Inhibition of platelet aggregation by novel triphenylethylene analogs.

abstract：:Plasma from patients with thrombotic thrombocytopenic purpura (TTP) caused the aggregation of washed human platelets, which was inhibited by preincubation with normal plasma. Using salt fractionation, ion exchange chromatography, and preparative agarose gel electrophoresis, we purified a protein from normal plasma whi...

journal_title：Thrombosis research

authors： Lian EC,Mui PT,Siddiqui FA,Chiu LL

更新日期：1984-01-01 00:00:00

abstract：:Antithrombin (AT) is a serpin capable of trapping thrombin (IIa) in a stable and covalent complex. Complex formation is prevented by leukocyte elastase (LE) cleavage near the AT reactive centre. We mutated the known LE cleavage sites of AT to explore the possibility of producing an LE-resistant AT molecule. Initially,...

journal_title：Thrombosis research

authors： Cunningham MA,Blajchman MA,Sheffield WP

更新日期：1997-10-15 00:00:00

abstract：BACKGROUND/AIMS:The plasminogen activator (PA)-plasmin system is primarily involved in fibrinolysis, but is also in the patho/physiological events in which breakdown of extracellular matrices is evoked topically. In this present study, we examined the expression of fibrinolytic factors, tissue-type PA (t-PA) and Type 1...

journal_title：Thrombosis research

authors： Noguchi T,Matsuyama S,Akao M,Hagiwara H,Uno S,Seki T,Ariga T

更新日期：2001-11-15 00:00:00

abstract：INTRODUCTION:High RDW values are associated with adverse prognosis in many clinical conditions including short and medium term outcome of patients with ST Elevation Myocardial Infarction (STEMI). The aim of the present study was to evaluate the association between RDW and long term mortality in STEMI patients undergoin...

journal_title：Thrombosis research

authors： Arbel Y,Shacham Y,Finkelstein A,Halkin A,Milwidsky A,Berliner S,Ziv-Baran T,Revivo M,Herz I,Keren G,Banai S

更新日期：2014-11-01 00:00:00

abstract：:The fibrinolytic system was evaluated in a patient with homozygous protein C deficiency as well as in several members of his family with a partial deficiency of this protein. Before anticoagulant therapy the patient showed skin lesions which quickly disappeared after administration of fresh plasma. After anticoagulant...

journal_title：Thrombosis research

authors： Aznar J,Dasi A,España F,Estellés A

更新日期：1986-05-01 00:00:00

abstract：INTRODUCTION:Inter-individual variability in clopidogrel responsiveness is dependent on genetic polymorphisms. We aimed to investigate the impact of 3 genetic polymorphisms involved in clopidogrel metabolism on a strategy of dose-adjustment according to platelet reactivity (PR) monitoring. MATERIAL AND METHODS:[correc...

journal_title：Thrombosis research

authors： Bonello L,Camoin-Jau L,Mancini J,Bessereau J,Grosdidier C,Alessi MC,Ostorero M,Dignat-George F,Paganelli F

更新日期：2012-07-01 00:00:00

abstract：:Twenty-five men and 26 women were studied to investigate the effects of acute strenuous exercise on hemostasis after obtaining their informed consent. After familiarization, they performed exercise on a bicycle ergometer at 75% of their predetermined maximal workload until exhaustion. Bleeding time, measured by the Si...

journal_title：Thrombosis research

authors： Chen HI,Tang YR,Wu HJ,Jen CJ

更新日期：1989-08-15 00:00:00

abstract：:Although significant advances in hemophilia treatment have improved patient outcomes and quality of life, one of the greatest complications in severe hemophilia A is the development of anti-Factor VIII (FVIII) antibodies that inhibit FVIII activity in almost 30% of previously untreated patients (PUPs). Inhibitors make...

journal_title：Thrombosis research

authors： Garagiola I,Palla R,Peyvandi F

更新日期：2018-08-01 00:00:00

abstract：:The concentration of the glycoprotein (GP) IIb-IIIa complex in thrombasthenic platelets of 8 patients of 6 families has been estimated. In the thrombasthenic platelets of 3 patients this complex is absent (thrombasthenia type I and subtype I). In 2 patients only traces are detectable and in 3 patients GP IIb-IIIa comp...

journal_title：Thrombosis research

authors： Herrmann FH,Meyer M,Gogstad GO,Solum NO

更新日期：1983-12-15 00:00:00

abstract：OBJECTIVE:In sepsis, activation of coagulation and inhibition of fibrinolysis lead to microvascular thrombosis. Thus, clot stability might be a critical issue in the development of multiple organ dysfunction syndrome. Activated FXIII (FXIIIa) forms stable fibrin clots by covalently cross-linking fibrin monomers. Theref...

