Effect of calcium and calcium antagonists on [3H]-Paf-acether binding to washed human platelets.

abstract：:Fibrin is found in most solid tumours, and there is speculation regarding its role in tumour invasion and metastasis. An assay to quantitate fibrin levels in tissues would be a useful preliminary tool in assessing the above. Such an assay to quantitatively detect levels of fibrin in various types of canine tumour was ...

journal_title：Thrombosis research

authors： Raut S,McEvoy F,Gaffney PJ

更新日期：1999-10-01 00:00:00

abstract：:The abnormal Antithrombin-III (AT-III) Toyama has no ability to interact with heparin in the mast cells or heparin-like glycosaminoglycans on the surface of vascular endothelial cells, so that it has low heparin cofactor activity. In the present study, we have measured the binding capacity of 125I-labeled AT-III to cu...

journal_title：Thrombosis research

authors： Saito S,Takahashi K,Sakuragawa N

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Although patients undergoing coronary stenting routinely receive dual antiplatelet treatment to reduce the risk of stent thrombosis, this undesired event still occurs. A suboptimal response to clopidogrel treatment (low responders) has been suggested to contribute to stent thrombosis. In the present study, p...

journal_title：Thrombosis research

authors： Angiolillo DJ,Fernandez-Ortiz A,Bernardo E,Ramírez C,Barrera-Ramirez C,Sabaté M,Hernández R,Moreno R,Escaned J,Alfonso F,Bañuelos C,Costa MA,Bass TA,Macaya C

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Even though thrombocytopenia following transcatheter aortic valve implantation (TAVI) has been described, further investigation of this phenomenon is needed. AIMS:To determine which factors may explain the fall in platelet count that occurs after implantation of a TAVI device, including markers of platele...

journal_title：Thrombosis research

authors： Mitrosz M,Kazimierczyk R,Sobkowicz B,Waszkiewicz E,Kralisz P,Frank M,Piszcz J,Galar M,Dobrzycki S,Musial WJ,Hirnle T,Kaminski KA,Tycinska AM

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Pre-eclampsia is an important cause of maternal morbidity and mortality. Its etiology is still unknown. Clinical symptoms correlate with activation of coagulation and inherited thrombophilia has been associated with pre-eclampsia. ABO blood group has been associated with thrombotic disorders and pre-eclamp...

journal_title：Thrombosis research

authors： Hiltunen LM,Laivuori H,Rautanen A,Kaaja R,Kere J,Krusius T,Paunio M,Rasi V

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:Congenital factor V (FV) deficiency is a rare inherited disorder. Three compound heterozygous missense mutations, Asp68His, His147Arg, and Arg2074Cys, were observed in a Taiwanese patient with moderately severe FV deficiency. METHOD:The novel His147Arg mutation in the A1 domain was investigated by protein...

journal_title：Thrombosis research

authors： Liu HC,Lin TM,Eng HL,Lin YT,Shen MC

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To date, only a few case studies have reported occurrence of thrombosis in patients with VonWillebrand disease (VWD). No studies have looked at its incidence in this patient population. The aim of this study was to test our hypothesis that decreased VonWillebrand factor (VWF) levels confer a protective effect...

journal_title：Thrombosis research

authors： Qureshi W,Hassan S,Dabak V,Kuriakose P

更新日期：2012-11-01 00:00:00

abstract：:The association between blood coagulation and cancer growth and metastatic dissemination is not yet completely understood. In this study we demonstrate that thrombin is capable of enhancing tumor cell adhesive properties and thereby increases tumor cell metastatic potential. Following exposure to alpha-thrombin, Walke...

journal_title：Thrombosis research

authors： Wojtukiewicz MZ,Tang DG,Nelson KK,Walz DA,Diglio CA,Honn KV

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Advances in medical and surgical therapy in children have resulted in increased survival in children with primary illnesses. However, thrombosis is a serious complication of this success and results in mortality and morbidity. Prevention or treatment of thrombosis using warfarin is challenging in children du...

journal_title：Thrombosis research

authors： Bauman ME,Black K,Kuhle S,Wang L,Legge L,Callen-Wicks D,Mitchell L,Bajzar L,Massicotte MP,Western Canadian Children's Heart Network WCCHN.

