Glu-plasminogen I and II: their activation by urokinase and streptokinase in the presence of fibrin and fibrinogen.

abstract：:In vitro exper iments showed that polymeric hydrogels containing covalently immobilized heparin affect the parameters of blood clotting system. This is not accounted for by the elution of heparin into the surrounding medium and this property of heparin-containing polymers is caused by specific interaction of immobiliz...

journal_title：Thrombosis research

authors： Platé NA,Valuev LI

更新日期：1982-07-15 00:00:00

abstract：:The protease inhibitor, aprotinin, has been examined for its ability to inhibit urokinase and tissue-type plasminogen activators at pH 7.4 in assays utilizing pyroGlu-Gly-Arg-p-nitroanilide and H-D-Ile-Pro-Arg-p-nitroanilide as substrates, respectively. Aprotinin inhibited both two-chain low molecular weight urokinase...

journal_title：Thrombosis research

authors： Lottenberg R,Sjak-Shie N,Fazleabas AT,Roberts RM

更新日期：1988-03-15 00:00:00

abstract：:The effects of locally deposited fibrin and of tranexamic acid-induced antifibrinolysis on forming granulation tissue were studied in the light of a recently developed method for treatment of postoperative fistulas by occlusion with a fibrin clot. Perforated teflon cylinders, either empty or fibrin-filled, were implan...

journal_title：Thrombosis research

authors： Hedelin H,Teger-Nilsson AC,Peterson HI,Pettersson S

更新日期：1984-01-01 00:00:00

abstract：:We have studied the synthesis and subcellular distribution of the glycosylated membrane protein tissue factor (TF) in human blood monocytes and the inducible monocyte like cell line, HL-60. Following induction with endotoxin or the phorbol ester, TPA, tissue factor specific activity was measured in intact cells, sonic...

journal_title：Thrombosis research

authors： Bona R,Lee E,Rickles F

更新日期：1987-11-15 00:00:00

abstract：:Megakaryocyte colony formation was increased in 13 patients with ITP. Out of splenectomized ITP patients Colony Forming Unit-Megakaryocyte (CFU-Mk) number normalized in four but was lower than normal in the remaining two. The proportion of immature megakaryocytes was higher in ITP than in normals or in ITP patients af...

journal_title：Thrombosis research

authors： Podolak-Dawidziak M

更新日期：1991-04-01 00:00:00

abstract：:A Ca++-ionophore, ionomycin, increased the volume of human platelets suspended in a Ca++-containing buffer. This change in cell volume was dependent upon ionomycin and extracellular Ca++ concentrations, suggesting that the volume change occurs when the intracellular Ca++ reaches a certain level (greater than uM as det...

journal_title：Thrombosis research

authors： Ozaki Y,Matsumoto Y,Yatomi Y,Higashihara M,Kariya T,Kume S

更新日期：1990-01-01 00:00:00

abstract：:Biological effects of the modification of the sulphate ester and carboxyl group content of poly(vinyl alcohol-acrylic acid) copolymers (PAVAS) and sulphated polyvinyl alcohol copolymers (PVAS) with mol. weight of 5,000 to 20,000 D were studied. The in vitro anticoagulant potency of PAVAS assessed by activated partial ...

journal_title：Thrombosis research

authors： Csomor K,Kárpáti E,Nagy M,Györgyi-Edelényi J,Machovich R

更新日期：1994-05-15 00:00:00

abstract：:To investigate the effects of new drugs on the prevention of venous thrombosis, the Wessler stasis model is extensively employed usually in the rabbit. In this model, a hypercoagulable state is achieved by the administration of either heterologous serum (often human serum) or an activated coagulation factor followed b...

journal_title：Thrombosis research

authors： Millet J,Vaillot M,Theveniaux J,Brown NL

更新日期：1996-02-15 00:00:00

abstract：:Interaction with circulating platelets is considered an important virulent mechanism for Staphylococcus aureus (S. aureus) bacteria to induce endocarditis, a severe infectious disease with high incidence of systemic thrombosis. It therefore represents an important target for pharmacological intervention. In this study...

journal_title：Thrombosis research

authors： Liu CZ,Huang HY,Tsai PJ,Shih MH

更新日期：2005-01-01 00:00:00

abstract：:The need for anticoagulation in dialysis patients is common and the incidence of venous thromboembolism (VTE) and atrial fibrillation in this population is high. While direct data are lacking on the management of anticoagulation in dialysis patients, careful weighing of risks and benefits on the basis of evidence from...

