当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > Formation of tissue factor activity following incubation of recombinant human tissue factor apoprotein with plasma lipoproteins.

Formation of tissue factor activity following incubation of recombinant human tissue factor apoprotein with plasma lipoproteins.

Abstract：

:Incubation of recombinant human tissue factor apoprotein (Apo-TF) with human plasma decreased the recalcified clotting time of this plasma in a time-and dose-dependent manner suggesting relipidation of the Apo-TF by plasma lipoproteins. Incubation of Apo-TF with purified preparations of human very low density, low density and high density lipoproteins resulted in tissue factor activity in a clotting assay. The order of effectiveness was VLDL greater than LDL much greater than HDL. Tissue factor activity generated by incubation of a fixed amount of Apo-TF with plasma lipoproteins was lipoprotein concentration-dependent and saturable. The association of Apo-TF with lipoprotein particles was supported by gel filtration studies in which 125I-Apo-TF coeluted with the plasma lipoprotein in the void volume of a Superose 6 column in the presence and absence of calcium ions. In addition, void-volume Apo-TF-lipoprotein fractions exhibited tissue factor activity. These results suggest that the factor VIII-bypassing activity of bovine Apo-TF observed in a canine hemophilic model may be due, in part, to its association with plasma lipoproteins and expression of functional tissue factor activity.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Sakai T,Kisiel W

doi

10.1016/0049-3848(90)90182-c

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

213-22

issue

3

eissn

0049-3848

issn

1879-2472

pii

0049-3848(90)90182-C

journal_volume

60

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • Genetic prothrombotic risk factors in women with unexplained pregnancy loss.

    abstract：INTRODUCTION:Inherited thrombophilia has been associated with unexplained recurrent pregnancy loss (RPL) and stillbirth. This thrombotic tendency can manifest as thrombotic lesions in the placenta, and may lead to abortion and stillbirth. The aim of our case-control study was to investigate the prevalence of FVL and FI...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2005.06.005

    authors： Sottilotta G,Oriana V,Latella C,Luise F,Piromalli A,Ramirez F,Mammì C,Santoro R,Iannaccaro P,Muleo G,Lombardo VT

    更新日期：2006-01-01 00:00:00

  • Protein C activity levels in endotoxin-induced disseminated intravascular coagulation in a dog model.

    abstract：:The levels of protein C (PC) and other coagulation factors were monitored during endotoxin-induced disseminated intravascular coagulation (DIC) in the dog. Initial evaluation of the effectiveness of intradermal administration of bolus endotoxin quantities into the dog, demonstrated induction of DIC in the canine, with...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90062-5

    authors： Madden RM,Ward M,Marlar RA

    更新日期：1989-08-01 00:00:00

  • Fibrin gel structure and clotting time.

    abstract：:Liquid permeation studies of fibrin gels, which were formed in the presence of thrombin (Fibrin II) and in the presence of Batroxobin (Fibrin I), showed that those gels have distinctly different flow properties. For both gels the permeability coefficient (Ks) and average pore size varied depending on the conditions fo...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(82)90214-6

    authors： Blombäck B,Okada M

    更新日期：1982-01-01 00:00:00

  • Heparin enhances thrombin-stimulated prostaglandin I2 production by cultured endothelial cells.

    abstract：:Endothelial cells from human umbilical vein were incubated in vitro with thrombin in the absence or presence of unfractionated heparin (UFH), low molecular weight heparin (LMWH) or dermatan sulfate (DS) to clarify the effect of these glycosaminoglycans on thrombin-stimulated prostaglandin I2 (PGI2) production. Althoug...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90065-k

    authors： Itoh F,Kaji T,Hayakawa Y,Oguma Y,Sakuragawa N

    更新日期：1990-02-15 00:00:00

  • Induction of tissue factor-like activity of human monoblastic leukemia cell line by tumor necrosis factor-alpha.

    abstract：:Cell lysates of the human monoblastic leukemia cell line, THP-1, have procoagulant activity (PCA) that is Ca++-dependent and not demonstrable in either Factor VII-, or Factor X-deficient plasma. The PCA of THP-1 cells was enhanced by human recombinant tumor necrosis factor-alpha (TNF-alpha) up to five fold. There was ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90162-x

    authors： Tanaka M

    更新日期：1989-10-15 00:00:00

  • Evaluation of two functional assays for protein C inhibitor/plasminogen activator inhibitor-3 activity.

    abstract：:Two functional assays for protein C inhibitor (PCI) were evaluated in parallel for the same plasma samples. One assay is specific for active PCI and measures its ability to form complexes with activated protein C (APC) in the presence of heparin (España et al, Thromb Res 64, 309, 1991) (Method A). After incubation of ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(93)90079-4

    authors： España F,Hendl S,Gilabert J,Estellés A,Aznar J

    更新日期：1993-06-01 00:00:00

  • Diagnosis and risk stratification in patients with acute coronary syndromes according to ESC guidelines.

