epidemiological and laboratory-based models. Diesel exhaust is a major contributor to ...

journal_title：Thrombosis research

authors： Carlsten C,Kaufman JD,Peretz A,Trenga CA,Sheppard L,Sullivan JH

更新日期：2007-01-01 00:00:00

abstract：:Megakaryocyte colony formation was increased in 13 patients with ITP. Out of splenectomized ITP patients Colony Forming Unit-Megakaryocyte (CFU-Mk) number normalized in four but was lower than normal in the remaining two. The proportion of immature megakaryocytes was higher in ITP than in normals or in ITP patients af...

journal_title：Thrombosis research

authors： Podolak-Dawidziak M

更新日期：1991-04-01 00:00:00

abstract：:The purpose of this study was to determine whether plasma von Willebrand factor concentrations are correlated with the degree of intestinal ischaemia-reperfusion injury. Forty-six anaesthetised adult Wistar rats were divided into five groups. The sham-operated group (S, n=10) had laparotomy and isolation of the superi...

journal_title：Thrombosis research

authors： Abu-Zidan FM,Farrant G,Zwi LJ,Simovic MO,Day T,Bonham MJ,Windsor JA

更新日期：1999-06-15 00:00:00

abstract：BACKGROUND:Troponin I (cTnI), myoglobin, heart-type fatty acid binding protein (H-FABP), and natriuretic peptides (BNP, NTproBNP) were all reported to be elevated in patients with pulmonary embolism (PE). METHODS:To assess the correlation between the aforementioned markers and helical computed tomography (hCT) right v...

journal_title：Thrombosis research

authors： Vuilleumier N,Righini M,Perrier A,Rosset A,Turck N,Sanchez JC,Bounameaux H,Le Gal G,Mensi N,Hochstrasser D

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Deep vein thrombosis (DVT) is a common complication of acute stroke, but the new incidence in the era of improved specialist input in stroke care is yet unknown. The models for VTE diagnosis is well established, but prediction models to target at-risk patients for pharmacological prophylaxis is lacking and r...

journal_title：Thrombosis research

authors： Balogun IO,Roberts LN,Patel R,Pathansali R,Kalra L,Arya R

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Preterm infants often require assisted ventilation, however ventilation when applied to the immature lung can initiate ventilator-induced lung injury (VILI). The biotrauma which underscores VILI is largely undefined, and is likely to involve vascular injury responses, including hemostasis. We aimed to use ...

journal_title：Thrombosis research

authors： Schmid C,Ignjatovic V,Pang B,Nie S,Williamson NA,Tingay DG,Pereira-Fantini PM

更新日期：2020-12-01 00:00:00

abstract：:There is now compelling evidence that use of oral contraceptives and postmenopausal hormonal therapies containing various estrogens is associated with a weak, but clinically relevant risk of both arterial and venous thrombosis. The increased risk is related to type and dose of both estrogen and combined progestagen an...

journal_title：Thrombosis research

authors： Sandset PM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Cocaine use has been related with the development of accelerated atherosclerosis and with an increased risk of cardiac and cerebrovascular events, such as myocardial infarction, sudden cardiac death, and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood, altho...

journal_title：Thrombosis research

authors： Sáez CG,Olivares P,Pallavicini J,Panes O,Moreno N,Massardo T,Mezzano D,Pereira J

更新日期：2011-10-01 00:00:00

abstract：:Three commercial thrombin preparations used clinically to stop topical bleeding were studied. The specific activities of these preparations were 1,064 U/mg (human); 59 U/mg (bovine) and 147 U/mg (bovine). SDS-PAGE analysis of the human product produced one major band corresponding to a molecular weight of alpha-thromb...

journal_title：Thrombosis research

authors： Suzuki S,Sakuragawa N

更新日期：1989-02-01 00:00:00

abstract：:Two isozymes of a native form of human plasminogen (plg), Glu-plg I and II, were isolated. Glu-plg I or II was activated by urokinase (UK) or streptokinase (SK) in the presence of fibrinogen or fibrin. The activation of Glu-plg I was enhanced more than that of Glu-plg II in the presence of fibrin. Fibrin caused better...

