当前位置： SCI文献检索 > THROMBOSIS RESEARCH期刊下所有文献 > A comparison of the antithrombotic and haemorrhagic effects of low molecular weight heparin fractions: the influence of the method of preparation.

A comparison of the antithrombotic and haemorrhagic effects of low molecular weight heparin fractions: the influence of the method of preparation.

Abstract：

:Bleeding is an important complication of heparin therapy. A number of low molecular weight heparin fractions produce less bleeding than standard heparin for an equivalent antithrombotic effect in experimental animals. Low molecular weight heparin fractions and fragments are produced by a number of different procedures but their relative effects on haemostasis and thrombosis have not been evaluated. We have compared the antithrombotic and haemorrhagic effects of two low molecular weight heparin fragments and of a heparinoid with porcine mucosa heparin and related these in vivo findings to the results of ex vivo tests of blood coagulation and in vitro tests of platelet vivo tests of blood coagulation and in vitro tests of platelet function. Haemorrhage was assessed using a rabbit ear bleeding model. The antithrombotic effects were assessed by measuring inhibition of a tissue thromboplastin-induced jugular vein thrombus and by inhibition of fibrin and platelet accumulation in an arterial-venous shunt. The ex vivo anticoagulant effects were assessed with the thrombin clotting time, activated partial thromboplastin time and anti-Xa assay, and the effect of these glycosaminoglycans on platelet function was assessed by measuring collagen-induced platelet aggregation. For a similar antithrombotic effect, standard heparin produced significantly more bleeding than the other 3 glycosaminoglycans. The antithrombotic effects of all 4 glycosaminoglycans occurred at similar levels of anti-Xa activity but there was no relationship between blood loss and the effects of these glycosaminoglycans on any of the other tests of blood coagulation. Standard heparin had a greater inhibitory effect on collagen-induced platelet aggregation than the low molecular weight glycosaminoglycans, supporting the possibility that the increased bleeding observed with heparin is related in part to its inhibitory effect on platelet function.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Cade JF,Buchanan MR,Boneu B,Ockelford P,Cater CJ,Cerskus AL,Hirsh J

doi

10.1016/0049-3848(84)90265-2

subject

Has Abstract

pub_date

1984-09-15 00:00:00

pages

613-25

issue

6

eissn

0049-3848

issn

1879-2472

journal_volume

35

pub_type

杂志文章

相关文献

THROMBOSIS RESEARCH文献大全
  • Dietary pectin influences fibrin network structure in hypercholesterolaemic subjects.

    abstract：:Fibrinogen is an important risk factor for atherosclerosis, stroke and cardiovascular heart disease (CHD). This risk is increased when associated with a high serum cholesterol. Furthermore, it is also believed that not only fibrinogen concentration, but also the quality of fibrin networks may be an important risk fact...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0049-3848(97)00062-5

    authors： Veldman FJ,Nair CH,Vorster HH,Vermaak WJ,Jerling JC,Oosthuizen W,Venter CS

    更新日期：1997-05-01 00:00:00

  • Inhibition of activated protein C by aprotinin and the use of the insolubilized inhibitor for its purification.

    abstract：:The study of the interaction between activated protein C (APC) and non-plasmatic inhibitors allowed us to demonstrate that aprotinin is a potent competitive inhibitor of APC with a Ki of 1.35 mumol/L. It was possible to adsorb immunopurified protein C (PC) activated by venom activator to insolubilized aprotinin and to...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(90)90268-h

    authors： Taby O,Chabbat J,Steinbuch M

    更新日期：1990-07-01 00:00:00

  • Fibrinolytic study in a homozygous protein C deficient patient.

    abstract：:The fibrinolytic system was evaluated in a patient with homozygous protein C deficiency as well as in several members of his family with a partial deficiency of this protein. Before anticoagulant therapy the patient showed skin lesions which quickly disappeared after administration of fresh plasma. After anticoagulant...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(86)90260-4

    authors： Aznar J,Dasi A,España F,Estellés A

    更新日期：1986-05-01 00:00:00

  • Acquired and congenital risk factors associated with cerebral venous sinus thrombosis.

