The role of biomarkers of endothelial activation in predicting morbidity and mortality in patients with severe sepsis and septic shock in intensive care: A prospective observational study.

abstract：:Bleeding is an important complication of heparin therapy. A number of low molecular weight heparin fractions produce less bleeding than standard heparin for an equivalent antithrombotic effect in experimental animals. Low molecular weight heparin fractions and fragments are produced by a number of different procedures...

journal_title：Thrombosis research

authors： Cade JF,Buchanan MR,Boneu B,Ockelford P,Cater CJ,Cerskus AL,Hirsh J

更新日期：1984-09-15 00:00:00

abstract：:To compare Canola a terrestrial (n-3) oil with fish oil (n-3) and common vegetable oil (n-6) in decreasing serum lipids and platelet aggregation, various oils were included in Chow-based diets and fed to rats in an eight-weeks feeding trial. The Chow diet contained 2% cholesterol along with either Canola, menhaden, sa...

journal_title：Thrombosis research

authors： Watkins T,Lenz P,Bierenbaum M

更新日期：1990-08-01 00:00:00

abstract：:Several clinical trials have demonstrated the benefits of thienopyridine monotherapy in ischaemic stroke patients. Non-human primate models of ischaemic stroke have been used for various antithrombotic agents; however, to the best of our knowledge, there is no data on the effects of P2Y12 antagonists in models, such a...

journal_title：Thrombosis research

authors： Tomizawa A,Ohno K,Jakubowski JA,Mizuno M,Sugidachi A

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The AMPLIFY trial found significantly lower major bleeding (MB) and similar recurrent venous thromboembolism (VTE) risks associated with apixaban vs warfarin among patients with VTE. OBJECTIVES:To compare MB, clinically-relevant non-major (CRNM) bleeding, and recurrent VTE risks among clinically-relevant su...

journal_title：Thrombosis research

authors： Guo JD,Hlavacek P,Rosenblatt L,Keshishian A,Russ C,Mardekian J,Ferri M,Poretta T,Yuce H,McBane R

更新日期：2020-12-08 00:00:00

abstract：:Atherothrombosis is the leading cause of morbidity and mortality in patients with diabetes mellitus. Several mechanisms contribute to the diabetic prothrombotic state, including endothelial dysfunction, coagulative activation and platelet hyper-reactivity. In particular, diabetic platelets are characterised by dysregu...

journal_title：Thrombosis research

authors： Vazzana N,Ranalli P,Cuccurullo C,Davì G

更新日期：2012-03-01 00:00:00

abstract：:ZK-807834 (also known as CI-1031) is a small molecule that potently and selectively inhibits Factor Xa. Studies in animals have shown that ZK-807834 attenuates thrombosis and thrombus progression after fibrinolysis and exhibits an increased antithrombotic-to-bleeding risk ratio compared with conventional agents. The p...

journal_title：Thrombosis research

authors： Post JM,Sullivan ME,Abendschein D,Ewing J,Hinchman JW,Light DR

更新日期：2002-02-15 00:00:00

abstract：BACKGROUND AND OBJECTIVE:According to US Food and Drugs Administration (FDA), 2 hour recombinant tissue plasminogen activator (rt-PA) 100mg infusion is recommended for eligible patients with acute pulmonary embolism (PE). However,there exists evidence implying that a lower dosage of rt-PA can be equally effective but p...

journal_title：Thrombosis research

authors： Zhang Z,Zhai ZG,Liang LR,Liu FF,Yang YH,Wang C

更新日期：2014-03-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) has become the most curable form of acute myeloid leukemia after the advent of all-trans retinoic acid (ATRA). However, early deaths (ED) mostly due to the disease-associated coagulopathy remain the major cause of treatment failure. In particular, hemorrhagic events account for 40-65...

journal_title：Thrombosis research

authors： Breccia M,Lo Coco F

更新日期：2014-05-01 00:00:00

abstract：:Cross reactive antigens to factor VIII have been measured in a range of vertebrate phyla. VIII coagulant antigen (VIII:CAg) measured using a human antibody was in general, much lower than reported values of VIII coagulant activity (VIII:C) except in simians and the guinea pig. The dose response curve for the assay was...

journal_title：Thrombosis research

authors： Rotblat F,Hawkey C,O'Brien DP,Tuddenham EG

更新日期：1982-03-01 00:00:00

abstract：:Hemorrhagic tendency is frequent in uremic patients and is often associated with prolonged bleeding time and decreased platelet functions in vitro. Similarly, in multiple myeloma, platelet functions are affected, mainly by the inhibitory effect of paraprotein. We have studied patients with renal insufficiency and mult...

