The role of agonist-induced activation and inhibition for the regulation of purinergic receptor expression in human platelets.

abstract：:We tested whether inhibition of platelet activation by nitric oxide (NO) might be altered by strenuous exercise. Sixteen healthy male non-smokers, aged 20-26 years, underwent treadmill testing. All subjects reached Bruce stage IV without chest pain or abnormal ST-T wave changes. Platelet aggregation by Born's method a...

journal_title：Thrombosis research

authors： Sakita S,Kishi Y,Numano F

更新日期：1997-09-01 00:00:00

abstract：INTRODUCTION:This study aimed to determine the risk factors for subclinical umbilical catheter-related thrombosis (UCRT) and its association with clinical morbidities. MATERIALS AND METHODS:In infants without any symptoms associated with umbilical catheterization, the presence of thrombosis was monitored using abdomin...

journal_title：Thrombosis research

authors： Hwang JH,Chung ML,Lim YJ

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Hemodialysis grafts often fail because of stenosis at the venous anastomosis resulting in thrombosis. Percutaneous intervention involves thrombolysis with plasminogen activators, mechanical removal of thrombus, and angioplasty of the stenotic lesions. OBJECTIVES:This article describes a phase I trial usin...

journal_title：Thrombosis research

authors： Shlansky-Goldberg R

更新日期：2008-01-01 00:00:00

abstract：:Severe rejection crises occurred in 13 out of 20 cadaver kidney recipients; removal of the graft was inevitable in 10 cases. The plasminogen levels were found to be lower (76.5 +/- 2.9%) in the 13 patients with impaired graft acceptance (group B) than in the 7 patients experiencing only moderate rejection (group A, 93...

journal_title：Thrombosis research

authors： Seitz R,Michalik R,Karges HE,Lange H,Egbring R

更新日期：1986-05-01 00:00:00

abstract：:The presence of Factor XIII subunit a was demonstrated in human monocytes by immunoperoxidase staining using specific antisera against Factor XIII and its subunits. This finding was verified by immunobiochemical techniques, as well. In an immunoblotting system after SDS polyacrylamide gel electrophoresis of denatured ...

journal_title：Thrombosis research

authors： Muszbek L,Adány R,Szegedi G,Polgár J,Kávai M

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Miniplasmin was a des-kringle variant of plasminogen with potential pharmacological application. We investigated the thrombolytic effect of miniplasmin in a canine model of femoral artery thrombosis. METHODS:In anesthetized dogs, a stable occlusive thrombus was formed by mechanical and electroly...

journal_title：Thrombosis research

authors： Fu J,Ren J,Zou L,Bian G,Li R,Lu Q

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Serious bleeding is a frequent and feared treatment complication in patients treated with oral anticoagulants (OACs). Levels of von Willebrand factor (VWF) antigen have been linked to the risk of bleeding complications, mortality, and cardiovascular events. OBJECTIVES:In this longitudinal cohort study of ev...

journal_title：Thrombosis research

authors： Lind M,Johansson L,Nilsson TK,Jansson JH,Hollestelle MJ

更新日期：2015-11-01 00:00:00

abstract：:Megakaryocyte colony formation was increased in 13 patients with ITP. Out of splenectomized ITP patients Colony Forming Unit-Megakaryocyte (CFU-Mk) number normalized in four but was lower than normal in the remaining two. The proportion of immature megakaryocytes was higher in ITP than in normals or in ITP patients af...

journal_title：Thrombosis research

authors： Podolak-Dawidziak M

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Plasminogen activator inhibitor type-1 (PAI-1) is considered to be the main inhibitor of fibrinolysis in sepsis. However, the contribution of TAFI to the inhibition of fibrinolysis in sepsis is currently unknown. METHODS:TAFI antigen and PAI-1 levels were measured in severe sepsis (n = 32) and septic shock ...

journal_title：Thrombosis research

authors： Zeerleder S,Schroeder V,Hack CE,Kohler HP,Wuillemin WA

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:In the pathogenesis of sepsis-induced acute lung injury (ALI), the crosstalk between inflammation and coagulation plays a pivotal role. The aim of this study was to investigate the role of Rho kinase (ROCK) inhibitor in alleviating pulmonary inflammation and coagulation in lipopolysaccharide (LPS)-induced ...

journal_title：Thrombosis research

authors： Ding R,Zhao D,Li X,Liu B,Ma X

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:Previous studies have suggested the used of off-label recombinant factor VII (rFVIIa) increases the risk of thromboembolic events, but the effect of the dose of rFVIIa is not well described in the literature. MATERIALS AND METHODS:All adult patients that received off-label rFVIIa from 2005-2012 were inclu...

