Mechanisms of hormonal therapy related thrombosis.

abstract：INTRODUCTION:Proteasome inhibitor bortezomib (PS-341) has been the first proteasome inhibitor that has entered clinical trials with its antiproliferative and proapoptotic effects in patients with multiple myeloma. Recent studies indicate that proteasome inhibitors can be useful in prevention of experimental arterial th...

journal_title：Thrombosis research

authors： Avcu F,Ural AU,Cetin T,Nevruz O

更新日期：2008-01-01 00:00:00

abstract：:Liquid permeation studies of fibrin gels, which were formed in the presence of thrombin (Fibrin II) and in the presence of Batroxobin (Fibrin I), showed that those gels have distinctly different flow properties. For both gels the permeability coefficient (Ks) and average pore size varied depending on the conditions fo...

journal_title：Thrombosis research

authors： Blombäck B,Okada M

更新日期：1982-01-01 00:00:00

abstract：INTRODUCTION:Growth differentiation factor-15 (GDF-15) has been identified as a predictor in cardiovascular diseases and acute pulmonary embolism. However, the association of GDF-15 and deep venous thrombosis (DVT) remains unclear. This study aimed to investigate levels of GDF-15 in patients with DVT, and determine its...

journal_title：Thrombosis research

authors： Liang W,Wei F,Yang C,Xie F,Shuai XX,Wang M,Yu M

更新日期：2020-03-01 00:00:00

abstract：:The soluble fibrin monomer complexes (SFMC) in 154 obstetric patients with possible disseminated intravascular coagulation (DIC) were evaluated in SDS polyacrylamide gel electrophoresis (PAGE) after precipitation with B-alanine. Other coagulation tests were performed on these patients. The patients were classified int...

journal_title：Thrombosis research

authors： Aznar J,Gilabert J,Estelles A,Fernandez MA,Villa P,Aznar JA

更新日期：1982-09-15 00:00:00

abstract：BACKGROUND:Clinical and epidemiological studies have associated selective COX-2 inhibitors with an increased risk of cardiovascular events. There are no clinical studies on the possible effects of these drugs on secondary hemostasis. The hypothesis for this study is that the use of selective COX-2 inhibitors could affe...

journal_title：Thrombosis research

authors： Schjerning O,Larsen TB,Damkier P

更新日期：2009-06-01 00:00:00

abstract：:The present study was designed to find out whether the synthetic pentasaccharide SR 90107A/Org 31540, which is presently being evaluated in clinical trials as an antithrombotic agent, influences lipoprotein metabolism in rats as determined by plasma triglyceride (TG) lipase activity. A comparison with three clinically...

journal_title：Thrombosis research

authors： Hoffmann P,Bernat A,Dumas A,Petitou M,Hérault JP,Herbert JM

更新日期：1997-05-15 00:00:00

abstract：BACKGROUND:HELLP (Hemolysis, elevated liver enzymes and low platelets) syndrome is a severe and acute pregnancy-related disorder that occurs in approximately 2.5 per 1000 deliveries and represents a major cause of maternal and perinatal morbidity and mortality. This syndrome has been suggested to be a microangiopathy a...

journal_title：Thrombosis research

authors： Bazzan M,Todros T,Tedeschi S,Ardissino G,Cardaropoli S,Stella S,Montaruli B,Marchese C,Roccatello D,Cugno M

更新日期：2020-12-01 00:00:00

abstract：:This study compares selected properties of purified tryptic fragments of human von Willebrand (vW) protein in order to better understand how the M(r) 116,000 fragment retains activity in ristocetin-induced platelet agglutination. Wheat germ agglutinin (WGA) aggregation of platelet-rich plasma was potentiated by preinc...

journal_title：Thrombosis research

authors： Martin SE,Francis CW,Marder VJ

更新日期：1983-08-01 00:00:00

abstract：INTRODUCTION:Portal vein thrombosis (PVT) is a well-known complication in patients with liver cirrhosis (LC). The aim of this study is to investigate the outcomes of cirrhotic patients with PVT treated with low-molecular-weight heparin (LMWH). METHOD:Ninety-one LC patients with PVT were treated with dalteparin or enox...

journal_title：Thrombosis research

authors： Kwon J,Koh Y,Yu SJ,Yoon JH

更新日期：2018-03-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) has become the most curable form of acute myeloid leukemia after the advent of all-trans retinoic acid (ATRA). However, early deaths (ED) mostly due to the disease-associated coagulopathy remain the major cause of treatment failure. In particular, hemorrhagic events account for 40-65...

journal_title：Thrombosis research

authors： Breccia M,Lo Coco F

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Thrombotic storm (TS) presents as a severe, acute thrombotic phenotype, characterized by multiple clotting events and frequently affecting younger adults. Understanding the extensive hypercoagulation of an extreme phenotype as TS will also provide insight into the pathogenesis of a wider spectrum of thromb...