journal_title：Thrombosis research

authors： Cieslar P,Másová L,Scheiner T,Rysavá J,Krízová P,Danzigová Z,Spicka I,Tesar V

更新日期：2002-02-15 00:00:00

abstract：BACKGROUND:Acquired von Willebrand Syndrome is a rare bleeding disorder, which arises in individuals with no personal or family history of bleeding, associated with lymphoproliferative and myeloproliferative disorders or other diseases. AIM:To develop a two-step approach assay to detect autoantibodies against VWF and ...

journal_title：Thrombosis research

authors： Franchi F,Biguzzi E,Stufano F,Siboni SM,Baronciani L,Peyvandi F

更新日期：2014-12-01 00:00:00

abstract：:We have studied the synthesis and subcellular distribution of the glycosylated membrane protein tissue factor (TF) in human blood monocytes and the inducible monocyte like cell line, HL-60. Following induction with endotoxin or the phorbol ester, TPA, tissue factor specific activity was measured in intact cells, sonic...

journal_title：Thrombosis research

authors： Bona R,Lee E,Rickles F

更新日期：1987-11-15 00:00:00

abstract：INTRODUCTION:The activation of coagulation is recognized as a universal event in severe sepsis. Both antithrombin and thrombomodulin play pivotal roles as suppressors of coagulation. Since the levels of both anticoagulants decrease significantly, we hypothesized that a combination therapy would be beneficial. METHODS:...

journal_title：Thrombosis research

authors： Iba T,Miki T,Hashiguchi N,Tabe Y,Nagaoka I

更新日期：2014-07-01 00:00:00

abstract：:The present investigation has used an aggregation-disaggregation-reaggregation model to determine if exposure to potent aggregating agents causing a refractory state in deaggregated platelets results in down-regulation and clearance of GPIb/IX, the receptor for von willebrand factor. Thrombin, the thrombin receptor ac...

journal_title：Thrombosis research

authors： White JG,Rao GH

更新日期：1996-11-15 00:00:00

abstract：:Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large, polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone marrow, lining blood vessel walls where they release their platelet progeny into circulation. Although little is known about how MKs dif...

journal_title：Thrombosis research

authors： Couldwell G,Machlus KR

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Prediction of venous thromboembolism (VTE) occurrence in cancer patients using individual risk factors may contribute to preventing the burden of disease associated with VTE. Congestive heart failure in patients with cancer may increase the risk of VTE and worsen the prognosis. AIM:We sought to investigat...

journal_title：Thrombosis research

authors： Königsbrügge O,Riedl J,Grilz E,Wiltschke C,Zielinski C,Pabinger I,Ay C

更新日期：2016-04-01 00:00:00

abstract：:A B S T R A C T Thrombotic events are a major cause of morbidity and mortality in cancer. While the association of venous thromboembolic events with cancer is well documented, in recent years arterial events (i.e. acute myocardial infarction and ischemic strokes) have also emerged as relatively common complications am...

journal_title：Thrombosis research

authors： Horowitz NA,Brenner B

更新日期：2020-07-01 00:00:00

abstract：:The lupus ratio (LR) test is a normalized ratio of the clotting times obtained with low and high phospholipid (PL) concentrations, where the test plasma is mixed 1:1 with normal pooled plasma (NP). As an integrated, automated, and computer-assisted assay, this principle has been applied to the dilute activated partial...

journal_title：Thrombosis research

authors： Liestøl S,Jacobsen EM,Wisløff F

更新日期：2002-01-15 00:00:00

abstract：:Plasma membranes of pig platelets were isolated and subjected to solubilization with digitonin. Binding of [3H]ketanserin to the solubilized membrane fraction, optimal at pH 7.5, was time and protein dependent and was greatly reduced by increasing ionic strength of the incubation buffer. Saturation analysis and inhibi...

journal_title：Thrombosis research

authors： Wesemann W,Hoffmann D

更新日期：1985-09-15 00:00:00

abstract：:Liquid permeation studies of fibrin gels, which were formed in the presence of thrombin (Fibrin II) and in the presence of Batroxobin (Fibrin I), showed that those gels have distinctly different flow properties. For both gels the permeability coefficient (Ks) and average pore size varied depending on the conditions fo...

