Abstract:
:The pharmacokinetics of a low molecular weight heparin (LMWH) with a mean mw of 4000-6000 D (KABI 2165, Fragmin) was studied in 6 healthy volunteers after intravenous (iv) and subcutaneous (sc) administration of 120 U (anti FXa)/kg. The half-life in plasma of the anti FXa activity after iv injection was 119 +/- 17 min, the volume of distribution (Vd) 3.4 +/- 0.5 1 and the total clearence 20.5 +/- 2.5 ml/min. The maximal anti FXa activity determined 3 min after iv bolus injection amounted to 2.2 +/- 0.3 U (anti FXa)/ml with a corresponding increase of the APTT from 31 +/- 7 sec to 113 +/- 35 sec. The elimination of the anti FXa activity was a monoexponential first order process. After sc administration the plasma half-life of the anti FXa activity was longer than after iv injection, 228 +/- 40 min, corresponding to the absorption rate thus found to be the rate limiting step. After sc administration the peak was reached after 4 hours (0.6 +/- 0.1 U (anti FXa)/ml; APTT increase 5 sec). The bioavailability after sc injection was calculated to be 87 +/- 6%. As a consequence of the high bioavailability and long T1/2 of the anti FXa activity, Fragmin administered sc seems to induce adequate levels of heparin-like activity making this regimen worth further investigation as an alternative for the treatment of deep venous thrombosis.
journal_name
Thromb Resjournal_title
Thrombosis researchauthors
Bratt G,Törnebohm E,Widlund L,Lockner Ddoi
10.1016/0049-3848(86)90340-3subject
Has Abstractpub_date
1986-06-01 00:00:00pages
613-20issue
5eissn
0049-3848issn
1879-2472journal_volume
42pub_type
杂志文章abstract::Selected coagulation and fibrinolytic parameters were assessed in 40 insulin dependent diabetes mellitus patients with varying degrees of metabolic control; 30 healthy subjects matched for age and sex formed the control group. Activated Partial Thromboplastin Time, Prothrombin Time, Fibrinogen, Factor VII, Antithrombi...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(92)90068-l
更新日期:1992-09-15 00:00:00
abstract:BACKGROUND:Statins have been shown to have a protective effect for venous thromboembolism (VTE) in the general population. This study sought to assess the association between statins and the risk for cancer-associated deep vein thrombosis (DVT) and pulmonary embolism (PE). METHODS:Patients with newly diagnosed cancer ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2017.08.001
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To explore the functional exercises of deep breathing and lower limb motions for the prevention of venous thrombosis in patients undergoing major surgery for gynecologic malignancy. METHODS:All eligible patients admitted to the gynecologic oncology unit were randomized into the study and control groups. A co...
journal_title:Thrombosis research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.thromres.2019.04.013
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Clopidogrel, cilostazol, and aspirin were compared in terms of efficacy and safety for primary prevention of stroke in peripheral artery disease (PAD) patients. METHODS:This retrospective cohort study analyzed data contained in the Taiwan National Health Insurance Bureau database for patients treated for PA...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2013.01.036
更新日期:2013-08-01 00:00:00
abstract::The pharmacodynamic and pharmacokinetic properties of endpoint-attached N'alkylamine derivatives of low molecular mass heparin (LMMH), low molecular mass heparin (LMMH), low molecular mass heparin-tyramine (LMMH-tyr) and low molecular mass heparin-tyramine-fluorescein-5-isothiocyanate (LMMH-tyr-fitc) were investigated...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(95)00172-n
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Cancer patients have an increased risk of thrombosis. Tissue factor (TF) antigen and TF activity associated with microparticles in plasma are elevated in patients with various types of cancer. Of these two measurements, TF activity is considered superior to TF antigen levels because the activity more closely...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2007.12.023
更新日期:2008-01-01 00:00:00
abstract::Human apolipoprotein B was purified by barium sulphate adsorption, subsequent delipidation and gel filtration. The protein was then reconstituted in soya bean lecithin and its inhibitory effect towards thromboplastin was assayed by incubation with rabbit brain thromboplastin. The use of an antibody against human apoli...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(92)90033-7
更新日期:1992-10-15 00:00:00
abstract::This study focused on the clinical outcomes in multiple myeloma (MM) patients with venous thromboembolism (VTE) who received low-molecular-weight heparin (dalteparin) therapy. Changes in D-dimer levels before and after VTE were also evaluated. Among 549 patients treated with various chemotherapeutic agents, a total of...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2015.09.021
更新日期:2015-11-01 00:00:00
abstract:INTRODUCTION:Adenosine diphosphate (ADP) as physiological activator of human platelets mediates its effects via three purinergic receptors: P2Y1, P2Y12 and P2X1. The inhibition of P2Y12 is used pharmacologically to suppress aggregation underlining the physiological significance of this receptor. Since the regulation of...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2018.05.029
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND AND AIM:Recent studies have documented that elevation of C-reactive protein (CRP) levels after percutaneous coronary intervention (PCI) have been predictive of adverse outcome. This study was performed to test the hypothesis that preprocedural use of naproxen sodium is associated with a reduction in the exte...