    abstract：:The mechanistic paradigm underlying venous thrombosis at atypical locations stems from the observation that most events occur as a result of pathology of the organ system drained by the involved venous segment. Cerebral venous sinus thrombosis stands apart as an exception to this general rule. Although brain and sinus...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2010.04.015

    authors： McBane RD 2nd,Tafur A,Wysokinski WE

    更新日期：2010-08-01 00:00:00

  • The role of thromboxane A2 in increased whole blood platelet aggregation in oral contraceptive users.

    abstract：:Epidemiological studies have shown that oral contraceptives increase the risk of thromboembolic disease in susceptible women however the mechanisms involved are unclear. We investigated whole blood platelet aggregation in 44 women randomly allocated to 6 cycles of treatment with either gestodene (75ug) or desogestrel ...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0049-3848(96)00013-8

    authors： Norris LA,Devitt M,Bonnar J

    更新日期：1996-02-15 00:00:00

  • Elevated levels of Factor XI are associated with cardiovascular disease in women.

    abstract：:Coronary artery disease (CAD) continues to be the most frequent cause of death among women in the United States. Although elevated levels of clotting factors have been associated with CAD, few of these studies have been performed in women. Elevated levels of Factor XI have previously been associated with venous thromb...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(02)00190-1

    authors： Berliner JI,Rybicki AC,Kaplan RC,Monrad ES,Freeman R,Billett HH

    更新日期：2002-07-15 00:00:00

  • Glycerophospholipid metabolism: back to the future.

    abstract：:It has become customary to regard the various glycerophospholipids as quite similar, and the acyl groups are considered to have little influence on the behaviour of the lipids in membranes or metabolism. Nevertheless, a number of recent observations by the authors and others indicate a high degree of metabolic compart...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/0049-3848(92)90006-v

    authors： Holmsen H,Hindenes JO,Fukami M

    更新日期：1992-08-01 00:00:00

  • Procoagulant activity, but not number, of microparticles increases with age and in individuals after a single venous thromboembolism.

    abstract：:The Calibrated Automated Thrombogram (CAT), a plate-based assay that measures thrombin generation and inhibition in plasma samples, is modified to measure the procoagulant activity of phospholipid associated with plasma microparticles (MP). The assay uses a tissue factor trigger without addition of 4 μM exogenous phos...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2010.10.018

    authors： Owen BA,Xue A,Heit JA,Owen WG

    更新日期：2011-01-01 00:00:00

  • Markers of endothelial dysfunction differ between subphenotypes in children with sickle cell disease.

    abstract：:In adult patients with sickle cell disease two distinct subphenotypes have previously been defined: patients with the viscosity-vaso-occlusion subphenotype (VVO) suffer mainly from vaso-occlusive pain crises and have a relatively high hemoglobin concentration. Patients classified as the hemolysis-endothelial dysfuncti...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2013.10.006

    authors： van der Land V,Peters M,Biemond BJ,Heijboer H,Harteveld CL,Fijnvandraat K

    更新日期：2013-01-01 00:00:00

  • Assessing the clinical and cost impact of on-demand immunoassay testing for the diagnosis of heparin induced thrombocytopenia.

    abstract：BACKGROUND:The diagnostic work-up for heparin induced thrombocytopenia (HIT) can take several days. Consequently patients may be speculatively switched onto replacement anticoagulant therapy before a diagnosis is confirmed. On-demand immunoassay diagnostic testing enables timely treatment decisions, based on test resul...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2016.01.025

    authors： Caton S,O'Brien E,Pannelay AJ,Cook RG

    更新日期：2016-04-01 00:00:00

  • The use of prothrombin complex concentrates in the treatment of hemorrhages induced by oral anticoagulation.

