Thromboembolic complications several days after a single-dose administration of aspirin.

abstract：:An unfractionated heparin (UFH) and a depolymerised derivative of low molecular weight heparin (LMWH) have been compared for their ability to activate platelets suspended in citrated plasma (PRP) or after washing and suspension in hepes buffered tyrode containing fibrinogen. Neither heparin alone induced aggregation o...

journal_title：Thrombosis research

authors： Westwick J,Scully MF,Poll C,Kakkar VV

更新日期：1986-05-15 00:00:00

abstract：:The presence of one acidifying Cl-/HCO3- exchange mechanism in human platelets has not been previously reported. This paper demonstrates that this mechanism does function and that it increases its activity after stimulation with thrombin. On resuspension of BCECF-loaded platelets in a chloride-free medium (gluconate r...

journal_title：Thrombosis research

authors： Gende OA

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Tissue factor (TF) pathway inhibitor (TFPI) is the physiological inhibitor of TF induced blood coagulation and two isoforms exists, TFPIα and TFPIβ. In atherosclerotic plaques, TFPI may inhibit TF activity and thrombus formation, which is the main cause of ischemic stroke in carotid artery disease. We aime...

journal_title：Thrombosis research

authors： Stavik B,Holm S,Espada S,Iversen N,Sporsheim B,Bjerkeli V,Dahl TB,Sandset PM,Skjelland M,Espevik T,Skretting G,Halvorsen B

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Ambient particulate matter (PM) is associated with cardiovascular morbidity and mortality. It has been proposed that PM induces a pro-thrombotic process, increasing the risk of cardiovascular events, with some support from epidemiological and laboratory-based models. Diesel exhaust is a major contributor to ...

journal_title：Thrombosis research

authors： Carlsten C,Kaufman JD,Peretz A,Trenga CA,Sheppard L,Sullivan JH

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Pregnancy has recently been described as a generalized intravascular inflammatory response to the conceptus. Total fibrinogen concentrations increase during pregnancy. The percentage high molecular weight fibrinogen (HMW-Fg) of the concentration total fibrinogen is known to increase during acute-phase cond...

journal_title：Thrombosis research

authors： Manten GT,Franx A,Sikkema JM,Hameeteman TM,Visser GH,de Groot PG,Voorbij HA

更新日期：2004-01-01 00:00:00

abstract：:Contact angle measurements, histological examinations and platelet adhesion tests on native and glutaraldehyde-treated porcine aortic valve leaflets, are reported. Contact angles measured with water or saline on native and treated leaflets do not differ appreciably. Values of less than 10 degrees for both the dry and ...

journal_title：Thrombosis research

authors： Hum OS,Ghista DN,Brash JL

更新日期：1985-04-15 00:00:00

abstract：:The effect of a low molecular weight heparin (Fragmin) (20-80 U/kg) was studied in 10 healthy male volunteers after intravenous administration. Clotting abnormalities are extensive shortly after injection, lasting for 1-2 hours depending on heparin dosage. Dilute thrombin time, showing a close correlation to anti-F-Xa...

journal_title：Thrombosis research

authors： Andrassy K,Mörike K,Koderisch J,Weber E

更新日期：1988-03-15 00:00:00

abstract：:Plasma from patients with thrombotic thrombocytopenic purpura (TTP) caused the aggregation of washed human platelets, which was inhibited by preincubation with normal plasma. Using salt fractionation, ion exchange chromatography, and preparative agarose gel electrophoresis, we purified a protein from normal plasma whi...

journal_title：Thrombosis research

authors： Lian EC,Mui PT,Siddiqui FA,Chiu LL

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Sampling small volumes of blood may be necessary, particularly in pediatric patients, or in case of difficult or recurrent venipunctures. METHODS:Routine hemostasis test results evaluated in partial- and full-draw evacuated polymer tubes obtained in 4 centers were compared. RESULTS:No relevant discrepancy ...

journal_title：Thrombosis research

authors： Toulon P,Abecassis L,Smahi M,Ternisien C

更新日期：2010-12-01 00:00:00

abstract：:In this study, the role of platelets in the human erectile response was assessed. Twenty patients with erectile dysfunction were studied by means of (111)In-oxine-platelets and blood pool imaging using 99mTc. Seventeen patients received intracavernously prostaglandin E1, and three patients received papaverine together...

