Additional testing following screening strategies for occult malignancy diagnosis in patients with unprovoked venous thromboembolism.

abstract：:The three polypeptide chains of fibrinogen, A alpha, B beta and gamma chain, are synthesized on separate polysomes. Fully formed fibrinogen is a six chain, disulfide-linked, dimeric molecule with a molecular weight of 340kDa. Previous pulse-chase studies with L-35 S methionine using the human hepatocellular carcinoma ...

journal_title：Thrombosis research

authors： Yu S,Kong V,Kudryk B,Redman C

更新日期：1987-04-15 00:00:00

abstract：BACKGROUND:Abdominal obesity has been found to be associated with an increased risk of deep vein thrombosis (DVT). Whether patients with abdominal obesity have an increased risk of recurrence is currently unknown. METHODS:Patients with objective diagnosis of DVT and a life expectancy of greater than 6 months underwent...

journal_title：Thrombosis research

authors： Romualdi E,Squizzato A,Ageno W

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Rate of thalidomide-related VTE and risk factors in Japanese myeloma patients are not clear and effects of thromboprophylaxis remain controvertial. PATIENTS AND METHODS:We retrospectively analyzed a cohort data of registered Japanese myeloma patients treated with thalidomide-based regimens between 2009 and ...

journal_title：Thrombosis research

authors： Kato A,Takano H,Ichikawa A,Koshino M,Igarashi A,Hattori K,Nagata K

更新日期：2013-02-01 00:00:00

abstract：:Hypercoagulable states can be detected by measuring activation peptides, enzyme-inhibitor complexes, and fibrin/fibrinogen degradation products, which are markers of hemostatic activation. A series of these prethrombotic markers has been evaluated in the elderly, pregnancy, diabetes and acute myocardial infarction pat...

journal_title：Thrombosis research

authors： López Y,Paloma MJ,Rifón J,Cuesta B,Páramo JA

更新日期：1999-01-15 00:00:00

abstract：BACKGROUND:Thrombin is the most potent platelet activator, and achieves rapid platelet activation even in the presence of antiplatelet therapy. Since activated platelets respond stronger to additional stimuli, the extent of endogenous thrombin generation may in part be responsible for the reported response variability ...

journal_title：Thrombosis research

authors： Gremmel T,Panzer S,Steiner S,Seidinger D,Koppensteiner R,Pabinger I,Kopp CW,Ay C

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The "HERDOO2 rule" is a prospectively validated clinical decision rule used to identify low-risk women who can safely discontinue anticoagulants after completing 5-12 months of anticoagulant treatment for unprovoked venous thromboembolism. The VIDAS®d-Dimer (DD) assay, a component of the rule, was used in th...

journal_title：Thrombosis research

authors： Rodger MA,Le Gal G,Langlois NJ,Gin B,Mallick R,Giulivi A,Freedman M,Kovacs MJ,REVERSE II investigators.

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Pulmonary embolism (PE) is a common cause of morbidity and mortality. In this study, we investigated patterns of morbidity and mortality from PE in Australia. MATERIALS & METHODS:Australian government databases were used to extract data on age and sex specific rates of mortality between 1997 and 2007, and...

journal_title：Thrombosis research

authors： Shiraev TP,Omari A,Rushworth RL

更新日期：2013-07-01 00:00:00

abstract：:To investigate the effects of new drugs on the prevention of venous thrombosis, the Wessler stasis model is extensively employed usually in the rabbit. In this model, a hypercoagulable state is achieved by the administration of either heterologous serum (often human serum) or an activated coagulation factor followed b...

journal_title：Thrombosis research

authors： Millet J,Vaillot M,Theveniaux J,Brown NL

更新日期：1996-02-15 00:00:00

abstract：INTRODUCTION:It is currently unclear whether chronic kidney disease (CKD) and the decrease in renal function can influence the risk of venous thromboembolism (VTE) recurrence. MATERIALS AND METHODS:We performed an ambispective observational study on 409 patients with a previous episode of VTE. All the patients were in...

journal_title：Thrombosis research

authors： Rattazzi M,Villalta S,De Lucchi L,Sponchiado A,Galliazzo S,Faggin E,Pagliara V,Zilli C,Callegari E,Caberlotto L,Puato M,Pauletto P

更新日期：2017-12-01 00:00:00

abstract：:Homocystinuria due to cystathionine-beta-synthase deficiency (CBS-def-HOCY) initially often presents with vascular disorders, e.g. thromboembolic events. The measurement of vascular endothelial markers in plasma could help to assess endothelial damage. We determined von Willebrand factor (measured as Ristocetincofacto...

journal_title：Thrombosis research

authors： Schienle HW,Seitz R,Nawroth P,Rohner I,Lerch L,Krumpholz B,Krauss G,Fowler B,Baumgartner R,Willenbockel U

