Interactions between sodium salicylate and acetyl salicylic acid evaluated using ADP induced platelet aggregation and bleeding time.

abstract：BACKGROUND:Platelet microparticles (PMPs) possess proatherogenic and procoagulant properties which may play a role in atherogenesis and subsequent thromboembolic complications. The present study was conducted to investigate the possible relationship between carotid atherosclerosis and plasma concentrations of PMPs, and...

journal_title：Thrombosis research

authors： Michelsen AE,Notø AT,Brodin E,Mathiesen EB,Brosstad F,Hansen JB

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Long-term dual antiplatelet therapy (DAPT) has substantially reduced the risk of post-percutaneous coronary intervention (PCI) myocardial infarction and stent thrombosis at the expense of major bleeding. We hypothesized that a short-term DAPT followed by extended P2Y12 inhibitor monotherapy might be approp...

journal_title：Thrombosis research

authors： Jin Y,Huang H,Shu X,Chen S,Lu L,Gao X,Wu Z

更新日期：2020-12-07 00:00:00

abstract：:Microheterogeneity of antithrombin III (ATIII) was examined in pooled normal human plasma and serum by IEF/PA and immunoblotting techniques. A pattern consisting of 8 bands varying in isoelectric point from 4.7 to 5.2 was observed in citrated plasma following IEF in a pH range of 4-6. A similar pattern was observed in...

journal_title：Thrombosis research

authors： Daly M,Hallinan F

更新日期：1985-10-15 00:00:00

abstract：:The effects of sodium salicylate (SS) on ADP-induced platelet aggregation and on a metabolism of calcium in platelets were studied, using gel-filtrated platelets (GFP). SS inhibited dose-responsively ADP-induced aggregation in the presence of fibrinogen and Ca2+. It was found that extracellular 45Ca2+ was rapidly take...

journal_title：Thrombosis research

authors： Irino O,Saitoh K,Ohkubo K,Hashimoto S

更新日期：1985-08-01 00:00:00

abstract：INTRODUCTION:Management of pregnant women at risk for venous thromboembolism (VTE) remains complex. Guidelines do not definitively fix optimal strategies due to limited trial data. Our objective was to build an easy-to-use tool allowing individualised, risk-adapted prophylaxis. MATERIALS AND METHODS:A Delphi exercise ...

journal_title：Thrombosis research

authors： Chauleur C,Gris JC,Laporte S,Rancon F,Varlet MN,Decousus H,Mismetti P,STRATHEGE Group.

更新日期：2010-08-01 00:00:00

abstract：:The time course and degree of collagen induced platelet shape change, aggregation and ATP-secretion in citrated human platelet rich plasma was monitored with a lumi-aggregometer. Onset of ATP-secretion was measurable within seconds after collagen challenge and always distinctly before onset of shape change. In absence...

journal_title：Thrombosis research

authors： Malmgren R

更新日期：1986-08-15 00:00:00

abstract：:Five criteria for poor response to a 20 min venous occlusion test were applied to 58 patients 3 months or more after acute deep vein thrombosis (DVT). The criteria were arbitrarily defined as the last 5 percentiles of response distributions in an age- and sex-matched healthy control group of 51 subjects. The criteria ...

journal_title：Thrombosis research

authors： Stegnar M,Peternel P,Keber D,Vene N

更新日期：1991-11-15 00:00:00

abstract：BACKGROUND:Many heparin-induced thrombocytopenia (HIT) antibodies cause platelet activation in the serotonin release assay (SRA) in the absence of heparin. This in vitro observation may help unravel the mechanism of delayed-onset HIT, where seropositive patients develop thrombocytopenia and associated thrombosis after ...

journal_title：Thrombosis research

authors： Prechel MM,Jeske WP,Walenga JM

更新日期：2010-04-01 00:00:00

abstract：:Washed human platelets were incubated with commercial factor VIII concentrate, or with purified factor VIII coagulant moiety. Platelets were then washed again and lysed by sonication. VIII:Ag and vWf:Ag were measured in the platelet lysate prior to and after incubation of the lysate with phospholipase C (PL-C). Platel...

journal_title：Thrombosis research

authors： Muntean W,Leschnik B,Haas J

更新日期：1987-02-15 00:00:00

abstract：:Human fibrinogen exposed to 46.5 degrees C was subjected to gel permeation chromatography. The protein eluted in two distinct peaks. The first peak appeared in the void volume containing soluble fibrinogen aggregates, while the other peak represented monomeric fibrinogen. In contrast to the monomeric peak material, th...

