Abstract：
:Heparin is an effective, relatively safe, inexpensive parenteral antithrombotic agent widely used in the prevention and treatment of thromboembolic disorders, but it has several limitations such as the marked intra- and inter-patient variability in its anticoagulant response, its poor bioavailability at low doses and its relatively narrow risk to benefit ratio. Low molecular weight heparins ( LMWHs), ultra LMWHs and synthetic pentasaccharides have been developed from heparin to overcome its limitations. The characteristics of these compounds are reviewed along with the description of their approved clinical uses.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Cosmi B,Palareti Gdoi
10.1016/j.thromres.2011.11.008subject
Has Abstractpub_date
2012-03-01 00:00:00pages
388-91issue
3eissn
0049-3848issn
1879-2472pii
S0049-3848(11)00585-8journal_volume
129pub_type
杂志文章,评审abstract：INTRODUCTION:Lung cancer is the leading cause of cancer-related death worldwide. Small cell lung cancer (SCLC) is thereby a highly aggressive neuroendocrine carcinoma representing about 15% of all lung cancer cases. Due to the highly metastatic behavior and multidrug resistance, the long-term survival of patients is ve...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/S0049-3848(16)30166-9
更新日期：2016-04-01 00:00:00
abstract：:In 1926, Erik von Willebrand, a Finnish physician, published the first manuscript describing a haemorrhagic disorder in people who were living on the Aland islands off the coast of Finland. This disorder is now known by the name of its discoverer. Since this early observation, von Willebrand disease has been extensive...
journal_title：Thrombosis research
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.thromres.2007.03.010
更新日期：2007-01-01 00:00:00
abstract：:Isolated rat liver macrophages (Kupffer cells) produce a factor(s) which stimulates fibrinogen synthesis 5-8 fold in hepatocyte cultures. The production of the stimulatory factor reached maximum during the first 24 hours the cells were in culture. When the cell culture medium was chromatographed on a calibrated Sephad...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(83)90025-7
更新日期：1983-10-15 00:00:00
abstract：INTRODUCTION:Guidelines recommend the assessment of stroke and bleeding risk before initiating warfarin anticoagulation in patients with atrial fibrillation. Many of the elements used to predict stroke also overlap with bleeding risk in atrial fibrillation patients and it is tempting to use stroke risk scores to effici...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2014.05.034
更新日期：2014-08-01 00:00:00
abstract：INTRODUCTION:Flow cytometry (FCM) is the most commonly used method for detection of platelet-derived microparticles (PDMPs), but it is poorly standardized and mainly used for "bedside" analyses in fresh samples. If PDMPs could be analyzed in previously frozen samples it would increase the usefulness of the method. Howe...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2009.10.006
更新日期：2010-03-01 00:00:00
abstract：:Catharsius protease-1 (CPM-1) was isolated from the whole body of the dung beetles, Catharsius molossus, using three purification steps (ammonium sulfate fractionation, gel filtration on Bio-Gel P-60, and affinity chromatography on DEAE Affi-Gel Blue gel). The purified CPM-1 that has a molecular weight of 27 kDa was a...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2004.01.005
更新日期：2003-01-01 00:00:00
abstract：:There are some issues in the current factor (F)VIII replacement therapy for severe hemophilia A. One is mental and physical burden for the multiple intravenous infusions, and the other is difficulty in the hemostatic treatment for the patients with FVIII inhibitor. The development of novel drug with fully hemostatic e...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/S0049-3848(16)30361-9
更新日期：2016-05-01 00:00:00
abstract：INTRODUCTION:Warfarin is the most widely prescribed vitamin K antagonist and in the United States and Europe more than 10 million people are currently in long-term oral anticoagulant treatment. This study aims to retrospectively validate a dynamic statistical model providing dosage suggestions to patients in warfarin t...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2013.12.042
更新日期：2014-03-01 00:00:00
abstract：:Radioactivity from I125-labeled human platelets was measured to estimate the extent of binding of platelet surface proteins to immobilized thrombin. 1-3% of the radioactivity was bound with 10-20% of this amount apparently irreversibly bound to the thrombin matrix. Site-specific chemical modification of thrombin with ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(92)90271-b
更新日期：1992-08-15 00:00:00
abstract：:Sulfation of the natural polysaccharide curdlan results in anticoagulantly active beta-1,3-glucan sulfates whose activity depends on various structural parameters. In this study the anticoagulant and antithrombotic effects of one of these beta-1,3-glucan sulfates (GS) were compared with those of a porcine mucosal hepa...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(95)00049-w