更新日期：1995-01-01 00:00:00

abstract：:Two isozymes of a native form of human plasminogen (plg), Glu-plg I and II, were isolated. Glu-plg I or II was activated by urokinase (UK) or streptokinase (SK) in the presence of fibrinogen or fibrin. The activation of Glu-plg I was enhanced more than that of Glu-plg II in the presence of fibrin. Fibrin caused better...

journal_title：Thrombosis research

authors： Takada Y,Makino Y,Takada A

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:Predictors of venous thromboembolism (VTE) after trauma are uncertain. OBJECTIVE:To identify independent predictors of VTE after acute trauma. METHODS:Using Rochester Epidemiology Project (REP) resources, we identified all Olmsted County, MN residents with objectively-diagnosed incident VTE within 92days a...

journal_title：Thrombosis research

authors： Park MS,Perkins SE,Spears GM,Ashrani AA,Leibson CL,Boos CM,Harmsen WS,Jenkins DH,Bailey KR,Ballman KV,Heit JA

更新日期：2016-08-01 00:00:00

abstract：:Heparin is known to exert its antithrombotic effects by accelerating the effect of antithrombin (AT) and by mobilizing tissue factor pathway inhibitor (TFPI) into the circulation from vascular endothelium. Heparin treatment has been reported to decrease FVIIa activity by 40%; this was suggested as a new antithrombotic...

journal_title：Thrombosis research

authors： Hansen JB,Svensson B,Sandset PM,Thijssen F

更新日期：2000-12-01 00:00:00

abstract：:Diabetes mellitus (DM) is associated with platelet and leukocyte dysfunction. Previous observations with regard to insulin effects on platelet and leukocyte function are less than consistent. We thus investigated the effects of insulin on platelets and leukocytes, as well as on platelet-leukocyte interactions in whole...

journal_title：Thrombosis research

authors： Hu H,Hjemdahl P,Li N

更新日期：2002-09-01 00:00:00

abstract：INTRODUCTION:Guidelines recommend the assessment of stroke and bleeding risk before initiating warfarin anticoagulation in patients with atrial fibrillation. Many of the elements used to predict stroke also overlap with bleeding risk in atrial fibrillation patients and it is tempting to use stroke risk scores to effici...

journal_title：Thrombosis research

authors： Barnes GD,Gu X,Haymart B,Kline-Rogers E,Almany S,Kozlowski J,Besley D,Krol GD,Froehlich JB,Kaatz S

更新日期：2014-08-01 00:00:00

abstract：:Bovine hide collagen dispersions were swollen in the pH range 1.6-7.0, treated with glutaraldehyde, and dialyzed to neutral pH. The intensity with which these collagens reacted with human platelets in plasma was studied by aggregometry and scanning electron microscopy. Collagen swollen at a pH below 4.25 +/- 0.30 and ...

journal_title：Thrombosis research

authors： Sylvester MF,Yannas IV,Salzman EW,Forbes MJ

更新日期：1989-07-01 00:00:00

abstract：:The susceptibility of von Willebrand factor /vWF/ to digestion by human neutrophil cathepsin G in highly purified FVIII/vWF concentrate /BHS/ and in cryoprecipitate has been studied. In contrast to human neutrophil elastase, cathepsin G inactivates and degrades vWF not only in BHS but also in cryoprecipitate. Fibrinog...

journal_title：Thrombosis research

authors： Jeleńska M,Kopeć M,Sopata I,Vigh Z,Scharrer I,Breddin K

更新日期：1991-02-15 00:00:00

abstract：INTRODUCTION:Aspirin inhibits the cyclooxygenase-1 (COX-1) mediated thromboxane A2 synthesis. Despite COX-1 inhibition, in patients with coronary artery disease (CAD), platelets can be activated through other mechanisms, like activation by thrombin. MATERIALS AND METHODS:At baseline in this cross-sectional substudy of...

journal_title：Thrombosis research

authors： Pettersen AÅ,Arnesen H,Opstad TB,Bratseth V,Seljeflot I

更新日期：2012-09-01 00:00:00

abstract：:Seven males with atherosclerotic disease received daily 1.6 g of the thromboxane antagonist BM 13.177 in two separate oral dosages over a period of four days. The drug significantly reduced elevated plasma levels of thromboxane B2, beta-thromboglobulin and platelet factor 4, whereas thromboxane B2 generation was only ...

journal_title：Thrombosis research

authors： Riess H,Hiller E,Reinhardt B,Bräuning C

更新日期：1984-08-15 00:00:00

abstract：INTRODUCTION:Electronic consultations (eConsults) are asynchronous, consultative electronic-based communications that are aimed to improve efficient and timely access to specialist advice. Our study aim was to evaluate the use and impact of the Canadian Champlain BASE™ (Building Access to Specialists through eConsultat...