journal_title：Thrombosis research

authors： Bucklin MH,Acquisto NM,Nelson C

更新日期：2014-05-01 00:00:00

abstract：:The effects of extracellular sodium on platelet aggregation and calcium mobilization in platelets stimulated with either rattlesnake (Crotalus atrox) lectin (RSL) or alpha-thrombin were compared. The absence of extracellular sodium had no effect on platelet aggregation or calcium mobilization in response to all levels...

journal_title：Thrombosis research

authors： Wilson-Byl JA,Dockter ME,Gartner TK

更新日期：1991-11-01 00:00:00

abstract：:The heparin-derived oligosaccharide C3 (C3) is currently underdevelopment for the prevention and treatment of vascular dementia and senile dementia of Alzheimer's type. C3 exhibits a molecular weight of 2200-2500 Da with a narrow distribution. The objective of the present study was to assess the pharmacodynamics and p...

journal_title：Thrombosis research

authors： Ma Q,Schultz C,Neville B,Jeske W,Hoppensteadt D,Cornelli U,Lee J,Lorens S,Hanin I,Fareed J

更新日期：2003-01-01 00:00:00

abstract：:Lipoprotein-Associated Coagulation Inhibitor (LACI) is a factor Xa dependent inhibitor of the factor VII(a)/Tissue Factor catalytic complex. Deduced from partial cDNA sequence, LACI's amino acid sequence has recently been reported. Northern blot analysis showed LACI cDNA hybridizes to RNAs of 1.4 and 4.0 kb in size. T...

journal_title：Thrombosis research

authors： Girard TJ,Warren LA,Novotny WF,Bejcek BE,Miletich JP,Broze GJ Jr

更新日期：1989-07-01 00:00:00

abstract：:The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific ...

journal_title：Thrombosis research

authors： Hoffmeister KM,Falet H

更新日期：2016-05-01 00:00:00

abstract：:Using an ACL 300R coagulometer (Instrumentation Laboratory) we assessed the clinical usefulness of a new method to measure PS activity (PS:Act), based on the prolongation of prothrombin time of a mixture of diluted plasma sample, PS depleted plasma previously incubated with Protac for protein C activation, bovine thro...

journal_title：Thrombosis research

authors： Maccaferri M,Legnani C,Preda L,Palareti G

更新日期：1991-12-15 00:00:00

abstract：:Bone marrow transplantation (BMT) is the only curable option for thalassemia major, β-thalassemia/HbE. However, some patients still have the risk of hypercoagulable complications. We used a whole blood flow cytometric analysis to measure the circulating microparticle (MP) levels, activated platelets, and leukocyte-pla...

journal_title：Thrombosis research

authors： Klaihmon P,Lertthammakiat S,Anurathapan U,Pakakasama S,Sirachainan N,Hongeng S,Pattanapanyasat K

更新日期：2018-09-01 00:00:00

abstract：:A new method, based on the observation that leukocytes contain PGI2-synthetase activity, was used to measure the effect of pharmacological levels of sulphinpyrazone on the TXA2 and PGI2 production in whole blood. Four human volunteers took 400 mg sulphinpyrazone twice daily for 5 1/2 days. Blood was drawn before the s...

journal_title：Thrombosis research

authors： Badenhorst PN,Deckmyn H,Vermylen J

更新日期：1982-10-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a lipid mediator generated by activated platelets and having various effects on numerous cell types. We investigated some effects of 1-oleyl LPA on vascular smooth muscle cells cultured from adult human normal arteries. At micromolar concentrations, LPA induced a mitogenic effect ([3H]-t...

journal_title：Thrombosis research

authors： Gennero I,Xuereb JM,Simon MF,Girolami JP,Bascands JL,Chap H,Boneu B,Sié P

更新日期：1999-06-01 00:00:00

abstract：:Endothelial cells from human umbilical vein were incubated in vitro with thrombin in the absence or presence of unfractionated heparin (UFH), low molecular weight heparin (LMWH) or dermatan sulfate (DS) to clarify the effect of these glycosaminoglycans on thrombin-stimulated prostaglandin I2 (PGI2) production. Althoug...

journal_title：Thrombosis research

authors： Itoh F,Kaji T,Hayakawa Y,Oguma Y,Sakuragawa N

更新日期：1990-02-15 00:00:00

abstract：:HC II functional assays are generally preferred with respect to immunochemical assays. Nevertheless functional assays can be biased by the antithrombin III (AT III)-heparin complex activity; in fact trace amounts of heparin generally contaminate dermatan sulfate (DS) commercial preparations used as HC II reaction acti...

