Hemostasis: old system, new players, new directions.

abstract：BACKGROUND AND PURPOSE:Miniplasmin was a des-kringle variant of plasminogen with potential pharmacological application. We investigated the thrombolytic effect of miniplasmin in a canine model of femoral artery thrombosis. METHODS:In anesthetized dogs, a stable occlusive thrombus was formed by mechanical and electroly...

journal_title：Thrombosis research

authors： Fu J,Ren J,Zou L,Bian G,Li R,Lu Q

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The Clauss fibrinogen method and thrombin clotting time (TCT) are still routinely used in patients with cirrhosis to define fibrinogen concentration and clotting potential. The thromboelastometric functional fibrinogen FIBTEM assay evaluates the strength of fibrin-based clots in whole blood, providing inform...

journal_title：Thrombosis research

authors： Vucelic D,Jesic R,Jovicic S,Zivotic M,Grubor N,Trajkovic G,Canic I,Elezovic I,Antovic A

更新日期：2015-06-01 00:00:00

abstract：:We have investigated the role of platelet activating factor (PAF) in the pathogenesis of a murine model of traumatic shock using WEB 2086, a specific antagonist of PAF. WEB 2086 (0.5 mg/kg) significantly reversed the decrease in mean arterial blood pressure (MABP) induced by PAF (0.3 micrograms/kg) in anesthetized rat...

journal_title：Thrombosis research

authors： Stahl GL,Bitterman H,Lefer AM

更新日期：1989-02-01 00:00:00

abstract：:This study compares selected properties of purified tryptic fragments of human von Willebrand (vW) protein in order to better understand how the M(r) 116,000 fragment retains activity in ristocetin-induced platelet agglutination. Wheat germ agglutinin (WGA) aggregation of platelet-rich plasma was potentiated by preinc...

journal_title：Thrombosis research

authors： Martin SE,Francis CW,Marder VJ

更新日期：1983-08-01 00:00:00

abstract：:Clinically unsuspected pulmonary embolism (UPE) is frequently diagnosed in cancer patients undergoing routine computed tomography scans for staging purposes or treatment response evaluation. The reported incidence of UPE ranges from 1% to 5% which probably represents an underestimation. A significant proportion of can...

journal_title：Thrombosis research

authors： van Es N,Bleker SM,Di Nisio M

更新日期：2014-05-01 00:00:00

abstract：:Changes in cytoplasmic free calcium in response to epinephrine in combination with other agonists were studied in human platelets loaded with the fluorescent calcium indicator, quin 2. In the presence of 1mM external calcium, epinephrine augmented the increase in cytoplasmic free calcium in response to collagen or thr...

journal_title：Thrombosis research

authors： Ardlie NG,Bell LK,McGuiness JA

更新日期：1987-05-15 00:00:00

abstract：OBJECTIVES:Dabigatran etexilate is widely used for stroke prevention in the patients with atrial fibrillation. The anticoagulation activity of dabigatran is not necessary monitored in routine clinical practice. We aimed to study the effect of dabigatran on thrombin generation (TG) and coagulation assays in rabbit and h...

journal_title：Thrombosis research

authors： Zhang C,Zhang P,Li H,Han L,Zhang L,Zhang L,Yang X

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Z4A5 is a novel peptide that inhibits platelet aggregation and formation of platelet thrombi, but the mechanism of its anti-platelet effects remains unknown. This study explores the anti-platelet effect and mechanism of Z4A5. METHODS:We investigated the anti-platelet activity of Z4A5 on platelet aggregati...

journal_title：Thrombosis research

authors： Li YX,Sun Q,Zhang H,Ren ST,Liao YR,Wang Y,Shen XL,Wang B

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder in children. Activated T cells have been shown to play important roles in ITP. The aims of this study were to evaluate whether these T cell activation markers could be used as indicators to differentiate ITP patients from controls, and to ...

journal_title：Thrombosis research

authors： Chen Y,Zhou Y,Chen P,Zhang P,Jia M,Tang Y

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Ticagrelor and prasugrel are recommended as first line therapy in patients with acute coronary syndromes (ACS). However, patients with anemia are commonly treated with clopidogrel in routine clinical practice. The RENAMI registry (REgistry of New Antiplatelet therapy in patients with acute Myocardial Infar...

