Warfarin-induced factor VII deficiency and the bleeding time.

abstract：:Thrombolysis is an effective but potential deleterious therapy and should therefore be limited to patients with acute intracerebral vessel occlusion and salvageable tissue. MRI currently develops towards the new diagnostic standard for the selection of stroke patients eligible for acute thrombolytic treatment and acut...

journal_title：Thrombosis research

authors： Röther J

更新日期：2001-09-30 00:00:00

abstract：INTRODUCTION:Recombinant members of the vitamin K-dependent protein family (factors IX and VII and protein C) have become important pharmaceuticals in treatment of bleeding disorders and sepsis. However, because the in vivo gamma-carboxylation system in stable cell lines used for transfection has a limited capacity of ...

journal_title：Thrombosis research

authors： Wajih N,Owen J,Wallin R

更新日期：2008-01-01 00:00:00

abstract：:Some previous reports indicated that a minimal amount of anti-IIa is necessary for the optimal anti-Xa activity of low molecular weight heparin (LMW-H). To know if we could improve the prophylactic activity of LMW-H, providing a mild antithrombin effect, we conducted an experiment in which we administered subcutaneous...

journal_title：Thrombosis research

authors： Pèrez-Requejo JL,Lucena-Solano O,Pérez-García M,Santarelli MT

更新日期：1997-02-01 00:00:00

abstract：:The presence of Factor XIII subunit a was demonstrated in human monocytes by immunoperoxidase staining using specific antisera against Factor XIII and its subunits. This finding was verified by immunobiochemical techniques, as well. In an immunoblotting system after SDS polyacrylamide gel electrophoresis of denatured ...

journal_title：Thrombosis research

authors： Muszbek L,Adány R,Szegedi G,Polgár J,Kávai M

更新日期：1985-02-01 00:00:00

abstract：:The effect of tissue factor pathway inhibitor (TFPI) on thrombin and factor Xa generation was studied in an in vitro system using a prothrombin complex concentrate. It was found that TFPI, via the direct inhibition of factor Xa and the tissue factor/factor VIIa complex, inhibited both the further generation of factor ...

journal_title：Thrombosis research

authors： Kaiser B,Hoppensteadt DA,Jeske W,Wun TC,Fareed J

更新日期：1994-09-15 00:00:00

abstract：:Binding of 3H-labeled 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor; PAF) to the intact, washed canine platelet has been defined and characterized as being specific and receptor-mediated. Under the conditions described, specific binding to 2 X 10(7) canine platelets reached saturation with...

journal_title：Thrombosis research

authors： Janero DR,Burghardt B,Burghardt C

更新日期：1988-06-15 00:00:00

abstract：INTRODUCTION:Data regarding the clinical relevance of pulmonary infarction (PI) in patients with pulmonary embolism (PE) are lacking. The aim of this study was to investigate the clinical features of PE patients with PI and the prognostic role of PI for PE patients. MATERIALS AND METHODS:Based on computed tomography s...

journal_title：Thrombosis research

authors： Cha SI,Shin KM,Lee J,Hwangbo Y,Yoo SS,Lee J,Lee SY,Kim CH,Park JY,Jung TH

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Miniplasmin was a des-kringle variant of plasminogen with potential pharmacological application. We investigated the thrombolytic effect of miniplasmin in a canine model of femoral artery thrombosis. METHODS:In anesthetized dogs, a stable occlusive thrombus was formed by mechanical and electroly...

journal_title：Thrombosis research

authors： Fu J,Ren J,Zou L,Bian G,Li R,Lu Q

更新日期：2008-01-01 00:00:00

abstract：:Practice variation, the differences in clinical management between physicians, is one reason why patient outcomes may differ. Identifying factors that contribute to practice variation in areas of clinical uncertainty or equipoise may have implications for understanding and improving patient care. To discern what facto...

journal_title：Thrombosis research

authors： Skeith L,Gonsalves C

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the effect of CYP2C19 polymorphism and co-therapy with esomeprazole on the antiplatelet efficacy of clopidogrel. BACKGROUND:The antiplatelet efficacy of clopidogrel depends on CYP2C19 polymorphism or the co-administration of some kind of proton pump inhibitor (PPI). ...

journal_title：Thrombosis research

authors： Hokimoto S,Akasaka T,Tabata N,Arima Y,Tsujita K,Sakamoto K,Kaikita K,Morita K,Kumagae N,Yamamoto E,Oniki K,Nakagawa K,Ogawa H

更新日期：2015-06-01 00:00:00

abstract：:The soluble fibrin monomer complexes (SFMC) in 154 obstetric patients with possible disseminated intravascular coagulation (DIC) were evaluated in SDS polyacrylamide gel electrophoresis (PAGE) after precipitation with B-alanine. Other coagulation tests were performed on these patients. The patients were classified int...