    abstract：:Diagnosis and risk stratification of patients with acute coronary syndromes remain extremely important in order to avoid unnecessary hospitalizations on the one hand, and to improve prognosis of these patients on the other. For diagnosis of acute coronary syndromes, an ECG should be obtained at rest, troponin T and I ...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/s0049-3848(01)00298-5

    authors： Klein W,Hödl R,Kraxner W

    更新日期：2001-09-30 00:00:00

  • Thermally induced conformational changes in fibrin film.

    abstract：:Fibrin film is prepared by compaction in one dimension of a fibrin clot (pH 6.3, ionic strength 0.15, fibrin concentration about 0.5%) by expulsion of fluid to reach a fibrin concentration of about 15%. Strips of film, equilibrated in the same buffer with very slowly increasing temperature, shrink in length in a narro...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(88)90020-5

    authors： Nakatani AI,Ferry JD

    更新日期：1988-12-01 00:00:00

  • Improvement of anticoagulant treatment using a dynamic decision support algorithm: a Danish Cohort study.

    abstract：INTRODUCTION:Warfarin is the most widely prescribed vitamin K antagonist and in the United States and Europe more than 10 million people are currently in long-term oral anticoagulant treatment. This study aims to retrospectively validate a dynamic statistical model providing dosage suggestions to patients in warfarin t...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.12.042

    authors： Nielsen PB,Lundbye-Christensen S,Rasmussen LH,Larsen TB

    更新日期：2014-03-01 00:00:00

  • The inhibition of thromboplastin by apolipoprotein-B and the effect of various associated lipids.

    abstract：:Human apolipoprotein B was purified by barium sulphate adsorption, subsequent delipidation and gel filtration. The protein was then reconstituted in soya bean lecithin and its inhibitory effect towards thromboplastin was assayed by incubation with rabbit brain thromboplastin. The use of an antibody against human apoli...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(92)90033-7

    authors： Ettelaie C,Howell RM

    更新日期：1992-10-15 00:00:00

  • The activity of constitutive nitric oxide synthase is increased by the pathway cAMP/cAMP-activated protein kinase in human platelets. New insights into the antiaggregating effects of cAMP-elevating agents.

    abstract：:Human platelets synthesize nitric oxide (NO) through an endothelial-type NO synthase (ecNOS) activated also by substances enhancing 3',5'-cyclic adenosine monophosphate (cAMP) concentrations, such as catecholamines, beta-adrenoceptor agonists and adenosine. To verify whether cAMP directly activates ecNOS through the c...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2004.06.036

    authors： Russo I,Doronzo G,Mattiello L,De Salve A,Trovati M,Anfossi G

    更新日期：2004-01-01 00:00:00

  • Antithrombotic effect of thiopurinol.

    abstract：:Antithrombotic activity of ten pyrazolo pyrimidine derivatives was tested in mouse pulmonary thromboembolism model. Out of these compounds, Thiopurinol (C5H4N4S) showed dose-dependent protection in mice from death/paralysis induced by collagen + adrenaline. It also caused dose-dependent inhibition of thrombus formatio...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90138-2

    authors： Srivastava R,Mishra A,Pratap R,Bhakuni DS,Srimal RC

    更新日期：1989-06-15 00:00:00

  • Evaluation of indirect microparticle activity and parameters of thrombin generation test in healthy infants.

    abstract：INTRODUCTION:Circulating microparticles support thrombin generation. The aim of this study is to determine the indirect microparticle activity and the parameters of thrombin generation in healthy infants. MATERIALS AND METHODS:A total of 85 infants who were brought to follow-up visits were taken into the study. Blood ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.11.011

    authors： Orhon FS,Egin Y,Ulukol B,Baskan S,Akar N

    更新日期：2014-02-01 00:00:00

  • Comparison of the binding character of triflavin on resting and activated alpha(IIb)beta(3) integrin in human platelets by electron microscopy.

    abstract：:Triflavin, an Arg-Gly-Asp (RGD)-containing disintegrin purified from venom peptide inhibited platelet aggregation by interfering with the interaction of fibrinogen with alpha(IIb)beta(3) integrin. Using an immunostaining technique and electron microscopy, we investigated and compared the distribution of triflavin bind...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(03)00104-x

    authors： Chuang WJ,Wu CH,Huang HN,Chen SH,Hsiao G,Lin CH,Sheu JR

    更新日期：2003-01-01 00:00:00

  • Mechanism of thrombin inhibition by heparin cofactor II and antithrombin in the presence of the ray (Raja radula) skin dermatan sulfate.

