当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > The effects of recombinant activated factor VII dose on the incidence of thromboembolic events in patients with coagulopathic bleeding.

The effects of recombinant activated factor VII dose on the incidence of thromboembolic events in patients with coagulopathic bleeding.

Abstract：

INTRODUCTION:Previous studies have suggested the used of off-label recombinant factor VII (rFVIIa) increases the risk of thromboembolic events, but the effect of the dose of rFVIIa is not well described in the literature. MATERIALS AND METHODS:All adult patients that received off-label rFVIIa from 2005-2012 were included in this single-center, retrospective cohort study. The primary endpoint was the incidence of a thromboembolic event in the low dose (<50 mcg/kg) compared to the high dose (≥50 mcg/kg) cohort. Secondary endpoints compared time to thromboembolic event, incidence of arterial compared to venous events, and mortality. RESULTS:There were 152 patients that received rFVIIa during the study period with 66 in the low dose cohort and 86 in the high dose cohort. Mean total dose of rFVIIa was 30.2 mcg/kg (SD ± 9.5 mcg/kg) in the low dose and 99.8 mcg/kg (SD ± 64.7 mcg/kg) in the high dose cohort (p=0.0001). The overall incidence of thromboembolic events was 12.5%. There were 12 (14%) events in the low dose cohort and seven (10.6%) in the high dose cohort, RR=0.76 (95% CI 0.31-1.82). There were no differences in any of the secondary outcomes. A higher incidence of thromboembolic events in cardiothoracic surgery (20.8%) and penetrating trauma patients (21.4%) was seen compared to the remaining cohort (6.7%). CONCLUSIONS:No significant difference in the incidence of thromboembolic events was seen between low dose versus high dose rFVIIa over a seven year period at our institution. However, due to the relatively low overall incidence and a small sample size, type II error may be present.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Bucklin MH,Acquisto NM,Nelson C

doi

10.1016/j.thromres.2014.02.026

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

768-71

issue

5

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(14)00105-4

journal_volume

133

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • Expression of PAI-1, t-PA and u-PA in cultured human umbilical vein endothelial cells derived from racial groups.

    abstract：:To determine whether inherent fibrinolytic differences may exist in racial groups (black americans, BA vs. white americans, WA), 55 different individual racially-derived human umbilical vein endothelial cell (HUVEC) cultures (35 BA and 20 WA) were analyzed in terms of their fibrinolytic protein (t-PA, u-PA and PAI-1) ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(95)91615-r

    authors： Frist ST,Taylor HA Jr,Kirk KA,Grammer JR,Li XN,Grenett HE,Booyse FM

    更新日期：1995-02-01 00:00:00

  • Excessive expressions of T cell activation markers in pediatric immune thrombocytopenia.

    abstract：BACKGROUND:Immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder in children. Activated T cells have been shown to play important roles in ITP. The aims of this study were to evaluate whether these T cell activation markers could be used as indicators to differentiate ITP patients from controls, and to ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2019.05.010

    authors： Chen Y,Zhou Y,Chen P,Zhang P,Jia M,Tang Y

    更新日期：2019-08-01 00:00:00

  • Aggregation of human and canine platelets: modulation by purine nucleotides.

    abstract：:This study compared the responses of canine and human platelets to various aggregating agonists in the presence or absence of extracellular ATP and ATP analogues. Canine and human platelets were approximately equally reactive with ADP or collagen while the canine platelets were about 10 fold more sensitive to thrombin...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(93)90214-9

    authors： Soslau G,Arabe L,Parker J,Pelleg A

    更新日期：1993-10-15 00:00:00

  • Known knowns and known unknowns: risks associated with combination antithrombotic therapy.

    abstract：BACKGROUND:Use of antiplatelet therapy in combination with oral anticoagulants remains controversial. The purpose of this article is to review current consensus recommendations for antithrombotic therapy, to evaluate risks for bleeding among patients taking combination antithrombotic therapy, and lastly to review singl...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2008.08.011

    authors： Johnson S

    更新日期：2008-01-01 00:00:00

  • Soluble fibrinogen derivatives generated by thrombin: affinity for elastin.

    abstract：:When human citrated plasma is dialysed against a phosphate buffer containing Ca++, citrate anions are removed, thrombin is generated and soluble fibrinogen derivatives (fibrin monomers and/or soluble fibrin polymers) are formed. These derivatives are able to combine with human or bovine elastin to form a very stable a...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(86)90061-7

    authors： Rabaud M,Lefebvre F,Piquet Y,Belloc F,Chevaleyre J,Roudaut MF,Bricaud H

    更新日期：1986-07-15 00:00:00

  • Estimation of EDRF and nitric oxide release using [3H]GTP-labeled human platelets.

