Efficacy and safety of prolonged thromboprophylaxis with a low molecular weight heparin (dalteparin) after total hip arthroplasty--the Danish Prolonged Prophylaxis (DaPP) Study.


:The aim of this study was to compare the efficacy and safety of prolonged (35 days) thromboprophylaxis with a standard length (7 days) regimen of a low molecular weight heparin in patients undergoing total hip arthroplasty. The study was multicentre, randomised, double-blind, and prospective with two groups. Following seven days on a standard length regimen of dalteparin (5000 antifactor Xa units subcutaneously once daily starting 12 h before surgery), patients were randomized to continue the prophylaxis with either subcutaneous injections of dalteparin or placebo injections for a further 28 days. Efficacy was evaluated at the end of the study (day 35) in all patients with bilateral ascending phlebography to detect deep vein thrombosis. Bleeding complications and other adverse events were registered throughout the study period. Three hundred consecutive patients agreed to participate before the operation: 281 were finally randomised and 215 completed the study; two patients died before randomisation; 17 developed deep vein thrombosis; none developed pulmonary embolism; and five of 113 patients (4.4%, 95% CI 1-10%) developed deep vein thrombosis in the dalteparin group, compared with 12 of 102 (11.8%; 95% CI 6-20%) in the placebo group (p=0.039). Deep vein thrombosis in the proximal veins was diagnosed in one patient (0.9%; 95% CI 0-5%) in the dalteparin group, and in five (5.0%; 95% CI 2-11%) in the placebo group (p=0.076). Major bleeding was observed in one patient in the placebo group; minor bleeding complications and adverse events were equally distributed between the groups. We concluded that prolonged (35 days) thrombo prophylaxis with dalteparin is more effective than a standard length (7 days) regimen without increased risk of bleeding complications or other adverse events.


Thromb Res


Thrombosis research


Lassen MR,Borris LC,Anderson BS,Jensen HP,Skejø Bro HP,Andersen G,Petersen AO,Siem P,Hørlyck E,Jensen BV,Thomsen PB,Hansen BR,Erin-Madsen J,Møller JC,Rotwitt L,Christensen F,Nielsen JB,Jørgensen PS,Paaske B,Tørholm




Has Abstract,Author List Incomplete


1998-03-15 00:00:00














  • Fibrinogen γ' levels in patients with intracerebral hemorrhage.

    abstract:BACKGROUND:The fibrinogen γ' variant (γ') has both antithrombotic and prothrombotic properties when compared to normal fibrinogen. It may therefore be of relevance in intracerebral hemorrhage and intraventricular extension of the bleeding. OBJECTIVE:To study the role of γ' in intracerebral hemorrhage, and in intravent...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: van den Herik EG,Cheung EY,de Lau LM,den Hertog HM,Leebeek FW,Dippel DW,Koudstaal PJ,de Maat MP

    更新日期:2012-06-01 00:00:00

  • Recombinant activated factor VII in an unselected series of cases with upper gastrointestinal bleeding.

    abstract:INTRODUCTION:The mortality rate associated with UGI bleeding remains high at 7-14%. Pharmacologic and endoscopic interventions are the current standard treatment, but there are few alternative options should these fail. This study aimed to assess the efficacy and safety of recombinant activated factor VII (rFVIIa) in t...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章


    authors: Vilstrup H,Markiewicz M,Biesma D,Brozovic VV,Laminoga N,Malik M,Milanov S,Patch D,Platikanov V

    更新日期:2006-01-01 00:00:00

  • Inhibition of human factor VIIa-tissue factor activity by placental anticoagulant protein.

    abstract::Previous studies indicated that human placental anticoagulant protein, a member of the lipocortin family, prolonged the clotting time of normal plasma when clotting was induced by brain thromboplastin or by kaolin in the presence of cephalin and calcium. Using a two-stage amidolytic assay to assess factor X activation...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Kondo S,Noguchi M,Funakoshi T,Fujikawa K,Kisiel W

