Abstract：
INTRODUCTION:It is currently unclear whether chronic kidney disease (CKD) and the decrease in renal function can influence the risk of venous thromboembolism (VTE) recurrence. MATERIALS AND METHODS:We performed an ambispective observational study on 409 patients with a previous episode of VTE. All the patients were included in the retrospective analysis whereas a subgroup of 260 individuals, without history of recurrence and that stopped oral anticoagulation, were then followed-up for a mean of 52.3±20.7months. RESULTS:At the enrollment, subjects with history of recurrent VTE were prevalently male with higher blood pressure and lower eGFR. Prevalence of CKD (defined as eGFR<60ml/min/1.73m2) was higher in patients with previous VTE recurrence with an adjusted OR of 5.69 (IC95% 2.17-14.90, p<0.001) compared to patients with normal eGFR. Similar findings were obtained from the prospective study where an adjusted 5.32 HR for VTE recurrence was seen in patients with CKD compared to subjects with normal renal function (IC95% 1.49-18.95, p=0.010). An increase in the risk of recurrent VTE was also observed in patients with mild decrease in renal function (eGFR 60-90 vs ≥90ml/min/1.73m2 adjusted HR 2.84, IC95% 1.13-7.11, p=0.025). Moreover, a multivariate Cox regression analysis including eGFR as continuous variable showed that renal function decrease was independently associated with the risk of VTE recurrence (p=0.001). CONCLUSIONS:CKD and mild decrease in renal function are associated with a significant increase in the risk of recurrent VTE.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Rattazzi M,Villalta S,De Lucchi L,Sponchiado A,Galliazzo S,Faggin E,Pagliara V,Zilli C,Callegari E,Caberlotto L,Puato M,Pauletto Pdoi
10.1016/j.thromres.2017.10.011subject
Has Abstractpub_date
2017-12-01 00:00:00pages
32-37eissn
0049-3848issn
1879-2472pii
S0049-3848(17)30526-1journal_volume
160pub_type
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journal_title：Thrombosis research
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doi：10.1016/j.thromres.2004.12.004
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journal_title：Thrombosis research
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doi：10.1016/0049-3848(93)90234-f
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journal_title：Thrombosis research
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journal_title：Thrombosis research
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journal_title：Thrombosis research
pub_type： 临床试验,杂志文章
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journal_title：Thrombosis research
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journal_title：Thrombosis research
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doi：10.1016/j.thromres.2014.07.025
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doi：10.1016/j.thromres.2008.04.001
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.thromres.2007.12.014
更新日期：2009-02-01 00:00:00
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doi：10.1016/0049-3848(89)90058-3
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doi：10.1016/j.thromres.2015.07.020
更新日期：2015-09-01 00:00:00
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doi：10.1016/0049-3848(85)90209-9
更新日期：1985-06-15 00:00:00
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doi：10.1016/j.thromres.2017.04.024
更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0049-3848(84)90229-9
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(03)00405-5
更新日期：2003-01-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(01)00370-x
更新日期：2001-11-15 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.04.003
更新日期：2015-06-01 00:00:00
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journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2009.06.023
更新日期：2010-04-01 00:00:00
