Abstract:
INTRODUCTION:Circulating microparticles support thrombin generation. The aim of this study is to determine the indirect microparticle activity and the parameters of thrombin generation in healthy infants. MATERIALS AND METHODS:A total of 85 infants who were brought to follow-up visits were taken into the study. Blood samples were collected. Thrombin generation parameters and indirect microparticle activity were measured. RESULTS:The infants were divided into four groups according to the time of follow-up visits. Mean ages were 1.18 ± 0.19 months in Group 1, 6.15 ± 0.16 months in Group 2, 12.38 ± 0.46 months in Group 3 and 24.53 ± 0.39 months in Group 4, respectively. There was no statistical difference among the age-based groups with respect to the indirect microparticle activity. The lag time and the TTP levels in Group 1 were lower than that found in Group 2. The ETP and peak levels were higher in Group 1 than that of Group 2. The ETP and peak levels in Group 2 were found lower than those found in older children, but the TTP level was found relatively higher. Statistically correlations were found between indirect microparticle activity and all parameters of thrombin generation. CONCLUSIONS:The absence of a difference in terms of age-based microparticle levels may suggest that the features of microparticles in healthy children of this age group are similar. Age-dependent changes in thrombin generation parameters may suggest a regulation mechanism for the thrombin generation system over the first years of life. The results may provide mean values for indirect microparticle activity and thrombin generation in this healthy group.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Orhon FS,Egin Y,Ulukol B,Baskan S,Akar Ndoi
10.1016/j.thromres.2013.11.011subject
Has Abstractpub_date
2014-02-01 00:00:00pages
281-4issue
2eissn
0049-3848issn
1879-2472pii
S0049-3848(13)00547-1journal_volume
133pub_type
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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doi:10.1016/j.thromres.2007.08.004
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-09-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/0049-3848(85)90147-1
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Thrombosis research
pub_type: 杂志文章
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pub_type: 杂志文章
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