Fibrinogen does not protect von Willebrand factor against proteolysis by human cathepsin G.

abstract：INTRODUCTION:The prevalence and etiology of occult bleeding among patients on warfarin who are screened systematically for new anemia is largely unknown. We aimed to estimate the usefulness of following hemoglobin and mean red cell volume (MCV) with INR in order to screen for developing anemia as an indicator of occult...

journal_title：Thrombosis research

authors： Johannsdottir GA,Onundarson PT,Gudmundsdottir BR,Bjornsson ES

更新日期：2012-09-01 00:00:00

abstract：:The effect of a low molecular weight heparin (Fragmin) (20-80 U/kg) was studied in 10 healthy male volunteers after intravenous administration. Clotting abnormalities are extensive shortly after injection, lasting for 1-2 hours depending on heparin dosage. Dilute thrombin time, showing a close correlation to anti-F-Xa...

journal_title：Thrombosis research

authors： Andrassy K,Mörike K,Koderisch J,Weber E

更新日期：1988-03-15 00:00:00

abstract：INTRODUCTION:The mortality rate associated with UGI bleeding remains high at 7-14%. Pharmacologic and endoscopic interventions are the current standard treatment, but there are few alternative options should these fail. This study aimed to assess the efficacy and safety of recombinant activated factor VII (rFVIIa) in t...

journal_title：Thrombosis research

authors： Vilstrup H,Markiewicz M,Biesma D,Brozovic VV,Laminoga N,Malik M,Milanov S,Patch D,Platikanov V

更新日期：2006-01-01 00:00:00

abstract：:The role of protein kinase C (PKC) in platelet activation by thrombin was assessed using a PKC inhibitor Ro 31-7549/001 (R2) which, in vitro, shows more selectivity for PKC than other kinase inhibitors. During early (1.5 s) thrombin-induced platelet activation, when phosphorylation of 47 kDa protein (pleckstrin) and m...

journal_title：Thrombosis research

authors： Geanacopoulos M,Turner J,Bowling KE,Vandenberg SR,Gear AR

更新日期：1993-01-01 00:00:00

abstract：:There are some issues in the current factor (F)VIII replacement therapy for severe hemophilia A. One is mental and physical burden for the multiple intravenous infusions, and the other is difficulty in the hemostatic treatment for the patients with FVIII inhibitor. The development of novel drug with fully hemostatic e...

journal_title：Thrombosis research

authors： Nogami K

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:A recent study suggested that the plasminogen activator inhibitor (PAI)-1 4G/5G genotype may play a role in the resolution of deep vein thrombosis (DVT) after surgery. In the present study, we investigated the association between PAI-1 4G/5G genotype and the persistence of venous occlusion after acute idiopa...

journal_title：Thrombosis research

authors： Giurgea GA,Brunner-Ziegler S,Jilma B,Sunder-Plassmann R,Koppensteiner R,Gremmel T

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:Thrombosis is one of the most frequent adverse events after cardiac catheterization, which can be reduced by anticoagulation with unfractionated heparin (UFH) in both children and adults. Low molecular weight heparin (LMWH) might possibly offer advantages. Laboratory signs of thrombin generation during ped...

journal_title：Thrombosis research

authors： Roschitz B,Beitzke A,Gamillscheg A,Sudi K,Koestenberger M,Leschnik B,Muntean W

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The optimal prevention measures against hemodialysis (HD)-associated complications, including all-cause thrombotic events and death, are unclear. METHODS:This prospective study was designed to assess the effect of aspirin on prevention of HD-associated complications. Patients were divided into four groups a...

journal_title：Thrombosis research

authors： Yang Y,Wang C,Jin L,Chen G,Li C,Qi K,Kong D,Wang Y,Song M,Ma L

更新日期：2015-07-01 00:00:00

abstract：:Data on the effect of hormone replacement therapy on hemostasis are inconsistent, and there are few data in women with coronary artery disease. In a single-center, open, randomized study, 118 postmenopausal women with angiographically verified coronary artery disease were randomized to hormone replacement therapy, giv...

journal_title：Thrombosis research

authors： Hoibraaten E,Os I,Seljeflot I,Andersen TO,Hofstad A,Sandset PM

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Serious bleeding is a frequent and feared treatment complication in patients treated with oral anticoagulants (OACs). Levels of von Willebrand factor (VWF) antigen have been linked to the risk of bleeding complications, mortality, and cardiovascular events. OBJECTIVES:In this longitudinal cohort study of ev...

