Effects of desmopressin and dextran on coagulation and fibrinolysis in healthy volunteers.

Abstract:

:The effects of desmopressin and dextran on haemostasis and fibrinolysis were studied in four healthy volunteers. Both drugs were compared to placebo, each volunteer being subject to four experiments. Dextran 70 (30 g i.v.) moderately decreased VIII:C and vWF:Ag and slightly increased antithrombin III, also when haemodilution and diurnal variation were considered. Desmopressin (0.3 micrograms/kg BW i.v.), alone as well as in combination with dextran, increased VIII: C, vWF:Ag, protein C and tPA and decreased PAI-1. The combination of desmopressin and dextran stimulated coagulation and fibrinolysis and might be of relevance to surgical blood loss as well as to postoperative thromboembolism.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Flordal PA,Svensson J,Ljungström KG

doi

10.1016/0049-3848(91)90009-l

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

355-64

issue

5

eissn

0049-3848

issn

1879-2472

journal_volume

62

pub_type

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