journal_title：Thrombosis research

authors： Bennick A,Haddeland U,Brosstad F

更新日期：1996-04-15 00:00:00

abstract：:Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large, polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone marrow, lining blood vessel walls where they release their platelet progeny into circulation. Although little is known about how MKs dif...

journal_title：Thrombosis research

authors： Couldwell G,Machlus KR

更新日期：2019-07-01 00:00:00

abstract：:The abnormal Antithrombin-III (AT-III) Toyama has no ability to interact with heparin in the mast cells or heparin-like glycosaminoglycans on the surface of vascular endothelial cells, so that it has low heparin cofactor activity. In the present study, we have measured the binding capacity of 125I-labeled AT-III to cu...

journal_title：Thrombosis research

authors： Saito S,Takahashi K,Sakuragawa N

更新日期：1988-04-01 00:00:00

abstract：:Indirect genetic diagnosis using polymorphic DNA markers can be useful in large-scale screening programs, which is technically simpler, more rapid and amenable. The main objective of this study was to test the informativeness of two common intragenic markers (TaqI and XmnI) in Iranian haemophilia B families to detect ...

journal_title：Thrombosis research

authors： Ghandil P,Ghadiri A,Farhud D,Zeinali S

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) often causes progressive loss of mobility, leading to limb paralysis. Venous and lymphatic stasis is a risk condition for venous thromboembolism (VTE). There is, however, no data on the frequency of VTE complicating the progression of MS. The aim of this study was to assess the freque...

journal_title：Thrombosis research

authors： Arpaia G,Bavera PM,Caputo D,Mendozzi L,Cavarretta R,Agus GB,Milani M,Ippolito E,Cimminiello C

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:Guidelines recommend the assessment of stroke and bleeding risk before initiating warfarin anticoagulation in patients with atrial fibrillation. Many of the elements used to predict stroke also overlap with bleeding risk in atrial fibrillation patients and it is tempting to use stroke risk scores to effici...

journal_title：Thrombosis research

authors： Barnes GD,Gu X,Haymart B,Kline-Rogers E,Almany S,Kozlowski J,Besley D,Krol GD,Froehlich JB,Kaatz S

更新日期：2014-08-01 00:00:00

abstract：:Platelet alpha adrenoceptor status was examined using the radioligands 3H-yohimbine (3H-YOH) and 3H-dihydroergocryptine (3H-DHE) in 14 patients with myeloproliferative disorder (MPD) and 10 normal controls. Platelets from normal controls and MPD patients sensitive to adrenaline induced aggregation exhibited approximat...

journal_title：Thrombosis research

authors： Swart SS,Wood JK,Barnett DB

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Pregnancy is a hypercoagulable state associated with an increased risk of venous thrombosis, which begins during the first trimester, but the exact time of onset is unknown. Thrombin generation, a laboratory marker of thrombosis risk, increases during normal pregnancy but it is unclear exactly how early this...

journal_title：Thrombosis research

authors： Bagot CN,Leishman E,Onyiaodike CC,Jordan F,Freeman DJ

更新日期：2017-09-01 00:00:00

abstract：:A synthetic pentasaccharide, representing the critical sequence required in heparin for binding to antithrombin III (AT III), produces strong anti-factor Xa activity in vitro in the presence of AT III and is devoid of any activity directed towards thrombin. This pentasaccharide provides a unique tool to study the ques...

journal_title：Thrombosis research

authors： Walenga JM,Petitou M,Lormeau JC,Samama M,Fareed J,Choay J

更新日期：1987-04-15 00:00:00

abstract：:We have recently demonstrated that contact activation of the intrinsic coagulation cascade in vitro is accompanied not only by thromboxane (TX) B2 generation but also by the formation of 5-lipoxygenase-derived cysteinyl-leukotrienes (LT). In our present study we have investigated the effects of the vascular wall on th...

journal_title：Thrombosis research

authors： Weide I,Winking M,Simmet T

更新日期：1993-10-01 00:00:00

abstract：:Activation of human platelets by PAF was augmented by C-reactive protein, an acute phase plasma protein. The concentration of PAF required for irreversible activation (secondary aggregation of platelet and release of serotonin) was decreased to 1/10 in the presence of C-reactive protein (CRP). The presence of CRP stim...

journal_title：Thrombosis research

authors： Kohayakawa M,Inoue K

更新日期：1986-03-01 00:00:00

abstract：:An anticoagulant activity was identified and isolated from the leaves of a West African plant, Aspilia africana by gel filtration on Sephadex G-100. The anticoagulant factor had an apparent molecular weight of approximately 60,000 d. Upon incubation with plasma, it prolonged the partial thromboplastin time, prothrombi...