    abstract：:Bleeding events are a common adverse effect in oral anticoagulation that frequently depend on the duration and intensity of treatment. Major bleeding events, particularly intracerebral hemorrhages, are a serious complication in cases that require the rapid reversal of anticoagulation. Urgent correction of the coagulat...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/s0049-3848(99)00085-7

    authors： Pindur G,Mörsdorf S

    更新日期：1999-08-15 00:00:00

  • Accumulation of platelets as a key mechanism of human erection.

    abstract：:In this study, the role of platelets in the human erectile response was assessed. Twenty patients with erectile dysfunction were studied by means of (111)In-oxine-platelets and blood pool imaging using 99mTc. Seventeen patients received intracavernously prostaglandin E1, and three patients received papaverine together...

    journal_title：Thrombosis research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0049-3848(98)00065-6

    authors： Rodrigues M,O'Grady J,Stackl W,Granegger S,Sinzinger H

    更新日期：1998-07-15 00:00:00

  • Interleukin 1 enhances arterial thrombogenicity in vitro.

    abstract：:An in vitro model of platelet adhesion, the annular perfusion chamber, was utilized to test the effects of Interleukin 1 on vascular thrombogenicity for platelets. De-endothelialized, everted human umbilical arteries were placed in cell culture media with or without Interleukin 1. The arteries were later perfused with...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90235-1

    authors： Schorer AE,White JG

    更新日期：1989-11-15 00:00:00

  • Pharmacodynamics assessment of Bemiparin after multiple prophylactic and single therapeutic doses in adult and elderly healthy volunteers and in subjects with varying degrees of renal impairment.

    abstract：INTRODUCTION:Aging and renal impairment may prolong the half-life and lead to accumulation of low molecular weight heparins. Correct dosing is critical to prevent bleeding or thrombosis. MATERIALS AND METHODS:Open, parallel study. Healthy adult [n=13] and elderly (>65yrs) [n=12] volunteers; and subjects with mild (ClC...

    journal_title：Thrombosis research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.thromres.2014.03.038

    authors： Rico S,Antonijoan RM,Ballester MR,Gutierro I,Ayani I,Martinez-Gonzalez J,Borrell M,Fontcuberta J,Gich I

    更新日期：2014-06-01 00:00:00

  • Pharmacokinetics of fragmin. A comparative study in the rabbit of its high and low affinity forms for antithrombin.

    abstract：:A tritium-labelled low molecular weight heparin fragment with an average molecular weight of 4000-6000 (Fragmin), was fractionated into its high and low affinity forms for antithrombin. The fractions obtained were injected into rabbits, and the plasma half-life (t1/2) volume of distribution (Vd), area under the curve ...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90345-8

    authors： Palm M,Mattsson C

    更新日期：1987-10-01 00:00:00

  • The use of aspirin for primary and secondary prevention in venous thromboembolism and other cardiovascular disorders.

    abstract：:Cardiovascular disease (CVD) includes a number of conditions such as myocardial infarction, coronary heart disease, stroke, and venous thromboembolism. CVD is a leading health problem worldwide and a major cause of mortality, morbidity, and disability; it is also associated with high healthcare costs. The incidence of...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2014.11.036

    authors： Cohen AT,Imfeld S,Markham J,Granziera S

    更新日期：2015-02-01 00:00:00

  • Plasma and platelet skimming at T-junctions.

    abstract：:Separation of plasma, erythrocytes, and platelets was studied in T-shaped bifurcations prepared by a casting technique. The diameters of the side and main channel were 100 microns and 200 microns, respectively. Small blood samples (about 20 microliters) were collected from the side channel for determination of erythro...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(87)90314-8

    authors： Perkkiö J,Wurzinger LJ,Schmid-Schönbein H

    更新日期：1987-03-01 00:00:00

  • Further studies on the role of red blood cells in spontaneous platelet aggregation.

