In vivo platelet response to lipopolysaccharide in mice: proposed method for evaluating new antiplatelet drugs.

abstract：BACKGROUND:The fibrinogen γ' variant (γ') has both antithrombotic and prothrombotic properties when compared to normal fibrinogen. It may therefore be of relevance in intracerebral hemorrhage and intraventricular extension of the bleeding. OBJECTIVE:To study the role of γ' in intracerebral hemorrhage, and in intravent...

journal_title：Thrombosis research

authors： van den Herik EG,Cheung EY,de Lau LM,den Hertog HM,Leebeek FW,Dippel DW,Koudstaal PJ,de Maat MP

更新日期：2012-06-01 00:00:00

abstract：:Seven males with atherosclerotic disease received daily 1.6 g of the thromboxane antagonist BM 13.177 in two separate oral dosages over a period of four days. The drug significantly reduced elevated plasma levels of thromboxane B2, beta-thromboglobulin and platelet factor 4, whereas thromboxane B2 generation was only ...

journal_title：Thrombosis research

authors： Riess H,Hiller E,Reinhardt B,Bräuning C

更新日期：1984-08-15 00:00:00

abstract：:The variant von Willebrand disease (vWd) variant type 2M (Vicenza) was identified in 13 patients of 7 unrelated families. 11 patients were from different parts of germany and 2 patients from Turkey. Hitherto this variant of vWd has been described only in two families originating from the province of Vicenza in Norther...

journal_title：Thrombosis research

authors： Zieger B,Budde U,Jessat U,Zimmermann R,Simon M,Kätzel R,Sutor AH

更新日期：1997-07-01 00:00:00

abstract：:A direct assay for plasminogen activator (PA) was developed. It employed polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and beta-mercaptoethanol to monitor PA-mediated conversion of single chain, 125I-plasminogen to two chain plasmin. By incorporating Triton X-100, albumin and trasylol in...

journal_title：Thrombosis research

authors： Mussoni L,Lawrence D,Loskutoff DJ

更新日期：1984-05-01 00:00:00

abstract：:125I-fibronectin is incorporated into fibrin when blood plasma is clotted with thrombin. This process is dependent upon fibronectin concentration, temperature, and the presence of calcium ions. Fibronectin appears to be a very strong inhibitor of fibrin formation and influences both the thrombin clotting time and fibr...

journal_title：Thrombosis research

authors： Niewiarowska J,Cierniewski CS

更新日期：1982-09-01 00:00:00

abstract：:Generation of active Factor XII (FXIIa) triggers blood clotting on artificial surfaces and may also enhance intravascular thrombosis. We developed a patterned kaolin (0 to 0.3 pg/μm(2))/type 1 collagen fibril surface for controlled microfluidic clotting assays. Perfusion of whole blood (treated only with a low level o...

journal_title：Thrombosis research

authors： Zhu S,Diamond SL

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:Though thrombin-activatable fibrinolysis inhibitor (TAFI) may contribute to hypercoagulability during pregnancy, limited data are available on the role of TAFI in women with recurrent fetal loss. MATERIAL/METHODS:We performed a case-control study aimed at evaluating any possible association between TAFI l...

journal_title：Thrombosis research

authors： Legnani C,Bovara M,Valdrè L,Cosmi B,Caniato A,Palareti G

更新日期：2012-08-01 00:00:00

abstract：:Previous studies indicated that human placental anticoagulant protein, a member of the lipocortin family, prolonged the clotting time of normal plasma when clotting was induced by brain thromboplastin or by kaolin in the presence of cephalin and calcium. Using a two-stage amidolytic assay to assess factor X activation...

journal_title：Thrombosis research

authors： Kondo S,Noguchi M,Funakoshi T,Fujikawa K,Kisiel W

更新日期：1987-11-15 00:00:00

abstract：:When single-chain pro-UK is activated by plasmin or kallikrein, the Lys158-Ile159 bond is cleaved, leaving a C-terminal lysine on the A-chain (Lys-UK). Two-chain, high molecular weight urokinase (UK) purified from urine, however, has been shown to contain a phenylalanine residue as the C-terminal of the A-chain (Phe-U...

journal_title：Thrombosis research

authors： Lenich C,Pannell R,Gurewich V

更新日期：1991-10-01 00:00:00

abstract：INTRODUCTION:Long-term dual antiplatelet therapy (DAPT) has substantially reduced the risk of post-percutaneous coronary intervention (PCI) myocardial infarction and stent thrombosis at the expense of major bleeding. We hypothesized that a short-term DAPT followed by extended P2Y12 inhibitor monotherapy might be approp...

