Acute hypoxemia does not increase blood fibrinolytic activity in man.

abstract：OBJECTIVE:To investigate the mechanism underlying the hypercoagulable state in severe pre-eclampsia. METHODS:Plasma tissue factor (TF) and tissue factor pathway inhibitor (TFPI) expression from pre-eclampsia patients and healthy pregnant controls were determined by ELISA. Placental TF and TFPI gene and protein express...

journal_title：Thrombosis research

authors： Teng Y,Jiang R,Lin Q,Ding C,Ye Z

更新日期：2010-07-01 00:00:00

abstract：:The present study was designed to find out whether the synthetic pentasaccharide SR 90107A/Org 31540, which is presently being evaluated in clinical trials as an antithrombotic agent, influences lipoprotein metabolism in rats as determined by plasma triglyceride (TG) lipase activity. A comparison with three clinically...

journal_title：Thrombosis research

authors： Hoffmann P,Bernat A,Dumas A,Petitou M,Hérault JP,Herbert JM

更新日期：1997-05-15 00:00:00

abstract：:Four calcium channel blockers (nimodipine, nifedipine, verapamil and diltiazem) of three chemical classes were tested in vitro for inhibition of platelet aggregation using heparinized human platelet rich plasma. Both ADP- and thrombin-induced aggregation were inhibited as was the biosynthesis of thromboxane A2 in resp...

journal_title：Thrombosis research

authors： Onoda JM,Sloane BF,Honn KV

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Bypassing agents are the first line therapy in patients with acquired haemophilia A (AHA). Activated prothrombin complex concentrate (aPCC) proved to be effective as initial treatment, but 20% of patients (pts) had relapses. aPCC as short-term prophylaxis to reduce subsequent bleeds is still not clear. AIM:...

journal_title：Thrombosis research

authors： Zanon E,Pasca S,Siragusa S,Napolitano M,Santoro C,Mameli L,Rocino A,FAIR Study Group.

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:There is some controversy regarding the effect of CYP2C19 polymorphism on clinical outcome in patients with dual antiplatelet therapy. Chronic kidney disease (CKD) is associated with increased risk of cardiovascular event, but the association between the possession of CYP2C19 loss-of-function (LOF) alleles...

journal_title：Thrombosis research

authors： Tabata N,Hokimoto S,Akasaka T,Arima Y,Kaikita K,Kumagae N,Morita K,Miyazaki H,Oniki K,Nakagawa K,Matsui K,Ogawa H

更新日期：2014-11-01 00:00:00

abstract：:[3H]-Platelet activating factor (Paf-acether, 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine) binds to washed human platelets in a specific, dose-dependent, and saturable manner. Scatchard analysis reveals a high affinity site with a KD value of 0.25 +/- 0.033 nM (245 +/- 30 sites per platelet), and a second low a...

journal_title：Thrombosis research

authors： Wade PJ,Lunt DO,Lad N,Tuffin DP,McCullagh KG

更新日期：1986-01-15 00:00:00

abstract：:Plasma from patients with thrombotic thrombocytopenic purpura (TTP) caused the aggregation of washed human platelets, which was inhibited by preincubation with normal plasma. Using salt fractionation, ion exchange chromatography, and preparative agarose gel electrophoresis, we purified a protein from normal plasma whi...

journal_title：Thrombosis research

authors： Lian EC,Mui PT,Siddiqui FA,Chiu LL

更新日期：1984-01-01 00:00:00

abstract：INTRODUCTION:Pre-eclampsia is an important cause of maternal morbidity and mortality. Its etiology is still unknown. Clinical symptoms correlate with activation of coagulation and inherited thrombophilia has been associated with pre-eclampsia. ABO blood group has been associated with thrombotic disorders and pre-eclamp...

journal_title：Thrombosis research

authors： Hiltunen LM,Laivuori H,Rautanen A,Kaaja R,Kere J,Krusius T,Paunio M,Rasi V

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:The recanalization rate in patients with deep venous thrombosis (DVT) of the legs treated with the direct oral anticoagulants (DOAC) is unknown. METHODS:In an Italian cohort, we investigated the rate of residual vein thrombosis (RVT) after three and/or six months in 352 patients with proximal DVT who had be...

journal_title：Thrombosis research

authors： Prandoni P,Ageno W,Mumoli N,Zanatta N,Imberti D,Visonà A,Ciammaichella M,Simioni L,Cappelli R,Bucherini E,Di Nisio M,Avruscio G,Camporese G,Parisi R,Cuppini S,Turatti G,Noventa F,Sarolo L

更新日期：2017-05-01 00:00:00

abstract：:The role of free radical generation and its scavenging enzymes in circulating mice polymorphonuclear leukocytes (PMNLs) has been studied following pulmonary thromboembolism. Levels of malonaldehyde (MDA), 02- radical generation, activity of superoxide dismutase (SOD), catalase (CAT), lactate dehydrogenase (LDH), myelo...