journal_title：Thrombosis research

authors： Lind M,Johansson L,Nilsson TK,Jansson JH,Hollestelle MJ

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:Different Klebsiella pneumoniae strains carry different virulence factors and antibiotic resistance and may cause thrombocytopenia. This study aimed to investigate the effects of different infections caused by K. pneumoniae on platelets. METHODS:Two hypermucoviscous K. pneumoniae strains and two classic s...

journal_title：Thrombosis research

authors： Wang Z,Ren J,Liu Q,Li J,Wu X,Wang W,Wu J,Wang G,Li J

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Plasma viscosity (PV) constitutes an independent important predictor of initial and recurrent cardiac events and mortality. It has been suggested that there is a geographical variation in PV values related to coronary event rates. Little information exists regarding PV in Spain. Therefore, our objective wa...

journal_title：Thrombosis research

authors： Vayá A,Simó M,Santaolaria M,Carrasco P,Corella D

更新日期：2007-01-01 00:00:00

abstract：:An anticoagulant activity was identified and isolated from the leaves of a West African plant, Aspilia africana by gel filtration on Sephadex G-100. The anticoagulant factor had an apparent molecular weight of approximately 60,000 d. Upon incubation with plasma, it prolonged the partial thromboplastin time, prothrombi...

journal_title：Thrombosis research

authors： Hanna MM,Niemetz J

更新日期：1987-08-15 00:00:00

abstract：:Stent implantation after balloon dilation of coronary arteries has improved clinical prognosis in patients undergoing transluminal coronary angioplasty (PTCA), but late restenosis remains a relevant problem. A previous study has indicated that PAI-1 activity changes immediately after PTCA without stent implantation ar...

journal_title：Thrombosis research

authors： Prisco D,Fedi S,Antonucci E,Capanni M,Chiarugi L,Chioccioli M,Falai M,Giglioli C,Abbate R,Gensini GF

更新日期：2001-11-01 00:00:00

abstract：:Triflavin, an Arg-Gly-Asp (RGD)-containing disintegrin purified from venom peptide inhibited platelet aggregation by interfering with the interaction of fibrinogen with alpha(IIb)beta(3) integrin. Using an immunostaining technique and electron microscopy, we investigated and compared the distribution of triflavin bind...

journal_title：Thrombosis research

authors： Chuang WJ,Wu CH,Huang HN,Chen SH,Hsiao G,Lin CH,Sheu JR

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Venous thromboembolism (VTE) occurs frequently in at-risk hospitalized patients, and prophylaxis of VTE is significantly underused. We sought to preliminarily assess the validity of Caprini risk assessment model, a famous individual VTE risk assessment model, in Chinese hospitalized patients with VTE. MAT...

journal_title：Thrombosis research

authors： Zhou HX,Peng LQ,Yan Y,Yi Q,Tang YJ,Shen YC,Feng YL,Wen FQ

更新日期：2012-11-01 00:00:00

abstract：:The antithrombotic effect of aspirin (ASA) and dipyridamole (DIP) was evaluated in rabbits in which platelet thromboxane A2 (TXA2) and arterial prostacyclin (PGI2) were measured. An intracarotid cannula thrombosis model previously shown to be sensitive to antiplatelet agents was used. Prostaglandins were determined by...

journal_title：Thrombosis research

authors： Louie S,Gurewich V

更新日期：1983-05-15 00:00:00

abstract：:Clot lysis induced by streptokinase has been studied and the influences of pH and the concentrations of plasminogen, fibrinogen and buffer composition investigated. Variations in the concentrations of plasminogen strongly effect the SK apparent activity, maxima being obtained at different plasminogen concentrations li...

journal_title：Thrombosis research

authors： Westlund LE,Andersson LO

更新日期：1991-12-15 00:00:00

abstract：:Catharsius protease-1 (CPM-1) was isolated from the whole body of the dung beetles, Catharsius molossus, using three purification steps (ammonium sulfate fractionation, gel filtration on Bio-Gel P-60, and affinity chromatography on DEAE Affi-Gel Blue gel). The purified CPM-1 that has a molecular weight of 27 kDa was a...

journal_title：Thrombosis research

authors： Ahn MY,Hahn BS,Ryu KS,Kim JW,Kim I,Kim YS

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Unfractionated heparin (UFH) does not cross the placenta and has demonstrated utility in the prevention and treatment of thrombosis during pregnancy. Limited information is available to guide initiation and monitoring of therapeutic UFH targeting an anti-Xa concentration of 0.3-0.7 u/ml during pregnancy. T...