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:To validate the diagnostic criteria for disseminated intravascular coagulation (DIC) established by the Japanese Association for Acute Medicine (JAAM) at an early stage of trauma and to evaluate the hypothesis that the JAAM criteria can diagnose DIC with a higher sensitivity than the International Society ...

journal_title：Thrombosis research

authors： Sawamura A,Hayakawa M,Gando S,Kubota N,Sugano M,Wada T,Katabami K

更新日期：2009-12-01 00:00:00

abstract：:Because of a thrombasthenia-like platelet aggregation defect, platelets from dogs affected with Basset Hound Hereditary Thrombopathy were compared to normal control dog platelets by three different techniques in order to assess platelet membrane glycoprotein content. Crossed immunoelectrophoresis (CIE), two-dimensiona...

journal_title：Thrombosis research

authors： Patterson WR,Kunicki TJ,Bell TG

更新日期：1986-04-15 00:00:00

abstract：OBJECTIVES:Screening of patients with sepsis for disseminated intravascular coagulation (DIC) has been recommended in several guidelines. However, DIC screening is still not widely accepted as an essential component of sepsis management, partly because of a lack of evidence that DIC screening has an effect on mortality...

journal_title：Thrombosis research

authors： Umemura Y,Yamakawa K,Hayakawa M,Hamasaki T,Fujimi S,Japan Septic Disseminated Intravascular Coagulation (J-Septic DIC) study group.

更新日期：2018-01-01 00:00:00

abstract：:Activation of plasma plasminogen to plasmin is the objective of current strategies for thrombolytic therapy. Although thrombolytic activity in blood involves a large cellular component as well as that in plasma, the contribution of this cellular phase to clinical thrombolysis has not been examined. Using a 125I-fibrin...

journal_title：Thrombosis research

authors： Langleben D,Moroz LA,Schlesinger RD

更新日期：1990-07-15 00:00:00

abstract：:Current therapies for treatment of hemophilia A involve infusion of factor VIII, but are ineffective for patients who develop inhibitory antibodies. We have previously proposed that bypassing the intrinsic pathway (VIIIa/IXa) with reversibly acylated factor Xa offers an improvement on existing therapies as it provides...

journal_title：Thrombosis research

authors： Lin PH,Laibelman AM,Sinha U

更新日期：1997-11-15 00:00:00

abstract：:Von Willebrand Factor is a multimer produced by endothelial cells and megakaryocytes, being stored in intracellular organelles, such as the Weibel-Palade bodies and alpha-granules in endothelial cells and platelets, respectively. This molecule acts as a carrier protein for factor VIIIc, involved in the intrinsic pathw...

journal_title：Thrombosis research

authors： Spadafora-Ferreira M,Lopes AA,Coelho V,Guilherme L,Kalil J

更新日期：2000-01-15 00:00:00

abstract：:1 g acetyl salicylic acid orally significantly enhanced the initial rate of platelet aggregation induced by 1 mumol/l and 2.5 mumol/l ADP. Sodium salicylate was without effects on the platelet aggregation and specifically it did not prevent acetylsalicylic acid from inhibiting the secondary aggregation. Sodium salicyl...

journal_title：Thrombosis research

authors： Ring T,Dyerberg J

更新日期：1985-06-15 00:00:00

abstract：INTRODUCTION:Normal pregnancy is associated with hypercoagulable state. Elevated markers of coagulation and fibrinolytic system activation indicate increased thrombin activity and increased fibrinolysis following fibrin formation throughout pregnancy. These changes exceed the biological variability in most cases. Haemo...

journal_title：Thrombosis research

authors： Réger B,Péterfalvi A,Litter I,Pótó L,Mózes R,Tóth O,Kovács GL,Losonczy H

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Endothelial dysfunction plays an essential role in the pathogenesis of sepsis. The study aimed to illustrate the associations between the dynamic change (from day 1 to day 7) in biomarker concentration of endothelial dysfunction and outcomes in severe sepsis and septic shock in the intensive care unit (ICU...

journal_title：Thrombosis research

authors： Fang Y,Li C,Shao R,Yu H,Zhang Q

更新日期：2018-11-01 00:00:00

abstract：:The action of AD6 as an anti-thrombotic agent was studied in a model of coronary artery thrombosis and on platelet aggregation in the dog. AD6 (10-100 microM) in vitro inhibited aggregation induced by ADP, epinephrine, collagen and PAF (platelet aggregating factor) used at their threshold concentration for maximal agg...

journal_title：Thrombosis research

authors： Prosdocimi M,Finesso M,Tessari F,Gorio A,Languino LR,de Gaetano G,Dejana E

更新日期：1985-08-15 00:00:00

abstract：INTRODUCTION:The use of oral anticoagulant therapy is increasing in children. Managing anticoagulant therapy in children presents unique challenges, including poor venous access. The advent of point-of-care (POC) monitoring of anticoagulant therapy offers a potential solution to this challenge. This paper reviews the p...