    更新日期:1987-11-15 00:00:00

  • Long-term treatment of venous thromboembolism with tinzaparin compared to vitamin K antagonists: a meta-analysis of 5 randomized trials in non-cancer and cancer patients.

    abstract:PURPOSE:Due to its specific pharmacokinetic profile, tinzaparin, a low-molecular-weight heparin (LMWH), appears not to be associated with anti-factor Xa accumulation. Our meta-analysis aimed at determining whether long-term curative doses of tinzaparin is a valuable alternative to vitamin K antagonists (VKA) for the tr...

    journal_title:Thrombosis research

    pub_type: 杂志文章,meta分析


    authors: Laporte S,Bertoletti L,Romera A,Mismetti P,Pérez de Llano LA,Meyer G

    更新日期:2012-12-01 00:00:00

  • Interventional treatment of venous thromboembolism: a review.

    abstract::Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular disease after coronary artery disease and cerebrovascular disease and is responsible for significant morbidity and mortality in the general population. Full dose anticoagulation is th...

    journal_title:Thrombosis research

    pub_type: 杂志文章,评审


    authors: Imberti D,Ageno W,Manfredini R,Fabbian F,Salmi R,Duce R,Gallerani M

    更新日期:2012-04-01 00:00:00

  • Evaluation of a new chronometric assay for factor V Leiden-dependent APC resistance.

    abstract::Since the first description by Dahlbäck et al (1) of a hereditary defect in the plasma of three unrelated thrombophilic patients characterized by a poor anticoagulant response to activated protein C (APC), many reports have shown a high prevalence of the APC resistance in both the general and thrombophilic populations...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Gouault-Heilmann M,Leroy-Matheron C

    更新日期:1997-02-15 00:00:00

  • Fluorescent activity-based probe for the selective detection of Factor VII activating protease (FSAP) in human plasma.

    abstract::The zymogen form of circulating Factor VII activating protease (FSAP) is activated by histones that are released as a consequence of tissue damage or excessive inflammation. This is likely to have consequences in a number of disease conditions such as stroke, atherosclerosis, liver fibrosis, thrombosis and cancer. To ...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Rut W,Nielsen NV,Czarna J,Poreba M,Kanse SM,Drag M

    更新日期:2019-10-01 00:00:00

  • Impaired flow mediated dilatation as evidence of endothelial dysfunction in chronic atrial fibrillation: relationship to plasma von Willebrand factor and soluble E-selectin levels.

    abstract:BACKGROUND:Impaired endothelial-dependent flow-mediated dilatation (FMD) has been used to demonstrate endothelial dysfunction in a wide variety of cardiovascular disease, but previous studies have excluded patients with atrial fibrillation(AF). We therefore hypothesised that endothelial dysfunction exists in AF and tha...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Freestone B,Chong AY,Nuttall S,Lip GY

    更新日期:2008-01-01 00:00:00

  • Electrochemical activity determination of trypsin-like enzymes. VIII. Kallikrein and prekallikrein in plasma and whole blood.

    abstract::In-vitro determinations of purified kallikrein on the one hand, of human plasma and whole blood prekallikrein on the other hand have been conducted with the S-2648 electrogenic substrate using the electroanalytical technique. Plasmatic evaluations have been checked photometrically for assessing the reliability of the ...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Corretge E,Nigretto JM

    更新日期:1984-12-15 00:00:00

  • Impact of implementation of an individualised thromboprophylaxis protocol in critically ill ICU patients with COVID-19: A longitudinal controlled before-after study.

    abstract:INTRODUCTION:An individualised thromboprophylaxis was implemented in critically ill patients suffering from coronavirus disease 2019 (COVID-19) pneumonia to reduce mortality and improve clinical outcome. The aim of this study was to evaluate the effect of this intervention on clinical outcome. METHODS:In this mono-cen...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Stessel B,Vanvuchelen C,Bruckers L,Geebelen L,Callebaut I,Vandenbrande J,Pellens B,Van Tornout M,Ory JP,van Halem K,Messiaen P,Herbots L,Ramaekers D,Dubois J