    abstract：:The influence of red blood cells on platelet aggregation has recently been a subject of considerable interest. We have studied the effect of red cells on spontaneously formed platelet aggregates in rotating vials at 37 degrees C. Platelet aggregation was quantified by measuring the fall in number of single platelets w...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(85)90150-1

    authors： Saniabadi AR,Lowe GD,Barbenel JC,Forbes CD

    更新日期：1985-05-01 00:00:00

  • Platelet adherence and thrombus formation with flowing human blood on atherosclerotic plaque: reduced thrombogenicity of Watanabe-heritable hyperlipidemic rabbit aortic subendothelium.

    abstract：:Platelet adherence and aggregation are important in the development of ischemic sequelae in atherosclerosis. To directly examine platelet interaction with plaque, everted, deendothelialized aortic fibrous plaques from Watanabe-heritable hyperlipidemic rabbits were exposed to flowing human blood in an annular perfusion...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(89)90040-6

    authors： Lawrence JB,Prevosti LG,Kramer WS,Lu DY,Leon MB

    更新日期：1989-04-15 00:00:00

  • KIDCLOT: the importance of validated educational intervention for optimal long term warfarin management in children.

    abstract：BACKGROUND:Advances in medical and surgical therapy in children have resulted in increased survival in children with primary illnesses. However, thrombosis is a serious complication of this success and results in mortality and morbidity. Prevention or treatment of thrombosis using warfarin is challenging in children du...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.07.012

    authors： Bauman ME,Black K,Kuhle S,Wang L,Legge L,Callen-Wicks D,Mitchell L,Bajzar L,Massicotte MP,Western Canadian Children's Heart Network WCCHN.

    更新日期：2009-03-01 00:00:00

  • Effects of fibrinogen and platelet supplementation on clot formation and platelet aggregation in blood samples from cardiac surgery patients.

    abstract：INTRODUCTION:Bleeding after cardiac surgery may be caused by surgical factors, impaired haemostasis, or a combination of both. Transfusion of blood products is used to improve haemostasis, but little is known about what combination is optimal. We hypothesized that addition of both fibrinogen and platelets to blood samp...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2014.05.023

    authors： Shams Hakimi C,Fagerberg Blixter I,Hansson EC,Hesse C,Wallén H,Jeppsson A

    更新日期：2014-10-01 00:00:00

  • Variations of protein C in uremic hemodialysed patients.

    abstract：:Protein C has been measured by three different assays (antigenic, amidolytic and chronometric) in 27 end-stage renal insufficient patients before and after hemodialysis. Protein C levels have been compared with other coagulation inhibitors (antithrombin III, protein S) and fibrinolytic parameters. Baseline anticoagula...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(93)90055-s

    authors： Nguyen P,Toupance O,Chanard J,Potron G

    更新日期：1993-03-15 00:00:00

  • A genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart Study.

    abstract：INTRODUCTION:Circulating levels of fibrinogen are associated with atherosclerosis and predict future coronary heart disease and stroke. Levels of fibrinogen are correlated among family members, suggesting a heritable component. Variants of the beta-fibrinogen gene subunit on 4q28 are associated with fibrinogen levels b...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(03)00288-3

    authors： Yang Q,Tofler GH,Cupples LA,Larson MG,Feng D,Lindpaintner K,Levy D,D'Agostino RB,O'Donnell CJ

    更新日期：2003-04-15 00:00:00

  • The effect of serum amyloid protein A fragment-SAA25-76 on blood platelet aggregation.

    abstract：:The effect of the major acute phase protein serum amyloid A (SAA) on collagen induced platelet aggregation was investigated. A truncated version of SAA, SAA25-76 was tested for inhibitory capacity of collagen induced platelet aggregation in platelet-rich plasma (PRP) and whole blood (WB). The tetrapeptide RGDV, a know...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(94)90201-1

    authors： Syversen PV,Saeter U,Cunha-Ribeiro L,Orvim U,Sletten K,Husby G,Sakariassen KS