journal_title：Thrombosis research

authors： Takada Y,Makino Y,Takada A

更新日期：1985-08-01 00:00:00

abstract：:It has been suggested that unstable angina at rest, like acute myocardial infarction, might be associated with a thrombotic process. In order to study the hypothesis that myocardial ischemia during exercise could also be associated with an activation of blood coagulation and/or fibrinolysis, we investigated the presen...

journal_title：Thrombosis research

authors： Bounameaux H,Righetti A,de Moerloose P,Bongard O,Reber G

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Clopidogrel, cilostazol, and aspirin were compared in terms of efficacy and safety for primary prevention of stroke in peripheral artery disease (PAD) patients. METHODS:This retrospective cohort study analyzed data contained in the Taiwan National Health Insurance Bureau database for patients treated for PA...

journal_title：Thrombosis research

authors： Lee WH,Chu CY,Hsu PC,Su HM,Lin TH,Voon WC,Lai WT,Sheu SH

更新日期：2013-08-01 00:00:00

abstract：:Heparin and other antithrombotic drugs besides their anticoagulant action could have a profibrinolytic effect. We have analyzed the effect of unfractionated heparin (UFH) and hirudin on PAI-1 gene expression in human umbilical vein endothelial cells (HUVEC). Cells were stimulated with UFH (1 and 10 IU/ml) and hirudin ...

journal_title：Thrombosis research

authors： Orbe J,Montes R,Zabalegui N,Pérez-Ruiz A,Páramo JA

更新日期：1999-05-01 00:00:00

abstract：INTRODUCTION:Normal pregnancy is associated with hypercoagulable state. Elevated markers of coagulation and fibrinolytic system activation indicate increased thrombin activity and increased fibrinolysis following fibrin formation throughout pregnancy. These changes exceed the biological variability in most cases. Haemo...

journal_title：Thrombosis research

authors： Réger B,Péterfalvi A,Litter I,Pótó L,Mózes R,Tóth O,Kovács GL,Losonczy H

更新日期：2013-04-01 00:00:00

abstract：:Surviving an embolism exposes patients to potential long-term complications, such as altered quality of life, persistent dyspnea, impaired exercise capacity or pulmonary hypertension. The common objective factor in most of these situations is the presence of residual pulmonary vascular obstruction (RPVO). Planar venti...

journal_title：Thrombosis research

authors： Bonnefoy PB,Margelidon-Cozzolino V,Catella-Chatron J,Ayoub E,Guichard JB,Murgier M,Bertoletti L

更新日期：2019-12-01 00:00:00

abstract：:Using high-resolution real-time two-dimensional ultrasound, we have investigated the role of red cells in the growth of already established platelet aggregates under controlled flow conditions. Platelet rich plasma (PRP) was circulated in vitro in horizontally and vertically arranged tubing at mean shear rate ranging ...

journal_title：Thrombosis research

authors： Machi J,Sigel B,Ramos JR,Justin JR,Feinberg H,LeBreton GC,Robertson AL Jr

更新日期：1984-10-01 00:00:00

abstract：:Fucoidan [sulfated poly (L-fucopyranose)] was compared with 6-aminohexanoic acid (6-AH) or CNBr-cleaved fibrinogen (CNBr-Fbg) alone or in combination in enhancing the activation of glutamic plasminogen (Glu-Plg) or lysine plasminogen (Lys-Plg) by two-chain tissue plasminogen activator (t-PA) or LMwt-urokinase or by st...

journal_title：Thrombosis research

authors： Doctor VM,Hill C,Jackson GJ

更新日期：1995-08-01 00:00:00

abstract：:The concentration of tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1) and the complex of t-PA and PAI-1 (t-PA-PAI-1 complex) were measured using an enzyme immunoassay, where the first antibody was monoclonal antibody against PAI-1 and the second one was polyclonal anti-t-PA Fab' antibody....

journal_title：Thrombosis research

authors： Takada Y,Takada A

更新日期：1989-09-01 00:00:00

abstract：:Major orthopaedic surgery is associated with an increased risk of venous thromboembolism. Direct oral anticoagulants (DOACs) are recommended as thromboprophylactic agents after orthopaedic surgery. Although routine monitoring of DOACs in general is not required, measuring DOAC concentration may be necessary in clinica...

