Very low doses of unfractionated heparin potentiate the anti-Xa activity of low molecular weight heparin (enoxaparin)

abstract：INTRODUCTION:Tissue Factor Pathway Inhibitor-2 (TFPI-2) is a Kunitz-type serine proteinase inhibitor whose expression is up-regulated by VEGF in microvascular and umbilical vein endothelial cells (EC). Despite this, TFPI-2 has been suggested as anti-angiogenic molecule, due to its ability to inhibit the migration/proli...

journal_title：Thrombosis research

authors： Ghilardi C,Anastasia A,Avigni R,Lupi M,Giavazzi R,Bani MR

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The quality of treatment with warfarin is mainly assessed by the time in therapeutic range (TTR) in patients with mechanical heart valve prosthesis (MHV). Our aim was to evaluate if International Normalized Ratio (INR) variability predicted a combined endpoint of thromboembolism, major bleeding and death bet...

journal_title：Thrombosis research

authors： Labaf A,Själander A,Stagmo M,Svensson PJ

更新日期：2015-12-01 00:00:00

abstract：:Activation of human plasminogen by human tissue-type plasminogen activator (t-PA) is accelerated in the presence of cyanogen bromide digests of human fibrin(ogen). In the present study a possible species specificity of this phenomenon was investigated. All combinations of the plasminogens, fibrin monomers and cyanogen...

journal_title：Thrombosis research

authors： Nieuwenhuizen W,Keyser J

更新日期：1985-06-15 00:00:00

abstract：:In adult patients with sickle cell disease two distinct subphenotypes have previously been defined: patients with the viscosity-vaso-occlusion subphenotype (VVO) suffer mainly from vaso-occlusive pain crises and have a relatively high hemoglobin concentration. Patients classified as the hemolysis-endothelial dysfuncti...

journal_title：Thrombosis research

authors： van der Land V,Peters M,Biemond BJ,Heijboer H,Harteveld CL,Fijnvandraat K

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Dabigatran etexilate is widely used for stroke prevention in the patients with atrial fibrillation. The anticoagulation activity of dabigatran is not necessary monitored in routine clinical practice. We aimed to study the effect of dabigatran on thrombin generation (TG) and coagulation assays in rabbit and h...

journal_title：Thrombosis research

authors： Zhang C,Zhang P,Li H,Han L,Zhang L,Zhang L,Yang X

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Arterial calcification is associated with increased risk of cardiovascular events. Osteoprotegerin (OPG) is a cytokine involved in the bone metabolism and vascular calcification. Recent data support a relationship between high serum levels of OPG and increased risk for cardiovascular disease in human. The ai...

journal_title：Thrombosis research

authors： Guldiken B,Guldiken S,Turgut B,Turgut N,Demir M,Celik Y,Arikan E,Tugrul A

更新日期：2007-01-01 00:00:00

abstract：:The extrinsic fibrinolytic system was assessed among 124 consecutive survivors of acute myocardial infarction below 70 years of age. In samples drawn 3 months after discharge from hospital, the PAI-1 levels were higher and the tPA activities were lower than among elderly healthy controls. In contrast, the AMI survivor...

journal_title：Thrombosis research

authors： Nilsson TK,Johnson O

更新日期：1987-12-15 00:00:00

abstract：:G619, a 4-OH-isophthalic acid derivative, was studied for its capacity to inhibit platelet aggregation. G619 dose-dependently inhibited U46619, collagen, ADP, PAF, thrombin and epinephrine-induced platelet aggregation in vitro. The IC50 values for inhibition of U46619-induced human and rabbit platelet aggregation were...

journal_title：Thrombosis research

authors： Yue TL,Smith EF 3rd,Ohlstein EH,Sulpizio A,Slivjak MJ,Rabinovici R,Sellers TS,Lynch KM,Poyser R,Feuerstein G

更新日期：1992-05-15 00:00:00

abstract：BACKGROUND:Reversal of anticoagulation can be needed in patients undergoing heart valve surgery. ROTEM® has been correlated with international normalized ratio (INR) in patients on warfarin but not with patients on acenocoumarol. This study investigates the reliability of ROTEM® for detecting INR values below the 1.5 t...

journal_title：Thrombosis research

authors： Blasi A,Muñoz G,de Soto I,Mellado R,Taura P,Rios J,Balust J,Beltran J

更新日期：2015-09-01 00:00:00

abstract：INTRODUCTION:Medically ill, hospitalized patients are at increased risk for venous thromboembolism (VTE) after discharge. This study aimed to examine thromboprophylaxis patterns, risk factors, and post-discharge outcomes. METHODS:This was a retrospective claims analysis involving administrative claims data and in-pati...

journal_title：Thrombosis research

authors： Mahan CE,Fisher MD,Mills RM,Fields LE,Stephenson JJ,Fu AC,Spyropoulos AC

