Intracranial hemorrhage in cancer patients treated with anticoagulation.

Abstract:

:Both venous thromboembolism and intracranial metastases are common complications in the setting of primary brain tumors and metastatic malignancies. Anticoagulation is indicated in the presence of cancer-associated thrombosis in order to limit the risk of pulmonary embolism; however, there is reluctance to initiate anticoagulation in the setting of intracranial metastatic disease due to potential for intracranial hemorrhage. Recent evidence suggests that therapeutic anticoagulation can be safely administered in the setting of metastatic brain tumors. This review examines the current understanding of the pathophysiology of intracranial hemorrhage in malignancy, describes the incidence of intracranial hemorrhage in the setting of brain tumors with therapeutic anticoagulation, and outlines management strategies relevant to the treatment of intracranial hemorrhage in the setting of anticoagulation.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Weinstock MJ,Uhlmann EJ,Zwicker JI

doi

10.1016/S0049-3848(16)30100-1

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

S60-5

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(16)30100-1

journal_volume

140 Suppl 1

pub_type

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