journal_title：Thrombosis research

authors： Guerrero C,Garay A,Ariza-Solé A,Formiga F,Raposeiras-Roubín S,Abu-Assi E,D'Ascenzo F,Kinnaird T,Manzano-Fernández S,Alegre O,Sánchez-Salado JC,Lorente V,Templin C,Velicki L,Xanthopoulou I,Cerrato E,Rognoni A,Boccuzzi G

更新日期：2018-07-01 00:00:00

abstract：:The reunification of Germany in 1990 brought with it major challenges in terms of unifying the care offered to haemophilia patients. At that time, most of the treatment centres belonged to the largest regional hospitals. The centre for paediatric haemophilia patients in Leipzig was at the University Hospital. In this ...

journal_title：Thrombosis research

authors： Lenk H

更新日期：2014-11-01 00:00:00

abstract：:The present study was designed to find out whether the synthetic pentasaccharide SR 90107A/Org 31540, which is presently being evaluated in clinical trials as an antithrombotic agent, influences lipoprotein metabolism in rats as determined by plasma triglyceride (TG) lipase activity. A comparison with three clinically...

journal_title：Thrombosis research

authors： Hoffmann P,Bernat A,Dumas A,Petitou M,Hérault JP,Herbert JM

更新日期：1997-05-15 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) often causes progressive loss of mobility, leading to limb paralysis. Venous and lymphatic stasis is a risk condition for venous thromboembolism (VTE). There is, however, no data on the frequency of VTE complicating the progression of MS. The aim of this study was to assess the freque...

journal_title：Thrombosis research

authors： Arpaia G,Bavera PM,Caputo D,Mendozzi L,Cavarretta R,Agus GB,Milani M,Ippolito E,Cimminiello C

更新日期：2010-04-01 00:00:00

abstract：:The inhibition of one- and two-chain forms of tissue-type plasminogen activator by a series of peptide derivatives of arginine chloromethyl ketone was studied. Both forms of the enzyme were inhibited by such reagents at varying rates, dependent on the peptide sequence of the inhibitor. The order of relative effectiven...

journal_title：Thrombosis research

authors： Green GD

更新日期：1986-10-15 00:00:00

abstract：BACKGROUND:Atherosclerosis occurs as a result of a chronic inflammatory response in the arterial wall associated with an increased uptake of low-density lipoprotein by macrophages and the subsequent transformation of this lipoprotein into foam cells. It has been found that miR-188-3p can suppress autophagy and myocardi...

journal_title：Thrombosis research

authors： Zhang XF,Yang Y,Yang XY,Tong Q

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Patients with nonvalvular atrial fibrillation are at increased risk for systemic embolism, predominantly disabling stroke. To study how stroke and mortality rates vary with different degrees of anticoagulation reflected by the international normalised ratio (INR) we critically assess information from diffe...

journal_title：Thrombosis research

authors： Odén A,Fahlén M,Hart RG

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Thrombin, a serine protease, plays an important role in such actions as coagulation, cell proliferation and inflammation. It has been sporadically reported that endothelial cells, when stimulated by thrombin via protease-activated receptors (PAR), express various mediators and proteins including cytokines,...

journal_title：Thrombosis research

authors： Okada M,Suzuki K,Takada K,Nakashima M,Nakanishi T,Shinohara T

更新日期：2006-01-01 00:00:00

abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...

journal_title：Thrombosis research

authors： Wesemann W,Hoffmann D

更新日期：1985-09-15 00:00:00

abstract：:A new approach to the investigation of accumulation of acridine derivatives and release by platelets is proposed. At high concentrations of acridine orange (AO) inside dense bodies, a two component fluorescence spectrum with maxima at 530 and 640 nm has been recorded. Computer deconvolution of spectra provided additio...

journal_title：Thrombosis research

authors： Popov EG,Gabbasov ZA,Gavrilov IYu,Pozin EYa,Mejlumian AG

更新日期：1987-09-15 00:00:00

abstract：:Individuals with more than one defect in the natural anticoagulant system exhibit an increased risk for thrombosis. We report on a family with two cases of combined protein C (PROC) and protein S (PROS) deficiency, five cases of isolated PROC deficiency Type I, and two cases of isolated PROS deficiency Type I. PROC an...

journal_title：Thrombosis research

authors： Knoll B,Hach-Wunderle V,Rieger S,Häring D,Mannhalter C

更新日期：2001-07-01 00:00:00

abstract：INTRODUCTION:Only sparse information exists on the use of direct oral anticoagulant (DOAC) testing and the impact on clinical management. Here, we evaluated the clinical impact of DOAC measurements in a real-life clinical setting. Moreover, number of tests performed in relation to number of DOAC-treated patients was ev...