journal_title：Thrombosis research

authors： Aznar J,Gilabert J,Estelles A,Fernandez MA,Villa P,Aznar JA

更新日期：1982-09-15 00:00:00

abstract：INTRODUCTION:Post-thrombotic syndrome (PTS) is a chronic sequel of deep vein thrombosis (DVT). The clot structure and fibrinolytic potential in PTS is currently unknown. OBJECTIVE:To assess the fibrinolytic potential and clot structure in patients with PTS. MATERIALS AND METHODS:Patients with a history of DVT were in...

journal_title：Thrombosis research

authors： Bouman AC,McPherson H,Cheung YW,Ten Wolde M,Ten Cate H,Ariëns RAS,Ten Cate-Hoek AJ

更新日期：2016-01-01 00:00:00

abstract：:The Fab fragment of a polyclonal antibody against platelet factor XIII inhibited the collagen-induced platelet aggregation in a dose-dependent manner. This inhibitory effect was specific for collagen, and it had no effect on arachidonic acid-, ADP-, and serotonin-induced aggregations. This finding strengthens our noti...

journal_title：Thrombosis research

authors： Kasahara K,Takagi J,Sekiya F,Inada Y,Saito Y

更新日期：1988-04-15 00:00:00

abstract：INTRODUCTION:We recently proposed a scale for assessment of patient-relevant functional limitations following an episode of venous thromboembolism (VTE). Further development of this post-VTE functional status (PVFS) scale is still needed. METHODS:Guided by the input of VTE experts and patients, we refined the PVFS sca...

journal_title：Thrombosis research

authors： Boon GJAM,Barco S,Bertoletti L,Ghanima W,Huisman MV,Kahn SR,Noble S,Prandoni P,Rosovsky RP,Sista AK,Siegerink B,Klok FA

更新日期：2020-06-01 00:00:00

abstract：:The lupus ratio (LR) test is a normalized ratio of the clotting times obtained with low and high phospholipid (PL) concentrations, where the test plasma is mixed 1:1 with normal pooled plasma (NP). As an integrated, automated, and computer-assisted assay, this principle has been applied to the dilute activated partial...

journal_title：Thrombosis research

authors： Liestøl S,Jacobsen EM,Wisløff F

更新日期：2002-01-15 00:00:00

abstract：:Antithrombin III (AT III) is increased in situations where there is increased platelet turnover. Plasma AT III levels measured in 39 renal transplant recipients were significantly higher than in 20 healthy subjects (p less than 0.001) and 20 patient controls (p less than 0.025). AT III levels were significantly correl...

journal_title：Thrombosis research

authors： Woo KT,Lee EJ,Lau YK,Lim CH

更新日期：1985-05-01 00:00:00

abstract：:Sandwich ELISA systems were developed to measure human von Willebrand factor (vWF). In one system the microtitre plates were coated with goat F(ab')2 to vWF. The F(ab')2 different molecular forms in the soluble phase. VWF antigen bound by the F(ab')2 antibody was subsequently determined by using horse-radish peroxidas...

journal_title：Thrombosis research

authors： Silveira AM,Yamamoto T,Adamson L,Hessel B,Blombäck B

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Few studies investigated the relationship between fibrinolysis abnormalities and residual pulmonary perfusion defects after acute pulmonary embolism (PE). OBJECTIVE:To assess the fibrinolytic profile in patients with prior PE in relation to the extent of scintigraphically detectable residual perfusion abnor...

journal_title：Thrombosis research

authors： Lami D,Cellai AP,Antonucci E,Fiorillo C,Becatti M,Grifoni E,Cenci C,Marcucci R,Mannini L,Miniati M,Abbate R,Prisco D

更新日期：2014-09-01 00:00:00

abstract：:A 79-year-old lean man with a height of 157cm and weight of 42kg (body mass index, 17.2kg/m(2)) receiving rivaroxaban developed an intracranial subdural hematoma and was treated conservatively. Because he had a reduced creatinine clearance of 44mL/min, his dosage of rivaroxaban was reduced from 15 to 10mg daily accord...

journal_title：Thrombosis research

authors： Yamaguchi Y,Koga M,Matsuki T,Hino T,Yokota C,Toyoda K

更新日期：2016-07-01 00:00:00

abstract：:The enzymatic and fibrinolytic properties of glycosylated and nonglycosylated recombinant human pro-urokinase (pro-UK) produced in yeast Pichia pastoris were characterized and compared with those of Escherichia coli and mammalian cell-derived pro-UK. Among the five different forms of pro-UK, the yeast glycosylated pro...