journal_title：Thrombosis research

authors： Jin Y,Huang H,Shu X,Chen S,Lu L,Gao X,Wu Z

更新日期：2020-12-07 00:00:00

abstract：:Heparin cofactor II (HCII) is a specific thrombin inhibitor; its inhibitory activity is stimulated by heparin (Hep) and dermatan sulfate (DS). Vitronectin (VN), a heparin binding adhesive glycoprotein present in plasma and extracellular matrix, has been shown to decrease the stimulatory effect of Hep but not of DS on ...

journal_title：Thrombosis research

authors： Petzelbauer E,Seiffert D,Beckmann R,Pusch B,Geiger M,Binder BR

更新日期：1992-06-01 00:00:00

abstract：:The concentration of the glycoprotein (GP) IIb-IIIa complex in thrombasthenic platelets of 8 patients of 6 families has been estimated. In the thrombasthenic platelets of 3 patients this complex is absent (thrombasthenia type I and subtype I). In 2 patients only traces are detectable and in 3 patients GP IIb-IIIa comp...

journal_title：Thrombosis research

authors： Herrmann FH,Meyer M,Gogstad GO,Solum NO

更新日期：1983-12-15 00:00:00

abstract：BACKGROUND:Administrative data can be used to identify venous thromboembolism (VTE) and major bleeding (MB) events. However, the validity of this data in emergency room discharge records in Canada is unknown. METHODS:We conducted a single-institution retrospective chart re-abstraction study in London, Canada. We ident...

journal_title：Thrombosis research

authors： Al-Ani F,Shariff S,Siqueira L,Seyam A,Lazo-Langner A

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Thrombotic storm (TS) presents as a severe, acute thrombotic phenotype, characterized by multiple clotting events and frequently affecting younger adults. Understanding the extensive hypercoagulation of an extreme phenotype as TS will also provide insight into the pathogenesis of a wider spectrum of thromb...

journal_title：Thrombosis research

authors： Nuytemans K,Ortel TL,Gomez L,Hofmann N,Alves N,Dueker N,Beecham A,Whitehead P,Hahn Estabrooks S,Kitchens CS,Erkan D,Brandão LR,James AH,Kulkarni R,Manco-Johnson MJ,Pericak-Vance MA,Vance JM

更新日期：2018-01-01 00:00:00

abstract：:Patients with protamine allergy present a difficult dilemma when reversal of heparin is required for excessive bleeding. Premedication with steroids and antihistamines has not been shown to effectively prevent anaphylactic reactions in patients with hypersensitivity to protamine. Other heparin antagonists are either n...

journal_title：Thrombosis research

authors： Sloand EM,Kessler CM,McIntosh CL,Klein HG

更新日期：1989-06-15 00:00:00

abstract：:A frequent complication of venous access devices (VADs) is axillary-subclavian venous thrombosis. To study this problem we have compared blood drawn through VADs with peripheral blood samples in a group of oncology patients with venographically demonstrated venous damage (N = 14) and a group with normal venograms (N =...

journal_title：Thrombosis research

authors： Horne MK 3rd,Merryman PK,Mayo DJ,Gralnick HR,Chang RC,Alexander HR

更新日期：1995-08-15 00:00:00

abstract：:[3H]-Platelet activating factor (Paf-acether, 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine) binds to washed human platelets in a specific, dose-dependent, and saturable manner. Scatchard analysis reveals a high affinity site with a KD value of 0.25 +/- 0.033 nM (245 +/- 30 sites per platelet), and a second low a...

journal_title：Thrombosis research

authors： Wade PJ,Lunt DO,Lad N,Tuffin DP,McCullagh KG

更新日期：1986-01-15 00:00:00

abstract：:Triflavin, an Arg-Gly-Asp (RGD)-containing disintegrin purified from venom peptide inhibited platelet aggregation by interfering with the interaction of fibrinogen with alpha(IIb)beta(3) integrin. Using an immunostaining technique and electron microscopy, we investigated and compared the distribution of triflavin bind...

journal_title：Thrombosis research

authors： Chuang WJ,Wu CH,Huang HN,Chen SH,Hsiao G,Lin CH,Sheu JR

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Elevated plasma homocysteine has been implicated as a risk factor for hypertension. C677T polymorphism in methylenetetrahydrofolate reductase gene (MTHFR) is a major determinant of hyperhomocysteinemia, which results in endothelial dysfunction. Angiotensin-converting enzyme (ACE) inhibitors appear to remedy ...

journal_title：Thrombosis research

authors： Jiang S,Hsu YH,Xu X,Xing H,Chen C,Niu T,Zhang Y,Peng S,Xu X

更新日期：2004-01-01 00:00:00

abstract：:18F-Fluorodesoxyglucose Positron-Emission-Tomography combined with Computed-Tomography (FDG PET/CT) might be an attractive tool for cancer screening in patients with venous thromboembolism (VTE), allowing non-invasive whole-body imaging. One of the frequent criticisms to the use of FDG PET/CT for screening is the pote...