journal_title:Thrombosis research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.thromres.2006.11.003
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Reversal of anticoagulation can be needed in patients undergoing heart valve surgery. ROTEM® has been correlated with international normalized ratio (INR) in patients on warfarin but not with patients on acenocoumarol. This study investigates the reliability of ROTEM® for detecting INR values below the 1.5 t...
journal_title:Thrombosis research
pub_type: 临床试验,杂志文章
doi:10.1016/j.thromres.2015.07.003
更新日期:2015-09-01 00:00:00
abstract::Change in the density of circulating platelets in monkeys was studied by using a method that removed greater than 90% of the platelet population from whole blood. These were labelled with 51-Cr and reinjected, having been protected by prostacyclin while in vitro. Platelets were separated into density subpopulations th...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(83)90238-4
更新日期:1983-04-15 00:00:00
abstract::Diagnosis and risk stratification of patients with acute coronary syndromes remain extremely important in order to avoid unnecessary hospitalizations on the one hand, and to improve prognosis of these patients on the other. For diagnosis of acute coronary syndromes, an ECG should be obtained at rest, troponin T and I ...
journal_title:Thrombosis research
pub_type: 杂志文章,评审
doi:10.1016/s0049-3848(01)00298-5
更新日期:2001-09-30 00:00:00
abstract::We investigated the effects of Defibrotide (D), a natural polydeoxyribonucleotide, on acute myocardial ischemia (AMI) in anesthetized cats. A permanent ligature was placed around the left anterior descending coronary artery (LAD) 12-14 mm from its origin. Ventricular fibrillation and death were exceptional and when th...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(85)90008-8
更新日期:1985-04-01 00:00:00
abstract::Mass-Length ratio of fibrin fibres (microT and microP) derived independently from turbidity and permeability respectively, in networks made in fibrinogen solution and plasma, have been compared under similar conditions of clotting. Amount of fibrinogen conversion to fibrin was similar in both systems when high thrombi...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90193-9
更新日期:1987-02-01 00:00:00
abstract::It has been suggested that plasma low density lipoprotein (LDL) may affect platelet and leukocyte activity and the release of biologically active eicosanoids which may contribute to the pathogenesis of coronary heart disease. To evaluate the possible biological effects of LDL further we have studied platelet aggregati...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(93)90032-j
更新日期:1993-02-15 00:00:00
abstract:PURPOSE:Due to its specific pharmacokinetic profile, tinzaparin, a low-molecular-weight heparin (LMWH), appears not to be associated with anti-factor Xa accumulation. Our meta-analysis aimed at determining whether long-term curative doses of tinzaparin is a valuable alternative to vitamin K antagonists (VKA) for the tr...
