Aprotinin inhibits urokinase but not tissue-type plasminogen activator.

abstract：INTRODUCTION:Available data on fibrin clot properties and fibrinolysis in hyperthyroidism and hypothyroidism are inconsistent. Our objective was to assess the impact of effective treatment of hyper- and hypothyroidism on fibrin clot characteristics. MATERIAL AND METHODS:In a case-control study, ex vivo plasma fibrin c...

journal_title：Thrombosis research

authors： Mazur P,Sokołowski G,Hubalewska-Dydejczyk A,Płaczkiewicz-Jankowska E,Undas A

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:Patients with multiple myeloma (MM) have an increased risk of thromboembolic events (TEE). Due to the complex nature of the prothrombotic state in MM, no single laboratory test has been designed to identify patients with the highest risk of developing TEE. Hence, this study is intended to assess the feasib...

journal_title：Thrombosis research

authors： Treliński J,Misiewicz M,Robak M,Smolewski P,Chojnowski K

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:D-dimer, a fibrin degradation product, is related to risk of cardiovascular disease and venous thromboembolism. Genetic determinants of D-dimer are not well characterized; notably, few data have been reported for African American (AA), Asian, and Hispanic populations. MATERIALS AND METHODS:We conducted a ...

journal_title：Thrombosis research

authors： Weng LC,Tang W,Rich SS,Smith NL,Redline S,O'Donnell CJ,Basu S,Reiner AP,Delaney JA,Tracy RP,Palmer CD,Young T,Yang Q,Folsom AR,Cushman M

更新日期：2014-08-01 00:00:00

abstract：:The ability of the COA-SET Fibrin monomer (COA-SET FM) test to detect soluble fibrin was evaluated by comparing the results of the COA-SET FM test with fibrinopeptide A (FPA) determinations following thrombin incubation of plasma or whole blood. In addition, two semiquantitative tests (erythrocytes-agglutination test ...

journal_title：Thrombosis research

authors： Halvorsen S,Skjønsberg OH,Ruyter R,Godal HC

更新日期：1990-02-15 00:00:00

abstract：:It has been suggested that plasma low density lipoprotein (LDL) may affect platelet and leukocyte activity and the release of biologically active eicosanoids which may contribute to the pathogenesis of coronary heart disease. To evaluate the possible biological effects of LDL further we have studied platelet aggregati...

journal_title：Thrombosis research

authors： Croft KD,Beilin LJ

更新日期：1993-02-15 00:00:00

abstract：BACKGROUND:Cocaine use has been related with the development of accelerated atherosclerosis and with an increased risk of cardiac and cerebrovascular events, such as myocardial infarction, sudden cardiac death, and ischemic stroke. The underlying mechanisms leading to these complications are not fully understood, altho...

journal_title：Thrombosis research

authors： Sáez CG,Olivares P,Pallavicini J,Panes O,Moreno N,Massardo T,Mezzano D,Pereira J

更新日期：2011-10-01 00:00:00

abstract：:Triflavin, an Arg-Gly-Asp (RGD)-containing disintegrin purified from venom peptide inhibited platelet aggregation by interfering with the interaction of fibrinogen with alpha(IIb)beta(3) integrin. Using an immunostaining technique and electron microscopy, we investigated and compared the distribution of triflavin bind...

journal_title：Thrombosis research

authors： Chuang WJ,Wu CH,Huang HN,Chen SH,Hsiao G,Lin CH,Sheu JR

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To characterize antithrombin (AT) levels in normal pregnancy. METHODS:We performed secondary analyses with data from 3 studies. Using a single measurement from each subject in the first analysis (cross-sectional), we correlated AT levels with gestational age from the middle of the second trimester throughout...

journal_title：Thrombosis research

authors： James AH,Rhee E,Thames B,Philipp CS

更新日期：2014-09-01 00:00:00

abstract：:Thrombin-activatable fibrinolysis inhibitor (TAFI), also known as procarboxypeptidase U or plasma procarboxypeptidase B, is a relatively recently described plasma glycoprotein synthesised in the liver. It can be activated into active enzyme TAFIa (carboxypeptidase U or plasma carboxypeptidase B) by a complex of thromb...

journal_title：Thrombosis research

authors： Antovic JP,Blombäck M

更新日期：2002-04-01 00:00:00

abstract：INTRODUCTION:Lung cancer is the leading cause of cancer-related death worldwide. Small cell lung cancer (SCLC) is thereby a highly aggressive neuroendocrine carcinoma representing about 15% of all lung cancer cases. Due to the highly metastatic behavior and multidrug resistance, the long-term survival of patients is ve...

