Right ventricular stroke distance predicts death and clinical deterioration in patients with pulmonary embolism.

abstract：:Analogs of the antithrombin peptide hirudin54-65 with C-terminal modifications have been synthesized in order to examine the requirements for alpha-thrombin inhibition. The C-terminal residue, Gln65, could be replaced with L-amino acids or amino alcohols with neutral or charged hydrophilic side chains without greatly ...

journal_title：Thrombosis research

authors： Krstenansky JL,Payne MH,Owen TJ,Yates MT,Mao SJ

更新日期：1989-05-15 00:00:00

abstract：:A significantly higher platelet malondialdehyde-like material (MDA--LM) content after physical and N-ethylmaleimide (NEM) stimulation is found in chronic ischemic heart disease (CHD) patients when compared to the control group. In subjects under aspirin treatment "in vivo" (1 gr/day) no difference is found between CHD...

journal_title：Thrombosis research

authors： Valles J,Aznar J,Santos MT,Fernandez MA

更新日期：1982-09-01 00:00:00

abstract：:To investigate the effects of new drugs on the prevention of venous thrombosis, the Wessler stasis model is extensively employed usually in the rabbit. In this model, a hypercoagulable state is achieved by the administration of either heterologous serum (often human serum) or an activated coagulation factor followed b...

journal_title：Thrombosis research

authors： Millet J,Vaillot M,Theveniaux J,Brown NL

更新日期：1996-02-15 00:00:00

abstract：:Rabbit platelets pretreated with CV-3988 had reduced responsiveness to platelet activating factor(PAF) even after the platelets had been washed with a buffer. This was due to its tight binding to receptor sites for PAF, but not conformational changes of the receptor, because the platelets that were pretreated with CV-...

journal_title：Thrombosis research

authors： Tokumura A,Yoshida J,Okasaka N,Fukuzawa K,Tsukatani H

更新日期：1987-04-01 00:00:00

abstract：:Protein C has been measured by three different assays (antigenic, amidolytic and chronometric) in 27 end-stage renal insufficient patients before and after hemodialysis. Protein C levels have been compared with other coagulation inhibitors (antithrombin III, protein S) and fibrinolytic parameters. Baseline anticoagula...

journal_title：Thrombosis research

authors： Nguyen P,Toupance O,Chanard J,Potron G

更新日期：1993-03-15 00:00:00

abstract：:Highly purified bovine von Willebrand protein (vWP) has been studied with two complementary techniques. Light scattering measurements on different samples give weight average molecular weights in the range from 7 to 13 million, radius of gyration between 75 and 140 nm and diffusion coefficient near 4.15 X 10(-8) cm2/s...

journal_title：Thrombosis research

authors： Binnie C,Wagner RH,Cooper H,Hermans J

更新日期：1985-11-15 00:00:00

abstract：:It has become customary to regard the various glycerophospholipids as quite similar, and the acyl groups are considered to have little influence on the behaviour of the lipids in membranes or metabolism. Nevertheless, a number of recent observations by the authors and others indicate a high degree of metabolic compart...

journal_title：Thrombosis research

authors： Holmsen H,Hindenes JO,Fukami M

更新日期：1992-08-01 00:00:00

abstract：:Platelet aggregation induced by ADP and collagen was monitored in 25 patients with increased serum levels of triglycerides (7 HLPs type IIb, 14 type IV, 4 type V patients) and compared with a group of 10 normolipidaemic control persons. Platelet aggregation was studied simultaneously in platelet rich plasma (PRP) by b...

journal_title：Thrombosis research

authors： Riess H,Merk W,Falkner C,Hiller E

更新日期：1986-02-01 00:00:00

abstract：:Sandwich ELISA systems were developed to measure human von Willebrand factor (vWF). In one system the microtitre plates were coated with goat F(ab')2 to vWF. The F(ab')2 different molecular forms in the soluble phase. VWF antigen bound by the F(ab')2 antibody was subsequently determined by using horse-radish peroxidas...

journal_title：Thrombosis research

authors： Silveira AM,Yamamoto T,Adamson L,Hessel B,Blombäck B

更新日期：1986-07-01 00:00:00

abstract：:Upon incubation for 24 hours with [3H]arachidonic acid (AA, 1 mu Ci/ml), cultured endothelial cells from human umbilical vein incorporated one half of the added radioactivity, mostly into phospholipids (83% of the total cell radioactivity). Distribution of the label between the various phospholipid classes was found t...