    更新日期:2020-10-01 00:00:00

  • Thrombomodulin and ristocetincofactor in homocystinuria: a study in two siblings.

    abstract::Homocystinuria due to cystathionine-beta-synthase deficiency (CBS-def-HOCY) initially often presents with vascular disorders, e.g. thromboembolic events. The measurement of vascular endothelial markers in plasma could help to assess endothelial damage. We determined von Willebrand factor (measured as Ristocetincofacto...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Schienle HW,Seitz R,Nawroth P,Rohner I,Lerch L,Krumpholz B,Krauss G,Fowler B,Baumgartner R,Willenbockel U

    更新日期:1995-01-01 00:00:00

  • Lower dosage of recombinant tissue-type plasminogen activator (rt-PA) in the treatment of acute pulmonary embolism: a systematic review and meta-analysis.

    abstract:BACKGROUND AND OBJECTIVE:According to US Food and Drugs Administration (FDA), 2 hour recombinant tissue plasminogen activator (rt-PA) 100mg infusion is recommended for eligible patients with acute pulmonary embolism (PE). However,there exists evidence implying that a lower dosage of rt-PA can be equally effective but p...

    journal_title:Thrombosis research

    pub_type: 杂志文章,meta分析,评审


    authors: Zhang Z,Zhai ZG,Liang LR,Liu FF,Yang YH,Wang C

    更新日期:2014-03-01 00:00:00

  • Inhibition by AD6 (8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarbonyl methoxy coumarin) of platelet aggregation in dog stenosed coronary artery.

    abstract::The action of AD6 as an anti-thrombotic agent was studied in a model of coronary artery thrombosis and on platelet aggregation in the dog. AD6 (10-100 microM) in vitro inhibited aggregation induced by ADP, epinephrine, collagen and PAF (platelet aggregating factor) used at their threshold concentration for maximal agg...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Prosdocimi M,Finesso M,Tessari F,Gorio A,Languino LR,de Gaetano G,Dejana E

    更新日期:1985-08-15 00:00:00

  • Risk of bleeding in low-risk atrial fibrillation patients on warfarin waiting for elective cardioversion.

    abstract:INTRODUCTION:Systemic embolism is the most serious complication of cardioversion of atrial fibrillation (AF) and the immediate post-cardioversion period is associated with increased risk for thrombus formation. For this reason, treatment with vitamin K antagonist (VKA) is recommended for patients with AF. No informatio...

    journal_title:Thrombosis research

    pub_type: 杂志文章,多中心研究


    authors: Poli D,Antonucci E,Grifoni E,Paoletti O,Rancan E,Dentali F,Testa S

    更新日期:2012-05-01 00:00:00

  • CYP2C19*2 and other genetic variants affecting platelet response to clopidogrel in patients undergoing percutaneous coronary intervention.

    abstract:INTRODUCTION:Information regarding any possible additional effect of genetic variants other than CYP2C19*2 on platelet reactivity in patients undergoing percutaneous coronary intervention (PCI), while on dual antiplatelet therapy, is sparse. MATERIALS AND METHODS:Genotyping for CYP2C19*2, CYP2C19*17, CYP2C9*3, CYP2B6*...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章


    authors: Kassimis G,Davlouros P,Xanthopoulou I,Stavrou EF,Athanassiadou A,Alexopoulos D

    更新日期:2012-04-01 00:00:00

  • Pharmacodynamics assessment of Bemiparin after multiple prophylactic and single therapeutic doses in adult and elderly healthy volunteers and in subjects with varying degrees of renal impairment.

    abstract:INTRODUCTION:Aging and renal impairment may prolong the half-life and lead to accumulation of low molecular weight heparins. Correct dosing is critical to prevent bleeding or thrombosis. MATERIALS AND METHODS:Open, parallel study. Healthy adult [n=13] and elderly (>65yrs) [n=12] volunteers; and subjects with mild (ClC...

