Abstract:
INTRODUCTION:Plasma viscosity (PV) constitutes an independent important predictor of initial and recurrent cardiac events and mortality. It has been suggested that there is a geographical variation in PV values related to coronary event rates. Little information exists regarding PV in Spain. Therefore, our objective was to determine PV in a large sample of randomly selected subjects from the Spanish population and to study which demographic or cardiovascular risk factors (CVRF) influence levels of PV in this population. MATERIALS AND METHODS:1277 subjects (503 males, 774 females) aged 43+/-14 years (range: 20-70) were randomly selected from an Eastern Spanish population. These subjects were free of cardiovascular diseases and other major diseases. PV was measured at 37 degrees C by means of the Fresenius GmbH plasma viscosimeter. In addition, total cholesterol, triglycerides, glucose and fibrinogen were measured. RESULTS:In the crude analysis, no differences in PV were observed regarding gender (males: 1.235+/-0.061 cP; females: 1.236+/-0.059 cP, P=0.952). Women older than 50 years showed higher PV:1.248+/-0.057 cP than those aged less than 50 years: 1.232+/-0.059 cP, P=0.001. No differences in PV by age groups were observed in men (P=0.842). Furthermore, we evaluated the prevalence of the following CVRF: hypercholesterolemia, hypertriglyceridemia, hypertension, diabetes, tobacco smoking, obesity, and high fibrinogen levels. Prevalence of these factors was: 28%, 4.3%, 8%, 2.3%, 33%, 8.8% and 15% respectively. As some of these CVRF were correlated with PV levels, we carried out a multivariate analysis to adjust PV levels for the potential confounding effect of each one of these factors. After multivariate adjustment, PV was positively associated with high fibrinogen (>320 mg/dL) levels in both men and women (P<0.001). In addition, in women, but not in men, PV levels were independently associated with obesity (P<0.001) and hypertriglyceridemia (P=0.01). After the multivariate adjustment, the association between PV and age older than 50 in women did not remain statistically significant, revealing a confusing effect of the CVRF in the crude analysis.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Vayá A,Simó M,Santaolaria M,Carrasco P,Corella Ddoi
10.1016/j.thromres.2006.11.009subject
Has Abstractpub_date
2007-01-01 00:00:00pages
489-95issue
4eissn
0049-3848issn
1879-2472pii
S0049-3848(06)00477-4journal_volume
120pub_type
杂志文章abstract:BACKGROUND AND AIM:Recent studies have documented that elevation of C-reactive protein (CRP) levels after percutaneous coronary intervention (PCI) have been predictive of adverse outcome. This study was performed to test the hypothesis that preprocedural use of naproxen sodium is associated with a reduction in the exte...
journal_title:Thrombosis research
pub_type: 杂志文章,随机对照试验
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更新日期:2007-01-01 00:00:00
abstract::Heat treatment is employed to diminish the transmission of hepatitis when blood products are administered. It is possible that such a procedure could reduce the biological activity of the proteins and induce changes in structure and aggregation state. We have therefore made in vitro and pharmacokinetic studies of heat...
journal_title:Thrombosis research
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doi:10.1016/0049-3848(91)90021-n
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abstract::There is growing evidence on the superior efficacy and safety of low molecular weight heparins (LMWHs) over unfractionated heparin (UFH) for the treatment of both venous and arterial thromboembolism. Heparin exerts its function by potentiating antithrombin and by mobilizing tissue factor pathway inhibitor (TFPI) into ...
journal_title:Thrombosis research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-08-15 00:00:00
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更新日期:2017-08-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:1986-02-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90268-h
更新日期:1990-07-01 00:00:00
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更新日期:2013-03-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2014.02.026
更新日期:2014-05-01 00:00:00
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更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0049-3848(86)90178-7
更新日期:1986-10-01 00:00:00
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更新日期:2018-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0049-3848(84)90375-x
更新日期:1984-10-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(97)00104-7
更新日期:1997-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.thromres.2017.11.016
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:To evaluate the pathogenetic role of tissue factor (TF), tissue factor pathway inhibitor (TFPI), and neutrophil elastase in acute respiratory distress syndrome (ARDS), as well as to test the hypothesis that TFPI levels modified by neutrophil activation are not sufficient to prevent TF-dependent intravascul...
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pub_type: 临床试验,杂志文章
doi:10.1016/s0049-3848(03)00151-8
更新日期:2003-01-25 00:00:00
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更新日期:2017-10-01 00:00:00
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1985-04-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:1982-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-02-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2005.11.015
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Cardiovascular mortality is especially low in southwest France (the French Paradox). In previous experimental studies, we found that alcohol-free extracts of armagnac could inhibit human platelet function in vitro and experimental thrombosis in vivo. To test the possible relevance of these findings, we teste...
journal_title:Thrombosis research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0049-3848(92)90130-3
更新日期:1992-10-01 00:00:00
abstract::The effect of several vitamin K (Vit K) analogues on the aggregation of human platelets was examined. The analogues were potent inhibitors of aggregation induced by ADP, thrombin, collagen and arachidonate but were less active against aggregation induced by the calcium ionophore A23187. Vit K3 also prevented platelet ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90037-4
更新日期:1985-01-01 00:00:00
abstract:INTRODUCTION:The standard dabigatran etexilate dosage for prevention of venous thromboembolism (VTE) after elective total hip or knee replacement (THR/TKR) is 220mg once daily (qd), with 150mg qd for patients with moderate renal impairment. As clinical trial experience in patients with moderate renal impairment was lim...
journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
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更新日期:2016-07-01 00:00:00