journal_title：Thrombosis research

authors： Thomas JM,Hullin F,Chap H,Douste-Blazy L

更新日期：1984-04-15 00:00:00

abstract：:Resistance to Activated Protein C (APC) was evaluated using 3 different methods: two of them were based on the prolongation of the Activated Partial Thromboplastin Time (APTT) using 2 different APTT reagents in the presence of APC, whereas the third method was based on the prolongation of prothrombin time when APC is ...

journal_title：Thrombosis research

authors： Vasse M,Leduc O,Borg JY,Chrétien MH,Monconduit M

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To investigate the mechanism underlying the hypercoagulable state in severe pre-eclampsia. METHODS:Plasma tissue factor (TF) and tissue factor pathway inhibitor (TFPI) expression from pre-eclampsia patients and healthy pregnant controls were determined by ELISA. Placental TF and TFPI gene and protein express...

journal_title：Thrombosis research

authors： Teng Y,Jiang R,Lin Q,Ding C,Ye Z

更新日期：2010-07-01 00:00:00

abstract：:Human apolipoprotein B was purified by barium sulphate adsorption, subsequent delipidation and gel filtration. The protein was then reconstituted in soya bean lecithin and its inhibitory effect towards thromboplastin was assayed by incubation with rabbit brain thromboplastin. The use of an antibody against human apoli...

journal_title：Thrombosis research

authors： Ettelaie C,Howell RM

更新日期：1992-10-15 00:00:00

abstract：INTRODUCTION:Warfarin is the most widely used oral anticoagulant. It has been suggested that anticoagulation effect of warfarin is significantly associated with the polymorphism of certain genes, including Cytochrome P450 complex subunit 2C9 (CYP2C9), Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1), Gamma-Glutam...

journal_title：Thrombosis research

authors： Yang L,Ge W,Yu F,Zhu H

更新日期：2010-04-01 00:00:00

abstract：:Defibrotide (D) was labelled with 125I or with 32P. The radiolabelled compounds ([125I]-Defibrotide ([125I]-D), [32P]-Defibrotide ([32P]-D) retained the same profibrinolytic activity, in vitro, as the parent drug, suggesting that the labelling procedures had not modified the pharmacological properties of D and hence t...

journal_title：Thrombosis research

authors： Fisher J,Holland TK,Pescador R,Porta R,Ferro L

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:In the prospective, randomised, double-blind, placebo-controlled Regenerate Vital Myocardium by Vigorous Activation of Bone Marrow Stem Cells (REVIVAL)-2 trial patients with acute myocardial infarction (AMI) and successful mechanical reperfusion received granulocyte-colony stimulating factor (G-CSF, 10 μg/...

journal_title：Thrombosis research

authors： Steppich BA,Demetz G,Schulz S,von Wedel J,Pogatsa-Murray G,Braun SL,Stein A,Kastrati A,Schömig A,Ott I

更新日期：2011-02-01 00:00:00

abstract：:To investigate the relationships between tumor necrosis factor-alpha (TNF), interleukin-1 beta (IL-1 beta), soluble thrombomodulin (TM), and disseminated intravascular coagulation (DIC) in patients with systemic inflammatory response syndrome (SIRS), twenty-nine SIRS patients were classified into three groups; 4 patie...

journal_title：Thrombosis research

authors： Gando S,Kameue T,Nanzaki S,Nakanishi Y

更新日期：1995-12-15 00:00:00

abstract：:The use of platinum based chemotherapy in ovarian malignancy and other cancer types is known to be associated with deep vein thrombosis. In a prospective study of 47 patients with ovarian cancer of International Federation of Gynecology and Obstetrics stage Ib-IV, serial rheological parameters were determined (plasma ...

journal_title：Thrombosis research

authors： von Tempelhoff GF,Niemann F,Schneider DM,Kirkpatrick CJ,Hommel G,Heilmann L

更新日期：1998-04-15 00:00:00

abstract：:The standard modality of administration of rFVIIa to patients with FVIII and FIX inhibitors is the intermittent infusion every 2 to 6 hours. No untoward local or systemic effects have been reported; laboratory data of activation of coagulation were reported in the presence of coexistent problems (sepsis, septic shock)...

journal_title：Thrombosis research

authors： Baudo F,Redaelli R,Caimi TM,Mostarda G,Somaini G,de Cataldo F

更新日期：2000-07-01 00:00:00

abstract：:The need for anticoagulation in dialysis patients is common and the incidence of venous thromboembolism (VTE) and atrial fibrillation in this population is high. While direct data are lacking on the management of anticoagulation in dialysis patients, careful weighing of risks and benefits on the basis of evidence from...