journal_title：Thrombosis research

authors： Skeith L,Mohamed M,Karovitch A,Liddy C,Afkham A,Archibald D,Keely E

更新日期：2017-12-01 00:00:00

abstract：:We investigated the intracellular processes of the shape change in human megakaryoblastic leukemic cells, MEG-01, by platelet agonists. Thrombin induced the formation of many pseudopods. This shape change was also induced by phorbol 12-myristate 13 acetate (TPA) and weakly by Ca2+ ionophore, A23187, but not by ADP, co...

journal_title：Thrombosis research

authors： Goto S,Kobayashi M,Murate T,Hotta T,Hagiwara M,Hoshino T,Hidaka H,Saito H

更新日期：1992-10-01 00:00:00

abstract：:Cardiovascular disease (CVD) includes a number of conditions such as myocardial infarction, coronary heart disease, stroke, and venous thromboembolism. CVD is a leading health problem worldwide and a major cause of mortality, morbidity, and disability; it is also associated with high healthcare costs. The incidence of...

journal_title：Thrombosis research

authors： Cohen AT,Imfeld S,Markham J,Granziera S

更新日期：2015-02-01 00:00:00

abstract：:Initiation of clotting cascade by tissue factor (TF): Factor VII (FVII) complex is essential for hemostasis however pathologic expression of TF leads to thrombosis. In contrast, the contact pathway factor XII, and to the smaller extent FXI are dispensable for normal hemostasis but still contribute to pathologic thromb...

journal_title：Thrombosis research

authors： Hoffman M,Pawlinski R

更新日期：2014-05-01 00:00:00

abstract：:The effect of several vitamin K (Vit K) analogues on the aggregation of human platelets was examined. The analogues were potent inhibitors of aggregation induced by ADP, thrombin, collagen and arachidonate but were less active against aggregation induced by the calcium ionophore A23187. Vit K3 also prevented platelet ...

journal_title：Thrombosis research

authors： Blackwell GJ,Radomski M,Moncada S

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:To evaluate the pathogenetic role of tissue factor (TF), tissue factor pathway inhibitor (TFPI), and neutrophil elastase in acute respiratory distress syndrome (ARDS), as well as to test the hypothesis that TFPI levels modified by neutrophil activation are not sufficient to prevent TF-dependent intravascul...

journal_title：Thrombosis research

authors： Gando S,Kameue T,Matsuda N,Hayakawa M,Morimoto Y,Ishitani T,Kemmotsu O

更新日期：2003-01-25 00:00:00

abstract：:The levels of protein C (PC) and other coagulation factors were monitored during endotoxin-induced disseminated intravascular coagulation (DIC) in the dog. Initial evaluation of the effectiveness of intradermal administration of bolus endotoxin quantities into the dog, demonstrated induction of DIC in the canine, with...

journal_title：Thrombosis research

authors： Madden RM,Ward M,Marlar RA

更新日期：1989-08-01 00:00:00

abstract：:Increased fibrinolytic activity is a well recognized constant finding observed during cardiopulmonary bypass (CPB). The purpose of the present work was to study and estimate the factors involved in the plasminogen activation and prekallikrein-kallikrein systems in a population of adult patients undergoing open heart s...

journal_title：Thrombosis research

authors： Baños G,de la Peña A,Izaguirre R

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:Exposure of the subendothelium to flowing blood following rupture of atherosclerotic lesions or during balloon angioplasty initiates platelet adhesion to the vascular wall. Because activated platelets release proinflammatory mediators (e.g., interleukin (IL)-1beta) and secrete growth factors, platelet adhesio...

journal_title：Thrombosis research

authors： Massberg S,Vogt F,Dickfeld T,Brand K,Page S,Gawaz M

更新日期：2003-06-01 00:00:00

abstract：:Patients with active cancer have a heightened risk of venous thromboembolism (VTE). This risk is further increased by the initiation of chemotherapy. Although previous studies have suggested that the use of parenteral thromboprophylaxis in all ambulatory cancer patients receiving chemotherapy significantly decreases t...

journal_title：Thrombosis research

authors： Kimpton M,Wells PS,Carrier M

更新日期：2018-04-01 00:00:00

abstract：:The role of Protein C in combined factor V/VIII deficiency was examined by reducing the Protein C concentration using warfarin therapy in a patient with the combined deficiency. The factor VIII deficiency was like Hemophilia-A, with deficiency of VIII:C and VIII:C(Ag), but normal VIIIR:Ag and VIIIR:cof. The factor V d...

journal_title：Thrombosis research

authors： Bern MM,Suzuki K,Mann K,Tracy P,Hoyer L,Jensen W,Gallivan M,Arkin C,Davis G

更新日期：1984-12-15 00:00:00