journal_title：Thrombosis research

authors： Taromi S,Catusse J,Elverfeldt DV,Reichardt W,Ledig B,Zeiser R,Burger M

更新日期：2016-04-01 00:00:00

abstract：:HC II functional assays are generally preferred with respect to immunochemical assays. Nevertheless functional assays can be biased by the antithrombin III (AT III)-heparin complex activity; in fact trace amounts of heparin generally contaminate dermatan sulfate (DS) commercial preparations used as HC II reaction acti...

journal_title：Thrombosis research

authors： Ruzzenente O,Ghidini R,Poli G,Schiavon R,Guidi GC

更新日期：1992-01-15 00:00:00

abstract：BACKGROUND:Administrative data can be used to identify venous thromboembolism (VTE) and major bleeding (MB) events. However, the validity of this data in emergency room discharge records in Canada is unknown. METHODS:We conducted a single-institution retrospective chart re-abstraction study in London, Canada. We ident...

journal_title：Thrombosis research

authors： Al-Ani F,Shariff S,Siqueira L,Seyam A,Lazo-Langner A

更新日期：2015-12-01 00:00:00

abstract：:Stimulation of rat platelets with U46619 induced Ca2+ mobilization and platelet shape change, but aggregation and secretion were induced when platelets were stimulated with U46619 plus phorbol 12-myristate 13-acetate (PMA). However, stimulation of rabbit platelets with U46619 induced all the three platelet responses. ...

journal_title：Thrombosis research

authors： Nakano T,Hanasaki K,Arita H

更新日期：1989-10-15 00:00:00

abstract：:Human platelets synthesize nitric oxide (NO) through an endothelial-type NO synthase (ecNOS) activated also by substances enhancing 3',5'-cyclic adenosine monophosphate (cAMP) concentrations, such as catecholamines, beta-adrenoceptor agonists and adenosine. To verify whether cAMP directly activates ecNOS through the c...

journal_title：Thrombosis research

authors： Russo I,Doronzo G,Mattiello L,De Salve A,Trovati M,Anfossi G

更新日期：2004-01-01 00:00:00

abstract：UNLABELLED:Suboptimal gastrointestinal absorption is a problem for many direct thrombin inhibitors. The studies presented herein describe the new oral direct thrombin inhibitor H 376/95, a prodrug with two protecting residues added to the direct thrombin inhibitor melagatran. Absorption properties in vitro: H 376/95 is...

journal_title：Thrombosis research

authors： Gustafsson D,Nyström J,Carlsson S,Bredberg U,Eriksson U,Gyzander E,Elg M,Antonsson T,Hoffmann K,Ungell A,Sörensen H,Någård S,Abrahamsson A,Bylund R

更新日期：2001-02-01 00:00:00

abstract：:The effect of extracellular matrix components on lipopolysaccharide-induced vascular endothelial cell injury was studied by using lipopolysaccharide-susceptible bovine aortic endothelial cells. For evaluation of lipopolysaccharide-induced injury, we estimated DNA synthesis and cell detachment of bovine aortic endothel...

journal_title：Thrombosis research

authors： Chakravortty D,Kato Y,Koide N,Sugiyama T,Kawai M,Fukada M,Yoshida T,Yokochi T

更新日期：2000-04-15 00:00:00

abstract：:Patients who had survived a stroke or transient ischaemic attacks (TIA) were admitted to a trial of low-dose aspirin (50 mg) alone, sustained release dipyridamole (400 mg/day) alone, or a combination of the two agents, and results compared with a placebo over 24 months. This low-dose aspirin regimen produced in pairwi...

journal_title：Thrombosis research

authors： Forbes CD

更新日期：1998-09-15 00:00:00

abstract：:The sequel of survivors after hospitalisation for an acute myocardial infarction was studied during the following 15 years in 48 patients treated with streptokinase and in 41 controls. No significant difference was seen in the morbidity or mortality during the first 6 months nor in the mortality thereafter. ...

journal_title：Thrombosis research

authors： Heikinheimo R,Leskinen O,Siitonen L

更新日期：1984-08-15 00:00:00

abstract：INTRODUCTION:Pathogenesis of idiopathic pulmonary arterial hypertension (iPAH) includes endothelial dysfunction and in situ thrombosis. A hypercoagulable state has also been postulated but never demonstrated. Our objective was to determine whether patients with iPAH had a hypercoagulable state using calibrated automate...

journal_title：Thrombosis research

authors： Tournier A,Wahl D,Chaouat A,Max JP,Regnault V,Lecompte T,Chabot F

更新日期：2010-12-01 00:00:00

abstract：:Four monoclonal antibodies have been produced, which are specific for the Ca2+ or Sr2(+)-induced conformation of human factor IX. Certain, but not all, gamma-carboxy-glutamic acid residues in factor IX are involved in the epitope expression together with the conformation stabilized by the adjacent region of Gla-domain...