journal_title：Thrombosis research

authors： Lo DS,Rabbat CG,Clase CM

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:In-vitro and in-vivo models suggest the influence of low-molecular weight heparin on conception in infertile women undergoing in vitro fertilization procedures (IVF). In this randomized controlled trial we assessed whether a low-molecular weight heparin (parnaparin) could affect IVF outcomes. MATERIALS AN...

journal_title：Thrombosis research

authors： Lodigiani C,Dentali F,Banfi E,Ferrazzi P,Librè L,Quaglia I,Cafaro L,Morenghi E,Pacetti V,Zannoni E,Baggiani AM,Levi-Setti PE

更新日期：2017-11-01 00:00:00

abstract：:Hemophilia A is an X-linked recessive bleeding disorder, widely prevalent throughout the world, for which, replacement therapy is the current treatment done by infusion of either recombinant FVIII or human plasma derived FVIII. The expression of FVIII is limited by many aspects, bioengineered FVIII with increased the ...

journal_title：Thrombosis research

authors： He B,Pan Y,Chen L,Xu Y,Chen N,Gu L,Nie Z,Wang S,Liu Z

更新日期：2011-12-01 00:00:00

abstract：UNLABELLED:Suboptimal gastrointestinal absorption is a problem for many direct thrombin inhibitors. The studies presented herein describe the new oral direct thrombin inhibitor H 376/95, a prodrug with two protecting residues added to the direct thrombin inhibitor melagatran. Absorption properties in vitro: H 376/95 is...

journal_title：Thrombosis research

authors： Gustafsson D,Nyström J,Carlsson S,Bredberg U,Eriksson U,Gyzander E,Elg M,Antonsson T,Hoffmann K,Ungell A,Sörensen H,Någård S,Abrahamsson A,Bylund R

更新日期：2001-02-01 00:00:00

abstract：:Coagulation is initiated by tissue factor (TF). Coagulant TF is constitutively expressed by extravascular cells, but there is increasing evidence that TF can also be present within the blood, in particular during pathological conditions. Such TF is exposed on circulating cell-derived vesicles, and its presence has bee...

journal_title：Thrombosis research

authors： Kleinjan A,Böing AN,Sturk A,Nieuwland R

更新日期：2012-10-01 00:00:00

abstract：:Generation of active Factor XII (FXIIa) triggers blood clotting on artificial surfaces and may also enhance intravascular thrombosis. We developed a patterned kaolin (0 to 0.3 pg/μm(2))/type 1 collagen fibril surface for controlled microfluidic clotting assays. Perfusion of whole blood (treated only with a low level o...

journal_title：Thrombosis research

authors： Zhu S,Diamond SL

更新日期：2014-12-01 00:00:00

abstract：:Experience with tranexamic acid, an indirect fibrinolytic inhibitor, started as soon as it was released from Shosuke Okamoto's lab in the early 1960s. It was first prescribed to females with heavy menstrual blood loss and to patients with hereditary bleeding disorders. Soon the indications were widened to elective sur...

journal_title：Thrombosis research

authors： Tengborn L,Blombäck M,Berntorp E

更新日期：2015-02-01 00:00:00

abstract：:Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), presents a large clinical burden. Prompt, effective and sustained anticoagulation is vital because of the risk of recurrent events, including life-threatening PE, and complications such as post-thrombotic syndrome and chro...

journal_title：Thrombosis research

authors： Prandoni P

更新日期：2014-08-01 00:00:00

abstract：:Pergularain e I, a cysteine protease with thrombin-like activity, was purified by ion exchange chromatography from the latex of Pergularia extensa. Its homogeneity was characterized by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), native PAGE and reverse-phase high-performance liquid chromatogr...

journal_title：Thrombosis research

authors： Shivaprasad HV,Rajaiah R,Frey BM,Frey FJ,Vishwanath BS

更新日期：2010-03-01 00:00:00

abstract：:The present study has evaluated the effect of some newly synthesized triphenylethylene (TPE) analogs on platelet arachidonic acid metabolism and function. All compounds tested inhibited arachidonic acid induced platelet aggregation and several were superior to aspirin in their relative potency. Introduction of a carbo...

journal_title：Thrombosis research

authors： Rao GH,John V,Hill TD,Vennerstrom JL,White JG,Holmes TJ Jr

更新日期：1986-11-15 00:00:00

abstract：:Several clinical trials have demonstrated the benefits of thienopyridine monotherapy in ischaemic stroke patients. Non-human primate models of ischaemic stroke have been used for various antithrombotic agents; however, to the best of our knowledge, there is no data on the effects of P2Y12 antagonists in models, such a...

journal_title：Thrombosis research

authors： Tomizawa A,Ohno K,Jakubowski JA,Mizuno M,Sugidachi A

更新日期：2015-12-01 00:00:00

abstract：:The behavior of hemostatic system activation during protracted physical exercise is well known, but the duration of its modification is not yet defined. In order to evaluate the time of hemostatic system activation after prolonged strenuous endurance physical exercise (typical marathon race: 42.195 km, v=15.35 km/h; m...

