Abstract:
INTRODUCTION:Anedoctal reports suggest that some thrombotic primary antiphospholipid antibody syndrome (PAPS) patients on oral anticoagulation require higher than average doses to achieve given targets international normalized ratios (INR). MATERIALS AND METHODS:To test the hypothesis of relative warfarin resistance in thrombotic PAPS and the effect of baseline IgG anticardiolipin antibodies, the cytochrome CYP2C9 and the vitamin K epoxide reductase (VKORC1) haplotypes we compared weekly warfarin consumption of 40 TPAPS (mean age 44 ± 16years) with that of 65 thrombotic patients with inherited thrombophilia (IT) (mean age 52 ± 18) at similar target INR 2.0-3.0 followed up between January-1994 and January 2003. To investigate an involvement of the epoxidation pathway in this difference and to assess enhanced residual fibrin turnover decarboxylated prothrombin (PIVKA-II) and D-dimers (DD) were cross-sectionally investigated in the same patients between March and May 2008. RESULTS:CEX7 and VKORC1 polymorphisms explained 45.1% of the variability in warfarin consumption, whose age-adjusted mean weekly consumption was greater in PAPS than IT (27.62 vs 21.24 mg, p = 0.03). In PAPS baseline IgG aCL and VKORC1 predicted weekly warfarin consumption (p = 0.028 and p = 0.024). IgG β(2)GPI and warfarin dose independently predicted plasma PIVKA-II (p = 0.01 and p = 0.02). Age and sex adjusted DD was greater in PAPS than IT (132 ± 34 vs 83 ± 37 mg/dl, p = 0.03). CONCLUSIONS:Thrombotic PAPS exhibit a degree of warfarin resistance partly accounted by antiphospholipid antibodies and are in a state of enhanced fibrin turnover despite oral anticoagulation that might have implications for re-thrombosis and atherosclerosis.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Ames PR,Margaglione M,Ciampa A,Colaizzo D,Ferrara F,Iannaccone L,Vincenzobrancacciodoi
10.1016/j.thromres.2011.01.014subject
Has Abstractpub_date
2011-06-01 00:00:00pages
595-9issue
6eissn
0049-3848issn
1879-2472pii
S0049-3848(11)00064-8journal_volume
127pub_type
杂志文章abstract:BACKGROUND:Thrombin is the most potent platelet activator, and achieves rapid platelet activation even in the presence of antiplatelet therapy. Since activated platelets respond stronger to additional stimuli, the extent of endogenous thrombin generation may in part be responsible for the reported response variability ...
journal_title:Thrombosis research
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更新日期:2013-07-01 00:00:00
abstract::Antithrombotic activity of ten pyrazolo pyrimidine derivatives was tested in mouse pulmonary thromboembolism model. Out of these compounds, Thiopurinol (C5H4N4S) showed dose-dependent protection in mice from death/paralysis induced by collagen + adrenaline. It also caused dose-dependent inhibition of thrombus formatio...
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更新日期:1989-02-01 00:00:00
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journal_title:Thrombosis research
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abstract::A simple and discriminating assay for the determination of the fast-acting plasminogen activator inhibitor (PAI) activity in human plasma is described. The method is based on the inhibition of purified tissue plasminogen activator (tPA) by plasma diluted with a PAI-depleted plasma and the subsequent measurement of res...
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doi:10.1016/0049-3848(85)90224-5
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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更新日期:1988-02-15 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1994-01-01 00:00:00
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更新日期:2009-12-01 00:00:00
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更新日期:2020-11-01 00:00:00
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更新日期:2007-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2002-11-01 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Thrombosis research
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:1989-11-15 00:00:00
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pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-11-15 00:00:00
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journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2005.06.005
更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0049-3848(96)00063-1
更新日期:1996-04-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.thromres.2010.11.025
更新日期:2011-02-01 00:00:00