journal_title：Thrombosis research

authors： Dikshit M,Kumari R,Srimal RC

更新日期：1992-05-01 00:00:00

abstract：INTRODUCTION:Electronic consultations (eConsults) are asynchronous, consultative electronic-based communications that are aimed to improve efficient and timely access to specialist advice. Our study aim was to evaluate the use and impact of the Canadian Champlain BASE™ (Building Access to Specialists through eConsultat...

journal_title：Thrombosis research

authors： Skeith L,Mohamed M,Karovitch A,Liddy C,Afkham A,Archibald D,Keely E

更新日期：2017-12-01 00:00:00

abstract：:Hemorrhagic and thrombotic complications are common in the term and preterm infant. Limited information is currently available about neonatal platelet structure and function, and how these may predispose infants to bleeding problems. This study comparing platelet ultrastructure of 71 different term and preterm infants...

journal_title：Thrombosis research

authors： Saving KL,Jennings DE,Aldag JC,Caughey RC

更新日期：1994-03-15 00:00:00

abstract：:Understanding the intracellular events triggered by antiphospholipid (aPL) antibodies in platelets and endothelial cells (ECs) is important in designing new modalities of targeted therapies for the treatment of thrombosis in Antiphospholipid Syndrome (APS). A recent study showed a significant increase in the expressio...

journal_title：Thrombosis research

authors： Pierangeli SS,Vega-Ostertag M,Harris EN

更新日期：2004-01-01 00:00:00

abstract：:The present investigation has used an aggregation-disaggregation-reaggregation model to determine if exposure to potent aggregating agents causing a refractory state in deaggregated platelets results in down-regulation and clearance of GPIb/IX, the receptor for von willebrand factor. Thrombin, the thrombin receptor ac...

journal_title：Thrombosis research

authors： White JG,Rao GH

更新日期：1996-11-15 00:00:00

abstract：:Epsilon-amino-caproic acid (EACA) induces a clinically-useful anti-haemorrhagic, mildly thrombotic state while ellagic acid (EA) induces a severe hypercoagulable one. Reversal of these states may on occasion be necessary. The effectiveness of the antiplatelet drugs, aspirin and dipyridamole (ASA/D), in reducing thromb...

journal_title：Thrombosis research

authors： Iomhair MM,Lavelle SM

更新日期：1996-06-15 00:00:00

abstract：:Individuals with more than one defect in the natural anticoagulant system exhibit an increased risk for thrombosis. We report on a family with two cases of combined protein C (PROC) and protein S (PROS) deficiency, five cases of isolated PROC deficiency Type I, and two cases of isolated PROS deficiency Type I. PROC an...

journal_title：Thrombosis research

authors： Knoll B,Hach-Wunderle V,Rieger S,Häring D,Mannhalter C

更新日期：2001-07-01 00:00:00

abstract：:It has been found in our laboratory that compression induces disaggregation and decompression induces aggregation of human platelets. The experimental design was based on the premise that oppositely charged amino acid residues of fibrinogen are juxtaposed in the specific adhesive site(s). This can be explained by the ...

journal_title：Thrombosis research

authors： Murayama M

更新日期：1987-03-15 00:00:00

abstract：:The immunoglobulin superfamily member EMMPRIN (CD147) plays an important role in a number of organ systems, including the cardiovascular system. Here we review the contemporary understanding of EMMPRIN and EMMPRIN-associated sequelae in the course of atherosclerosis. A significant body of data documents the pivotal ro...

journal_title：Thrombosis research

authors： Joghetaei N,Stein A,Byrne RA,Schulz C,King L,May AE,Schmidt R

更新日期：2013-06-01 00:00:00

abstract：:Pregnancy induces several haemostatic perturbations. Some authors described possible acquired activated protein C resistance (APCR) during normal pregnancy. We wanted to test this possibility and to evaluate if this acquired APCR might contribute to the known increased tendency to thrombosis associated with pregnancy....

journal_title：Thrombosis research

authors： Schlit AF,Col-De Beys C,Moriau M,Lavenne-Pardonge E

更新日期：1996-11-01 00:00:00

abstract：:The effect of red wine drinking was tested on fibrinolytic parameters and blood cells in nine healthy students at rest and after acute exercise. The subjects were randomly assigned in a crossover design to one of three treatment regimes: control situation, low-dose wine group, and high-dose wine group. Blood samples w...

journal_title：Thrombosis research

authors： Johansen KM,Skorpe S,Olsen JO,Osterud B

更新日期：1999-12-01 00:00:00

abstract：INTRODUCTION:Conventional Vacutainer® Sodium Citrate blood collection tubes contain a relatively high concentration of contaminating magnesium ions, which may result in shortening of the prothrombin time (PT) and the International Normalized Ratio (INR). Recently the manufacturer of Vacutainer® Sodium Citrate tubes int...