更新日期：2013-11-01 00:00:00

abstract：:We purified the urinary procoagulant from frozen human urine by introducing phenyl-Sepharose hydrophobic chromatography. By this method, the apoprotein of the procoagulant and the lipid-like substance were separately recovered. Upon reassociation with the lipid-like substance or exogenous crude phospholipids, the apop...

journal_title：Thrombosis research

authors： Kurosawa S,Matsuda M,Aoki N

更新日期：1984-03-15 00:00:00

abstract：:An in vitro test system was developed to examine the effects of red blood cells (RBC) on shear-induced platelet adhesion (SIPAD) and platelet aggregation (SIPAG). Suspensions of human platelets labeled with Mepacrine and suspended in citrated plasma were exposed to single, continuous or repetitive (120-300x) one secon...

journal_title：Thrombosis research

authors： Joist JH,Bauman JE,Sutera SP

更新日期：1998-12-15 00:00:00

abstract：INTRODUCTION:Incidence and risk factors of venous thromboembolism (VTE) are well established in surgical and medical settings, but data in psychiatric units are lacking. The aim of this study was to estimate the incidence of VTE in hospitalized psychiatric patients, and to assess the risk factors for VTE in this specif...

journal_title：Thrombosis research

authors： Delluc A,Montavon S,Canceil O,Carpentier M,Nowak E,Mercier B,Bressollette L,Etienne S,Walter M,Mottier D,Lacut K

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The recanalization rate in patients with deep venous thrombosis (DVT) of the legs treated with the direct oral anticoagulants (DOAC) is unknown. METHODS:In an Italian cohort, we investigated the rate of residual vein thrombosis (RVT) after three and/or six months in 352 patients with proximal DVT who had be...

journal_title：Thrombosis research

authors： Prandoni P,Ageno W,Mumoli N,Zanatta N,Imberti D,Visonà A,Ciammaichella M,Simioni L,Cappelli R,Bucherini E,Di Nisio M,Avruscio G,Camporese G,Parisi R,Cuppini S,Turatti G,Noventa F,Sarolo L

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:The effects of multiple inherited and acquired thrombophilic defects on the outcome of in-vitro fertilization (IVF) remain unexplored. The aim of this study was to evaluate the association between multiple thrombophilia and clinical outcomes in a large prospective cohort of women undergoing IVF. MATERIALS...

journal_title：Thrombosis research

authors： Di Nisio M,Ponzano A,Tiboni GM,Guglielmi MD,Rutjes AWS,Porreca E

更新日期：2018-07-01 00:00:00

abstract：:A tritium-labelled low molecular weight heparin fragment with an average molecular weight of 4000-6000 (Fragmin), was fractionated into its high and low affinity forms for antithrombin. The fractions obtained were injected into rabbits, and the plasma half-life (t1/2) volume of distribution (Vd), area under the curve ...

journal_title：Thrombosis research

authors： Palm M,Mattsson C

更新日期：1987-10-01 00:00:00

abstract：:Recombinant factor IX (rFIX) is increasingly used to treat patients with hemophilia B. CHO (Chinese Hamster Ovary) cells are commonly used for the production of rFIX but they have a limited capacity for introducing post-translational modifications (PTM) leading to incomplete γ-carboxylation, low phosphorylation and su...

journal_title：Thrombosis research

authors： Enjolras N,Dargaud Y,Pérot E,Guillaume F,Becchi M,Négrier C

更新日期：2012-11-01 00:00:00

abstract：:Activation of human platelets by PAF was augmented by C-reactive protein, an acute phase plasma protein. The concentration of PAF required for irreversible activation (secondary aggregation of platelet and release of serotonin) was decreased to 1/10 in the presence of C-reactive protein (CRP). The presence of CRP stim...

journal_title：Thrombosis research

authors： Kohayakawa M,Inoue K

更新日期：1986-03-01 00:00:00

abstract：:Two isozymes of a native form of human plasminogen (plg), Glu-plg I and II, were isolated. Glu-plg I or II was activated by urokinase (UK) or streptokinase (SK) in the presence of fibrinogen or fibrin. The activation of Glu-plg I was enhanced more than that of Glu-plg II in the presence of fibrin. Fibrin caused better...

journal_title：Thrombosis research

authors： Takada Y,Makino Y,Takada A

更新日期：1985-08-01 00:00:00

abstract：INTRODUCTION:Information regarding any possible additional effect of genetic variants other than CYP2C19*2 on platelet reactivity in patients undergoing percutaneous coronary intervention (PCI), while on dual antiplatelet therapy, is sparse. MATERIALS AND METHODS:Genotyping for CYP2C19*2, CYP2C19*17, CYP2C9*3, CYP2B6*...