journal_title：Thrombosis research

authors： Nuytemans K,Ortel TL,Gomez L,Hofmann N,Alves N,Dueker N,Beecham A,Whitehead P,Hahn Estabrooks S,Kitchens CS,Erkan D,Brandão LR,James AH,Kulkarni R,Manco-Johnson MJ,Pericak-Vance MA,Vance JM

更新日期：2018-01-01 00:00:00

abstract：:High molecular weight kininogen has been shown to be the principal plasma inhibitor of cellular thiol proteases including cathepsins B, H and L and calpains 1 and 2. Since these same enzymes have been reported to be elevated in animals with muscular dystrophy, we studied plasmas from hamsters with muscular dystrophy a...

journal_title：Thrombosis research

authors： Colman RW,Bradford HN,Warner AH

更新日期：1989-04-15 00:00:00

abstract：:Platelet alpha adrenoceptor status was examined using the radioligands 3H-yohimbine (3H-YOH) and 3H-dihydroergocryptine (3H-DHE) in 14 patients with myeloproliferative disorder (MPD) and 10 normal controls. Platelets from normal controls and MPD patients sensitive to adrenaline induced aggregation exhibited approximat...

journal_title：Thrombosis research

authors： Swart SS,Wood JK,Barnett DB

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Nuclear factor kappa B (NF-kappa B) activation and tissue factor (TF) expression may contribute to lethality in sepsis. Inappropriate in vivo expression of TF is likely responsible for fibrin deposition in sepsis-associated disseminated intravascular coagulation (DIC). Clinical assessment of TF expression ha...

journal_title：Thrombosis research

authors： Marsik C,Quehenberger P,Mackman N,Osterud B,Luther T,Jilma B

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Ultrasound can accelerate clot dissolution in vitro and in vivo. We used an ex vivo canine shunt to investigate low frequency ultrasound effects on platelet-rich stent thrombosis. METHODS AND RESULTS:Nitinol stents were expanded to 2 mm in diameter in two perfusion chambers in a parallel shunt and exposed...

journal_title：Thrombosis research

authors： Neuman Y,Rukshin V,Tsang V,Atar S,Miyamoto T,Luo H,Kobal S,Thompson T,Birnbaum Y,Horzewski M,Siegel RJ,Kaul S

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Circulating levels of fibrinogen are associated with atherosclerosis and predict future coronary heart disease and stroke. Levels of fibrinogen are correlated among family members, suggesting a heritable component. Variants of the beta-fibrinogen gene subunit on 4q28 are associated with fibrinogen levels b...

journal_title：Thrombosis research

authors： Yang Q,Tofler GH,Cupples LA,Larson MG,Feng D,Lindpaintner K,Levy D,D'Agostino RB,O'Donnell CJ

更新日期：2003-04-15 00:00:00

abstract：INTRODUCTION:Pulmonary embolism (PE) has a high morbidity and mortality. Hence it is important to recognize factors associated with higher risk of adverse outcomes in hemodynamically stable patients. Heart-type fatty acid binding protein (H-FABP) is a novel marker evaluated in recent years for prognosis in acute PE. Ou...

journal_title：Thrombosis research

authors： Liu M,Yuan X,Qiu X,Shan X,Lin D,Zhu L

更新日期：2015-01-01 00:00:00

abstract：:Incubation of recombinant human tissue factor apoprotein (Apo-TF) with human plasma decreased the recalcified clotting time of this plasma in a time-and dose-dependent manner suggesting relipidation of the Apo-TF by plasma lipoproteins. Incubation of Apo-TF with purified preparations of human very low density, low den...

journal_title：Thrombosis research

authors： Sakai T,Kisiel W

更新日期：1990-11-01 00:00:00

abstract：INTRODUCTION:Thrombomodulin (TM) has been described as a marker of endothelial injury in atherosclerosis. The role of TM as a predictor of PAD severity is to be proven. The goal of the present study is to compare the level of plasmatic (TMp) in patients with intermittent claudication with patients with critical ischemi...

journal_title：Thrombosis research

authors： Nasser M,Wolosker N,Uint L,Rosoky RA,Lobato M,Wajngarten M,Puech-Leao P

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:A paradox seems to exist: exercising leads to clotting activation in conventional clotting tests, but exercising persons have a low risk of thrombosis. In this study we tried to evaluate the effect of exercise performance status on in vitro plasma thrombin generation, which represents an overall function t...

journal_title：Thrombosis research

authors： Cimenti C,Schlagenhauf A,Leschnik B,Schretter M,Tschakert G,Gröschl W,Seibert FJ,Hofmann P,Muntean WE