journal_title：Thrombosis research

authors： Wang P,Zhang J,Sun Z,Chen Y,Gurewich V,Liu JN

更新日期：2000-12-01 00:00:00

abstract：:Trimethylamine-N-oxide (TMAO), one of the products in choline metabolite, is recently reported to be associated with cardiovascular diseases (CVD) that mainly attribute to atherothrombosis. However, the mechanisms how TMAO functions in the pathogenesis of CVD and atherothrombosis remain elusive. Tissue factor (TF) has...

journal_title：Thrombosis research

authors： Cheng X,Qiu X,Liu Y,Yuan C,Yang X

更新日期：2019-05-01 00:00:00

abstract：:Data on the effect of hormone replacement therapy on hemostasis are inconsistent, and there are few data in women with coronary artery disease. In a single-center, open, randomized study, 118 postmenopausal women with angiographically verified coronary artery disease were randomized to hormone replacement therapy, giv...

journal_title：Thrombosis research

authors： Hoibraaten E,Os I,Seljeflot I,Andersen TO,Hofstad A,Sandset PM

更新日期：2000-04-01 00:00:00

abstract：:Fucoidan [sulfated poly (L-fucopyranose)] was compared with 6-aminohexanoic acid (6-AH) or CNBr-cleaved fibrinogen (CNBr-Fbg) alone or in combination in enhancing the activation of glutamic plasminogen (Glu-Plg) or lysine plasminogen (Lys-Plg) by two-chain tissue plasminogen activator (t-PA) or LMwt-urokinase or by st...

journal_title：Thrombosis research

authors： Doctor VM,Hill C,Jackson GJ

更新日期：1995-08-01 00:00:00

abstract：INTRODUCTION:High RDW values are associated with adverse prognosis in many clinical conditions including short and medium term outcome of patients with ST Elevation Myocardial Infarction (STEMI). The aim of the present study was to evaluate the association between RDW and long term mortality in STEMI patients undergoin...

journal_title：Thrombosis research

authors： Arbel Y,Shacham Y,Finkelstein A,Halkin A,Milwidsky A,Berliner S,Ziv-Baran T,Revivo M,Herz I,Keren G,Banai S

更新日期：2014-11-01 00:00:00

abstract：:The three main components involved in thrombosis and haemostasis are thrombin, platelets, and plasmin. Almost all inhibitors of thrombosis are focused either on the inhibition of thrombin or on the inhibition of platelets. We designed a construct using the fibrinolytic activity of staphylokinase, fused via a cleavable...

journal_title：Thrombosis research

authors： van Zyl WB,Pretorius GH,Hartmann M,Kotzé HF

更新日期：1997-12-01 00:00:00

abstract：INTRODUCTION:Previous studies have suggested the used of off-label recombinant factor VII (rFVIIa) increases the risk of thromboembolic events, but the effect of the dose of rFVIIa is not well described in the literature. MATERIALS AND METHODS:All adult patients that received off-label rFVIIa from 2005-2012 were inclu...

journal_title：Thrombosis research

authors： Bucklin MH,Acquisto NM,Nelson C

更新日期：2014-05-01 00:00:00

abstract：:Hemostatic challenges occur throughout the period of stem cell transplantation (SCT). Endothelial cells injury due to chemotherapy, growth factors, intravenous catheter, and graft-versus-host disease and profound thrombocytopenia are the major components involved in the hemostatic complications. Diffuse alveolar hemor...

journal_title：Thrombosis research

authors： Nadir Y,Brenner B

更新日期：2007-01-01 00:00:00

abstract：:Two monoclonal antibodies against plasminogen and two against alpha-2-antiplasmin were characterized regarding their binding properties towards their respective native and modified antigens and towards the plasmin-alpha-2-antiplasmin complex. Using an ELISA system, the two monoclonal antibodies against plasminogen (MP...

journal_title：Thrombosis research

authors： Hattey E,Wojta J,Binder BR

更新日期：1987-03-01 00:00:00

abstract：:Pulmonary embolism (PE) is a common, lethal yet treatable disease. The clinical diagnosis of PE remains to be a problem due to the nonspecific presenting signs, symptoms, electrocardiographic findings, arterial blood gas abnormalities and chest X-ray changes. Despite these nonspecific clinical findings, clinicians are...

journal_title：Thrombosis research

authors： Rodger M,Wells PS

更新日期：2001-09-15 00:00:00

abstract：:It has previously been observed that aspirin diminishes the increase in blood fibrinolytic activity during arm venous occlusion. We studied the duration of this inhibitory effect on fibrinolytic response during 20 minutes arm venous occlusion and its effect on fibrinolytic response during acute physical activity (stan...

journal_title：Thrombosis research

authors： Keber I,Jereb M,Keber D

更新日期：1987-04-15 00:00:00