On the interaction of heparin-containing polymers with plasma proteins and blood.

abstract：INTRODUCTION:Venous thromboembolism (VTE) is a frequent clinical event in patients with gynecologic cancer. However, studies that exclusively address the incidence of VTE according the type of gynecologic cancer are poorly reported. OBJECTIVE:To analyze the incidence of VTE and the associated factors in women with dif...

journal_title：Thrombosis research

authors： Trugilho IA,Renni MJP,Medeiros GC,Thuler LCS,Bergmann A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Clinical parameters, biomarkers and imaging-based risk stratification are widely accepted in pulmonary embolism(PE). The present study has investigated the prognostic role of simplified Pulmonary Embolism Severity Index (sPESI) score and the European Society of Cardiology (ESC) model. METHODS:This prospecti...

journal_title：Thrombosis research

authors： Ozsu S,Ozlu T,Sentürk A,Uçar EY,Kırkıl G,Kadıoğlu EE,Altınsoy B,Saylan B,Selimoğlu HŞ,Dabak G,Tutar N,Uysal A,TUPEG Study Investigators.

更新日期：2014-06-01 00:00:00

abstract：:Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large, polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone marrow, lining blood vessel walls where they release their platelet progeny into circulation. Although little is known about how MKs dif...

journal_title：Thrombosis research

authors： Couldwell G,Machlus KR

更新日期：2019-07-01 00:00:00

abstract：:To investigate the effects of new drugs on the prevention of venous thrombosis, the Wessler stasis model is extensively employed usually in the rabbit. In this model, a hypercoagulable state is achieved by the administration of either heterologous serum (often human serum) or an activated coagulation factor followed b...

journal_title：Thrombosis research

authors： Millet J,Vaillot M,Theveniaux J,Brown NL

更新日期：1996-02-15 00:00:00

abstract：:An insertion/deletion (4G/5G) polymorphism in what has been shown to be an enhancer/repressor binding site in the promoter region of the PAI-1 gene has been related to plasma PAI-1 activity. Transfection studies demonstrated increased interleukin-1 stimulated PAI-1 synthesis in cells containing the 4G sequence. To stu...

journal_title：Thrombosis research

authors： McCormack LJ,Semple JI,Stickland MH,Barrett JH,Grant PJ

更新日期：1998-12-01 00:00:00

abstract：:Clot adherence to peritoneal cavity mesothelium was studied in rats in an attempt to contribute to the problem of thrombus embolization. The adherence was decreased by platelets and the active constituent was identified as adenosine diphosphate which decreased the sticking of fibrin to cellular linings as well as to a...

journal_title：Thrombosis research

authors： Hladovec J

更新日期：1982-12-15 00:00:00

abstract：INTRODUCTION:Extracellular histones are reported to increase thrombin generation in the plasma and induce endothelial cell death in vitro. These effects of histones were suggested to involve histone-induced inhibition of TM-dependent activated protein C (APC) generation. Therefore, we hypothesized that TM alfa, a recom...

journal_title：Thrombosis research

authors： Osada K,Minami T,Arioka T,Sakai T,Tawara S,Kawasaki K,Fareed J,Matsuzaki O

更新日期：2017-12-01 00:00:00

abstract：:The multiligand receptor, low density lipoprotein receptor-related protein (LRP), is implicated in processes such as atherosclerosis and fibrinolysis through its mediation of the catabolism of lipoproteins, proteases, and protease inhibitor complexes. The hepatoma cell line Hep G2 expresses LRP and has been used widel...

journal_title：Thrombosis research

authors： Grimsley PG,Quinn KA,Chesterman CN,Owensby DA

更新日期：1997-12-15 00:00:00

abstract：:Lp(a) lipoprotein contains a unique apolipoprotein, apolipoprotein (a), that has a striking homology with plasminogen. This homology has brought forward speculations as to an inhibitory effect of Lp(a) lipoproteins on fibrinolysis. The present investigation was undertaken to study the influence of Lp(a) lipoprotein on...

journal_title：Thrombosis research

authors： Halvorsen S,Skjønsberg OH,Berg K,Ruyter R,Godal HC

更新日期：1992-11-01 00:00:00

abstract：:The protease inhibitor, aprotinin, has been examined for its ability to inhibit urokinase and tissue-type plasminogen activators at pH 7.4 in assays utilizing pyroGlu-Gly-Arg-p-nitroanilide and H-D-Ile-Pro-Arg-p-nitroanilide as substrates, respectively. Aprotinin inhibited both two-chain low molecular weight urokinase...

journal_title：Thrombosis research

authors： Lottenberg R,Sjak-Shie N,Fazleabas AT,Roberts RM

更新日期：1988-03-15 00:00:00

abstract：INTRODUCTION:Elevated soluble urokinase-type plasminogen activator receptor (suPAR) indicates an inflammatory state caused by conditions such as HIV and cancer. Recently suPAR was identified as an indicator of cardiovascular disease (CVD). CVD is highly prevalent in black South Africans, but the potential role of suPAR...

