D-dimer specific monoclonal antibodies react with fibrinogen aggregates.

abstract：INTRODUCTION:A close association exists between oral health and cardiovascular disease. Periodontal disease induces early vascular changes while oral pathogens have been detected in sub gingival and atheromatous plaques. We examined the interrelationship between Periodontal disease, oral bacteria, surrogate sub-clinica...

journal_title：Thrombosis research

authors： Shanker J,Setty P,Arvind P,Nair J,Bhasker D,Balakrishna G,Kakkar VV

更新日期：2013-07-01 00:00:00

abstract：:Human apolipoprotein B was purified by barium sulphate adsorption, subsequent delipidation and gel filtration. The protein was then reconstituted in soya bean lecithin and its inhibitory effect towards thromboplastin was assayed by incubation with rabbit brain thromboplastin. The use of an antibody against human apoli...

journal_title：Thrombosis research

authors： Ettelaie C,Howell RM

更新日期：1992-10-15 00:00:00

abstract：:Fasting plasma homocysteine level and the related clinical findings were analysed in 240 consecutive patients with venous thromboembolism. Hyperhomocysteinemia, defined as a plasma level above 20 micromol/l (corresponding to the percentile 95th in the controls), was present in 11.2% of the patients. Plasma homocystein...

journal_title：Thrombosis research

authors： Hainaut P,Jaumotte C,Verhelst D,Wallemacq P,Gala JL,Lavenne E,Heusterspreute M,Zech F,Moriau M

更新日期：2002-04-15 00:00:00

abstract：:Protein C has been measured by three different assays (antigenic, amidolytic and chronometric) in 27 end-stage renal insufficient patients before and after hemodialysis. Protein C levels have been compared with other coagulation inhibitors (antithrombin III, protein S) and fibrinolytic parameters. Baseline anticoagula...

journal_title：Thrombosis research

authors： Nguyen P,Toupance O,Chanard J,Potron G

更新日期：1993-03-15 00:00:00

abstract：:In the present study a new clotting assay for the detection of an increased resistance of coagulation factor V against degradation by activated protein C (Factor V Leiden mutation, FVLM) was evaluated. The Factor V (Leiden) Test (Gradipore, North Ryde NSW, Australia) is based on the dilute Russell Viper Venom Time (DR...

journal_title：Thrombosis research

authors： Quehenberger P,Handler S,Mannhalter C,Kyrle PA,Speiser W

更新日期：1999-10-15 00:00:00

abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...

journal_title：Thrombosis research

authors： Wesemann W,Hoffmann D

更新日期：1985-09-15 00:00:00

abstract：PURPOSE:A poor implementation of VTE prophylactic measures recommended for critically ill patients has been observed in several epidemiological studies. The clinical factors associated with this have not been clearly established. The objective of our study was to identify which factors could be related to the inappropr...

journal_title：Thrombosis research

authors： García-Olivares P,Guerrero JE,Keough E,Galdos P,Carriedo D,Murillo F,Rivera A,PROF-ETEV study investigators.

更新日期：2016-07-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) have been reported to reduce platelet aggregation induced by ADP. ADP induces platelet aggregation through two purinergic receptors P2Y1 and P2Y12. We characterized the inhibitory properties of SSRIs on ADP-induced platelet aggregation and investigated the effects of SSR...

journal_title：Thrombosis research

authors： Tseng YL,Chiang ML,Lane HY,Su KP,Lai YC

更新日期：2013-04-01 00:00:00

abstract：:RheothRx Injection, an aqueous solution of a nonionic block copolymer (poloxamer 188) formulated for intravenous administration, was investigated as an inhibitor of red blood cell (RBC)-induced platelet aggregation at plasma concentrations of 0.05-5mgmL-1. Platelet aggregation was determined by measuring the fall in s...

journal_title：Thrombosis research

authors： Armstrong JK,Meiselman HJ,Fisher TC

更新日期：1995-09-15 00:00:00

abstract：:The heparin-binding properties of human plasma apolipoproteins B-100 and E (apoB-100 and E) of low density lipoproteins (LDL), thrombin, and antithrombin-III (AT-III) were investigated. A highly reactive heparin (HRH) to apoB-100 was isolated by chromatography of crude heparin on a column of LDL immobilized to Affi-Ge...

journal_title：Thrombosis research

authors： Cardin AD,Barnhart RL,Witt KR,Jackson RL

更新日期：1984-06-15 00:00:00

abstract：:The alpha-chymotrypsin-like proteinase from rat peritoneal mast cells (RMCP I) rapidly destroyed the normal clotting activity of purified, calcium-free, bovine prothrombin, human prothrombin and bovine factor X and simultaneously removed similar N-terminal peptides (Mr approximately 5,000) from both prothrombin and th...