    abstract：:We have developed a new bioassay for endothelium-derived relaxing factor (EDRF) or nitric oxide (NO) using human [3H]guanosine triphosphate (GTP)-labeled platelets. The labeled platelets were preincubated with isobutyl-methylxanthine and co-cultured with endothelial cells and the [3H]cyclic guanosine monophosphate (cG...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(95)00082-3

    authors： Kishi Y,Watanabe R,Ashikaga T,Numano F

    更新日期：1995-06-15 00:00:00

  • Role of protein kinase C in U46619-induced platelet shape change, aggregation and secretion.

    abstract：:Stimulation of rat platelets with U46619 induced Ca2+ mobilization and platelet shape change, but aggregation and secretion were induced when platelets were stimulated with U46619 plus phorbol 12-myristate 13-acetate (PMA). However, stimulation of rabbit platelets with U46619 induced all the three platelet responses. ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90171-0

    authors： Nakano T,Hanasaki K,Arita H

    更新日期：1989-10-15 00:00:00

  • Comparison of four rapid D-Dimer tests for diagnosis of pulmonary embolism.

    abstract：:Aim of this study was to evaluate rapid D-Dimer tests for their utility in diagnosis of acute pulmonary embolism (PE). Tests were performed in 183 consecutive pats referred for lung scanning because of clinically suspected PE. According to lung scans and the clinical course of disease 19 pats were classified to have P...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(96)00089-8

    authors： Veitl M,Hamwi A,Kurtaran A,Virgolini I,Vukovich T

    更新日期：1996-06-01 00:00:00

  • Characterization of functional P2X(1) receptors in mouse megakaryocytes.

    abstract：INTRODUCTION:Although accumulating evidence within the past 5 years strongly supports the importance of platelet P2X(1) receptors in hemostasis and thrombosis, P2X(1) receptors of platelet and/or its progenitor cell, megakaryocyte, have not been fully characterized. The aim of this study was to electrophysiologically a...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2006.03.007

    authors： Ikeda M

    更新日期：2007-01-01 00:00:00

  • The relationship between the age and density of circulating 51-Cr labelled platelets in the sub-human primate.

    abstract：:Change in the density of circulating platelets in monkeys was studied by using a method that removed greater than 90% of the platelet population from whole blood. These were labelled with 51-Cr and reinjected, having been protected by prostacyclin while in vitro. Platelets were separated into density subpopulations th...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90238-4

    authors： Martin JF,Penington DG

    更新日期：1983-04-15 00:00:00

  • Chronic kidney disease is associated with increased risk of venous thromboembolism recurrence.

    abstract：INTRODUCTION:It is currently unclear whether chronic kidney disease (CKD) and the decrease in renal function can influence the risk of venous thromboembolism (VTE) recurrence. MATERIALS AND METHODS:We performed an ambispective observational study on 409 patients with a previous episode of VTE. All the patients were in...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2017.10.011

    authors： Rattazzi M,Villalta S,De Lucchi L,Sponchiado A,Galliazzo S,Faggin E,Pagliara V,Zilli C,Callegari E,Caberlotto L,Puato M,Pauletto P

    更新日期：2017-12-01 00:00:00

  • VTE prophylaxis for the medical patient: where do we stand? - a focus on cancer patients.

    abstract：:Acutely ill medical patients are at moderate to high risk of venous thromboembolism (VTE): approximately 10-30% of general medical patients may develop deep-vein thrombosis or pulmonary embolism, and the latter is a leading contributor to deaths in hospital. Medical conditions associated with a high risk of VTE includ...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/S0049-3848(10)70008-6

    authors： Cohen AT,Nandini B,Wills JO,Ota S

    更新日期：2010-04-01 00:00:00

  • Protein S activity in patients with heredofamilial protein S deficiency and in patients with juvenile venous thrombosis. Results of a functional method.

    abstract：:Using an ACL 300R coagulometer (Instrumentation Laboratory) we assessed the clinical usefulness of a new method to measure PS activity (PS:Act), based on the prolongation of prothrombin time of a mixture of diluted plasma sample, PS depleted plasma previously incubated with Protac for protein C activation, bovine thro...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(91)90065-5

    authors： Maccaferri M,Legnani C,Preda L,Palareti G

    更新日期：1991-12-15 00:00:00

  • 'Pergularain e I'--a plant cysteine protease with thrombin-like activity from Pergularia extensa latex.

    abstract：:Pergularain e I, a cysteine protease with thrombin-like activity, was purified by ion exchange chromatography from the latex of Pergularia extensa. Its homogeneity was characterized by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), native PAGE and reverse-phase high-performance liquid chromatogr...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2009.10.002

    authors： Shivaprasad HV,Rajaiah R,Frey BM,Frey FJ,Vishwanath BS

    更新日期：2010-03-01 00:00:00

  • Activation contact system (ACS) and tissue factor (TF) in human amniotic fluid: measurements of ACS components and TF, and some implications on the pathophysiology of amniotic fluid embolism.