    更新日期：1994-11-01 00:00:00

  • Reduction in epistaxis and emergency department visits in patients taking warfarin after implementation of an education program.

    abstract：BACKGROUND:Anticoagulated patients are often seen unnecessarily in the emergency department (ED) for epistaxis, leading to increased healthcare costs. Patients are often unaware of preventative and management techniques for handling epistaxis in the home. METHODS:In 2016, the Michigan Anticoagulation Quality Improveme...

    journal_title：Thrombosis research

    pub_type： 信件

    doi：10.1016/j.thromres.2021.01.007

    authors： Neshewat J,Wasserman A,Alexandris-Souphis C,Haymart B,Feldeisen D,Kong X,Harvey RS,Pynnonen M,Froehlich JB,Kline-Rogers E,Barnes GD

    更新日期：2021-01-16 00:00:00

  • An ultrastructural study of Porphyromonas gingivalis-induced platelet aggregation.

    abstract：:One of the major pathogens of periodontitis, Porphyromonas gingivalis (P. gingivalis), has the ability to aggregate human platelets. To investigate the interaction between P. gingivalis and human platelets in platelet rich plasma (PRP), platelet aggregation was measured by an aggregometer based on laser light scatteri...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2008.03.011

    authors： Li X,Iwai T,Nakamura H,Inoue Y,Chen Y,Umeda M,Suzuki H

    更新日期：2008-01-01 00:00:00

  • Arsenic trioxide induces procoagulant activity through phosphatidylserine exposure and microparticle generation in endothelial cells.

    abstract：BACKGROUND:Coagulopathy is a major cause of early death when arsenic trioxide (As(2)O(3)) therapy fails. In addition to the procoagulant properties of blast cells, the cytotoxic therapy may contribute to the coagulation disorders. The aim of the present study was to evaluate the possible impact of As(2)O(3) on membrane...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/j.thromres.2011.01.003

    authors： Zhou J,Li H,Fu Y,Shi J,Hou J,Zhang Y,Liu X,Song P

    更新日期：2011-05-01 00:00:00

  • Detection of procoagulant phospholipid interfering in tests for lupus anticoagulant.

    abstract：:Excess platelets shorten most clotting tests for lupus anticoagulant (LA). Often it is not clear if a shortened, normal or slightly prolonged result in a test masks a weak LA in combination with activated platelets, which express procoagulant phospholipid (PPL). Our aim was to investigate a new LA-insensitive factor X...

    journal_title：Thrombosis research

    pub_type： 杂志文章,评审

    doi：10.1016/j.thromres.2004.06.001

    authors： Exner T,Low J

    更新日期：2004-01-01 00:00:00

  • A direct, plasmin-independent assay for plasminogen activator.

    abstract：:A direct assay for plasminogen activator (PA) was developed. It employed polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and beta-mercaptoethanol to monitor PA-mediated conversion of single chain, 125I-plasminogen to two chain plasmin. By incorporating Triton X-100, albumin and trasylol in...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/0049-3848(84)90008-2

    authors： Mussoni L,Lawrence D,Loskutoff DJ

    更新日期：1984-05-01 00:00:00

  • Induction of hepatic tissue-type plasminogen activator and type 1 plasminogen activator-inhibitor gene expressions and appearance of their translation products in the bile following acute liver injury in rats.

    abstract：BACKGROUND/AIMS:The plasminogen activator (PA)-plasmin system is primarily involved in fibrinolysis, but is also in the patho/physiological events in which breakdown of extracellular matrices is evoked topically. In this present study, we examined the expression of fibrinolytic factors, tissue-type PA (t-PA) and Type 1...

    journal_title：Thrombosis research

    pub_type： 杂志文章

    doi：10.1016/s0049-3848(01)00370-x

    authors： Noguchi T,Matsuyama S,Akao M,Hagiwara H,Uno S,Seki T,Ariga T

    更新日期：2001-11-15 00:00:00