    abstract：INTRODUCTION:The kinetics of the thrombin inhibition by heparin cofactor II (HCII) and antithrombin (AT) have been studied as a function of the concentration of a dermatan sulfate (DS) from the skin of the ray Raja radula. MATERIALS AND METHODS:The initial concentrations of inhibitor (I), HCII or AT, and thrombin (E) ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.10.003

    authors： Ben Mansour M,Dhahri M,Vénisse L,Jandrot-Perrus M,Chaubet F,Maaroufi RM

    更新日期：2009-04-01 00:00:00

  • The predictive ability of the CHADS2 and CHA2DS2-VASc scores for bleeding risk in atrial fibrillation: the MAQI(2) experience.

    abstract：INTRODUCTION:Guidelines recommend the assessment of stroke and bleeding risk before initiating warfarin anticoagulation in patients with atrial fibrillation. Many of the elements used to predict stroke also overlap with bleeding risk in atrial fibrillation patients and it is tempting to use stroke risk scores to effici...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.05.034

    authors： Barnes GD,Gu X,Haymart B,Kline-Rogers E,Almany S,Kozlowski J,Besley D,Krol GD,Froehlich JB,Kaatz S

    更新日期：2014-08-01 00:00:00

  • Role of protein kinase C in U46619-induced platelet shape change, aggregation and secretion.

    abstract：:Stimulation of rat platelets with U46619 induced Ca2+ mobilization and platelet shape change, but aggregation and secretion were induced when platelets were stimulated with U46619 plus phorbol 12-myristate 13-acetate (PMA). However, stimulation of rabbit platelets with U46619 induced all the three platelet responses. ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90171-0

    authors： Nakano T,Hanasaki K,Arita H

    更新日期：1989-10-15 00:00:00

  • Impact of VKORC1 gene polymorphism on interindividual and interethnic warfarin dosage requirement--a systematic review and meta analysis.

    abstract：INTRODUCTION:Warfarin is the most widely used oral anticoagulant. It has been suggested that anticoagulation effect of warfarin is significantly associated with the polymorphism of certain genes, including Cytochrome P450 complex subunit 2C9 (CYP2C9), Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1), Gamma-Glutam...

    journal_title：Thrombosis research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.thromres.2009.10.017

    authors： Yang L,Ge W,Yu F,Zhu H

    更新日期：2010-04-01 00:00:00

  • Prior simvastatin treatment is associated with reduced thrombin generation and platelet activation in patients with acute ST-segment elevation myocardial infarction.

    abstract：BACKGROUND:It has been reported that statin therapy produces additional effects including impaired activation of blood coagulation. It is not clear whether statins can affect hemostasis in patients with acute coronary syndrome. The aim of this study was to investigate the effect of prior statin treatment on thrombin ge...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2009.06.021

    authors： Pastuszczak M,Kotlarz A,Mostowik M,Zalewski J,Zmudka K,Undas A

    更新日期：2010-05-01 00:00:00

  • Extracellular matrix components prevent lipopolysaccharide-induced bovine arterial endothelial cell injury by inhibiting p38 mitogen-activated protein kinase.

    abstract：:The effect of extracellular matrix components on lipopolysaccharide-induced vascular endothelial cell injury was studied by using lipopolysaccharide-susceptible bovine aortic endothelial cells. For evaluation of lipopolysaccharide-induced injury, we estimated DNA synthesis and cell detachment of bovine aortic endothel...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(99)00226-1

    authors： Chakravortty D,Kato Y,Koide N,Sugiyama T,Kawai M,Fukada M,Yoshida T,Yokochi T

    更新日期：2000-04-15 00:00:00

  • Elevated levels of platelet microparticles in carotid atherosclerosis and during the postprandial state.

    abstract：BACKGROUND:Platelet microparticles (PMPs) possess proatherogenic and procoagulant properties which may play a role in atherogenesis and subsequent thromboembolic complications. The present study was conducted to investigate the possible relationship between carotid atherosclerosis and plasma concentrations of PMPs, and...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.10.016

    authors： Michelsen AE,Notø AT,Brodin E,Mathiesen EB,Brosstad F,Hansen JB

    更新日期：2009-04-01 00:00:00

  • Accumulation of platelets as a key mechanism of human erection.

    abstract：:In this study, the role of platelets in the human erectile response was assessed. Twenty patients with erectile dysfunction were studied by means of (111)In-oxine-platelets and blood pool imaging using 99mTc. Seventeen patients received intracavernously prostaglandin E1, and three patients received papaverine together...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0049-3848(98)00065-6

    authors： Rodrigues M,O'Grady J,Stackl W,Granegger S,Sinzinger H

    更新日期：1998-07-15 00:00:00

  • Pharmacokinetics of fragmin. A comparative study in the rabbit of its high and low affinity forms for antithrombin.