更新日期：1995-05-01 00:00:00
abstract：INTRODUCTION:Normal pregnancy is associated with hypercoagulable state. Elevated markers of coagulation and fibrinolytic system activation indicate increased thrombin activity and increased fibrinolysis following fibrin formation throughout pregnancy. These changes exceed the biological variability in most cases. Haemo...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2013.02.005
更新日期：2013-04-01 00:00:00
abstract：:Seven peptides were synthesized to analyze the mechanism of the intramolecular binding of the N-terminal peptide of Glu-plasminogen (Glu-plg) to its kringles. They were Ala44-Lys50, Ala44-Glu51, Ala44-Ser49, Val17-Gly23, Lys19-Gly23, Lys19-Gln21 and Lys19-Lys20. Ala44-Lys50, Ala44-Glu51 and Lys19-Lys20.enhanced the ac...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(93)90156-i
更新日期：1993-04-15 00:00:00
abstract：:When activated in vitro, thrombin-activatable fibrinolysis inhibitor (TAFI) slows clot lysis by cleaving the C-terminal lysine and arginine residues from partially degraded fibrin. An inhibitor of carboxypeptidase isolated from potato (CPI) reverses prolongation of clot lysis by inhibiting activated TAFI. We investiga...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/s0049-3848(00)00184-5
更新日期：2000-05-15 00:00:00
abstract：BACKGROUND:Abdominal obesity has been found to be associated with an increased risk of deep vein thrombosis (DVT). Whether patients with abdominal obesity have an increased risk of recurrence is currently unknown. METHODS:Patients with objective diagnosis of DVT and a life expectancy of greater than 6 months underwent...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2006.05.013
更新日期：2007-01-01 00:00:00
abstract：:The antithrombotic effect of a synthetic symmetrical triglyceride having eicosapentaenoic acid (EPA) at positions 1 and 3, and gamma-linolenic acid (GLA) at position 2 was investigated. Administration of the triglyceride significantly increased thrombus formation time and thrombotic occlusion time induced by light irr...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(95)99610-k
更新日期：1995-06-01 00:00:00
abstract：:The present study has evaluated the effect of some newly synthesized triphenylethylene (TPE) analogs on platelet arachidonic acid metabolism and function. All compounds tested inhibited arachidonic acid induced platelet aggregation and several were superior to aspirin in their relative potency. Introduction of a carbo...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(86)90330-0
更新日期：1986-11-15 00:00:00
abstract：INTRODUCTION:Animal models of thrombosis and hemostasis are critical for target validation in pharmaceutical research. Guinea pig haemostatic mechanisms, such as the platelet thrombin receptor repertoire, resemble those of humans. Measuring the performance characteristics of marketed antithrombotic drugs in guinea pig ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2008.03.010
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:Although the procoagulant reactivity of monocytes largely depends on expression and cell surface presentation of tissue factor (TF), little is known about the impact of tissue factor pathway inhibitor (TFPI) on regulation of TF function on the monocyte surface. MATERIALS AND METHODS:Peripheral blood monon...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2010.07.014
更新日期：2010-11-01 00:00:00
abstract：:Platelet aggregation in platelet-rich plasma (PRP) is more sensitive to agonists and more resistant to antagonists than that in whole blood. In this study, we show that the presence of neutrophils in whole blood accounts at least in part for diminished platelet aggregation in whole blood. The platelet-inhibitory effec...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(90)90216-y
更新日期：1990-12-01 00:00:00
abstract：:To demonstrate that human alpha-thrombin is effectively inactivated by human antithrombin III (AT) during the production of a fibrin clot we measured the amount of alpha-thrombin activity which can be recovered from a clot generated from purified human proteins. We discovered that 0.05-0.07% of the original alpha-thro...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(93)90234-f
更新日期：1993-03-01 00:00:00
abstract：:It has been suggested that unstable angina at rest, like acute myocardial infarction, might be associated with a thrombotic process. In order to study the hypothesis that myocardial ischemia during exercise could also be associated with an activation of blood coagulation and/or fibrinolysis, we investigated the presen...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(92)90222-v
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:The immediate administration of oral antiplatelet therapy in the form of aspirin plus a P2Y12 inhibitor is the universally recognised standard of care for patients who present with acute myocardial infarction. Despite strong recommendations for their use, there are a paucity of data describing their onset of...