    abstract：BACKGROUND/AIM:It is believed that the amniotic fluid-derived TF, in the case of amniotic fluid embolism (AFE), contributes to acute disseminated intravascular coagulation (DIC) and obstetric shock in the mother. However, the role of amniotic fluid-derived contact phase coagulation factors that irrupt into the bloodstr...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.10.014

    authors： Uszyński W,Żekanowska E,Uszyński M,Kieszkowski P

    更新日期：2015-04-01 00:00:00

  • Biodistribution of the recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in rats.

    abstract：INTRODUCTION:The recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) is undergoing clinical trials for prophylaxis and on-demand treatment of haemophilia B patients. The aim of this study was to investigate the pharmacokinetics, whole-body and knee joint distribution of rIX-FP following intra...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.02.010

    authors： Herzog E,Harris S,Henson C,McEwen A,Schenk S,Nolte MW,Pragst I,Dickneite G,Schulte S,Zollner S

    更新日期：2014-05-01 00:00:00

  • Plasma endothelin-1 level as a predictor for poor collaterals in patients with ≥95% coronary chronic occlusion.

    abstract：BACKGROUND:Coronary collateral circulation (CCC) plays an important role in protecting myocardium from ischemic damage. The studies on factors which impact on CCC might be of great clinical interest. The aim of the present study was to evaluate endothelin-1 (ET-1) as a potential predictor for poor or good CCC in patien...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2016.04.007

    authors： Fan Y,Li S,Li XL,Lin XL,Zhu CG,Xu RX,Qing P,Wu NQ,Jiang LX,Xu B,Gao RL,Li JJ

    更新日期：2016-06-01 00:00:00

  • Application of the Japanese Association for Acute Medicine disseminated intravascular coagulation diagnostic criteria for patients at an early phase of trauma.

    abstract：INTRODUCTION:To validate the diagnostic criteria for disseminated intravascular coagulation (DIC) established by the Japanese Association for Acute Medicine (JAAM) at an early stage of trauma and to evaluate the hypothesis that the JAAM criteria can diagnose DIC with a higher sensitivity than the International Society ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2009.06.036

    authors： Sawamura A,Hayakawa M,Gando S,Kubota N,Sugano M,Wada T,Katabami K

    更新日期：2009-12-01 00:00:00

  • Effect of dietary canola and reference oils upon serum lipids and platelet aggregation.

    abstract：:To compare Canola a terrestrial (n-3) oil with fish oil (n-3) and common vegetable oil (n-6) in decreasing serum lipids and platelet aggregation, various oils were included in Chow-based diets and fed to rats in an eight-weeks feeding trial. The Chow diet contained 2% cholesterol along with either Canola, menhaden, sa...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90420-h

    authors： Watkins T,Lenz P,Bierenbaum M

    更新日期：1990-08-01 00:00:00

  • Thrombomodulin and ristocetincofactor in homocystinuria: a study in two siblings.

    abstract：:Homocystinuria due to cystathionine-beta-synthase deficiency (CBS-def-HOCY) initially often presents with vascular disorders, e.g. thromboembolic events. The measurement of vascular endothelial markers in plasma could help to assess endothelial damage. We determined von Willebrand factor (measured as Ristocetincofacto...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(95)90867-f

    authors： Schienle HW,Seitz R,Nawroth P,Rohner I,Lerch L,Krumpholz B,Krauss G,Fowler B,Baumgartner R,Willenbockel U

    更新日期：1995-01-01 00:00:00

  • A two-step approach (Enzyme-linked immunosorbent assay and confirmation assay) to detect antibodies against von Willebrand factor in patients with Acquired von Willebrand Syndrome.

    abstract：BACKGROUND:Acquired von Willebrand Syndrome is a rare bleeding disorder, which arises in individuals with no personal or family history of bleeding, associated with lymphoproliferative and myeloproliferative disorders or other diseases. AIM:To develop a two-step approach assay to detect autoantibodies against VWF and ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.09.020

    authors： Franchi F,Biguzzi E,Stufano F,Siboni SM,Baronciani L,Peyvandi F

    更新日期：2014-12-01 00:00:00

  • Response to antiplatelet therapy is independent of endogenous thrombin generation potential.