journal_title：Thrombosis research

authors： Rodrigues M,O'Grady J,Stackl W,Granegger S,Sinzinger H

更新日期：1998-07-15 00:00:00

abstract：INTRODUCTION:Thrombomodulin (TM) has been described as a marker of endothelial injury in atherosclerosis. The role of TM as a predictor of PAD severity is to be proven. The goal of the present study is to compare the level of plasmatic (TMp) in patients with intermittent claudication with patients with critical ischemi...

journal_title：Thrombosis research

authors： Nasser M,Wolosker N,Uint L,Rosoky RA,Lobato M,Wajngarten M,Puech-Leao P

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The effects of multiple inherited and acquired thrombophilic defects on the outcome of in-vitro fertilization (IVF) remain unexplored. The aim of this study was to evaluate the association between multiple thrombophilia and clinical outcomes in a large prospective cohort of women undergoing IVF. MATERIALS...

journal_title：Thrombosis research

authors： Di Nisio M,Ponzano A,Tiboni GM,Guglielmi MD,Rutjes AWS,Porreca E

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:Unfractionated heparin (UFH) potentiates platelet aggregation induced by some agonists. P2Y12 and P2Y1 receptors play a major role in amplifying platelet aggregation. We assessed the ability of cangrelor, a selective P2Y12 antagonist, A2P5P, a selective P2Y1 antagonist, and aspirin to block the potentiatin...

journal_title：Thrombosis research

authors： Storey RF,May JA,Heptinstall S

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Clinical trials have provided evidence about efficacy and safety of extended thromboprophylaxis among total hip replacement (THR) patients. There is a lack of evidence on effectiveness and safety of extended treatment in unselected patients from routine clinical practice. We examined the effectiveness and ...

journal_title：Thrombosis research

authors： Pedersen AB,Sorensen HT,Mehnert F,Johnsen SP,Overgaard S

更新日期：2015-02-01 00:00:00

abstract：:Ca2+ influx and efflux in unstimulated platelets and Ca2+ uptake by simultaneously isolated two membrane fractions of platelets from patients with myeloproliferative disorders (MPD) have been investigated. In MPD, Ca2+ influx and efflux across the plasma membrane in unstimulated platelets were in equilibrium at signif...

journal_title：Thrombosis research

authors： Fujimoto T,Fujimura K,Kuramoto A

更新日期：1989-01-15 00:00:00

abstract：OBJECTIVES:Screening of patients with sepsis for disseminated intravascular coagulation (DIC) has been recommended in several guidelines. However, DIC screening is still not widely accepted as an essential component of sepsis management, partly because of a lack of evidence that DIC screening has an effect on mortality...

journal_title：Thrombosis research

authors： Umemura Y,Yamakawa K,Hayakawa M,Hamasaki T,Fujimi S,Japan Septic Disseminated Intravascular Coagulation (J-Septic DIC) study group.

更新日期：2018-01-01 00:00:00

abstract：:Cardiovascular diseases (CVD) remain a leading cause of death worldwide. In the past years new biomarkers have drawn the clinician's attention for their use in primary prevention and in the identification of individuals at cardiovascular risk. Biomarkers also provide information on the progression and possible recurre...

journal_title：Thrombosis research

authors： Badimon L,Romero JC,Cubedo J,Borrell-Pagès M

更新日期：2012-10-01 00:00:00

abstract：:Chloroquine inhibited aggregation of rat blood platelets in a dose-dependent way. The inhibitory effect decreased, depending on the aggregation stimulus used, in the rank order of potency: ADP > thrombin > A23187. Effect of 1 millimolar chloroquine on A23187-stimulated aggregation was significantly decreased or comple...

journal_title：Thrombosis research

authors： Jancinová V,Nosál R,Petríková M

更新日期：1994-06-01 00:00:00

abstract：:The cerebral vascular supply is constructed to protect the cerebral hemispheres and brainstem from the consequences of blood flow cessation. Reversal of blood flow around local obstructions is a feature of the microvascular beds of the striatum and cerebral cortex. Cerebral capillaries of these beds consist of endothe...

journal_title：Thrombosis research

authors： del Zoppo GJ,Hallenbeck JM

更新日期：2000-05-01 00:00:00

abstract：:[3H]-Platelet activating factor (Paf-acether, 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine) binds to washed human platelets in a specific, dose-dependent, and saturable manner. Scatchard analysis reveals a high affinity site with a KD value of 0.25 +/- 0.033 nM (245 +/- 30 sites per platelet), and a second low a...

journal_title：Thrombosis research

authors： Wade PJ,Lunt DO,Lad N,Tuffin DP,McCullagh KG

更新日期：1986-01-15 00:00:00

abstract：:Collagen-induced platelet aggregation and secretion (ATP-release) in whole-blood and platelet-rich plasma was compared. Although the amount of ATP released was comparable in whole-blood and platelet-rich plasma, the maximum extent of aggregation was greater when platelets were studied in their natural milieu, i.e. who...