journal_title：Thrombosis research

authors： Sugo T,Mizuguchi J,Kamikubo Y,Matsuda M

更新日期：1990-06-15 00:00:00

abstract：INTRODUCTION:Dermatan sulfate, a sulfated glycosaminoglycan, acts as an anticoagulant by accelerating the inhibition of thrombin by heparin cofactor II. MATERIALS AND METHODS:A low molecular mass dermatan sulfate was obtained by peroxy-radical depolymerization from a parent dermatan sulfate. Chemical characterization ...

journal_title：Thrombosis research

authors： Fabiana Alberto M,Giaquinta Romero D,Lazzari M,Calabrese GC

更新日期：2008-01-01 00:00:00

abstract：:Anticoagulants are effective for preventing both venous and arterial thrombosis. Although antithrombotic agents have been reported to reduce thrombin formation, to our knowledge, the relation between blood viscosity (BV) and antithrombotic agents has not been examined. We examined the effects on whole BV of various do...

journal_title：Thrombosis research

authors： Hitosugi M,Niwa M,Takatsu A

更新日期：2001-12-01 00:00:00

abstract：INTRODUCTION:Thrombin, a serine protease, plays an important role in such actions as coagulation, cell proliferation and inflammation. It has been sporadically reported that endothelial cells, when stimulated by thrombin via protease-activated receptors (PAR), express various mediators and proteins including cytokines,...

journal_title：Thrombosis research

authors： Okada M,Suzuki K,Takada K,Nakashima M,Nakanishi T,Shinohara T

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The mortality rate associated with UGI bleeding remains high at 7-14%. Pharmacologic and endoscopic interventions are the current standard treatment, but there are few alternative options should these fail. This study aimed to assess the efficacy and safety of recombinant activated factor VII (rFVIIa) in t...

journal_title：Thrombosis research

authors： Vilstrup H,Markiewicz M,Biesma D,Brozovic VV,Laminoga N,Malik M,Milanov S,Patch D,Platikanov V

更新日期：2006-01-01 00:00:00

abstract：:Bovine hide collagen dispersions were swollen in the pH range 1.6-7.0, treated with glutaraldehyde, and dialyzed to neutral pH. The intensity with which these collagens reacted with human platelets in plasma was studied by aggregometry and scanning electron microscopy. Collagen swollen at a pH below 4.25 +/- 0.30 and ...

journal_title：Thrombosis research

authors： Sylvester MF,Yannas IV,Salzman EW,Forbes MJ

更新日期：1989-07-01 00:00:00

abstract：INTRODUCTION:Pseudoprolongation of activated partial thromboplastin time (APTT) is a serious problem in anticoagulation therapy for patients with high hematocrit, such as cyanotic congenital heart diseases. APTT pseudoprolongation occurs when APTT assay is performed using routinely used vacuum sampling tubes containing...

journal_title：Thrombosis research

authors： Kanahara M,Kai H,Okamura T,Wada T,Suda K,Imaizumi T,Sagawa K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Treatment of deep-vein thrombosis (DVT) with a once-daily regimen of enoxaparin, rather than a continuous infusion of unfractionated heparin (UFH) is more convenient and allows for home care in some patients. This study was designed to compare the efficacy and safety of these two regimens for the treatment o...

journal_title：Thrombosis research

authors： Ramacciotti E,Araújo GR,Lastoria S,Maffei FH,Karaoglan de Moura L,Michaelis W,Sandri JL,Dietrich-Neto F,CLETRAT Investigators.

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Quercetin is widely distributed in plants and has been reported to have effects of anti-inflammation and anti-thrombosis. In this study, we evaluated the protective effect of quercetin on LPS-induced experimental DIC in rabbits, and tried to clarify its mechanism against DIC. MATERIALS AND METHODS:LPS-ind...

journal_title：Thrombosis research

authors： Yu PX,Zhou QJ,Zhu WW,Wu YH,Wu LC,Lin X,Chen MH,Qiu BT

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Post-thrombotic syndrome (PTS) is a chronic sequel of deep vein thrombosis (DVT). The clot structure and fibrinolytic potential in PTS is currently unknown. OBJECTIVE:To assess the fibrinolytic potential and clot structure in patients with PTS. MATERIALS AND METHODS:Patients with a history of DVT were in...

journal_title：Thrombosis research

authors： Bouman AC,McPherson H,Cheung YW,Ten Wolde M,Ten Cate H,Ariëns RAS,Ten Cate-Hoek AJ

更新日期：2016-01-01 00:00:00

abstract：:Two functional assays for protein C inhibitor (PCI) were evaluated in parallel for the same plasma samples. One assay is specific for active PCI and measures its ability to form complexes with activated protein C (APC) in the presence of heparin (España et al, Thromb Res 64, 309, 1991) (Method A). After incubation of ...

journal_title：Thrombosis research

authors： España F,Hendl S,Gilabert J,Estellés A,Aznar J

更新日期：1993-06-01 00:00:00