    abstract：BACKGROUND:Thrombin is the most potent platelet activator, and achieves rapid platelet activation even in the presence of antiplatelet therapy. Since activated platelets respond stronger to additional stimuli, the extent of endogenous thrombin generation may in part be responsible for the reported response variability ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.04.008

    authors： Gremmel T,Panzer S,Steiner S,Seidinger D,Koppensteiner R,Pabinger I,Kopp CW,Ay C

    更新日期：2013-07-01 00:00:00

  • Possible contribution of solid surface for inactivation of thrombin.

    abstract：:Dextran sulfate and polybrene were immobilized on polypropylene tubes with plastic adhesive. Serum albumin was also immobilized on the tube by heat-denaturation. In the those tubes thrombin was protected from inactivation in the presence of 0.1 M NaCl remarkably. Cholesterol coated on the tube also protected the enzym...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(88)90277-0

    authors： Oshima G

    更新日期：1988-07-01 00:00:00

  • Filter bleeding time: a new in vitro test of hemostasis. I. Evaluation in normal and thrombocytopenic subjects.

    abstract：:Disadvantages of current bleeding time methods include poor reproducibility, limited repeatability, and at times scar formation. We report a new, in vitro technique which circumvents these problems. Venous blood is collected in sodium citrate, stored capped in a siliconized tube at 37 degrees C until use, and made to ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(83)90011-7

    authors： Uchiyama S,Stropp JQ,Claypool DA,Didisheim P,Dewanjee MK

    更新日期：1983-07-01 00:00:00

  • The effect of calcium ionophore A23187 on tissue factor activity and mRNA in endothelial cells.

    abstract：:Tissue factor (TF) is an integral membrane glycoprotein that serves as a cofactor for blood coagulation factor VIIa. The induction of TF on the surface of endothelial cells is initiated by various kinds of stimuli including lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta), and tumor necrosis factor alpha (TNF ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(94)90002-7

    authors： Wakita K,Stearns-Kurosawa DJ,Marumoto Y

    更新日期：1994-04-15 00:00:00

  • Membrane fluidity and platelet fibrinogen receptor exposure by proteolytic enzymes.

    abstract：:Incubation of platelets with pronase or chymotrypsin results in the exposure of fibrinogen receptors. We determined that these enzymes did not affect the membrane fluidity as evaluated by the depolarization of the fluorescence of 1,6-diphenyl-1,3,5 hexatriene (DPH). There was no significant difference in either the de...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90124-0

    authors： Simons E,Whitin JC,Morinelli TA,Stewart GJ,Niewiarowski S

    更新日期：1985-07-01 00:00:00

  • The effect of parnaparin sodium on in vitro fertilization outcome: A prospective randomized controlled trial.

    abstract：INTRODUCTION:In-vitro and in-vivo models suggest the influence of low-molecular weight heparin on conception in infertile women undergoing in vitro fertilization procedures (IVF). In this randomized controlled trial we assessed whether a low-molecular weight heparin (parnaparin) could affect IVF outcomes. MATERIALS AN...

    journal_title：Thrombosis research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.thromres.2017.08.006

    authors： Lodigiani C,Dentali F,Banfi E,Ferrazzi P,Librè L,Quaglia I,Cafaro L,Morenghi E,Pacetti V,Zannoni E,Baggiani AM,Levi-Setti PE

    更新日期：2017-11-01 00:00:00

  • Aspirin decreases fibrinolytic potential during venous occlusion, but not during acute physical activity.

    abstract：:It has previously been observed that aspirin diminishes the increase in blood fibrinolytic activity during arm venous occlusion. We studied the duration of this inhibitory effect on fibrinolytic response during 20 minutes arm venous occlusion and its effect on fibrinolytic response during acute physical activity (stan...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90282-9

    authors： Keber I,Jereb M,Keber D

    更新日期：1987-04-15 00:00:00

  • Systematic review of anticoagulant treatment of catheter-related thrombosis.

    abstract：:Central venous catheter-related thrombosis (CRT) is a complication seen in patients requiring long-term intravenous access. Treatment of CRT is not standardized and international guidelines for treatment are based on extrapolation of evidence from lower extremity thrombosis. We performed a systematic review of the lit...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2015.08.020

    authors： Baumann Kreuziger L,Onwuemene O,Kolesar E,Crowther M,Lim W

    更新日期：2015-12-01 00:00:00

  • Cardioprotective effects of defibrotide in acute myocardial ischemia in the cat.

    abstract：:We investigated the effects of Defibrotide (D), a natural polydeoxyribonucleotide, on acute myocardial ischemia (AMI) in anesthetized cats. A permanent ligature was placed around the left anterior descending coronary artery (LAD) 12-14 mm from its origin. Ventricular fibrillation and death were exceptional and when th...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90008-8

    authors： Niada R,Porta R,Pescador R,Mantovani M,Prino G

    更新日期：1985-04-01 00:00:00