journal_title：Thrombosis research

authors： Winther-Larsen A,Hvas AM

更新日期：2019-03-01 00:00:00

abstract：:The alpha-chymotrypsin-like proteinase from rat peritoneal mast cells (RMCP I) rapidly destroyed the normal clotting activity of purified, calcium-free, bovine prothrombin, human prothrombin and bovine factor X and simultaneously removed similar N-terminal peptides (Mr approximately 5,000) from both prothrombin and th...

journal_title：Thrombosis research

authors： Wylie AR,Lonsdale-Eccles JD,Blumsom NL,Elmore DT

更新日期：1986-11-01 00:00:00

abstract：:Vascular endothelial injury (VEI) triggers pathological processes in various cardiovascular diseases, such as coronary heart disease and hypertension. To further elucidate the in vivo pathological mechanisms of VEI, many animal models have been established. For the easiness of genetic manipulation and feeding, murine ...

journal_title：Thrombosis research

authors： Wu Y,Su SA,Xie Y,Shen J,Zhu W,Xiang M

更新日期：2018-09-01 00:00:00

abstract：:Eicosapentaenoic acid (EPA) has been reported to have a potent anti-aggregatory activity and to be efficiently metabolized by 12-lipoxygenase, not by cyclooxygenase in platelets. In vitro effect of 12-lipoxygenase metabolites of EPA on platelet function was studied and compared with those of arachidonic acid (AA). The...

journal_title：Thrombosis research

authors： Takenaga M,Hirai A,Terano T,Tamura Y,Kitagawa H,Yoshida S

更新日期：1986-02-01 00:00:00

abstract：INTRODUCTION:There is some controversy regarding the effect of CYP2C19 polymorphism on clinical outcome in patients with dual antiplatelet therapy. Chronic kidney disease (CKD) is associated with increased risk of cardiovascular event, but the association between the possession of CYP2C19 loss-of-function (LOF) alleles...

journal_title：Thrombosis research

authors： Tabata N,Hokimoto S,Akasaka T,Arima Y,Kaikita K,Kumagae N,Morita K,Miyazaki H,Oniki K,Nakagawa K,Matsui K,Ogawa H

更新日期：2014-11-01 00:00:00

abstract：:Venous thromboembolism (VTE) affects approximately 1 per 1000 persons annually. Although patients are increasingly treated with direct oral anticoagulants, many patients continue to be anticoagulated with vitamin K antagonists (VKA). The most important adverse events during VKA treatment, bleeding and the risk of recu...

journal_title：Thrombosis research

authors： Schmidt DE,Chaireti R,Bruzelius M,Holmström M,Antovic J,Ågren A

更新日期：2019-06-01 00:00:00

abstract：:Enzymatic treatment used for passaging of endothelial cells may induce release of von Willebrand factor (vWF). Decreased ability to replenish intracellular stores results in decreased secretion of vWF in later passages of cells. Since both trypsin and pancreatin complex have been used for passaging endothelial cells, ...

journal_title：Thrombosis research

authors： Lopes AA,Peranovich TM,Maeda NY,Bydlowski SP

更新日期：2001-02-15 00:00:00

abstract：:To estimate the effect of dilazep in preventing restenosis after a transluminal angioplasty, we have attempted an animal experiment in which the efficacy of drug was tested on an angioplastic injury superimposed on to atherosclerotic lesions. Using a modification of Block's method, atherosclerotic lesions first were m...

journal_title：Thrombosis research

authors： Nobuyoshi M,Tanaka M,Fujii M,Asanuma A,Takimoto M

更新日期：1989-06-15 00:00:00

abstract：:Patients with the nephrotic syndrome are at increased risk of developing venous and arterial thromboembolism, the most common of which is renal vein thrombosis. There are several unanswered or controversial issues relating to the nephrotic syndrome and thromboembolism, which include the mechanism of thromboembolism, a...

journal_title：Thrombosis research

authors： Singhal R,Brimble KS

更新日期：2006-01-01 00:00:00

abstract：:The inability of the heparin-antithrombin complex to inhibit fibrin-bound thrombin limits the utility of heparin for treatment of arterial thrombosis. In contrast with heparin, melagatran, a direct thrombin inhibitor (DTI), is equally effective at inhibiting fluid-phase thrombin and thrombin bound to fibrin. This refl...

journal_title：Thrombosis research

authors： Weitz JI

更新日期：2003-07-15 00:00:00