journal_title：Thrombosis research

authors： Hanna MM,Niemetz J

更新日期：1987-08-15 00:00:00

abstract：:We have determined that pp60c-src, a protein tyrosine kinase abundant in normal platelets, is present at comparable levels in platelets that are deficient in dense granules (Hermansky-Pudlak syndrome). Relative quantitation of pp60c-src was performed by immunoblot analysis after protein separation by sodium dodecyl su...

journal_title：Thrombosis research

authors： Sorisky A,Lages B,Weiss HJ,Rittenhouse SE

更新日期：1992-01-01 00:00:00

abstract：INTRODUCTION:Genetic and autoimmune risk factors contribute to the development of thrombotic thrombocytopenic purpura (TTP) but triggers are needed to bring about acute disease. The aim of the study was to investigate the association of neutrophil activation with acute TTP, to assess whether neutrophil activation chang...

journal_title：Thrombosis research

authors： Mikes B,Sinkovits G,Farkas P,Csuka D,Schlammadinger A,Rázsó K,Demeter J,Domján G,Réti M,Prohászka Z

更新日期：2014-04-01 00:00:00

abstract：:Fibrin film is prepared by compaction in one dimension of a fibrin clot (pH 6.3, ionic strength 0.15, fibrin concentration about 0.5%) by expulsion of fluid to reach a fibrin concentration of about 15%. Strips of film, equilibrated in the same buffer with very slowly increasing temperature, shrink in length in a narro...

journal_title：Thrombosis research

authors： Nakatani AI,Ferry JD

更新日期：1988-12-01 00:00:00

abstract：:A validated method for assessing hemostasis in vivo is critical for testing the hemostatic efficacy of therapeutic agents in preclinical animal models and in patients with inherited bleeding disorders, such as von Willebrand disease (VWD) and hemophilia A, or with acquired bleeding disorders such as those resulting fr...

journal_title：Thrombosis research

authors： Scola MR,Baggesen LM,Nichols TC,Key NS,Gallippi CM

更新日期：2012-05-01 00:00:00

abstract：:beta-Factor XIIa (beta-XIIa, Mr approximately 30,000) was isolated from human plasma by a procedure which utilized, as an initial step, the adsorption of Factor XII to celite. Activation of Factor XII and subsequent release of beta-XIIa was brought about by the proteolytic action of co-adsorbed kallikrein. Two success...

journal_title：Thrombosis research

authors： Tankersley DL,Alving BM,Finlayson JS

更新日期：1982-02-15 00:00:00

abstract：:The brain and the placenta synthesize identical peptides and proteins, such as brain-derived neurotrophic factor, oxytocin, vascular endothelial growth factor, cortisol, and matrix metalloproteinases. Given the promiscuity between neurochemistry and the mechanism of placentation, it would be expected that mental disor...

journal_title：Thrombosis research

authors： Hoirisch-Clapauch S,Brenner B,Nardi AE

更新日期：2015-02-01 00:00:00

abstract：:Rabbit platelets pretreated with CV-3988 had reduced responsiveness to platelet activating factor(PAF) even after the platelets had been washed with a buffer. This was due to its tight binding to receptor sites for PAF, but not conformational changes of the receptor, because the platelets that were pretreated with CV-...

journal_title：Thrombosis research

authors： Tokumura A,Yoshida J,Okasaka N,Fukuzawa K,Tsukatani H

更新日期：1987-04-01 00:00:00

abstract：:The antithrombotic effect of a synthetic symmetrical triglyceride having eicosapentaenoic acid (EPA) at positions 1 and 3, and gamma-linolenic acid (GLA) at position 2 was investigated. Administration of the triglyceride significantly increased thrombus formation time and thrombotic occlusion time induced by light irr...

journal_title：Thrombosis research

authors： Akahane N,Ohba S,Suzuki J,Wakabayashi T,Nakahara T,Yanagi K,Ohshima N

更新日期：1995-06-01 00:00:00

abstract：INTRODUCTION:Reports on the prevalence and risk factors of atherothrombotic events (AEs) are conflicting in persons with hemophilia (PWH). METHODS:This study evaluated the prevalence and risk factors of AEs among 1054 male hemophilia patients, using data collected from Taiwan's National Health Insurance Research Datab...

journal_title：Thrombosis research

authors： Wang JD,Chan WC,Fu YC,Tong KM,Chang ST,Hwang WL,Lin CH,Tsan YT

更新日期：2015-03-01 00:00:00