Diagnosis of pulmonary embolism.

Abstract:

:Pulmonary embolism (PE) is a common, lethal yet treatable disease. The clinical diagnosis of PE remains to be a problem due to the nonspecific presenting signs, symptoms, electrocardiographic findings, arterial blood gas abnormalities and chest X-ray changes. Despite these nonspecific clinical findings, clinicians are adept at assigning pretest probability using overall clinical assessment. Clinical models have been developed to improve the accuracy of pretest probability assessment. D-dimers are becoming a widely available clinical tool useful in the diagnostic management of suspected PE. The limitations of the imaging modalities for PE [ventilation-perfusion (V/Q) scanning, spiral computerised tomography, pulmonary angiography and venous leg imaging] necessitate the use of these tests in series and in combination with clinical pretest probability assessment and D-dimer in diagnostic management algorithms. These algorithms permit safe diagnostic management of patients with suspected PE while limiting invasiveness, inaccessibility and expense.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Rodger M,Wells PS

doi

10.1016/s0049-3848(01)00326-7

subject

Has Abstract

pub_date

2001-09-15 00:00:00

pages

V225-38

issue

6

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(01)00326-7

journal_volume

103

pub_type

杂志文章,评审
  • Identifying venous thromboembolism and major bleeding in emergency room discharges using administrative data.

    abstract:BACKGROUND:Administrative data can be used to identify venous thromboembolism (VTE) and major bleeding (MB) events. However, the validity of this data in emergency room discharge records in Canada is unknown. METHODS:We conducted a single-institution retrospective chart re-abstraction study in London, Canada. We ident...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2015.10.035

    authors: Al-Ani F,Shariff S,Siqueira L,Seyam A,Lazo-Langner A

    更新日期:2015-12-01 00:00:00

  • Thrombin treated plasma employed as a standard for determination of soluble fibrin.

    abstract::The Coa-set Fibrin Monomer test (CFM-test) is a quantitative method for determination of soluble fibrin in plasma. The fibrin standard of the CFM-test is produced by bathroxobin conversion of purified fibrinogen to fibrin. Plasma treated with minute amounts of thrombin may be considered as a more physiological way of ...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(93)90139-f

    authors: Halvorsen S,Skjønsberg OH,Godal HC

    更新日期:1993-11-15 00:00:00

  • Physiological changes in membrane-expressed platelet factor 4: implications in heparin-induced thrombocytopenia.

    abstract:BACKGROUND:Many heparin-induced thrombocytopenia (HIT) antibodies cause platelet activation in the serotonin release assay (SRA) in the absence of heparin. This in vitro observation may help unravel the mechanism of delayed-onset HIT, where seropositive patients develop thrombocytopenia and associated thrombosis after ...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2009.10.021

    authors: Prechel MM,Jeske WP,Walenga JM

    更新日期:2010-04-01 00:00:00

  • Glycoprotein IIb-IIIa complex in platelets of patients and heterozygotes of Glanzmann's thrombasthenia.

    abstract::The concentration of the glycoprotein (GP) IIb-IIIa complex in thrombasthenic platelets of 8 patients of 6 families has been estimated. In the thrombasthenic platelets of 3 patients this complex is absent (thrombasthenia type I and subtype I). In 2 patients only traces are detectable and in 3 patients GP IIb-IIIa comp...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(83)90063-4

    authors: Herrmann FH,Meyer M,Gogstad GO,Solum NO

    更新日期:1983-12-15 00:00:00

  • Effect of suloctidil on platelet function in patients with shortened platelet survival time.

    abstract::The effect of suloctidil (600 mg/day) on platelet survival time (PST) and plasma and urine betathromboglobulin (BTG) was studied in a double-blind, placebo-controlled six-week crossover trial in 13 patients with shortened PST (less than 110 hrs, exponential model). Mean PST after suloctidil (110.6 hrs) was significant...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章

    doi:10.1016/0049-3848(84)90231-7

    authors: Turpie AG,Gent M,deBoer AC,Giroux M,Kinch D,Butt R,Gunstensen J,Saerens E,Genton E

    更新日期:1984-08-15 00:00:00

  • Relationship between preoperative status of the fibrinolytic system and occurrence of deep vein thrombosis after major abdominal surgery.

    abstract::This study comprised 50 patients subjected to major abdominal surgery, of which 13 developed deep vein thrombosis (DVT) according to the 125I-fibrinogen test. Plasma was sampled preoperatively, for the specific analysis of tissue plasminogen activator (t-PA) before and during venous occlusion. The recently described f...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(85)90103-3

    authors: Mellbring G,Dahlgren S,Wiman B,Sunnegårdh O

    更新日期:1985-07-15 00:00:00

  • Effects of acute exercise on bleeding time, bleeding amount and blood cell counts: a comparative study.

