Human platelets deficient in dense granules contain normal amounts of pp60c-src.

abstract：:Whole blood electrical aggregometry (WBEA) has become an accepted method to gain quick information on platelet disorders. Compared to the optical method WBEA is closer to physiology and less complicated, but on the other hand more difficult to standardize. Different approaches have been attempted in the past to improv...

journal_title：Thrombosis research

authors： Müller MR,Schreiner W,Wohlfahrt A,Salat A,Wolner E

更新日期：1990-12-15 00:00:00

abstract：OBJECTIVE:In sepsis, activation of coagulation and inhibition of fibrinolysis lead to microvascular thrombosis. Thus, clot stability might be a critical issue in the development of multiple organ dysfunction syndrome. Activated FXIII (FXIIIa) forms stable fibrin clots by covalently cross-linking fibrin monomers. Theref...

journal_title：Thrombosis research

authors： Zeerleder S,Schroeder V,Lämmle B,Wuillemin WA,Hack CE,Kohler HP

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Antiphospholipid syndrome (APS) is a pro-thrombotic autoimmune disease that affects different vascular beds, with potential risk for recurrence. Systemic lupus erythematosus (SLE), specific autoantibodies profile and atherogenic disorders have been described as risk factors for the occurrence of first thro...

journal_title：Thrombosis research

authors： Saraiva Sda S,Custódio IF,Mazetto Bde M,Collela MP,de Paula EV,Appenzeller S,Annichino-Bizzachi J,Orsi FA

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Congenital factor V (FV) deficiency is a rare inherited disorder. Three compound heterozygous missense mutations, Asp68His, His147Arg, and Arg2074Cys, were observed in a Taiwanese patient with moderately severe FV deficiency. METHOD:The novel His147Arg mutation in the A1 domain was investigated by protein...

journal_title：Thrombosis research

authors： Liu HC,Lin TM,Eng HL,Lin YT,Shen MC

更新日期：2014-07-01 00:00:00

abstract：:Practice variation, the differences in clinical management between physicians, is one reason why patient outcomes may differ. Identifying factors that contribute to practice variation in areas of clinical uncertainty or equipoise may have implications for understanding and improving patient care. To discern what facto...

journal_title：Thrombosis research

authors： Skeith L,Gonsalves C

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Elevated plasma homocysteine has been implicated as a risk factor for hypertension. C677T polymorphism in methylenetetrahydrofolate reductase gene (MTHFR) is a major determinant of hyperhomocysteinemia, which results in endothelial dysfunction. Angiotensin-converting enzyme (ACE) inhibitors appear to remedy ...

journal_title：Thrombosis research

authors： Jiang S,Hsu YH,Xu X,Xing H,Chen C,Niu T,Zhang Y,Peng S,Xu X

更新日期：2004-01-01 00:00:00

abstract：:Patients with essential hypertension (EH) and hyperhomocysteinemia (HHCY) suffer from more increased thrombotic events than those in EH alone. However, the underlying mechanisms for this effect are not well understood. This study hypothesized that neutrophil extracellular trap (NET) releasing may be triggered by HHCY ...

journal_title：Thrombosis research

authors： Li JH,Tong DX,Wang Y,Gao L,Liu Y,Zhang XH,Chen WJ,Chi JY,Liu N,Yang K,Wang SP,Xu Y,Li Y,Yin XH,Liu WX

更新日期：2021-01-01 00:00:00

abstract：:Triflavin, an Arg-Gly-Asp (RGD)-containing disintegrin purified from venom peptide inhibited platelet aggregation by interfering with the interaction of fibrinogen with alpha(IIb)beta(3) integrin. Using an immunostaining technique and electron microscopy, we investigated and compared the distribution of triflavin bind...

journal_title：Thrombosis research

authors： Chuang WJ,Wu CH,Huang HN,Chen SH,Hsiao G,Lin CH,Sheu JR

更新日期：2003-01-01 00:00:00

abstract：:Thirty-four derivatives of benzamidine were tested for their inhibitory activities on bovine and human thrombins using the chromogenic peptide substrate N-D-Phe-Pip-Arg-pNA. The inhibition constants of small molecular size inhibitors of comparatively low affinity as well as those of tight binding inhibitors did not di...

journal_title：Thrombosis research

authors： Stürzebecher J,Walsmann P,Voigt B,Wagner G

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:SARS-CoV-2 infection has noted derangements in coagulation markers along with significant thrombotic complications. Post-mortem examinations show severe endothelial injury and widespread thrombotic microangiopathy in the pulmonary vasculature. Early reports describing the use of prophylactic anticoagulation ...