journal_title：Thrombosis research

authors： Kassimis G,Davlouros P,Xanthopoulou I,Stavrou EF,Athanassiadou A,Alexopoulos D

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:A higher level of health insurance coverage may be related to better quality of care and outcomes. Whether insurance status is associated with anticoagulation quality and clinical outcomes in patients with venous thromboembolism (VTE) is unknown. METHODS:We studied 819 elderly patients treated with vitami...

journal_title：Thrombosis research

authors： Zumbrunn B,Stalder O,Méan M,Limacher A,Tritschler T,Rodondi N,Aujesky D

更新日期：2019-01-01 00:00:00

abstract：:The ability of parenteral heparin to release the capillary-bound enzymes lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) into the circulation is shared by several other sulphated polysaccharides. The lipase-releasing activity in rats of two unfractionated heparins has been compared with that of charact...

journal_title：Thrombosis research

authors： Williams SP,Johnson EA

更新日期：1989-08-01 00:00:00

abstract：INTRODUCTION:No data are available regarding appropriate strategies for the transition of patients undergoing total hip or knee replacement (THR/TKR) surgery from subcutaneous low molecular weight heparin (LMWH) to rivaroxaban. This study determined the pharmacodynamic effects of rivaroxaban on the first day of adminis...

journal_title：Thrombosis research

authors： Mills RM,Berkowitz RD,Damaraju CV,Jennings LK,Wildgoose P

更新日期：2012-11-01 00:00:00

abstract：:The pharmacokinetics of a low molecular weight heparin (LMWH) with a mean mw of 4000-6000 D (KABI 2165, Fragmin) was studied in 6 healthy volunteers after intravenous (iv) and subcutaneous (sc) administration of 120 U (anti FXa)/kg. The half-life in plasma of the anti FXa activity after iv injection was 119 +/- 17 min...

journal_title：Thrombosis research

authors： Bratt G,Törnebohm E,Widlund L,Lockner D

更新日期：1986-06-01 00:00:00

abstract：INTRODUCTION:Available data on fibrin clot properties and fibrinolysis in hyperthyroidism and hypothyroidism are inconsistent. Our objective was to assess the impact of effective treatment of hyper- and hypothyroidism on fibrin clot characteristics. MATERIAL AND METHODS:In a case-control study, ex vivo plasma fibrin c...

journal_title：Thrombosis research

authors： Mazur P,Sokołowski G,Hubalewska-Dydejczyk A,Płaczkiewicz-Jankowska E,Undas A

更新日期：2014-08-01 00:00:00

abstract：AIM:Postprandial platelet activation was related to postprandial insulin rather than glucose levels in a previous meal insulin study in type 2 diabetes mellitus (T2DM). We therefore compared postprandial platelet activation in type 1 (T1DM) patients without insulin secretion and T2DM patients with high postprandial ins...

journal_title：Thrombosis research

authors： Spectre G,Stålesen R,Östenson CG,Hjemdahl P

更新日期：2016-05-01 00:00:00

abstract：:We have determined that pp60c-src, a protein tyrosine kinase abundant in normal platelets, is present at comparable levels in platelets that are deficient in dense granules (Hermansky-Pudlak syndrome). Relative quantitation of pp60c-src was performed by immunoblot analysis after protein separation by sodium dodecyl su...

journal_title：Thrombosis research

authors： Sorisky A,Lages B,Weiss HJ,Rittenhouse SE

更新日期：1992-01-01 00:00:00

abstract：:Several single-nucleotide polymorphisms (SNPs) have been recognized as associated with ischemic heart disease (IHD) although the optimal set of risk genotypes has not be identified. This study aimed to examine whether identified high-risk SNPs are associated with early onset of IHD. In the GENOCOR study, 44 high-risk ...

journal_title：Thrombosis research

authors： Vecoli C,Adlerstein D,Shehi E,Bigazzi F,Sampietro T,Foffa I,Carpeggiani C,L'abbate A,Andreassi MG

更新日期：2014-05-01 00:00:00

abstract：:Carotid artery dissections are the second leading cause of stroke in young adults. The hemostatic response to a dissection involves exposure of the subendothelium to the intravascular environment. Platelet activation/aggregation superimposed by secondary coagulation cascade activity attempts to heal the injury. Failur...

journal_title：Thrombosis research

authors： Stevic I,Chan HH,Chan AK

更新日期：2011-10-01 00:00:00

abstract：:Beta-thromboglobulin (beta-TG) is a platelet-specific protein present in the alpha-granules and secreted into the surrounding medium on cell activation. The sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) of platelet releasate after inhibition of metalloproteinases with ethyleneglycol-bis-(beta-a...

journal_title：Thrombosis research

authors： Resmi KR,Krishnan LK

更新日期：2002-05-15 00:00:00