journal_title：Thrombosis research

authors： Schutte AE,Myburgh A,Olsen MH,Eugen-Olsen J,Schutte R

更新日期：2012-08-01 00:00:00

abstract：:An in vivo rabbit model of venous thrombosis which includes physiological blood flow was used to compare the efficacy of the potent and specific factor Xa inhibitor recombinant tick anticoagulant peptide (rTAP) with standard heparin in the prevention of venous thrombus formation. In anesthetized rabbits, an autologous...

journal_title：Thrombosis research

authors： Fioravanti C,Burkholder D,Francis B,Siegl PK,Gibson RE

更新日期：1993-08-15 00:00:00

abstract：:To compare Canola a terrestrial (n-3) oil with fish oil (n-3) and common vegetable oil (n-6) in decreasing serum lipids and platelet aggregation, various oils were included in Chow-based diets and fed to rats in an eight-weeks feeding trial. The Chow diet contained 2% cholesterol along with either Canola, menhaden, sa...

journal_title：Thrombosis research

authors： Watkins T,Lenz P,Bierenbaum M

更新日期：1990-08-01 00:00:00

abstract：INTRODUCTION:Increased levels of circulating tissue factor (TF)-positive microvesicles (MVs) may increase the risk of thrombosis. Indeed, TF-positive MVs are detected in plasma of patients with various types of diseases. In this study, we measured levels of MV TF activity in non-cancer severely ill patients and cancer ...

journal_title：Thrombosis research

authors： Hisada Y,Thålin C,Lundström S,Wallén H,Mackman N

更新日期：2018-05-01 00:00:00

abstract：:Whilst the term cancer associated thrombosis (CAT) offers an overarching term for all thrombotic events encountered during the cancer journey, the reality is that this is a far too simplistic reflection of a complex multifactorial process occurring within a heterogeneous population. The management of CAT needs to cons...

journal_title：Thrombosis research

authors： Noble S,Sui J

更新日期：2016-04-01 00:00:00

abstract：:Endothelial cells in biopsied blood vessels from von Willebrand factor (vWf)-deficient Doberman pinscher dogs contain immunologically detectable vWf. These dogs and normal dogs were treated with DDAVP (0.6 microgram/kg) and epinephrine (0.5 microgram/kg/min for 30 minutes) and were exercised, using 5 different exercis...

journal_title：Thrombosis research

authors： Meyers KM,Wardrop KJ,Dodds WJ,Brassard J

更新日期：1990-01-01 00:00:00

abstract：:Ten studies of the effect of cryoprecipitate infusion in four patients with von Willebrand's Disease (vWD) are reported. The doses studied (4, 8 and in one case 10 bags of cryoprecipitate) were based on previous reports of correction of the bleeding time (BT) with such doses. A modest shortening of the BT was observed...

journal_title：Thrombosis research

authors： Smiley RK,Tittley P,Rock G

更新日期：1989-03-01 00:00:00

abstract：:A new type of assay for heparins has been devised, in which the test material competes with 125I-labelled heparin for binding to protamine-Sepharose. The assay is very sensitive and will measure heparin concentrations down to 10 ng ml-1. It responds to both the degree of sulphation and the molecular weight of acidic p...

journal_title：Thrombosis research

authors： Dawes J,Pepper DS

更新日期：1982-08-15 00:00:00

abstract：:Endothelial cells from human umbilical vein were incubated in vitro with thrombin in the absence or presence of unfractionated heparin (UFH), low molecular weight heparin (LMWH) or dermatan sulfate (DS) to clarify the effect of these glycosaminoglycans on thrombin-stimulated prostaglandin I2 (PGI2) production. Althoug...

journal_title：Thrombosis research

authors： Itoh F,Kaji T,Hayakawa Y,Oguma Y,Sakuragawa N

更新日期：1990-02-15 00:00:00

abstract：INTRODUCTION:Anedoctal reports suggest that some thrombotic primary antiphospholipid antibody syndrome (PAPS) patients on oral anticoagulation require higher than average doses to achieve given targets international normalized ratios (INR). MATERIALS AND METHODS:To test the hypothesis of relative warfarin resistance i...

journal_title：Thrombosis research

authors： Ames PR,Margaglione M,Ciampa A,Colaizzo D,Ferrara F,Iannaccone L,Vincenzobrancaccio

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Growth differentiation factor-15 (GDF-15) has been identified as a predictor in cardiovascular diseases and acute pulmonary embolism. However, the association of GDF-15 and deep venous thrombosis (DVT) remains unclear. This study aimed to investigate levels of GDF-15 in patients with DVT, and determine its...