journal_title：Thrombosis research

authors： Prisco D,Paniccia R,Bandinelli B,Fedi S,Cellai AP,Liotta AA,Gatteschi L,Giusti B,Colella A,Abbate R,Gensini GF

更新日期：1998-01-15 00:00:00

abstract：BACKGROUND:Pulmonary embolism (PE) is diagnosed with imaging techniques such as ventilation/perfusion (V/P) lung scintigraphy or multidetector computed tomography of the pulmonary arteries (MDCT). Lung scintigraphy can be performed with planar (V/P PLANAR) and tomographic (V/P SPECT) techniques. V/P SPECT has higher se...

journal_title：Thrombosis research

authors： Alhadad A,Miniati M,Alhadad H,Gottsäter A,Bajc M

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:Von Willebrand Disease (VWD) is the most common inherited bleeding disorder. Measurement of von Willebrand factor (VWF) activity in plasma is often based on platelet agglutination stimulated by the ristocetin cofactor activity. Novel assays, based on latex beads with recombinant glycoprotein Ib instead of ...

journal_title：Thrombosis research

authors： Timm A,Hillarp A,Philips M,Goetze JP

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Vitamin K antagonists are often used for anticoagulant treatment in hip fracture patients. The optimal handling with such anticoagulants is unclear. We aimed to determine when anticoagulation reversal occurred after vitamin K administration and how often prothrombin complex concentrates (PCCs) were adminis...

journal_title：Thrombosis research

authors： Buecking B,Eschbach D,Bliemel C,Oberkircher L,Struewer J,Ruchholtz S,Sachs UJ

更新日期：2014-01-01 00:00:00

abstract：:All the thrombolytic agents currently in clinical use act as plasminogen activators. In this study evidence is presented that also oxidants of the phagocyte type are of fibrinolytic efficiency in vivo. Activated phagocytes participate in physiologic fibrinolysis. The cells generate plasminogen activators and reactive ...

journal_title：Thrombosis research

authors： Stief TW

更新日期：1991-05-01 00:00:00

abstract：:This work was designed to investigate the influence of rat platelet adrenoceptors on the early thrombin-induced serotonin release. In washed platelets prelabeled with [3H]-serotonin, adrenaline and isoproterenol both inhibited, in a dose-dependent manner, the early thrombin-induced secretion of serotonin. Inhibitory r...

journal_title：Thrombosis research

authors： Koutouzov S,Cothenet-Vernoux L,Marche P,Dausse JP

更新日期：1985-10-15 00:00:00

abstract：:Patients who had survived a stroke or transient ischaemic attacks (TIA) were admitted to a trial of low-dose aspirin (50 mg) alone, sustained release dipyridamole (400 mg/day) alone, or a combination of the two agents, and results compared with a placebo over 24 months. This low-dose aspirin regimen produced in pairwi...

journal_title：Thrombosis research

authors： Forbes CD

更新日期：1998-09-15 00:00:00

abstract：INTRODUCTION:Available data on fibrin clot properties and fibrinolysis in hyperthyroidism and hypothyroidism are inconsistent. Our objective was to assess the impact of effective treatment of hyper- and hypothyroidism on fibrin clot characteristics. MATERIAL AND METHODS:In a case-control study, ex vivo plasma fibrin c...

journal_title：Thrombosis research

authors： Mazur P,Sokołowski G,Hubalewska-Dydejczyk A,Płaczkiewicz-Jankowska E,Undas A

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The Clauss fibrinogen method and thrombin clotting time (TCT) are still routinely used in patients with cirrhosis to define fibrinogen concentration and clotting potential. The thromboelastometric functional fibrinogen FIBTEM assay evaluates the strength of fibrin-based clots in whole blood, providing inform...

journal_title：Thrombosis research

authors： Vucelic D,Jesic R,Jovicic S,Zivotic M,Grubor N,Trajkovic G,Canic I,Elezovic I,Antovic A

更新日期：2015-06-01 00:00:00

abstract：:The hemolytic uremic syndrome involves the presence of Shiga toxin producing strains of Escherichia coli and is associated with thrombocytopenia, platelet activation, and microthrombi formation. We have, therefore, investigated the ability of Shiga toxin isotypes 1 and 2 to cause or enhance platelet aggregation under ...

journal_title：Thrombosis research

authors： Viisoreanu D,Polanowska-Grabowska R,Suttitanamongkol S,Obrig TG,Gear AR

更新日期：2000-06-01 00:00:00