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Morphology of the interaction of collagen fibrils with normal human platelets and thrombasthenic platelets.

Abstract：

:The ultrastructure of the platelet contacts with collagen fibrils (CF) as well as the course taken by CF on the platelet surface were studied on ultrathin sections of platelets and CF. Platelets from normal donors and from a patient with thrombasthenia were incubated in citrated plasma with collagen. For electron microscopy a protein-stabilizing fixation procedure was applied. Platelet-collagen contacts (PCC) are characterized by a distance of 7 +/- 3 nm between the platelet membrane and the CF; the gap contains electron-dense bridges. The PCC of normal and thrombasthenic platelets are morphologically identical. Hence, it is unlikely that the glycoproteins IIb/IIIa-complex, which is absent in thrombasthenic platelets, plays a significant role in the platelet collagen interaction. The CF induce random movements of the platelets and their pseudopods, whereby the fibrils, which often show multisite attachment, coil up around the platelet surface; they become bent and often display drastic directional changes. CF are found inside invaginations of the platelet membrane as well as in depressions of the platelet surface. These processes require an involvement of the platelet's contractile system, which appears to interact reversibly with the platelet plasma membrane.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Ruf A,Morgenstern E,Janzarik H,Lüscher EF

doi

10.1016/0049-3848(86)90326-9

subject

Has Abstract

pub_date

1986-11-15 00:00:00

pages

477-87

issue

4

eissn

0049-3848

issn

1879-2472

journal_volume

44

pub_type

杂志文章

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