journal_title：Thrombosis research

authors： Wylie AR,Lonsdale-Eccles JD,Blumsom NL,Elmore DT

更新日期：1986-11-01 00:00:00

abstract：:Forty women undergoing surgery under general anaesthesia for hyperplasia mammae were randomized to treatment with low dose heparin (5000 IU twice daily) or not. Preoperatively, and repeated on the 3. postoperative day, assays of euglobulin clot lysis time (ELT) after venous stasis, tissue plasminogen activator (t-PA) ...

journal_title：Thrombosis research

authors： Arnesen H,Engebretsen LF,Ugland OM,Seljeflot I,Kierulf P

更新日期：1987-03-01 00:00:00

abstract：:Systemic autoimmune diseases are characterised by the development of a relatively narrow spectrum of autoantibodies. These are of considerable diagnostic value. In addition, in some diseases, including anti-phospholipid syndrome, these autoantibodies can be directly pathogenic. Understanding how these autoantibodies a...

journal_title：Thrombosis research

authors： Cook MC

更新日期：2004-01-01 00:00:00

abstract：:Surviving an embolism exposes patients to potential long-term complications, such as altered quality of life, persistent dyspnea, impaired exercise capacity or pulmonary hypertension. The common objective factor in most of these situations is the presence of residual pulmonary vascular obstruction (RPVO). Planar venti...

journal_title：Thrombosis research

authors： Bonnefoy PB,Margelidon-Cozzolino V,Catella-Chatron J,Ayoub E,Guichard JB,Murgier M,Bertoletti L

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVES:In this randomized management study, we examined the safety of withholding anticoagulation on the basis of negative impedance plethysmography (IPG) compared to negative contrast venography (CV) in symptomatic patients with a first episode of clinically suspected deep vein thrombosis (DVT), and we determined ...

journal_title：Thrombosis research

authors： Kahn SR,Joseph L,Grover SA,Leclerc JR

更新日期：2001-04-01 00:00:00

abstract：:Lipoprotein(a) [Lp(a)] has been demonstrated to be an independent risk factor for coronary heart disease. However, the precise mechanism by which it contributes to the development of atherosclerosis remains unclear. P-selectin is one of the major adhesion molecules to mediate the interaction between monocytes, platele...

journal_title：Thrombosis research

authors： Zhao SP,Xu DY

更新日期：2000-12-15 00:00:00

abstract：:Von Willebrand Factor is a multimer produced by endothelial cells and megakaryocytes, being stored in intracellular organelles, such as the Weibel-Palade bodies and alpha-granules in endothelial cells and platelets, respectively. This molecule acts as a carrier protein for factor VIIIc, involved in the intrinsic pathw...

journal_title：Thrombosis research

authors： Spadafora-Ferreira M,Lopes AA,Coelho V,Guilherme L,Kalil J

更新日期：2000-01-15 00:00:00

abstract：INTRODUCTION:The contact system proteins factor XII (FXII), prekallikrein (PK) and high molecular weight kininogen (HK) have roles in coagulation, fibrinolysis, thrombin-induced platelet activation, cell adhesion and angeogenisis. It has been suggested that inherited or acquired deficiencies of these proteins may be ri...

journal_title：Thrombosis research

authors： Gallimore MJ,Harris SL,Jones DW,Winter M

更新日期：2004-01-01 00:00:00

abstract：:Bovine hide collagen dispersions were swollen in the pH range 1.6-7.0, treated with glutaraldehyde, and dialyzed to neutral pH. The intensity with which these collagens reacted with human platelets in plasma was studied by aggregometry and scanning electron microscopy. Collagen swollen at a pH below 4.25 +/- 0.30 and ...

journal_title：Thrombosis research

authors： Sylvester MF,Yannas IV,Salzman EW,Forbes MJ

更新日期：1989-07-01 00:00:00

abstract：INTRODUCTION:In contrast to unfractionated heparin (UFH), use of low-molecular weight heparin (LMWH) during pregnancy has not been reported to be associated with a significant decrease in bone mineral density (BMD). The aim of this study was to investigate whether long-term use of LMWH during pregnancy is associated wi...

journal_title：Thrombosis research

authors： Galambosi P,Hiilesmaa V,Ulander VM,Laitinen L,Tiitinen A,Kaaja R

更新日期：2016-07-01 00:00:00

abstract：:The immunogenic potential of natural and recombinant hirudin was investigated using baboons. Animals received 4 intravenous hirudin injections of 1,000 antithrombin units/kg at certain times (day 1, 3, 8 and 42) and were checked for an immune response. None of the tests performed (in vitro histamine-release, ELISA for...