    abstract::Twenty-five men and 26 women were studied to investigate the effects of acute strenuous exercise on hemostasis after obtaining their informed consent. After familiarization, they performed exercise on a bicycle ergometer at 75% of their predetermined maximal workload until exhaustion. Bleeding time, measured by the Si...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(89)90058-3

    authors: Chen HI,Tang YR,Wu HJ,Jen CJ

    更新日期:1989-08-15 00:00:00

  • Tissue factor expression in atrial endothelia associated with nonvalvular atrial fibrillation: possible involvement in intracardiac thrombogenesis.

    abstract:INTRODUCTION:Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. Atrial myocarditis has been detected recently in some patients with lone atrial fibrillation. Virchow's triad of low blood flow, hypercoagulability, and endothelial dysfunction, enhances thrombus f...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/s0049-3848(03)00405-5

    authors: Nakamura Y,Nakamura K,Fukushima-Kusano K,Ohta K,Matsubara H,Hamuro T,Yutani C,Ohe T

    更新日期:2003-01-01 00:00:00

  • Changes in blood viscosity by heparin and argatroban.

    abstract::Anticoagulants are effective for preventing both venous and arterial thrombosis. Although antithrombotic agents have been reported to reduce thrombin formation, to our knowledge, the relation between blood viscosity (BV) and antithrombotic agents has not been examined. We examined the effects on whole BV of various do...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/s0049-3848(01)00359-0

    authors: Hitosugi M,Niwa M,Takatsu A

    更新日期:2001-12-01 00:00:00

  • Clinical impact of direct oral anticoagulant measuring in a real-life setting.

    abstract:INTRODUCTION:Only sparse information exists on the use of direct oral anticoagulant (DOAC) testing and the impact on clinical management. Here, we evaluated the clinical impact of DOAC measurements in a real-life clinical setting. Moreover, number of tests performed in relation to number of DOAC-treated patients was ev...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2019.01.016

    authors: Winther-Larsen A,Hvas AM

    更新日期:2019-03-01 00:00:00

  • Treatment of venous thromboembolism in patients with cancer: from clinical trials to real life.

    abstract::Approximately one-fifth of all cases of venous thromboembolism (VTE) are related to cancer. VTE complications may have a substantial impact on prognosis, quality of life and care in patients with cancer. Patients with cancer-related VTE are at increased risk of developing recurrent VTE compared to patients without can...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/S0049-3848(20)30409-6

    authors: Verso M,Agnelli G

    更新日期:2020-07-01 00:00:00

  • The effect of uremia on platelet contractile force, clot elastic modulus and bleeding time in hemodialysis patients.

    abstract:INTRODUCTION:Uremic bleeding frequently occurs in dialysis patients. Although its mechanism is not well characterized, acquired platelet dysfunction has been implicated in its pathogenesis. Skin bleeding time has been used to characterize platelet dysfunction in this population. However, the bleeding time is prone to e...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2006.02.013

    authors: Brophy DF,Martin EJ,Carr SL,Kirschbaum B,Carr ME Jr

    更新日期:2007-01-01 00:00:00

  • Abnormally high prevalence of major components of the metabolic syndrome in subjects with early-onset idiopathic venous thromboembolism.

    abstract:BACKGROUND:Although patients with idiopathic VTE are at higher than normal risk of asymptomatic atherosclerosis and of cardiovascular events, the impact of cardiovascular risk factors on VTE is poorly understood. OBJECTIVE:To assess the prevalence of the metabolic syndrome and of its components in patients with early-...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2010.12.005

    authors: Di Minno MN,Tufano A,Guida A,Di Capua M,De Gregorio AM,Cerbone AM,Tarantino G,Di Minno G

    更新日期:2011-03-01 00:00:00

  • Kinetic study on the initial stage of the fibrinogen-fibrin conversion by thrombin. (IV). Effects of heparin and its analogues.

    abstract::From kinetic analysis on the initial stage of the fibrinogen-fibrin conversion catalyzed by thrombin, inhibition constants, Kip, of heparin and heparin analogues were obtained by the turbidimetrical method. The inhibitory effect per unit amount in weight of heparin and heparin analogues increased generally with decrea...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(85)90235-x

    authors: Sato H,Nakajima A,Shimohira T

    更新日期:1985-09-01 00:00:00

  • Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.

