Abstract:
INTRODUCTION:Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. Atrial myocarditis has been detected recently in some patients with lone atrial fibrillation. Virchow's triad of low blood flow, hypercoagulability, and endothelial dysfunction, enhances thrombus formation. The present study was designed to elucidate the role of endothelial dysfunction in thrombogenesis associated with nonvalvular atrial fibrillation. MATERIAL AND METHODS:We investigated tissue factor expression in the endothelia of left atrial appendages obtained from seven patients with nonvalvular atrial fibrillation and cardiogenic thromboembolism. Tissues were divided into 7-13 sections and compared with control specimens from four patients who died of noncardiac events. Expression of tissue factor, von Willebrand factor and tissue factor pathway inhibitor was evaluated by immunohistochemistry. RESULTS:Histopathologically, inflammatory cells infiltrated the endocardium and all seven patients showed features of persistent myocarditis. Activated T cells [15.3+/-9.4 cells/high power field (HPF, mean+/-S.D.) vs. control 2.2+/-4.4/HPF (P=0.0294)] and a few macrophages [5.1+/-8.4 cells/HPF vs. control 2.4+/-3.5 cells/HPF (P=NS)] infiltrated the endocardium. Tissue factor was overexpressed in the endothelia particularly in tissues containing inflammatory cells and denuded matrix of the endocardium, compared with the control group. Von Willebrand factor, but not tissue factor pathway inhibitor, was also overexpressed in these tissues. CONCLUSION:Tissue factor expression induced by local inflammation is involved in the pathogenesis of thrombosis in patients with nonvalvular atrial fibrillation.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Nakamura Y,Nakamura K,Fukushima-Kusano K,Ohta K,Matsubara H,Hamuro T,Yutani C,Ohe Tdoi
10.1016/s0049-3848(03)00405-5subject
Has Abstractpub_date
2003-01-01 00:00:00pages
137-42issue
3eissn
0049-3848issn
1879-2472pii
S0049384803004055journal_volume
111pub_type
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2004-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 信件
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pub_type: 杂志文章
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
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