journal_title：Thrombosis research

authors： Blombäck B,Okada M

更新日期：1982-01-01 00:00:00

abstract：:Patients with the nephrotic syndrome are at increased risk of developing venous and arterial thromboembolism, the most common of which is renal vein thrombosis. There are several unanswered or controversial issues relating to the nephrotic syndrome and thromboembolism, which include the mechanism of thromboembolism, a...

journal_title：Thrombosis research

authors： Singhal R,Brimble KS

更新日期：2006-01-01 00:00:00

abstract：:The experiments in this work were focused on determination of the extent to which fibrinogen component of fibrin glue (Hemaseel HMN, Haemacure Biotech.) retained the conformation of the parent molecule after dry heat antiviral treatment (one hour at 100 degrees C). For this purpose antigenic structure of the fibrinoge...

journal_title：Thrombosis research

authors： Cierniewski CS,Pluskota E,Cieslak M,Brodniewicz T,Nowotarski M

更新日期：1996-05-15 00:00:00

abstract：BACKGROUND:The results of the EINSTEIN-DVT/PE and AMPLIFY trials, which compared rivaroxaban and apixaban with conventional anticoagulation therapy for acute venous thromboembolism (VTE), respectively, are often compared. However, the trials differed in duration of therapy (3-12 and 6months, respectively) and in patien...

journal_title：Thrombosis research

authors： Beyer-Westendorf J,Lensing AW,Arya R,Bounameaux H,Cohen AT,Wells PS,Middeldorp S,Verhamme P,Hughes R,Kucher N,Pap AF,Trajanovic M,Prins MH,Prandoni P,Weitz JI

更新日期：2017-01-01 00:00:00

abstract：:We provide a centralised thrombophilia screening service with sample transfer by courier or first class mail, a practice common to many centres. Sample quality is of prime importance, thus we have assessed the effect of delayed sample handling upon the haemostatic variables within our thrombophilia profile. This compr...

journal_title：Thrombosis research

authors： Luddington R,Peters J,Baker P,Baglin T

更新日期：1997-09-15 00:00:00

abstract：INTRODUCTION:This study determines the impact of tissue factor (TF)-signaling on the extrinsic pathway of apoptosis in cancer cells and propose death associated protein kinase-1 (DAPK1) as a novel key regulator. MATERIALS AND METHODS:In MDA-MB-231 breast and PC3 prostate cancer cells, mRNA levels were analyzed by real...

journal_title：Thrombosis research

authors： Aberg M,Johnell M,Wickström M,Siegbahn A

更新日期：2011-02-01 00:00:00

abstract：:We have previously described a stimulus-specific defect in platelet aggregation in polycythaemia vera (PV) after stimulation with surface receptor dependent agonists such as platelet activating factor (PAF). In contrast, responses to phorbol myristate acetate (PMA) were normal. We now report that after PAF stimulation...

journal_title：Thrombosis research

authors： Le Blanc K,Lindahl T,Rosendahl K,Samuelsson J

更新日期：1998-09-15 00:00:00

abstract：:The turnover of tissue plasminogen activator (tPA) was studied in rabbits using a double-label technique which allowed the comparison of various tPA derivatives with a standard tPA in individual animals. Purified recombinant tPA (Alteplase) was labelled with 125I and used as a standard for each experiment. Various tPA...

journal_title：Thrombosis research

authors： Beebe DP,Aronson DL

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Abdominal obesity has been found to be associated with an increased risk of deep vein thrombosis (DVT). Whether patients with abdominal obesity have an increased risk of recurrence is currently unknown. METHODS:Patients with objective diagnosis of DVT and a life expectancy of greater than 6 months underwent...

journal_title：Thrombosis research

authors： Romualdi E,Squizzato A,Ageno W

更新日期：2007-01-01 00:00:00

abstract：:Human fibrinogen exposed to 46.5 degrees C was subjected to gel permeation chromatography. The protein eluted in two distinct peaks. The first peak appeared in the void volume containing soluble fibrinogen aggregates, while the other peak represented monomeric fibrinogen. In contrast to the monomeric peak material, th...

journal_title：Thrombosis research

authors： Bennick A,Haddeland U,Brosstad F

更新日期：1996-04-15 00:00:00

abstract：:Thirty-four derivatives of benzamidine were tested for their inhibitory activities on bovine and human thrombins using the chromogenic peptide substrate N-D-Phe-Pip-Arg-pNA. The inhibition constants of small molecular size inhibitors of comparatively low affinity as well as those of tight binding inhibitors did not di...

journal_title：Thrombosis research

authors： Stürzebecher J,Walsmann P,Voigt B,Wagner G

更新日期：1984-12-01 00:00:00