    abstract::The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific ...

    journal_title:Thrombosis research

    pub_type: 杂志文章,评审

    doi:10.1016/S0049-3848(16)30370-X

    authors: Hoffmeister KM,Falet H

    更新日期:2016-05-01 00:00:00

  • Compartmentation of 4,6-difluoro-5HT studied by nuclear magnetic resonance in normal and CHS bovine platelets.

    abstract::A platelet storage pool deficiency (SPD) is present in platelets from cattle with the Chediak-Higashi syndrome (CHS). The most plausible hypothesis for the SPD is that dense granule precursors are simply not formed in CHS megakaryocytes. There is, however, evidence that some recently acquired 5-hydroxytryptamine (5HT)...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(90)90096-u

    authors: Meyers KM,Costa JL,Magnuson J

    更新日期:1990-05-01 00:00:00

  • Experimental model of thrombus adherence to the vessel wall.

    abstract::Clot adherence to peritoneal cavity mesothelium was studied in rats in an attempt to contribute to the problem of thrombus embolization. The adherence was decreased by platelets and the active constituent was identified as adenosine diphosphate which decreased the sticking of fibrin to cellular linings as well as to a...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(82)90100-1

    authors: Hladovec J

    更新日期:1982-12-15 00:00:00

  • Effectiveness of alternative treatments for reducing potential viral contaminants from plasma-derived products.

    abstract::An issue of great importance and continuing concern with regard to all products derived from human plasma is their safety from potential contaminants in the source material from which they are purified. Since viral contaminants are a major safety consideration with these products, a number of different methods, includ...

    journal_title:Thrombosis research

    pub_type: 杂志文章,评审

    doi:10.1016/s0049-3848(02)00044-0

    authors: Chandra S,Groener A,Feldman F

    更新日期:2002-03-01 00:00:00

  • Evaluation of a new chronometric assay for factor V Leiden-dependent APC resistance.

    abstract::Since the first description by Dahlbäck et al (1) of a hereditary defect in the plasma of three unrelated thrombophilic patients characterized by a poor anticoagulant response to activated protein C (APC), many reports have shown a high prevalence of the APC resistance in both the general and thrombophilic populations...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/s0049-3848(97)00022-4

    authors: Gouault-Heilmann M,Leroy-Matheron C

    更新日期:1997-02-15 00:00:00

  • Effects of mechanical trauma of blood cells on dynamic viscoelasticity of blood during clotting.

    abstract::Effects of mechanical trauma of platelets and red blood cells on dynamic viscoelasticity of blood during clotting were examined. Two different methods were attempted to give the mechanical damage to blood cells. In one method, a flow apparatus consisting of a thin teflon tube and two sample reservoirs connecting to bo...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(86)90084-8

    authors: Kaibara M,Ukiya Y,Sekiguchi M

    更新日期:1986-08-15 00:00:00

  • Blood coagulation and fibrinolysis after extreme short-term exercise.

    abstract:INTRODUCTION:Maximal exercise may be a trigger for cardiovascular events. The aim of the study was to investigate changes in blood coagulation and fibrinolysis following maximal short-term exercises with different durations up to 90 s. METHODS:A total of 15 healthy nonsmokers underwent three isokinetic maximal tests o...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/s0049-3848(03)00283-4

    authors: Hilberg T,Prasa D,Stürzebecher J,Gläser D,Schneider K,Gabriel HH

    更新日期:2003-03-15 00:00:00

  • Differential effects of low molecular weight heparin and unfractionated heparin on circulating levels of antithrombin and tissue factor pathway inhibitor (TFPI): a possible mechanism for difference in therapeutic efficacy.

    abstract::There is growing evidence on the superior efficacy and safety of low molecular weight heparins (LMWHs) over unfractionated heparin (UFH) for the treatment of both venous and arterial thromboembolism. Heparin exerts its function by potentiating antithrombin and by mobilizing tissue factor pathway inhibitor (TFPI) into ...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0049-3848(98)00079-6

    authors: Hansen JB,Sandset PM

    更新日期:1998-08-15 00:00:00

  • The effect of oral versus intravenous tranexamic acid in reducing blood loss after primary total hip arthroplasty: A randomized clinical trial.

    abstract:BACKGROUND:The purpose of this study was to determine whether the administration of multiple boluses of oral and intravenous tranexamic acid (TXA) postoperatively was equivalent in reducing blood loss in primary THA. METHODS:A total of 108 patients were randomized into two groups: oral TXA group (54 patients receiving...