journal_title：Thrombosis research

authors： Lo DS,Rabbat CG,Clase CM

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Profuse postpartum hemorrhage (PPH) and red blood cell (RBC) transfusion have been suggested to be associated with venous thromboembolic events (VTE). However, it is not fully clear if they are independent major risk factors. METHODS:Women who gave birth in the Stockholm area between 1999 and 2002 were th...

journal_title：Thrombosis research

authors： Thurn L,Wikman A,Lindqvist PG

更新日期：2018-05-01 00:00:00

abstract：:The immunogenic potential of natural and recombinant hirudin was investigated using baboons. Animals received 4 intravenous hirudin injections of 1,000 antithrombin units/kg at certain times (day 1, 3, 8 and 42) and were checked for an immune response. None of the tests performed (in vitro histamine-release, ELISA for...

journal_title：Thrombosis research

authors： Bichler J,Gemmerli R,Fritz H

更新日期：1991-01-01 00:00:00

abstract：:The sequel of survivors after hospitalisation for an acute myocardial infarction was studied during the following 15 years in 48 patients treated with streptokinase and in 41 controls. No significant difference was seen in the morbidity or mortality during the first 6 months nor in the mortality thereafter. ...

journal_title：Thrombosis research

authors： Heikinheimo R,Leskinen O,Siitonen L

更新日期：1984-08-15 00:00:00

abstract：BACKGROUND:The results of the EINSTEIN-DVT/PE and AMPLIFY trials, which compared rivaroxaban and apixaban with conventional anticoagulation therapy for acute venous thromboembolism (VTE), respectively, are often compared. However, the trials differed in duration of therapy (3-12 and 6months, respectively) and in patien...

journal_title：Thrombosis research

authors： Beyer-Westendorf J,Lensing AW,Arya R,Bounameaux H,Cohen AT,Wells PS,Middeldorp S,Verhamme P,Hughes R,Kucher N,Pap AF,Trajanovic M,Prins MH,Prandoni P,Weitz JI

更新日期：2017-01-01 00:00:00

abstract：:Bovine myelin basic protein (BP) induced a shape change and endogenous phosphorylation of a 45,000 (45K) molecular weight protein of intact human platelets. This effect occurred rapidly over an effective concentration range of 5-100 microM BP. BP peptides encompassing residues 1-42, 43-88, and 89-169 from the BP molec...

journal_title：Thrombosis research

authors： Chiang TM,Whitaker JN,Kang AH,Beachey EH

更新日期：1982-03-15 00:00:00

abstract：:The antithrombotic actions of selective factor Xa (FXa) inhibitors, recombinant tick anticoagulant peptide (rTAP) and DX-9065a, were evaluated in experimental thrombosis models in anesthetized rats. In the first model, thrombosis was induced by exposing flowing blood to a silk thread anchored in an arteriovenous (AV) ...

journal_title：Thrombosis research

authors： Wong PC,Crain EJ Jr,Nguan O,Watson CA,Racanelli A

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND/AIMS:The plasminogen activator (PA)-plasmin system is primarily involved in fibrinolysis, but is also in the patho/physiological events in which breakdown of extracellular matrices is evoked topically. In this present study, we examined the expression of fibrinolytic factors, tissue-type PA (t-PA) and Type 1...

journal_title：Thrombosis research

authors： Noguchi T,Matsuyama S,Akao M,Hagiwara H,Uno S,Seki T,Ariga T

更新日期：2001-11-15 00:00:00

abstract：INTRODUCTION:Hemodialysis grafts often fail because of stenosis at the venous anastomosis resulting in thrombosis. Percutaneous intervention involves thrombolysis with plasminogen activators, mechanical removal of thrombus, and angioplasty of the stenotic lesions. OBJECTIVES:This article describes a phase I trial usin...

journal_title：Thrombosis research

authors： Shlansky-Goldberg R

更新日期：2008-01-01 00:00:00

abstract：:There is growing evidence on the superior efficacy and safety of low molecular weight heparins (LMWHs) over unfractionated heparin (UFH) for the treatment of both venous and arterial thromboembolism. Heparin exerts its function by potentiating antithrombin and by mobilizing tissue factor pathway inhibitor (TFPI) into ...

journal_title：Thrombosis research

authors： Hansen JB,Sandset PM

更新日期：1998-08-15 00:00:00

abstract：:In spite of numerous studies on the involvement of fibrinogen in transendothelial migration of leukocytes and thereby inflammation, there is still no clear understanding of which fibrin(ogen) species can stimulate leukocyte transmigration. Although we have previously proposed that interaction of fibrin with the VLDL r...

journal_title：Thrombosis research

authors： Yakovlev S,Medved L

更新日期：2018-02-01 00:00:00