journal_title：Thrombosis research

authors： Hsu A,Liu Y,Zayac AS,Olszewski AJ,Reagan JL

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Right heart dysfunction is a crucial factor in risk stratification of normotensive patients with pulmonary embolism. Apart from biomarkers, determinants of right heart dysfunction in this group of patients are not yet well established. AIM AND METHOD:In order to identify such determinants, we analysed data ...

journal_title：Thrombosis research

authors： Berghaus TM,Haeckel T,Behr W,Wehler M,von Scheidt W,Schwaiblmair M

更新日期：2010-09-01 00:00:00

abstract：:Eight patients with femoro-popliteal or sural DVT, confirmed by phlebography, were treated with intravenous Desmin (LMW-dermatan sulphate): on the first day, after an initial i.v. injection of 400 mg, all patients received an infusion of 800 mg in 500 ml of saline, during 24 hours; this infusion was repeated in each o...

journal_title：Thrombosis research

authors： Kretz JG,Chakfe N,Wiesel ML,Grunebaum L,Zamboni V,Palazzini E,Cazenave JP

更新日期：1996-12-15 00:00:00

abstract：:Initiation of clotting cascade by tissue factor (TF): Factor VII (FVII) complex is essential for hemostasis however pathologic expression of TF leads to thrombosis. In contrast, the contact pathway factor XII, and to the smaller extent FXI are dispensable for normal hemostasis but still contribute to pathologic thromb...

journal_title：Thrombosis research

authors： Hoffman M,Pawlinski R

更新日期：2014-05-01 00:00:00

abstract：:We investigated the effects of Defibrotide (D), a natural polydeoxyribonucleotide, on acute myocardial ischemia (AMI) in anesthetized cats. A permanent ligature was placed around the left anterior descending coronary artery (LAD) 12-14 mm from its origin. Ventricular fibrillation and death were exceptional and when th...

journal_title：Thrombosis research

authors： Niada R,Porta R,Pescador R,Mantovani M,Prino G

更新日期：1985-04-01 00:00:00

abstract：:Antithrombin (AT) is a serpin capable of trapping thrombin (IIa) in a stable and covalent complex. Complex formation is prevented by leukocyte elastase (LE) cleavage near the AT reactive centre. We mutated the known LE cleavage sites of AT to explore the possibility of producing an LE-resistant AT molecule. Initially,...

journal_title：Thrombosis research

authors： Cunningham MA,Blajchman MA,Sheffield WP

更新日期：1997-10-15 00:00:00

abstract：:Resistance to Activated Protein C (APC) was evaluated using 3 different methods: two of them were based on the prolongation of the Activated Partial Thromboplastin Time (APTT) using 2 different APTT reagents in the presence of APC, whereas the third method was based on the prolongation of prothrombin time when APC is ...

journal_title：Thrombosis research

authors： Vasse M,Leduc O,Borg JY,Chrétien MH,Monconduit M

更新日期：1994-10-01 00:00:00

abstract：:Clinically unsuspected pulmonary embolism (UPE) is frequently diagnosed in cancer patients undergoing routine computed tomography scans for staging purposes or treatment response evaluation. The reported incidence of UPE ranges from 1% to 5% which probably represents an underestimation. A significant proportion of can...

journal_title：Thrombosis research

authors： van Es N,Bleker SM,Di Nisio M

更新日期：2014-05-01 00:00:00

abstract：:Both venous thromboembolism and intracranial metastases are common complications in the setting of primary brain tumors and metastatic malignancies. Anticoagulation is indicated in the presence of cancer-associated thrombosis in order to limit the risk of pulmonary embolism; however, there is reluctance to initiate an...

journal_title：Thrombosis research

authors： Weinstock MJ,Uhlmann EJ,Zwicker JI

更新日期：2016-04-01 00:00:00

abstract：:Activated platelets may adhere to leukocytes and form circulating mixed aggregates. The latter are considered a reliable marker of a prothrombotic state and are associated with several cardiovascular conditions. The molecular mechanisms responsible of this cellular interaction include a central role of platelet P-sele...

journal_title：Thrombosis research

authors： Cerletti C,Tamburrelli C,Izzi B,Gianfagna F,de Gaetano G

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:The CHADS2 and CHA2DS2-VASc scores are well-established clinical scales to estimate the risk of stroke in patients with atrial fibrillation (AF). However, the predictive power of the two scales concerning left atrial thrombus (LAT) or spontaneous echo contrast (SEC) has not been well investigated. Therefore,...