    journal_title:Thrombosis research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.thromres.2018.02.007

    authors: Cao G,Huang Z,Xie J,Huang Q,Xu B,Zhang S,Pei F

    更新日期:2018-04-01 00:00:00

  • Use of the Delphi method to facilitate antithrombotics prescription during pregnancy.

    abstract:INTRODUCTION:Management of pregnant women at risk for venous thromboembolism (VTE) remains complex. Guidelines do not definitively fix optimal strategies due to limited trial data. Our objective was to build an easy-to-use tool allowing individualised, risk-adapted prophylaxis. MATERIALS AND METHODS:A Delphi exercise ...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2010.01.012

    authors: Chauleur C,Gris JC,Laporte S,Rancon F,Varlet MN,Decousus H,Mismetti P,STRATHEGE Group.

    更新日期:2010-08-01 00:00:00

  • Obligatory role of lipid mediators in platelet-neutrophil adhesion.

    abstract::Platelet-neutrophil interactions play an important role in thrombotic and inflammatory responses. Although it is well known that adhesion of platelets to neutrophils requires interactions of adhesion molecules on platelets such as P-selectin, or GPIIb/IIIa with their counterparts on neutrophils, little is known on the...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/s0049-3848(03)00413-4

    authors: Chlopicki S,Lomnicka M,Gryglewski RJ

    更新日期:2003-06-15 00:00:00

  • Increasing the sensitivity of the human microvesicle tissue factor activity assay.

    abstract:INTRODUCTION:The TF-FVIIa complex is the primary activator of coagulation. Elevated levels of microvesicle (MV) bearing tissue factor (TF)-dependent procoagulant activity are detectable in patients with an increased risk of thrombosis. Several methods have been described to measure MV TF activity but they are hampered ...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2019.07.011

    authors: Vallier L,Bouriche T,Bonifay A,Judicone C,Bez J,Franco C,Guervilly C,Hisada Y,Mackman N,Houston R,Poncelet P,Dignat-George F,Lacroix R

    更新日期:2019-10-01 00:00:00

  • Retrievable vena cava filters: key considerations.

    abstract::Retrievable filters are a new generation of inferior vena cava (IVC) filters and represent an attractive option because they may be either left in place permanently or safely retrieved after a quite long period when they become unnecessary. In this review the currently available literature regarding retrievable IVC fi...

    journal_title:Thrombosis research

    pub_type: 杂志文章,评审

    doi:10.1016/j.thromres.2007.06.017

    authors: Imberti D,Prisco D

    更新日期:2008-01-01 00:00:00

  • Clinical evaluation of a pasteurized factor XIII concentrate administration in Henoch-Schönlein purpura. Japanese Pediatric Group.

    abstract::Arthral, abdominal and renal symptoms in Henoch-Schönlein purpura (HSP) were scored. Coagulation factor XIII (F XIII) activity was determined in fifty-six children with HSP and the correlation with the severity score of the clinical symptoms was investigated. As a result, it was found that the decrease in F XIII level...

    journal_title:Thrombosis research

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/0049-3848(89)90284-3

    authors: Fukui H,Kamitsuji H,Nagao T,Yamada K,Akatsuka J,Inagaki M,Shike S,Kobayashi Y,Yoshioka K,Maki S

    更新日期:1989-12-15 00:00:00

  • Antithrombotic activity of recombinant tick anticoagulant peptide and heparin in a rabbit model of venous thrombosis.

    abstract::An in vivo rabbit model of venous thrombosis which includes physiological blood flow was used to compare the efficacy of the potent and specific factor Xa inhibitor recombinant tick anticoagulant peptide (rTAP) with standard heparin in the prevention of venous thrombus formation. In anesthetized rabbits, an autologous...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/0049-3848(93)90200-8

    authors: Fioravanti C,Burkholder D,Francis B,Siegl PK,Gibson RE

    更新日期:1993-08-15 00:00:00

  • Prevalence and risk factors of atherothrombotic events among 1054 hemophilia patients: a population-based analysis.

    abstract:INTRODUCTION:Reports on the prevalence and risk factors of atherothrombotic events (AEs) are conflicting in persons with hemophilia (PWH). METHODS:This study evaluated the prevalence and risk factors of AEs among 1054 male hemophilia patients, using data collected from Taiwan's National Health Insurance Research Datab...

    journal_title:Thrombosis research

    pub_type: 杂志文章

    doi:10.1016/j.thromres.2014.12.027

    authors: Wang JD,Chan WC,Fu YC,Tong KM,Chang ST,Hwang WL,Lin CH,Tsan YT

    更新日期:2015-03-01 00:00:00