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Clinical characteristics and laboratory testing of patients with suspected HIT: a survey on current practice in 11 university hospitals in France.

Abstract：

UNLABELLED:We undertook a survey of French university hospital hematological laboratories to ascertain the clinical characteristics of patients with suspected HIT, the laboratory tests performed, and the therapeutic strategy adopted in current practice. METHODS:A standardized medical records database for patients with suspected HIT was sent to 19 laboratories. During two months, all consecutive patients for whom a biological test was performed were included. RESULTS:169 patients were included, 27 (16%) patients having a final diagnosis of HIT. At the time HIT was suspected, the heparin duration and the level of thrombocytopenia were similar in HIT- positive and HIT-negative groups. The use of unfractionated heparin, a therapeutic heparin dose regimen and the presence of thrombotic complications were significantly more frequent in HIT-positive patients. When the heparin dose regimen was taken into account, only thrombotic complications under a therapeutic dose regimen were significantly increased in HIT-positive patients. Eighty-six percent of patients presented at least one alternative diagnosis of thrombocytopenia without significant difference between the two groups. Laboratory tests were performed after a mean of 0.3days and mainly consisted of antigen assays. At the time HIT was suspected, heparin was stopped in 56 (33%) patients, being replaced mainly by danaparoid. Only three laboratories declared they usually received all the necessary clinical information to establish the likelihood of HIT. CONCLUSION:In current practice in France, the clinical probability of HIT is rarely established, leading to systematic requests for laboratory HIT tests.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Bidet A,Tardy Poncet B,Desprez D,de Maistre E,Presles E,Lecompte T,Lavenu-Bombled C,Huisse MG,Wolf M,Morange P,Racadot E,Mouton C,Grunebaum L,Pouplard C,Tardy B,GEHT-HIT study group.

doi

10.1016/j.thromres.2010.02.003

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

e294-9

issue

eissn

0049-3848

issn

1879-2472

pii

S0049-3848(10)00130-1

journal_volume

125

pub_type

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Clinical characteristics and laboratory testing of patients with suspected HIT: a survey on current practice in 11 university hospitals in France.