journal_title：Thrombosis research

authors： Bichler J,Gemmerli R,Fritz H

更新日期：1991-01-01 00:00:00

abstract：:Since the 19(th) century an association between cancer and thromboembolic events has been described, with a poorer survival prognosis. Production and secretion of procoagulant factors affect tumor biology and cancer-associated thrombosis. Tissue factor (TF) exerts coagulant and protease activated receptor (PAR)-depend...

journal_title：Thrombosis research

authors： Ünlü B,Versteeg HH

更新日期：2014-05-01 00:00:00

abstract：:This prospective randomized study investigated the influence of normotensive and hypotensive general anesthesia on platelet aggregability, intraoperative blood loss and parameters of plasmatic coagulation during extensive orthognathic surgery. A total of 30 patients were randomly allocated for either normotensive anes...

journal_title：Thrombosis research

authors： Felfernig-Boehm D,Salat A,Kinstner C,Fleck T,Felfernig M,Kimberger O,Andel H,Mueller MR

更新日期：2001-08-01 00:00:00

abstract：INTRODUCTION:The low-molecular-weight heparins have been demonstrated to have antiangiogenic effects in various assays. We aimed to demonstrate and compare the antiangiogenic effects of four types of commercially available low-molecular weight heparins in the chick embryo chorioallantoic membrane model. MATERIALS AND ...

journal_title：Thrombosis research

authors： Dogan OT,Polat ZA,Karahan O,Epozturk K,Altun A,Akkurt I,Cetin A

更新日期：2011-10-01 00:00:00

abstract：:Platelets from rats fed a diet high in linoleic acid (6%) bound increased amounts of fibrinogen on stimulation with ADP, compared to those from rats fed diets with low (2%) or no linoleic acid. However, this increased fibrinogen binding was associated with a decrease in platelet aggregation induced by ADP. Changes in ...

journal_title：Thrombosis research

authors： McGregor L,Toor B,McGregor JL,Renaud S,Clemetson KJ

更新日期：1984-04-01 00:00:00

abstract：:A 79-year-old lean man with a height of 157cm and weight of 42kg (body mass index, 17.2kg/m(2)) receiving rivaroxaban developed an intracranial subdural hematoma and was treated conservatively. Because he had a reduced creatinine clearance of 44mL/min, his dosage of rivaroxaban was reduced from 15 to 10mg daily accord...

journal_title：Thrombosis research

authors： Yamaguchi Y,Koga M,Matsuki T,Hino T,Yokota C,Toyoda K

更新日期：2016-07-01 00:00:00

abstract：:Chloroquine inhibited aggregation of rat blood platelets in a dose-dependent way. The inhibitory effect decreased, depending on the aggregation stimulus used, in the rank order of potency: ADP > thrombin > A23187. Effect of 1 millimolar chloroquine on A23187-stimulated aggregation was significantly decreased or comple...

journal_title：Thrombosis research

authors： Jancinová V,Nosál R,Petríková M

更新日期：1994-06-01 00:00:00

abstract：:It has long been recognised that the function of platelets in health and disease span far beyond their roles in haemostasis and thrombosis. The observation that tumour cells induce platelet aggregation was followed by extensive experimental evidence linking platelets to cancer progression. Aggregated platelets coat tu...

journal_title：Thrombosis research

authors： Lowe KL,Navarro-Nunez L,Watson SP

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor type-1 (PAI-1) is considered to be the main inhibitor of fibrinolysis in sepsis. However, the contribution of TAFI to the inhibition of fibrinolysis in sepsis is currently unknown. METHODS:TAFI antigen and PAI-1 levels were measured in severe sepsis (n = 32) and septic shock ...

journal_title：Thrombosis research

authors： Zeerleder S,Schroeder V,Hack CE,Kohler HP,Wuillemin WA

更新日期：2006-01-01 00:00:00

abstract：:RS-5186, sodium 6-[2-[1-(1H)-imidazolyl]methyl-4,5-dihydrobenzo[b]thiophene]- carboxylate, inhibited platelet thromboxane A2 (TXA2) synthetase with IC50 values of 6 nM and 13 nM for human and rabbit microsomes, respectively. It had a selectivity for TXA2 synthetase 10(5)-fold greater than that for cyclooxygenase, PGI2...

journal_title：Thrombosis research

authors： Ushiyama S,Ito T,Asai F,Oshima T,Terada A,Matsuda K,Yamazaki M

更新日期：1988-09-01 00:00:00