    journal_title:Thrombosis research

    pub_type: 杂志文章,多中心研究


    authors: Rico S,Antonijoan RM,Ballester MR,Gutierro I,Ayani I,Martinez-Gonzalez J,Borrell M,Fontcuberta J,Gich I

    更新日期:2014-06-01 00:00:00

  • The concomitant augmentation of urokinase-type plasminogen activator and collagenase-like proteinase activities in X-ray irradiated cells of a human metastatic carcinomatous line.

    abstract::The enzymatic activities of uPA, and a collagenase-like proteinase in the post-nuclear fraction of cell homogenates of a metastatic carcinomatous cell line following X-ray irradiation were examined by the use of chromogenic substrates and by casein- or gelatin-containing zymographies and electrophoretic gel stained wi...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Uchida N,Takahashi K,Kasai T,Ishida T,Kwaan HC

    更新日期:1994-06-15 00:00:00

  • Cilostazol inhibits HMGB1 release in LPS-activated RAW 264.7 cells and increases the survival of septic mice.

    abstract:INTRODUCTION:Inflammation and coagulation play important roles in the pathogenesis of sepsis. Anticoagulants with anti-inflammatory action draw attention as therapeutic agent in sepsis. OBJECTIVE:Whether cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2-(1H)-quinolinone), anticoagulant, protects m...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Chang KC

    更新日期:2015-08-01 00:00:00

  • Aggregation of human and canine platelets: modulation by purine nucleotides.

    abstract::This study compared the responses of canine and human platelets to various aggregating agonists in the presence or absence of extracellular ATP and ATP analogues. Canine and human platelets were approximately equally reactive with ADP or collagen while the canine platelets were about 10 fold more sensitive to thrombin...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Soslau G,Arabe L,Parker J,Pelleg A

    更新日期:1993-10-15 00:00:00

  • Prasugrel reduces ischaemic infarct volume and ameliorates neurological deficits in a non-human primate model of middle cerebral artery thrombosis.

    abstract::Several clinical trials have demonstrated the benefits of thienopyridine monotherapy in ischaemic stroke patients. Non-human primate models of ischaemic stroke have been used for various antithrombotic agents; however, to the best of our knowledge, there is no data on the effects of P2Y12 antagonists in models, such a...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Tomizawa A,Ohno K,Jakubowski JA,Mizuno M,Sugidachi A

    更新日期:2015-12-01 00:00:00

  • Signs of thrombin generation in pediatric cardiac catheterization with unfractionated heparin bolus or subcutaneous low molecular weight heparin for antithrombotic cover.

    abstract:INTRODUCTION:Thrombosis is one of the most frequent adverse events after cardiac catheterization, which can be reduced by anticoagulation with unfractionated heparin (UFH) in both children and adults. Low molecular weight heparin (LMWH) might possibly offer advantages. Laboratory signs of thrombin generation during ped...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章


    authors: Roschitz B,Beitzke A,Gamillscheg A,Sudi K,Koestenberger M,Leschnik B,Muntean W

    更新日期:2003-01-01 00:00:00

  • Platelet activation and endogenous thrombin potential in pre-eclampsia.

    abstract:INTRODUCTION:Platelets and the coagulation system may be involved in the pathogenesis of pre-eclampsia. We investigated whether platelet and coagulation activation markers, are elevated in pre-eclampsia. MATERIALS/METHODS:Case-control study in which activated platelets, platelet-monocyte/ neutrophil aggregates, platel...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Macey MG,Bevan S,Alam S,Verghese L,Agrawal S,Beski S,Thuraisingham R,MacCallum PK

    更新日期:2010-03-01 00:00:00

  • Venous thrombosis during assisted reproduction: novel risk reduction strategies.

    abstract::Ovarian hyperstimulation syndrome (OHSS) affects 5% of IVF cycles and incurs a 100-fold increase in risk of venous thrombosis over natural conceptions. Identification of women at risk of OHSS can be achieved using antral follicle count (AFC) and anti-Müllerian hormone (AMH). For those women with a high AFC or AMH comb...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Nelson SM