journal_title：Thrombosis research
pub_type： 杂志文章,评审
doi：10.1016/j.thromres.2016.05.019
更新日期：2016-07-01 00:00:00
abstract：:Therapeutic developments have seen significant improvement in mortality over the past thirty years for breast, colorectal and prostate cancer. Lung cancer is the commonest cancer in the world, but has seen little improvement in survival figures. The role of low-molecular-weight heparin (LMWH) in improving cancer survi...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/S0049-3848(12)70029-4
更新日期：2012-04-01 00:00:00
abstract：INTRODUCTION:Pathogenesis of idiopathic pulmonary arterial hypertension (iPAH) includes endothelial dysfunction and in situ thrombosis. A hypercoagulable state has also been postulated but never demonstrated. Our objective was to determine whether patients with iPAH had a hypercoagulable state using calibrated automate...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2010.08.020
更新日期：2010-12-01 00:00:00
abstract：:The Coa-set Fibrin Monomer test (CFM-test) is a quantitative method for determination of soluble fibrin in plasma. The fibrin standard of the CFM-test is produced by bathroxobin conversion of purified fibrinogen to fibrin. Plasma treated with minute amounts of thrombin may be considered as a more physiological way of ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(93)90139-f
更新日期：1993-11-15 00:00:00
abstract：INTRODUCTION:Dabigatran (Dabi) is not routinely monitored. However, in emergency cases quantitative assessment is required and laboratories must provide suitable tests at all hours. Little is known about Dabi effects on thrombin generation. MATERIALS AND METHODS:Patient samples (n=241) were analyzed for functional Dab...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2015.04.032
更新日期：2015-07-01 00:00:00
abstract：:Thrombus formation was electrically induced in the left common carotid artery of rats with preoccluded both vertebral and right carotid arteries. Following thrombus induction, animals became unresponsive and lost their righting reflex. The loss of righting reflex was observed when cortical tissular pO2 reached 55 +/- ...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90340-9
更新日期：1987-10-01 00:00:00
abstract：INTRODUCTION:Extracellular histones are reported to increase thrombin generation in the plasma and induce endothelial cell death in vitro. These effects of histones were suggested to involve histone-induced inhibition of TM-dependent activated protein C (APC) generation. Therefore, we hypothesized that TM alfa, a recom...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2017.10.019
更新日期：2017-12-01 00:00:00
abstract：INTRODUCTION:Patients with type 1 diabetes have high risk of developing microvascular complications, and microangiopathy contributes to premature cardiovascular disease in this population. The role that microvesicles (MVs) may play in the development of microangiopathy in type 1 diabetes remains unclear. MATERIALS AND...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/j.thromres.2020.08.012
更新日期：2020-12-01 00:00:00
abstract：:Nineteen patients, (2 adults, 17 children) with inherited bleeding disorders were infused with n-heptane-suspended-heated clotting factor concentrates. Twelve of the nineteen were previously untreated. Six patients were infused with Profilnine Heat-Treated and 13 with Profilate Heat-Treated. Five separate centers part...
journal_title：Thrombosis research
pub_type： 杂志文章
doi：10.1016/0049-3848(87)90074-0
更新日期：1987-06-15 00:00:00