journal_title：Thrombosis research

authors： Joseph R,Welch KM,D'Andrea G,Riddle JM

更新日期：1989-03-01 00:00:00

abstract：INTRODUCTION:Though thrombin-activatable fibrinolysis inhibitor (TAFI) may contribute to hypercoagulability during pregnancy, limited data are available on the role of TAFI in women with recurrent fetal loss. MATERIAL/METHODS:We performed a case-control study aimed at evaluating any possible association between TAFI l...

journal_title：Thrombosis research

authors： Legnani C,Bovara M,Valdrè L,Cosmi B,Caniato A,Palareti G

更新日期：2012-08-01 00:00:00

abstract：:The proteinase, brinase (Mr approximately 35000), from Aspergillus oryzae, which has been used in therapeutic attempts as a thrombolytic agent in arterial thrombosis, binds to purified human alpha 2-macroglobulin (alpha 2M) with a stoichiometry of 1.7-1.9 mol of enzyme/mol inhibitor. This binding leads to quantitative...

journal_title：Thrombosis research

authors： Larsson LJ,Frisch EP,Törneke K,Lindblom T,Björk I

更新日期：1988-01-01 00:00:00

abstract：:The effect of activated protein C (APC) on agonist-induced platelet activation and on thrombin generation after intrinsic (IA) and extrinsic (EA) activation of the coagulation system was studied by flow cytometry and by measuring levels of prothrombin fragment F1+2. In platelet activation studies blood drawn from heal...

journal_title：Thrombosis research

authors： Kaiser B,Jeske W,Hoppensteadt DH,Walenga JM,Drohan W,Fareed J

更新日期：1997-07-15 00:00:00

abstract：:Interaction with circulating platelets is considered an important virulent mechanism for Staphylococcus aureus (S. aureus) bacteria to induce endocarditis, a severe infectious disease with high incidence of systemic thrombosis. It therefore represents an important target for pharmacological intervention. In this study...

journal_title：Thrombosis research

authors： Liu CZ,Huang HY,Tsai PJ,Shih MH

更新日期：2005-01-01 00:00:00

abstract：:We investigated on how to effectively administer orally factor VIII preparation to two patients with von Willebrand's disease as volunteers, and the following results were obtained: Bleeding time and aPTT were shortened, but no change of PT was observed. Factor VIII:C increased slightly, but no significant increase wa...

journal_title：Thrombosis research

authors： Sakuragawa N,Niiya K,Kondo S

更新日期：1985-06-15 00:00:00

abstract：:Lp(a) lipoprotein contains a unique apolipoprotein, apolipoprotein (a), that has a striking homology with plasminogen. This homology has brought forward speculations as to an inhibitory effect of Lp(a) lipoproteins on fibrinolysis. The present investigation was undertaken to study the influence of Lp(a) lipoprotein on...

journal_title：Thrombosis research

authors： Halvorsen S,Skjønsberg OH,Berg K,Ruyter R,Godal HC

更新日期：1992-11-01 00:00:00

abstract：:The enzymatic and fibrinolytic properties of glycosylated and nonglycosylated recombinant human pro-urokinase (pro-UK) produced in yeast Pichia pastoris were characterized and compared with those of Escherichia coli and mammalian cell-derived pro-UK. Among the five different forms of pro-UK, the yeast glycosylated pro...

journal_title：Thrombosis research

authors： Wang P,Zhang J,Sun Z,Chen Y,Gurewich V,Liu JN

更新日期：2000-12-01 00:00:00

abstract：:Thrombin-activatable fibrinolysis inhibitor (TAFI), also known as procarboxypeptidase U or plasma procarboxypeptidase B, is a relatively recently described plasma glycoprotein synthesised in the liver. It can be activated into active enzyme TAFIa (carboxypeptidase U or plasma carboxypeptidase B) by a complex of thromb...

journal_title：Thrombosis research

authors： Antovic JP,Blombäck M

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Plasma coagulation Factor XII (FXII) plays a crucial role in contact activation, ultimately regulating both the kinin-kallikrein system and the intrinsic pathway of coagulation. A growing body of evidence suggests that inhibition of FXII can prevent thrombosis. Given FXII does not appear to modulate hemostas...

journal_title：Thrombosis research

authors： Liu J,Cooley BC,Akinc A,Butler J,Borodovsky A

更新日期：2020-12-01 00:00:00