journal_title：Thrombosis research

authors： Newall F,Bauman M

更新日期：2006-01-01 00:00:00

abstract：:In this study, the role of platelets in the human erectile response was assessed. Twenty patients with erectile dysfunction were studied by means of (111)In-oxine-platelets and blood pool imaging using 99mTc. Seventeen patients received intracavernously prostaglandin E1, and three patients received papaverine together...

journal_title：Thrombosis research

authors： Rodrigues M,O'Grady J,Stackl W,Granegger S,Sinzinger H

更新日期：1998-07-15 00:00:00

abstract：INTRODUCTION:Patients with multiple myeloma (MM) have an increased risk of thromboembolic events (TEE). Due to the complex nature of the prothrombotic state in MM, no single laboratory test has been designed to identify patients with the highest risk of developing TEE. Hence, this study is intended to assess the feasib...

journal_title：Thrombosis research

authors： Treliński J,Misiewicz M,Robak M,Smolewski P,Chojnowski K

更新日期：2014-04-01 00:00:00

abstract：:Binding of 3H-labeled 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor; PAF) to the intact, washed canine platelet has been defined and characterized as being specific and receptor-mediated. Under the conditions described, specific binding to 2 X 10(7) canine platelets reached saturation with...

journal_title：Thrombosis research

authors： Janero DR,Burghardt B,Burghardt C

更新日期：1988-06-15 00:00:00

abstract：:Thrombocytopenia is a common finding in cancer patients and can have different and/or multifactorial pathogenesis. While in solid tumors it occurs often as a consequence of chemotherapy treatment, it is frequently observed at diagnosis in patients with hematological malignancies being aggravated to a potentially life-...

journal_title：Thrombosis research

authors： Castaman G,Pieri L

更新日期：2018-04-01 00:00:00

abstract：:Cancer is frequently associated with activation of blood coagulation, which in turn has been suggested to promote tumor growth and metastasis. Indeed, low molecular weight heparin treatment significantly prolongs the survival of a wide variety of patients with cancer. Based on this notion that anticoagulant treatment ...

journal_title：Thrombosis research

authors： Spek CA,Arruda VR

更新日期：2012-04-01 00:00:00

abstract：:The zymogen form of circulating Factor VII activating protease (FSAP) is activated by histones that are released as a consequence of tissue damage or excessive inflammation. This is likely to have consequences in a number of disease conditions such as stroke, atherosclerosis, liver fibrosis, thrombosis and cancer. To ...

journal_title：Thrombosis research

authors： Rut W,Nielsen NV,Czarna J,Poreba M,Kanse SM,Drag M

更新日期：2019-10-01 00:00:00

abstract：:Protein C (PC) is the central protein in a major antithrombotic regulatory mechanism. Hereditary deficiencies of PC are associated with thrombosis. Therapeutic PC replacement may be an important treatment if pure functional human protein C is available in sufficient quantity. Human PC has been produced on a commercial...

journal_title：Thrombosis research

authors： Madden RM,Oppenheimer C,Wydro R,Marlar RA

更新日期：1990-02-01 00:00:00

abstract：:Epidemiologic data have indicated that the intake of polyphenols is inversely associated with mortality from cardiovascular disease. Mitogen-activated protein kinases (MAPKs) are ubiquitous signaling proteins that have been associated with gene regulation. This study determined whether polyphenols (catechin and querce...

journal_title：Thrombosis research

authors： Pasten C,Olave NC,Zhou L,Tabengwa EM,Wolkowicz PE,Grenett HE

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Pulmonary embolism (PE) is diagnosed with imaging techniques such as ventilation/perfusion (V/P) lung scintigraphy or multidetector computed tomography of the pulmonary arteries (MDCT). Lung scintigraphy can be performed with planar (V/P PLANAR) and tomographic (V/P SPECT) techniques. V/P SPECT has higher se...

journal_title：Thrombosis research

authors： Alhadad A,Miniati M,Alhadad H,Gottsäter A,Bajc M

更新日期：2012-12-01 00:00:00

abstract：:We investigated the age-related changes in blood coagulation, fibrinolysis, and platelet aggregation in male WBN/Kob rats, animals that exhibit spontaneously diabetes mellitus at more than 6 months of age. The rats aged 6 months or more showed significant hyperglycemia, hypoinsulinemia, and hyperlipidemia. As changes ...

journal_title：Thrombosis research

authors： Nobukata H,Ishikawa T,Obata M,Shibutani Y

更新日期：2000-06-15 00:00:00