journal_title：Thrombosis research

authors： Zeerleder S,Schroeder V,Lämmle B,Wuillemin WA,Hack CE,Kohler HP

更新日期：2007-01-01 00:00:00

abstract：:Platelet aggregation, lipoprotein lipase activity, coagulation parameters and routine blood chemistry were measured in a randomised study of 21 surgical patients before, immediately after and 3 months after operation. Sodium heparin 5000 IU was given subcutaneously to 11 patients every 12 hours for 7 days, the first i...

journal_title：Thrombosis research

authors： Törngren S,Norén I,Forsskåhl B,Sipilä H

更新日期：1983-06-01 00:00:00

abstract：:The extrinsic fibrinolytic system was assessed among 124 consecutive survivors of acute myocardial infarction below 70 years of age. In samples drawn 3 months after discharge from hospital, the PAI-1 levels were higher and the tPA activities were lower than among elderly healthy controls. In contrast, the AMI survivor...

journal_title：Thrombosis research

authors： Nilsson TK,Johnson O

更新日期：1987-12-15 00:00:00

abstract：INTRODUCTION:Metastases are responsible for more than 90% of cancer related mortality. The hematogenous metastatic invasion is a complex process in which the endothelium plays a key role. Extravasation is a dynamic process involving remodeling and change in cell shape and in cytoskeleton whereby a series of strongly de...

journal_title：Thrombosis research

authors： Gilardi M,Bersini S,Calleja AB,Kamm RD,Vanoni M,Moretti M

更新日期：2016-04-01 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long term complication of acute pulmonary embolism (PE). Untreated, CTEPH is associated with a very poor prognosis and high risk of mortality, although curation can be achieved by surgical removal of the obstructive endothelialised thromboemboli ...

journal_title：Thrombosis research

authors： Ende-Verhaar YM,Huisman MV,Klok FA

更新日期：2017-03-01 00:00:00

abstract：:Low circulating protein C (PC) levels have been observed in sepsis, especially in patients with Neisseriae Meningitides infections. Poor clinical outcome and high limb amputation rates have been associated in infected patients with low circulating PC levels. Published studies using activated PC replacement therapy pat...

journal_title：Thrombosis research

authors： Piccin A,O' Marcaigh A,Mc Mahon C,Murphy C,Okafor I,Marcheselli L,Casey W,Claffey L,Smith OP

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:The recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) is undergoing clinical trials for prophylaxis and on-demand treatment of haemophilia B patients. The aim of this study was to investigate the pharmacokinetics, whole-body and knee joint distribution of rIX-FP following intra...

journal_title：Thrombosis research

authors： Herzog E,Harris S,Henson C,McEwen A,Schenk S,Nolte MW,Pragst I,Dickneite G,Schulte S,Zollner S

更新日期：2014-05-01 00:00:00

abstract：:Bone marrow transplantation (BMT) is the only curable option for thalassemia major, β-thalassemia/HbE. However, some patients still have the risk of hypercoagulable complications. We used a whole blood flow cytometric analysis to measure the circulating microparticle (MP) levels, activated platelets, and leukocyte-pla...

journal_title：Thrombosis research

authors： Klaihmon P,Lertthammakiat S,Anurathapan U,Pakakasama S,Sirachainan N,Hongeng S,Pattanapanyasat K

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:An individualised thromboprophylaxis was implemented in critically ill patients suffering from coronavirus disease 2019 (COVID-19) pneumonia to reduce mortality and improve clinical outcome. The aim of this study was to evaluate the effect of this intervention on clinical outcome. METHODS:In this mono-cen...

journal_title：Thrombosis research

authors： Stessel B,Vanvuchelen C,Bruckers L,Geebelen L,Callebaut I,Vandenbrande J,Pellens B,Van Tornout M,Ory JP,van Halem K,Messiaen P,Herbots L,Ramaekers D,Dubois J

更新日期：2020-10-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) has become the most curable form of acute myeloid leukemia after the advent of all-trans retinoic acid (ATRA). However, early deaths (ED) mostly due to the disease-associated coagulopathy remain the major cause of treatment failure. In particular, hemorrhagic events account for 40-65...

journal_title：Thrombosis research

authors： Breccia M,Lo Coco F

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:The purpose of the present study was to study the concept of aspirin resistance or non-responsiveness by investigating the response to long-term aspirin therapy in patients with a former acute myocardial infarction (AMI). MATERIALS AND METHODS:Patients with an AMI (n=202) randomly assigned to aspirin 160 ...