    更新日期:2013-01-01 00:00:00

  • Tissue factor apoprotein: intracellular transport and expression in shed membrane vesicles.

    abstract::We have studied the synthesis and subcellular distribution of the glycosylated membrane protein tissue factor (TF) in human blood monocytes and the inducible monocyte like cell line, HL-60. Following induction with endotoxin or the phorbol ester, TPA, tissue factor specific activity was measured in intact cells, sonic...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Bona R,Lee E,Rickles F

    更新日期:1987-11-15 00:00:00

  • Naproxen treatment prevents periprocedural inflammatory response but not myocardial injury after percutaneous coronary intervention.

    abstract:BACKGROUND AND AIM:Recent studies have documented that elevation of C-reactive protein (CRP) levels after percutaneous coronary intervention (PCI) have been predictive of adverse outcome. This study was performed to test the hypothesis that preprocedural use of naproxen sodium is associated with a reduction in the exte...

    journal_title:Thrombosis research

    pub_type: 杂志文章,随机对照试验


    authors: Ozdol C,Gulec S,Rahimov U,Atmaca Y,Turhan S,Erol C

    更新日期:2007-01-01 00:00:00

  • The role of protein kinase C in the initial events of platelet activation by thrombin assessed with a selective inhibitor.

    abstract::The role of protein kinase C (PKC) in platelet activation by thrombin was assessed using a PKC inhibitor Ro 31-7549/001 (R2) which, in vitro, shows more selectivity for PKC than other kinase inhibitors. During early (1.5 s) thrombin-induced platelet activation, when phosphorylation of 47 kDa protein (pleckstrin) and m...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Geanacopoulos M,Turner J,Bowling KE,Vandenberg SR,Gear AR

    更新日期:1993-01-01 00:00:00

  • Activation contact system (ACS) and tissue factor (TF) in human amniotic fluid: measurements of ACS components and TF, and some implications on the pathophysiology of amniotic fluid embolism.

    abstract:BACKGROUND/AIM:It is believed that the amniotic fluid-derived TF, in the case of amniotic fluid embolism (AFE), contributes to acute disseminated intravascular coagulation (DIC) and obstetric shock in the mother. However, the role of amniotic fluid-derived contact phase coagulation factors that irrupt into the bloodstr...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Uszyński W,Żekanowska E,Uszyński M,Kieszkowski P

    更新日期:2015-04-01 00:00:00

  • Glycerophospholipid metabolism: back to the future.

    abstract::It has become customary to regard the various glycerophospholipids as quite similar, and the acyl groups are considered to have little influence on the behaviour of the lipids in membranes or metabolism. Nevertheless, a number of recent observations by the authors and others indicate a high degree of metabolic compart...

    journal_title:Thrombosis research

    pub_type: 杂志文章,评审


    authors: Holmsen H,Hindenes JO,Fukami M

    更新日期:1992-08-01 00:00:00

  • Comparison of antithrombin activity of the polysulphate chitosan derivatives in in vivo and in vitro system.

    abstract::In order to choose the proper method for evaluating the antithrombin activity in samples of chitosan polysulphate (CP) with different polymerization degrees and sulphation degrees, we estimated the ability of direct anticoagulants to depress the coagulability of recalcified sheep blood using the third international he...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Drozd NN,Sher AI,Makarov VA,Galbraikh LS,Vikhoreva GA,Gorbachiova IN

    更新日期:2001-06-01 00:00:00

  • The role of agonist-induced activation and inhibition for the regulation of purinergic receptor expression in human platelets.

    abstract:INTRODUCTION:Adenosine diphosphate (ADP) as physiological activator of human platelets mediates its effects via three purinergic receptors: P2Y1, P2Y12 and P2X1. The inhibition of P2Y12 is used pharmacologically to suppress aggregation underlining the physiological significance of this receptor. Since the regulation of...

    journal_title:Thrombosis research

    pub_type: 杂志文章


    authors: Koessler J,Trulley VN,Bosch A,Weber K,Koessler A,Boeck M,Kobsar A

    更新日期:2018-08-01 00:00:00