journal_title：Thrombosis research

authors： Clark NP,Delate T,Cleary SJ,Witt DM

更新日期：2010-05-01 00:00:00

abstract：:The effects of hydrogen peroxide on factor Xa-catalyzed prothrombin activation on the surface of vascular endothelial cells, and the inhibitory effect of sphingosine on prothrombin activation were studied in cultured calf pulmonary artery endothelial cells (CPAEC). Hydrogen peroxide enhanced factor Xa-catalyzed prothr...

journal_title：Thrombosis research

authors： Tanabe S,Tamaki T,Wada Y

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Bypassing agents are the first line therapy in patients with acquired haemophilia A (AHA). Activated prothrombin complex concentrate (aPCC) proved to be effective as initial treatment, but 20% of patients (pts) had relapses. aPCC as short-term prophylaxis to reduce subsequent bleeds is still not clear. AIM:...

journal_title：Thrombosis research

authors： Zanon E,Pasca S,Siragusa S,Napolitano M,Santoro C,Mameli L,Rocino A,FAIR Study Group.

更新日期：2019-02-01 00:00:00

abstract：:A simple and discriminating assay for the determination of the fast-acting plasminogen activator inhibitor (PAI) activity in human plasma is described. The method is based on the inhibition of purified tissue plasminogen activator (tPA) by plasma diluted with a PAI-depleted plasma and the subsequent measurement of res...

journal_title：Thrombosis research

authors： Contant G,Martinoli JL

更新日期：1989-11-01 00:00:00

abstract：OBJECTIVES:To evaluate the role of filter implantation in reducing the incidence of fatal pulmonary embolism during the endovascular treatment of thrombosis in the major tributary of the superior vena cava (SVC). METHODS:From October 2004 to October 2008, we conducted a cohort study of 40 patients with thrombosis of t...

journal_title：Thrombosis research

authors： Liang Z,Han R,Qu Y,Cao W,Cui J

更新日期：2014-07-01 00:00:00

abstract：:Lupus anticoagulants (LA) are IgG or IgM antibodies which prolong phospholipid-dependent coagulation tests. For the detection and quantitation of such antibodies, we have developed an ELISA with cephalin as the coating antigen. The sensitivity of this assay was compared to the activated partial thromboplastin time (AP...

journal_title：Thrombosis research

authors： Sletnes KE,Keirung G,Wisløff F

更新日期：1990-01-15 00:00:00

abstract：INTRODUCTION:Increased levels of circulating tissue factor (TF)-positive microvesicles (MVs) may increase the risk of thrombosis. Indeed, TF-positive MVs are detected in plasma of patients with various types of diseases. In this study, we measured levels of MV TF activity in non-cancer severely ill patients and cancer ...

journal_title：Thrombosis research

authors： Hisada Y,Thålin C,Lundström S,Wallén H,Mackman N

更新日期：2018-05-01 00:00:00

abstract：:A variant of type II von Willebrand disease (vWd) is described in a young woman and her mother with severe lifelong bleeding histories. On electrophoresis with low-resolution agarose gels the plasma of the proband lacked large and intermediate-size multimers of von Willebrand factor (vWF) but the platelet multimeric s...

journal_title：Thrombosis research

authors： Castaman G,Rodeghiero F,Lattuada A,Mannucci PM

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:The usefulness of coagulation tests performed before epidural analgesia for surgery or to alleviate labour pain is controversial. The aims of this study were: (1) to evaluate the prevalence of abnormal tests in a large cohort of healthy pregnant women and their association with epidural hematoma; (2) to asse...

journal_title：Thrombosis research

authors： Franchi F,Ibrahim B,Rossi F,Maspero ML,Morabito O,Asti D,Bucciarelli P,Biguzzi E

更新日期：2011-07-01 00:00:00

abstract：:The effect of tissue factor pathway inhibitor (TFPI) on thrombin and factor Xa generation was studied in an in vitro system using a prothrombin complex concentrate. It was found that TFPI, via the direct inhibition of factor Xa and the tissue factor/factor VIIa complex, inhibited both the further generation of factor ...

journal_title：Thrombosis research

authors： Kaiser B,Hoppensteadt DA,Jeske W,Wun TC,Fareed J

更新日期：1994-09-15 00:00:00

abstract：:Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), presents a large clinical burden. Prompt, effective and sustained anticoagulation is vital because of the risk of recurrent events, including life-threatening PE, and complications such as post-thrombotic syndrome and chro...

journal_title：Thrombosis research

authors： Prandoni P

更新日期：2014-08-01 00:00:00