journal_title:Thrombosis research
pub_type: 杂志文章,meta分析
doi:10.1016/j.thromres.2012.08.290
更新日期:2012-12-01 00:00:00
abstract:INTRODUCTION:Venous thromboembolism (VTE) is a frequent clinical event in patients with gynecologic cancer. However, studies that exclusively address the incidence of VTE according the type of gynecologic cancer are poorly reported. OBJECTIVE:To analyze the incidence of VTE and the associated factors in women with dif...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2019.11.009
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Unfractionated heparin (UFH) does not cross the placenta and has demonstrated utility in the prevention and treatment of thrombosis during pregnancy. Limited information is available to guide initiation and monitoring of therapeutic UFH targeting an anti-Xa concentration of 0.3-0.7 u/ml during pregnancy. T...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2009.07.014
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:Aspirin is a common antiplatelet drug used in the prevention of ischemic stroke due to its inhibitory effect on platelet cyclooxygenase-1 (Cox-1). Patients can be categorized as either aspirin 'responders' or 'non-responders' depending on whether they are protected against a secondary stroke event or not. ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2003.12.005
更新日期:2003-01-01 00:00:00
abstract::The release of arachidonic acid, and its subsequent conversion to thromboxane A2, is an important component of platelet activation. The precise mechanism of arachidonic acid release is unknown although cytosolic phospholipase A2 (cPLA2) has been implicated. In the present study the effects of three agonists, the serin...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(98)00097-8
更新日期:1998-10-01 00:00:00
abstract::The concentrations of tissue plasminogen activator (t-PA) and urokinase (UK) were measured in the plasma of patients with benign or malignant ovarian and uterine tumors. Plasma levels of t-PA were higher in patients with malignant ovarian and uterine tumors than in patients with benign tumors. Plasma UK levels were, h...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(90)90207-s
更新日期:1990-05-15 00:00:00
abstract::We investigated the alteration of heparan sulfate proteoglycans induced by thrombin in cultured vascular endothelial cells. Heparan sulfate proteoglycans, which were metabolically labeled with [3H] glucosamine and [35S] sulfate, were isolated by DEAE-Sephacel ion-exchange chromatography and characterized by molecular ...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(97)00257-0
更新日期:1997-11-01 00:00:00
abstract::Defibrotide (D) is a natural polydeoxyribonucleotide from mammalian lungs with profibrinolytic and antithrombotic activities. D also has PGI2-stimulating and tissue plasminogen activator (TPA)-releasing activities, but has no anticoagulant properties. The protective effects of D were demonstrated very recently in a mo...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(86)90265-3
更新日期:1986-05-01 00:00:00
abstract::Three methods commonly used for isolation of blood platelets from plasma were compared. Platelets were isolated by: 1) a washing method; 2) a method of metrizamide-gradient centrifugation; 3) a modified method of gel-filtration. The last method employed BSA-Sepharose gel instead of routinely used Sepharose gel saturat...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/s0049-3848(00)00282-6
更新日期:2000-09-01 00:00:00
abstract::Defibrotide both "in vitro" and "ex vivo" decreases PMN adhesion to nylon columns. This activity is blunted by 8-phenyltheophylline, a known blocker of adenosine A1/A2 receptors, suggesting that Defibrotide acts on that kind of receptors. Indomethacin, a blocker of PGI2 synthesis, did not cancel DFT's activity, sugges...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(95)00178-t
更新日期:1995-11-15 00:00:00
abstract::Platelet and clotting abnormalities have been described in diabetes, but little is known about their relationship to daily stresses. In order to evaluate whether states of abnormal carbohydrate metabolism modify the hemostatic response to stress, 12 subjects with type I diabetes mellitus, 9 with type II, 7 with impair...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(88)90348-9
更新日期:1988-06-15 00:00:00
abstract::Activation of washed platelets in the presence of EDTA with either 1 U/ml of alpha-thrombin or 2 microM calcium ionophore (A23187) caused the release of one-third to one-half of the platelet factor VIII/von Willebrand factor (FVIII/vWF) into the supernatant. When calcium was present in excess, only 10% of the platelet...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(84)90282-2
更新日期:1984-09-01 00:00:00
abstract::It has previously been observed that aspirin diminishes the increase in blood fibrinolytic activity during arm venous occlusion. We studied the duration of this inhibitory effect on fibrinolytic response during 20 minutes arm venous occlusion and its effect on fibrinolytic response during acute physical activity (stan...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/0049-3848(87)90282-9
更新日期:1987-04-15 00:00:00
abstract::Disseminated intravascular coagulation (DIC) is a severe complication of septic shock. Polymorphonuclear neutrophils (PMNs) may play a key role in septic shock-induced DIC via the release of neutrophils extracellular traps (NETs). NETs capture invading pathogens, but also act as a pro-coagulant surface at the interfac...
journal_title:Thrombosis research
pub_type: 杂志文章
doi:10.1016/j.thromres.2019.09.036
更新日期:2019-11-01 00:00:00