journal_title：Thrombosis research

authors： Robin P,Le Roux PY,Le Moigne E,Planquette B,Prévot-Bitot N,Roy PM,Pastre J,Merah A,Couturaud F,Le Gal G,Salaun PY

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:Cytomegalovirus (CMV)-associated thrombosis has been reported sporadically in the medical literature until now. However, thrombosis incidence and its risk factors have never been studied in a cohort of patients with acute CMV infection. MATERIALS AND METHODS:A retrospective case-control study. Medical cha...

journal_title：Thrombosis research

authors： Atzmony L,Halutz O,Avidor B,Finn T,Zimmerman O,Steinvil A,Zeltser D,Giladi M,Justo D

更新日期：2010-12-01 00:00:00

abstract：:The protease inhibitor, aprotinin, has been examined for its ability to inhibit urokinase and tissue-type plasminogen activators at pH 7.4 in assays utilizing pyroGlu-Gly-Arg-p-nitroanilide and H-D-Ile-Pro-Arg-p-nitroanilide as substrates, respectively. Aprotinin inhibited both two-chain low molecular weight urokinase...

journal_title：Thrombosis research

authors： Lottenberg R,Sjak-Shie N,Fazleabas AT,Roberts RM

更新日期：1988-03-15 00:00:00

abstract：:Arthral, abdominal and renal symptoms in Henoch-Schönlein purpura (HSP) were scored. Coagulation factor XIII (F XIII) activity was determined in fifty-six children with HSP and the correlation with the severity score of the clinical symptoms was investigated. As a result, it was found that the decrease in F XIII level...

journal_title：Thrombosis research

authors： Fukui H,Kamitsuji H,Nagao T,Yamada K,Akatsuka J,Inagaki M,Shike S,Kobayashi Y,Yoshioka K,Maki S

更新日期：1989-12-15 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor type-1 (PAI-1) is considered to be the main inhibitor of fibrinolysis in sepsis. However, the contribution of TAFI to the inhibition of fibrinolysis in sepsis is currently unknown. METHODS:TAFI antigen and PAI-1 levels were measured in severe sepsis (n = 32) and septic shock ...

journal_title：Thrombosis research

authors： Zeerleder S,Schroeder V,Hack CE,Kohler HP,Wuillemin WA

更新日期：2006-01-01 00:00:00

abstract：:Disseminated intravascular coagulation (DIC) is a severe complication of septic shock. Polymorphonuclear neutrophils (PMNs) may play a key role in septic shock-induced DIC via the release of neutrophils extracellular traps (NETs). NETs capture invading pathogens, but also act as a pro-coagulant surface at the interfac...

journal_title：Thrombosis research

authors： Stiel L,Mayeur-Rousse C,Helms J,Meziani F,Mauvieux L

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To characterize antithrombin (AT) levels in normal pregnancy. METHODS:We performed secondary analyses with data from 3 studies. Using a single measurement from each subject in the first analysis (cross-sectional), we correlated AT levels with gestational age from the middle of the second trimester throughout...

journal_title：Thrombosis research

authors： James AH,Rhee E,Thames B,Philipp CS

更新日期：2014-09-01 00:00:00

abstract：:In this study, we investigated the effects of a 3-min insulin incubation both at physiological and at supraphysiological concentrations on platelet aggregation and intraplatelet cyclic guanosine monophosphate (cGMP) levels both in the absence and in the presence of phosphodiesterase inhibition. We observed that insuli...

journal_title：Thrombosis research

authors： Anfossi G,Massucco P,Mattiello L,Piretto V,Mularoni E,Cavalot F,Paoletti G,Trovati M

更新日期：1996-04-01 00:00:00

abstract：:Incubation of recombinant human tissue factor apoprotein (Apo-TF) with human plasma decreased the recalcified clotting time of this plasma in a time-and dose-dependent manner suggesting relipidation of the Apo-TF by plasma lipoproteins. Incubation of Apo-TF with purified preparations of human very low density, low den...

journal_title：Thrombosis research

authors： Sakai T,Kisiel W

更新日期：1990-11-01 00:00:00

abstract：:A nephelometric method is described for determination of plasminogen and two types of plasmin inhibitors in human plasma having different affinity toward plasmin. This method is based on the kinetic analysis of effects of whole plasma and plasmin inhibitor fraction obtained from plasma on the activity of exogenously a...

journal_title：Thrombosis research

authors： Saito Y,Takabayashi K,Tsukada T,Inada Y

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Ambient particulate matter (PM) is associated with cardiovascular morbidity and mortality. It has been proposed that PM induces a pro-thrombotic process, increasing the risk of cardiovascular events, with some support from epidemiological and laboratory-based models. Diesel exhaust is a major contributor to ...

journal_title：Thrombosis research

authors： Carlsten C,Kaufman JD,Peretz A,Trenga CA,Sheppard L,Sullivan JH

更新日期：2007-01-01 00:00:00