    abstract：:A tritium-labelled low molecular weight heparin fragment with an average molecular weight of 4000-6000 (Fragmin), was fractionated into its high and low affinity forms for antithrombin. The fractions obtained were injected into rabbits, and the plasma half-life (t1/2) volume of distribution (Vd), area under the curve ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90345-8

    authors： Palm M,Mattsson C

    更新日期：1987-10-01 00:00:00

  • Granulocyte colony-stimulating factor decreases the Th1/Th2 ratio in peripheral blood mononuclear cells from patients with chronic immune thrombocytopenic purpura in vitro.

    abstract：:Chronic immune thrombocytopenia purpura (ITP) is an autoimmune disease that exhibits an abnormally high Th1/Th2 ratio. Granulocyte colony-stimulating factor (G-CSF) has been shown to decrease the Th1/Th2 ratio in healthy donors. In this study, we investigated the effects of G-CSF treatment on the Th1/Th2 cells and the...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2016.10.028

    authors： Ge F,Zhang Z,Hou J,Cao F,Zhang Y,Wang P,Wei H,Zhou J

    更新日期：2016-12-01 00:00:00

  • The influence of sample age on collagen-induced platelet aggregation in whole blood.

    abstract：:Whole blood electrical aggregometry (WBEA) has become an accepted method to gain quick information on platelet disorders. Compared to the optical method WBEA is closer to physiology and less complicated, but on the other hand more difficult to standardize. Different approaches have been attempted in the past to improv...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90232-2

    authors： Müller MR,Schreiner W,Wohlfahrt A,Salat A,Wolner E

    更新日期：1990-12-15 00:00:00

  • The protein C pathway in cancer metastasis.

    abstract：:Cancer is frequently associated with activation of blood coagulation, which in turn has been suggested to promote tumor growth and metastasis. Indeed, low molecular weight heparin treatment significantly prolongs the survival of a wide variety of patients with cancer. Based on this notion that anticoagulant treatment ...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/S0049-3848(12)70022-1

    authors： Spek CA,Arruda VR

    更新日期：2012-04-01 00:00:00

  • An open-label, comparative study of the efficacy and safety of once-daily dose of enoxaparin versus unfractionated heparin in the treatment of proximal lower limb deep-vein thrombosis.

    abstract：BACKGROUND:Treatment of deep-vein thrombosis (DVT) with a once-daily regimen of enoxaparin, rather than a continuous infusion of unfractionated heparin (UFH) is more convenient and allows for home care in some patients. This study was designed to compare the efficacy and safety of these two regimens for the treatment o...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.thromres.2004.05.009

    authors： Ramacciotti E,Araújo GR,Lastoria S,Maffei FH,Karaoglan de Moura L,Michaelis W,Sandri JL,Dietrich-Neto F,CLETRAT Investigators.

    更新日期：2004-01-01 00:00:00

  • Outcome of patients with splanchnic venous thrombosis presenting without overt MPN: a role for the JAK2 V617F mutation re-evaluation.

    abstract：INTRODUCTION:Although investigation for JAK2 V617F mutation is recommended in patients presenting with splanchnic venous thrombosis (SVT), no specific clinical advice is given to SVT patients presenting without myeloproliferative neoplasms (MPN) and JAK2 V617F mutation. In MPN-free SVT patients, to investigate the clin...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.07.014

    authors： Colaizzo D,Amitrano L,Guardascione MA,Tiscia GL,D'Andrea G,Longo VA,Grandone E,Margaglione M

    更新日期：2013-08-01 00:00:00

  • PROPLEX vs. PROPLEX SX: a controlled double blind study of the effectiveness in treating acute hemarthroses in hemophilia A patients with inhibitors to factor VIII.

    abstract：:A blinded randomized multicenter trial of two non-activated prothrombin complex concentrates was carried out to determine the clinical effectivity in the treatment of acute hemarthrosis in hemophiliac patients with inhibitors. The one product was prepared via DEAE Sephadex chromatography, while the second was fraction...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0049-3848(86)90115-5

    authors： Gomperts ED,Fannon RB,Lee ML,Kingdon HS,Kantrowitz JL,Addiego JE Jr,Carney J,Corrigan JJ,Hathaway W,Hilgartner MW

    更新日期：1986-06-15 00:00:00

  • Glycoprotein V hydrolysis by thrombin. Lack of correlation with secretion.

    abstract：:Platelet membrane glycoprotein V (GPV) was hydrolyzed during thrombin-induced platelet aggregation releasing a fragment GPVfl into the supernatant. Hydrolysis of GPV required catalytically active thrombin and was diminished by chemical modification of the fibrinogen binding site of thrombin. Half-maximal liberation of...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90207-5

    authors： White GC 2nd,Knupp CL

    更新日期：1985-06-15 00:00:00