journal_title：Thrombosis research

authors： Liang W,Wei F,Yang C,Xie F,Shuai XX,Wang M,Yu M

更新日期：2020-03-01 00:00:00

abstract：INTRODUCTION:Tissue factor (TF) pathway inhibitor (TFPI) is the physiological inhibitor of TF induced blood coagulation and two isoforms exists, TFPIα and TFPIβ. In atherosclerotic plaques, TFPI may inhibit TF activity and thrombus formation, which is the main cause of ischemic stroke in carotid artery disease. We aime...

journal_title：Thrombosis research

authors： Stavik B,Holm S,Espada S,Iversen N,Sporsheim B,Bjerkeli V,Dahl TB,Sandset PM,Skjelland M,Espevik T,Skretting G,Halvorsen B

更新日期：2017-07-01 00:00:00

abstract：:Tissue factor, the cofactor for factor VIIa-catalyzed activation of factors IX and X, plays an important role in the initiation of hemostasis. However, the distribution of tissue factor in the body has not been defined until recently. In the present study frozen sections of non-malignant human tissues were immunostain...

journal_title：Thrombosis research

authors： Fleck RA,Rao LV,Rapaport SI,Varki N

更新日期：1990-07-15 00:00:00

abstract：BACKGROUND:Arterial calcification is associated with increased risk of cardiovascular events. Osteoprotegerin (OPG) is a cytokine involved in the bone metabolism and vascular calcification. Recent data support a relationship between high serum levels of OPG and increased risk for cardiovascular disease in human. The ai...

journal_title：Thrombosis research

authors： Guldiken B,Guldiken S,Turgut B,Turgut N,Demir M,Celik Y,Arikan E,Tugrul A

更新日期：2007-01-01 00:00:00

abstract：:The effect of warfarin-induced factor VII deficiency on the skin bleeding time was investigated in 10 consecutive patients with mean prothrombin times of 33 sec and factor VII levels of 7%. Bleeding times in all but one subject were entirely within the normal range. We conclude that warfarin administration, even to th...

journal_title：Thrombosis research

authors： Green D,Ts'ao CH

更新日期：1983-02-15 00:00:00

abstract：:Concentration-response relationships of human platelet aggregation rates were analyzed for a variety of agonists and inhibitors. Their approximation by the Hill equation showed that the values of the Hill coefficient (h) were agonist-dependent and increased as follows: hADP = hL-EPINEPHRINE = hPAF = hPGH2 = hU46619 le...

journal_title：Thrombosis research

authors： Vrzheshch PV,Tatarintsev AV,Yershov DE,Varfolomeyev SD

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Cerebral vein thrombosis (CVT) is a rare, life-threatening disease affecting one adult per 100,000 per year. Genetic risk factors are deficiencies of the natural anticoagulant proteins antithrombin, protein C, protein S or single nucleotide polymorphisms such as factor V Leiden and prothrombin 20210A. In 20%...

journal_title：Thrombosis research

authors： Gorski MM,de Haan HG,Mancini I,Lotta LA,Bucciarelli P,Passamonti SM,Cairo A,Pappalardo E,van Hylckama Vlieg A,Martinelli I,Rosendaal FR,Peyvandi F

更新日期：2018-09-01 00:00:00

abstract：:A recently developed platelet aggregometer using a laser light scattering method is capable of monitoring the increase in size of small-sized platelet aggregates (diameter 9-25 microm), which cannot be detected with the conventional methods. Whether coronary spasm can cause platelet aggregation in the coronary circula...

journal_title：Thrombosis research

authors： Miyamoto S,Ogawa H,Soejima H,Takazoe K,Kajiwara I,Shimomura H,Sakamoto T,Yoshimura M,Kugiyama K,Yasue H,Ozaki Y

更新日期：2001-09-01 00:00:00

abstract：INTRODUCTION:Pulmonary embolism (PE) is a common cause of morbidity and mortality. In this study, we investigated patterns of morbidity and mortality from PE in Australia. MATERIALS & METHODS:Australian government databases were used to extract data on age and sex specific rates of mortality between 1997 and 2007, and...

journal_title：Thrombosis research

authors： Shiraev TP,Omari A,Rushworth RL

更新日期：2013-07-01 00:00:00

abstract：:Endothelial cell activation or damage is believed to play a key role in preeclampsia (PE) and may underlie the hemostatic changes observed in this syndrome. The aim of this study was to evaluate a relationship between maternal and cord blood hemostatic disturbances in preeclamptic pregnancies. We measured the plasma l...

journal_title：Thrombosis research

authors： Catarino C,Rebelo I,Belo L,Rocha S,Castro EB,Patricio B,Quintanilha A,Santos-Silva A

更新日期：2008-01-01 00:00:00