journal_title：Thrombosis research

authors： Ruzzenente O,Ghidini R,Poli G,Schiavon R,Guidi GC

更新日期：1992-01-15 00:00:00

abstract：:The three polypeptide chains of fibrinogen, A alpha, B beta and gamma chain, are synthesized on separate polysomes. Fully formed fibrinogen is a six chain, disulfide-linked, dimeric molecule with a molecular weight of 340kDa. Previous pulse-chase studies with L-35 S methionine using the human hepatocellular carcinoma ...

journal_title：Thrombosis research

authors： Yu S,Kong V,Kudryk B,Redman C

更新日期：1987-04-15 00:00:00

abstract：:The candidate-gene approach can be used to locate and identify genetic variations that are associated with a particular phenotype. This gene-centric approach assumes that there exists important genetic variation within genes that can influence health. Identifying known genes which are candidates for the phenotype of i...

journal_title：Thrombosis research

authors： Smith NL,Rice KM,Lumley T,Heckbert SR,Psaty BM

更新日期：2009-01-01 00:00:00

abstract：:Homocystinuria due to cystathionine-beta-synthase deficiency (CBS-def-HOCY) initially often presents with vascular disorders, e.g. thromboembolic events. The measurement of vascular endothelial markers in plasma could help to assess endothelial damage. We determined von Willebrand factor (measured as Ristocetincofacto...

journal_title：Thrombosis research

authors： Schienle HW,Seitz R,Nawroth P,Rohner I,Lerch L,Krumpholz B,Krauss G,Fowler B,Baumgartner R,Willenbockel U

更新日期：1995-01-01 00:00:00

abstract：UNLABELLED:We undertook a survey of French university hospital hematological laboratories to ascertain the clinical characteristics of patients with suspected HIT, the laboratory tests performed, and the therapeutic strategy adopted in current practice. METHODS:A standardized medical records database for patients with...

journal_title：Thrombosis research

authors： Bidet A,Tardy Poncet B,Desprez D,de Maistre E,Presles E,Lecompte T,Lavenu-Bombled C,Huisse MG,Wolf M,Morange P,Racadot E,Mouton C,Grunebaum L,Pouplard C,Tardy B,GEHT-HIT study group.

更新日期：2010-06-01 00:00:00

abstract：AIMS:acutely ill medical patients are at increased risk of venous thromboembolism (VTE) and often require thromboprophylaxis, but patient selection and adequate therapeutic decisions may be difficult due to the heterogeneity and the complexity of this population. We conducted a survey among a large cohort of Italian ph...

journal_title：Thrombosis research

authors： Dentali F,Pomero F,La Regina M,Orlandini F,Turato S,Mazzone A,Nozzoli C,Fontanella A,Ageno W,Agnelli G,Campanini M

更新日期：2014-09-01 00:00:00

abstract：:Platelet aggregate size was determined with a newly-developed platelet aggregometer, PA-100 (KOWA), which can quantitatively evaluate the size and number of platelet aggregates by means of the particle counting method based upon light scattering. Epinephrine-induced platelet aggregation consists of two phases, the for...

journal_title：Thrombosis research

authors： Satoh K,Ozaki Y,Qi R,Yang L,Asazuma N,Yatomi Y,Kume S

更新日期：1996-03-01 00:00:00

abstract：:COVID-19 has been associated with an increased risk of thrombotic events; however, the reported incidence of deep vein thrombosis varies depending, at least in part, on the severity of the disease. Aim of this prospective, multicenter, observational study was to investigate the incidence of lower limb deep vein thromb...

journal_title：Thrombosis research

authors： Pancani R,Villari L,Foci V,Parri G,Barsotti F,Patrucco F,Malerba M,Vincenti R,Carrozzi L,Celi A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Although risk of hospital-associated venous thromboembolism (HA-VTE) differs between critically and non-critically ill children, studies to date have not led to distinct, pragmatic risk scores. OBJECTIVE:To determine risk factors for HA-VTE in critically ill children not undergoing cardiothoracic surgery, i...

journal_title：Thrombosis research

authors： Arlikar SJ,Atchison CM,Amankwah EK,Ayala IA,Barrett LA,Branchford BR,Streiff MB,Takemoto CM,Goldenberg NA

更新日期：2015-10-01 00:00:00

abstract：:The multiligand receptor, low density lipoprotein receptor-related protein (LRP), is implicated in processes such as atherosclerosis and fibrinolysis through its mediation of the catabolism of lipoproteins, proteases, and protease inhibitor complexes. The hepatoma cell line Hep G2 expresses LRP and has been used widel...

journal_title：Thrombosis research

authors： Grimsley PG,Quinn KA,Chesterman CN,Owensby DA

更新日期：1997-12-15 00:00:00