Abstract:
BACKGROUND:The fibrinogen γ' variant (γ') has both antithrombotic and prothrombotic properties when compared to normal fibrinogen. It may therefore be of relevance in intracerebral hemorrhage and intraventricular extension of the bleeding. OBJECTIVE:To study the role of γ' in intracerebral hemorrhage, and in intraventricular extension of the hemorrhage. PATIENTS/METHODS:We performed a case-control study in 156 controls and 55 patients with intracerebral hemorrhage, with and without intraventricular extension. Levels of fibrinogen γ' and the γ'/total fibrinogen ratio were measured in all participants. RESULTS:Levels of γ' were increased in patients with intracerebral hemorrhage when compared with controls (0.40 vs 0.32g/l, p<0.001). The γ'/total fibrinogen ratio was similar in patients and controls (0.092 vs 0.096 p=0.42). There was evidence for an unfavorable outcome in patients with fibrinogen levels in the highest tertile compared with the lowest tertile (OR 4.0, 95%CI 1.1-15.2), and a nonsignificant trend toward unfavorable outcome with higher levels of γ' (p-value for trend=0.06). CONCLUSIONS:Our study shows that absolute levels of fibrinogen γ' are increased in patients with intracerebral hemorrhage, but relative levels are similar in patients and controls, suggesting that the absolute rise in γ' is an acute phase response.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
van den Herik EG,Cheung EY,de Lau LM,den Hertog HM,Leebeek FW,Dippel DW,Koudstaal PJ,de Maat MPdoi
10.1016/j.thromres.2011.08.017subject
Has Abstractpub_date
2012-06-01 00:00:00pages
807-9issue
6eissn
0049-3848issn
1879-2472pii
S0049-3848(11)00440-3journal_volume
129pub_type
杂志文章abstract:INTRODUCTION:Atherosclerosis, the underlying disorder of coronary artery disease (CAD), is an inflammatory process involving multiple molecular pathways. Chemokine-mediated mechanisms are potent regulators of atherosclerosis. Genetic variations that alter such signaling pathways could affect susceptibility to CAD. We i...
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更新日期:2007-01-01 00:00:00
abstract::The need for anticoagulation in dialysis patients is common and the incidence of venous thromboembolism (VTE) and atrial fibrillation in this population is high. While direct data are lacking on the management of anticoagulation in dialysis patients, careful weighing of risks and benefits on the basis of evidence from...
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journal_title:Thrombosis research
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journal_title:Thrombosis research
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journal_title:Thrombosis research
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更新日期:2008-01-01 00:00:00
abstract::A platelet storage pool deficiency (SPD) is present in platelets from cattle with the Chediak-Higashi syndrome (CHS). The most plausible hypothesis for the SPD is that dense granule precursors are simply not formed in CHS megakaryocytes. There is, however, evidence that some recently acquired 5-hydroxytryptamine (5HT)...
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journal_title:Thrombosis research
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journal_title:Thrombosis research
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doi:10.1016/s0049-3848(97)00277-6
更新日期:1997-12-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:1984-12-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:1998-07-15 00:00:00
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pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.thromres.2014.11.020
更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1987-05-15 00:00:00
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pub_type: 历史文章,杂志文章,评审
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更新日期:2014-11-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(92)90165-7
更新日期:1992-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00