journal_title：Thrombosis research

authors： van den Besselaar AM,van Vlodrop IJ,Berendes PB,Cobbaert CM

更新日期：2014-07-01 00:00:00

abstract：:A synthetic xanthone derivative, 3-[2-(cyclopropylamino)ethoxy] xanthone (CPEX), was investigated for its antiplatelet activities in washed rabbit platelets and human platelet-rich plasma. CPEX inhibited concentration-dependently the aggregation and ATP release of rabbit platelets caused by arachidonic acid (AA; 100 m...

journal_title：Thrombosis research

authors： Chen WY,Ko FN,Lin CN,Teng CM

更新日期：1994-07-01 00:00:00

abstract：:Diabetes mellitus (DM) is associated with platelet and leukocyte dysfunction. Previous observations with regard to insulin effects on platelet and leukocyte function are less than consistent. We thus investigated the effects of insulin on platelets and leukocytes, as well as on platelet-leukocyte interactions in whole...

journal_title：Thrombosis research

authors： Hu H,Hjemdahl P,Li N

更新日期：2002-09-01 00:00:00

abstract：:Nineteen patients, (2 adults, 17 children) with inherited bleeding disorders were infused with n-heptane-suspended-heated clotting factor concentrates. Twelve of the nineteen were previously untreated. Six patients were infused with Profilnine Heat-Treated and 13 with Profilate Heat-Treated. Five separate centers part...

journal_title：Thrombosis research

authors： Carnelli V,Gomperts ED,Friedman A,Aledort L,Hilgartner M,Dietrich S,Fedor EJ

更新日期：1987-06-15 00:00:00

abstract：:We investigated the intracellular processes of the shape change in human megakaryoblastic leukemic cells, MEG-01, by platelet agonists. Thrombin induced the formation of many pseudopods. This shape change was also induced by phorbol 12-myristate 13 acetate (TPA) and weakly by Ca2+ ionophore, A23187, but not by ADP, co...

journal_title：Thrombosis research

authors： Goto S,Kobayashi M,Murate T,Hotta T,Hagiwara M,Hoshino T,Hidaka H,Saito H

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Sampling small volumes of blood may be necessary, particularly in pediatric patients, or in case of difficult or recurrent venipunctures. METHODS:Routine hemostasis test results evaluated in partial- and full-draw evacuated polymer tubes obtained in 4 centers were compared. RESULTS:No relevant discrepancy ...

journal_title：Thrombosis research

authors： Toulon P,Abecassis L,Smahi M,Ternisien C

更新日期：2010-12-01 00:00:00

abstract：:Eight patients with femoro-popliteal or sural DVT, confirmed by phlebography, were treated with intravenous Desmin (LMW-dermatan sulphate): on the first day, after an initial i.v. injection of 400 mg, all patients received an infusion of 800 mg in 500 ml of saline, during 24 hours; this infusion was repeated in each o...

journal_title：Thrombosis research

authors： Kretz JG,Chakfe N,Wiesel ML,Grunebaum L,Zamboni V,Palazzini E,Cazenave JP

更新日期：1996-12-15 00:00:00

abstract：:Tissue factor (TF) is an integral membrane glycoprotein that serves as a cofactor for blood coagulation factor VIIa. The induction of TF on the surface of endothelial cells is initiated by various kinds of stimuli including lipopolysaccharide (LPS), interleukin-1 beta (IL-1 beta), and tumor necrosis factor alpha (TNF ...

journal_title：Thrombosis research

authors： Wakita K,Stearns-Kurosawa DJ,Marumoto Y

更新日期：1994-04-15 00:00:00

abstract：BACKGROUND:Clopidogrel, cilostazol, and aspirin were compared in terms of efficacy and safety for primary prevention of stroke in peripheral artery disease (PAD) patients. METHODS:This retrospective cohort study analyzed data contained in the Taiwan National Health Insurance Bureau database for patients treated for PA...

journal_title：Thrombosis research

authors： Lee WH,Chu CY,Hsu PC,Su HM,Lin TH,Voon WC,Lai WT,Sheu SH

更新日期：2013-08-01 00:00:00

abstract：:Enzymatic treatment used for passaging of endothelial cells may induce release of von Willebrand factor (vWF). Decreased ability to replenish intracellular stores results in decreased secretion of vWF in later passages of cells. Since both trypsin and pancreatin complex have been used for passaging endothelial cells, ...

journal_title：Thrombosis research

authors： Lopes AA,Peranovich TM,Maeda NY,Bydlowski SP

更新日期：2001-02-15 00:00:00