Human pharmacological studies of a defined low molecular weight heparin fraction (Fragmin) evidence for a simultaneous inhibition of factor Xa and IIa (thrombin).

Abstract:

:The effect of a low molecular weight heparin (Fragmin) (20-80 U/kg) was studied in 10 healthy male volunteers after intravenous administration. Clotting abnormalities are extensive shortly after injection, lasting for 1-2 hours depending on heparin dosage. Dilute thrombin time, showing a close correlation to anti-F-Xa activity, is as sensitive as anti-F-Xa. The parallel time course of dilute thrombin time and anti-F-Xa activity clearly demonstrates that LMWH has an effect on F-IIa lasting as long as that of F-Xa. After subcutaneous administration clotting abnormalities are only slight with 40-60 U/kg, in contrast to the intravenous study. The platelet system remains unchanged.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Andrassy K,Mörike K,Koderisch J,Weber E

doi

10.1016/0049-3848(88)90257-5

subject

Has Abstract

pub_date

1988-03-15 00:00:00

pages

601-11

issue

6

eissn

0049-3848

issn

1879-2472

journal_volume

49

pub_type

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