journal_title：Thrombosis research

authors： Andersen K,Hurlen M,Arnesen H,Seljeflot I

更新日期：2002-10-01 00:00:00

abstract：:The role of thrombin in vascular physiology and pathophysiology continues to impact our understanding of many cellular processes and systems including the function of platelets, endothelial cells, smooth muscle cells, leukocytes and the regulation of the coagulation cascade. Recent acute coronary syndrome clinical tri...

journal_title：Thrombosis research

authors： Giri S,Jennings LK

更新日期：2015-05-01 00:00:00

abstract：:Heparinase degraded heparin fragments (HDHF) are enriched with a UV chromophore and can be utilized as calibrators to determine the molecular weight profile of low molecular weight heparins (LMWH's). In a standard protocol (1), the second to the last peak is assumed to be a hexasaccharide with a molecular weight of 1....

journal_title：Thrombosis research

authors： Jeske W,Ahsan A,Fareed J

更新日期：1993-04-01 00:00:00

abstract：INTRODUCTION:Proteasome inhibitor bortezomib (PS-341) has been the first proteasome inhibitor that has entered clinical trials with its antiproliferative and proapoptotic effects in patients with multiple myeloma. Recent studies indicate that proteasome inhibitors can be useful in prevention of experimental arterial th...

journal_title：Thrombosis research

authors： Avcu F,Ural AU,Cetin T,Nevruz O

更新日期：2008-01-01 00:00:00

abstract：:Radioactivity from I125-labeled human platelets was measured to estimate the extent of binding of platelet surface proteins to immobilized thrombin. 1-3% of the radioactivity was bound with 10-20% of this amount apparently irreversibly bound to the thrombin matrix. Site-specific chemical modification of thrombin with ...

journal_title：Thrombosis research

authors： Wu HF,White GC 2nd,Workman EF Jr,Jenzano JW,Lundblad RL

更新日期：1992-08-15 00:00:00

abstract：:Severe rejection crises occurred in 13 out of 20 cadaver kidney recipients; removal of the graft was inevitable in 10 cases. The plasminogen levels were found to be lower (76.5 +/- 2.9%) in the 13 patients with impaired graft acceptance (group B) than in the 7 patients experiencing only moderate rejection (group A, 93...

journal_title：Thrombosis research

authors： Seitz R,Michalik R,Karges HE,Lange H,Egbring R

更新日期：1986-05-01 00:00:00

abstract：:Reproducible disseminated intravascular coagulation in rabbits was provoked by two intravenous injections 24 hours apart of endotoxin from Salmonella enteritidis. There were mild symptoms of DIC before the second injection which considerably increased thereafter. In detail there was a sharp drop of the platelet count ...

journal_title：Thrombosis research

authors： Zawilska K,Zozulinska M,Turowiecka Z,Blahut M,Drobnik L,Vinazzer H

更新日期：1993-02-01 00:00:00

abstract：INTRODUCTION:Elevated soluble urokinase-type plasminogen activator receptor (suPAR) indicates an inflammatory state caused by conditions such as HIV and cancer. Recently suPAR was identified as an indicator of cardiovascular disease (CVD). CVD is highly prevalent in black South Africans, but the potential role of suPAR...

journal_title：Thrombosis research

authors： Schutte AE,Myburgh A,Olsen MH,Eugen-Olsen J,Schutte R

更新日期：2012-08-01 00:00:00

abstract：:The effect of activated protein C (APC) on agonist-induced platelet activation and on thrombin generation after intrinsic (IA) and extrinsic (EA) activation of the coagulation system was studied by flow cytometry and by measuring levels of prothrombin fragment F1+2. In platelet activation studies blood drawn from heal...

journal_title：Thrombosis research

authors： Kaiser B,Jeske W,Hoppensteadt DH,Walenga JM,Drohan W,Fareed J

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND/AIM:It is believed that the amniotic fluid-derived TF, in the case of amniotic fluid embolism (AFE), contributes to acute disseminated intravascular coagulation (DIC) and obstetric shock in the mother. However, the role of amniotic fluid-derived contact phase coagulation factors that irrupt into the bloodstr...

journal_title：Thrombosis research

authors： Uszyński W,Żekanowska E,Uszyński M,Kieszkowski P

更新日期：2015-04-01 00:00:00

abstract：:To examine whether moderate hyperhomocyst(e)inemia is associated with coronary artery disease and the number of diseased coronary vessels in Koreans, we investigated 201 patients with angiographically documented coronary artery disease and 187 healthy subjects without evidence of stroke and coronary artery disease. Th...

journal_title：Thrombosis research

authors： Yoo JH,Park JE,Hong KP,Lee SH,Kim DK,Lee WR,Park SC

更新日期：1999-04-01 00:00:00