journal_title：Thrombosis research

authors： Schellings MW,Boonen K,Schmitz EM,Jonkers F,van den Heuvel DJ,Besselaar A,Hendriks JG,van de Kerkhof D

更新日期：2016-03-01 00:00:00

abstract：:Since the first description by Dahlbäck et al (1) of a hereditary defect in the plasma of three unrelated thrombophilic patients characterized by a poor anticoagulant response to activated protein C (APC), many reports have shown a high prevalence of the APC resistance in both the general and thrombophilic populations...

journal_title：Thrombosis research

authors： Gouault-Heilmann M,Leroy-Matheron C

更新日期：1997-02-15 00:00:00

abstract：BACKGROUND:Clinical and epidemiological studies have associated selective COX-2 inhibitors with an increased risk of cardiovascular events. There are no clinical studies on the possible effects of these drugs on secondary hemostasis. The hypothesis for this study is that the use of selective COX-2 inhibitors could affe...

journal_title：Thrombosis research

authors： Schjerning O,Larsen TB,Damkier P

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:Apoptotic cell death is a highly regulated genetic program, which has been observed in mature megakaryocytes fragmenting into platelets. The clock gene Per2, a key component of core clock oscillator, was involved in affecting both cell cycle control and apoptosis. Thus, loss of Per2 function may be conside...

journal_title：Thrombosis research

authors： Zhao Y,Zhang Y,Wang S,Hua Z,Zhang J

更新日期：2011-02-01 00:00:00

abstract：:D-dimer of human fibrin was used as antigen to obtain monoclonal antibodies (mAbs). We have obtained 16 hybridomas producing mAbs of different specificity. Only two of these mAbs inhibited fibrin polymerization. They are of the IgG-class. One mAb (II-4d) inhibited fibrin polymerization to 100% and another (II-3b) to 6...

journal_title：Thrombosis research

authors： Lugovskoy EV,Gritsenko PG,Kolesnikova IN,Zolotarova EN,Chernishov VI,Nieuwenhuizen W,Komisarenko SV

更新日期：2004-01-01 00:00:00

abstract：UNLABELLED:Disturbances of coagulation and fibrinolysis have been reported in patients with chronic uremia. Studies of different coagulation and fibrinolysis parameters in regularly dialyzed patients have yielded conflicting results. Global fibrinolytic capacity (GFC) examines the function of the entire fibrinolytic sy...

journal_title：Thrombosis research

authors： Agras PI,Baskin E,Cengiz N,Kirazli S,Saatci U,Ozbek N

更新日期：2005-01-01 00:00:00

abstract：:Microheterogeneity of antithrombin III (ATIII) was examined in pooled normal human plasma and serum by IEF/PA and immunoblotting techniques. A pattern consisting of 8 bands varying in isoelectric point from 4.7 to 5.2 was observed in citrated plasma following IEF in a pH range of 4-6. A similar pattern was observed in...

journal_title：Thrombosis research

authors： Daly M,Hallinan F

更新日期：1985-10-15 00:00:00

abstract：:Human platelets synthesize nitric oxide (NO) through an endothelial-type NO synthase (ecNOS) activated also by substances enhancing 3',5'-cyclic adenosine monophosphate (cAMP) concentrations, such as catecholamines, beta-adrenoceptor agonists and adenosine. To verify whether cAMP directly activates ecNOS through the c...

journal_title：Thrombosis research

authors： Russo I,Doronzo G,Mattiello L,De Salve A,Trovati M,Anfossi G

更新日期：2004-01-01 00:00:00

abstract：:Central venous catheters (CVC) have revolutionized the care of patients requiring long-term venous access. With increasing use of CVCs, the incidence of catheter-related thrombosis (CRT) has been on the rise. CRT constitutes 10% of all deep venous thromboses (DVT) in adults and 50-80% of all DVTs among children. The i...

journal_title：Thrombosis research

authors： Citla Sridhar D,Abou-Ismail MY,Ahuja SP

更新日期：2020-03-01 00:00:00