更新日期：2013-06-01 00:00:00

abstract：:Platelet membrane glycoprotein V (GPV) was hydrolyzed during thrombin-induced platelet aggregation releasing a fragment GPVfl into the supernatant. Hydrolysis of GPV required catalytically active thrombin and was diminished by chemical modification of the fibrinogen binding site of thrombin. Half-maximal liberation of...

journal_title：Thrombosis research

authors： White GC 2nd,Knupp CL

更新日期：1985-06-15 00:00:00

abstract：BACKGROUND:The Clauss fibrinogen method and thrombin clotting time (TCT) are still routinely used in patients with cirrhosis to define fibrinogen concentration and clotting potential. The thromboelastometric functional fibrinogen FIBTEM assay evaluates the strength of fibrin-based clots in whole blood, providing inform...

journal_title：Thrombosis research

authors： Vucelic D,Jesic R,Jovicic S,Zivotic M,Grubor N,Trajkovic G,Canic I,Elezovic I,Antovic A

更新日期：2015-06-01 00:00:00

abstract：:Lupus anticoagulants (LA) are IgG or IgM antibodies which prolong phospholipid-dependent coagulation tests. For the detection and quantitation of such antibodies, we have developed an ELISA with cephalin as the coating antigen. The sensitivity of this assay was compared to the activated partial thromboplastin time (AP...

journal_title：Thrombosis research

authors： Sletnes KE,Keirung G,Wisløff F

更新日期：1990-01-15 00:00:00

abstract：:In this study we examined in 100 patients testing positive for Helicobacter pylori infection whether successful eradication therapy with pantoprazole, clarithromycin, and metronidazole alters fibrinogen and other acute phase response markers. Of 100 patients, only 11 showed a fibrinogen level above 300 mg/dL. Successf...

journal_title：Thrombosis research

authors： Schweeger I,Fitscha P,Sinzinger H

更新日期：2000-03-15 00:00:00

abstract：:Pulmonary embolism (PE) is a common, lethal yet treatable disease. The clinical diagnosis of PE remains to be a problem due to the nonspecific presenting signs, symptoms, electrocardiographic findings, arterial blood gas abnormalities and chest X-ray changes. Despite these nonspecific clinical findings, clinicians are...

journal_title：Thrombosis research

authors： Rodger M,Wells PS

更新日期：2001-09-15 00:00:00

abstract：:Cardiovascular disease (CVD) includes a number of conditions such as myocardial infarction, coronary heart disease, stroke, and venous thromboembolism. CVD is a leading health problem worldwide and a major cause of mortality, morbidity, and disability; it is also associated with high healthcare costs. The incidence of...

journal_title：Thrombosis research

authors： Cohen AT,Imfeld S,Markham J,Granziera S

更新日期：2015-02-01 00:00:00

abstract：:Chronic immune thrombocytopenia purpura (ITP) is an autoimmune disease that exhibits an abnormally high Th1/Th2 ratio. Granulocyte colony-stimulating factor (G-CSF) has been shown to decrease the Th1/Th2 ratio in healthy donors. In this study, we investigated the effects of G-CSF treatment on the Th1/Th2 cells and the...

journal_title：Thrombosis research

authors： Ge F,Zhang Z,Hou J,Cao F,Zhang Y,Wang P,Wei H,Zhou J

更新日期：2016-12-01 00:00:00

abstract：:A new approach to the investigation of accumulation of acridine derivatives and release by platelets is proposed. At high concentrations of acridine orange (AO) inside dense bodies, a two component fluorescence spectrum with maxima at 530 and 640 nm has been recorded. Computer deconvolution of spectra provided additio...

journal_title：Thrombosis research

authors： Popov EG,Gabbasov ZA,Gavrilov IYu,Pozin EYa,Mejlumian AG

更新日期：1987-09-15 00:00:00

abstract：:ZK-807834 (also known as CI-1031) is a small molecule that potently and selectively inhibits Factor Xa. Studies in animals have shown that ZK-807834 attenuates thrombosis and thrombus progression after fibrinolysis and exhibits an increased antithrombotic-to-bleeding risk ratio compared with conventional agents. The p...

journal_title：Thrombosis research

authors： Post JM,Sullivan ME,Abendschein D,Ewing J,Hinchman JW,Light DR

更新日期：2002-02-15 00:00:00

abstract：:This study investigates the effect on human platelet function of two sesquiterpene lactones from Arnica montana L., helenalin (H) and 11 alpha,13-dihydrohelenalin (DH). Both compounds inhibited collagen-induced platelet aggregation, thromboxane formation and 5-hydroxytryptamine secretion in a concentration-dependent m...

journal_title：Thrombosis research

authors： Schröder H,Lösche W,Strobach H,Leven W,Willuhn G,Till U,Schrör K

更新日期：1990-03-15 00:00:00