journal_title：Thrombosis research

authors： Han D,Chu Y,Wu Y,Wang X

更新日期：2020-11-01 00:00:00

abstract：:A Ca++-ionophore, ionomycin, increased the volume of human platelets suspended in a Ca++-containing buffer. This change in cell volume was dependent upon ionomycin and extracellular Ca++ concentrations, suggesting that the volume change occurs when the intracellular Ca++ reaches a certain level (greater than uM as det...

journal_title：Thrombosis research

authors： Ozaki Y,Matsumoto Y,Yatomi Y,Higashihara M,Kariya T,Kume S

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Animal models of thrombosis and hemostasis are critical for target validation in pharmaceutical research. Guinea pig haemostatic mechanisms, such as the platelet thrombin receptor repertoire, resemble those of humans. Measuring the performance characteristics of marketed antithrombotic drugs in guinea pig ...

journal_title：Thrombosis research

authors： Bird JE,Giancarli MR,Allegretto N,Barbera F,Wong P,Schumacher WA,Ogletree ML,Seiffert D

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Few studies investigated the relationship between fibrinolysis abnormalities and residual pulmonary perfusion defects after acute pulmonary embolism (PE). OBJECTIVE:To assess the fibrinolytic profile in patients with prior PE in relation to the extent of scintigraphically detectable residual perfusion abnor...

journal_title：Thrombosis research

authors： Lami D,Cellai AP,Antonucci E,Fiorillo C,Becatti M,Grifoni E,Cenci C,Marcucci R,Mannini L,Miniati M,Abbate R,Prisco D

更新日期：2014-09-01 00:00:00

abstract：:The effect of extracellular matrix components on lipopolysaccharide-induced vascular endothelial cell injury was studied by using lipopolysaccharide-susceptible bovine aortic endothelial cells. For evaluation of lipopolysaccharide-induced injury, we estimated DNA synthesis and cell detachment of bovine aortic endothel...

journal_title：Thrombosis research

authors： Chakravortty D,Kato Y,Koide N,Sugiyama T,Kawai M,Fukada M,Yoshida T,Yokochi T

更新日期：2000-04-15 00:00:00

abstract：:The ultrastructure of the platelet contacts with collagen fibrils (CF) as well as the course taken by CF on the platelet surface were studied on ultrathin sections of platelets and CF. Platelets from normal donors and from a patient with thrombasthenia were incubated in citrated plasma with collagen. For electron micr...

journal_title：Thrombosis research

authors： Ruf A,Morgenstern E,Janzarik H,Lüscher EF

更新日期：1986-11-15 00:00:00

abstract：:The release of arachidonic acid, and its subsequent conversion to thromboxane A2, is an important component of platelet activation. The precise mechanism of arachidonic acid release is unknown although cytosolic phospholipase A2 (cPLA2) has been implicated. In the present study the effects of three agonists, the serin...

journal_title：Thrombosis research

authors： McNicol A,Shibou TS

更新日期：1998-10-01 00:00:00

abstract：:Human platelets synthesize nitric oxide (NO) through an endothelial-type NO synthase (ecNOS) activated also by substances enhancing 3',5'-cyclic adenosine monophosphate (cAMP) concentrations, such as catecholamines, beta-adrenoceptor agonists and adenosine. To verify whether cAMP directly activates ecNOS through the c...

journal_title：Thrombosis research

authors： Russo I,Doronzo G,Mattiello L,De Salve A,Trovati M,Anfossi G

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:There is a need to identify and develop novel thrombolytic agents that can directly digest fibrin clots from various biological resources. OBJECTIVE:To clone, express, purify, and characterize a recombinant protease named rvFMP capable of cleaving fibrinogen, fibrin polymer, and cross-linked fibrin in human...

journal_title：Thrombosis research

authors： Lim DS,Park JE,Park JW,Cho YH,Park JK,Lee JS

更新日期：2020-07-01 00:00:00

abstract：:Activation of the coagulation and inflammatory systems are physiologically occurring during pregnancy. However, excess activation of either system is well documented in gestational vascular diseases (GVD). GVD are placenta-mediated pregnancy complications and a major cause of feto-maternal morbidity and mortality. The...

journal_title：Thrombosis research

authors： Kohli S,Isermann B

更新日期：2017-03-01 00:00:00

abstract：:The concentration of tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1) and the complex of t-PA and PAI-1 (t-PA-PAI-1 complex) were measured using an enzyme immunoassay, where the first antibody was monoclonal antibody against PAI-1 and the second one was polyclonal anti-t-PA Fab' antibody....

journal_title：Thrombosis research

authors： Takada Y,Takada A

更新日期：1989-09-01 00:00:00