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Activated platelets and leukocyte activations in young patients with β-thalassemia/HbE following bone marrow transplantation.

Abstract：

:Bone marrow transplantation (BMT) is the only curable option for thalassemia major, β-thalassemia/HbE. However, some patients still have the risk of hypercoagulable complications. We used a whole blood flow cytometric analysis to measure the circulating microparticle (MP) levels, activated platelets, and leukocyte-platelet aggregates in 59 young β-thalassemia/HbE patients compared with 20- and 28-matched healthy and patients receiving regular blood transfusion (RT), respectively. Results from the studies showed that blood samples from BMT group contained a significantly higher numbers of circulating MPs originated from platelets (ann-V+CD41a+), leukocyte (ann-V+CD45+) and endothelial cells (ann-V+CD146+) when compared to samples from healthy subjects and RT patients. In contrast, the percentages of activated/procoagulant platelets (CD62P and CD142 expressing platelets) were decreased in BMT group. In addition, monocytes forming microaggregates were the major population among other leukocyte-platelet complexes. Different patterns of CD11b, CD62P and CD142 expression on platelet-leukocyte microaggregate surface were also found. These data suggest that circulating MPs together with leukocyte-platelet aggregates may be responsible, in part, in pathogenesis of hypercoagulable state in β-thalassemia/HbE patients who undergone BMT.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Klaihmon P,Lertthammakiat S,Anurathapan U,Pakakasama S,Sirachainan N,Hongeng S,Pattanapanyasat K

doi

10.1016/j.thromres.2018.07.007

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

8-14

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(18)30414-6

journal_volume

169

pub_type

杂志文章

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