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The effect of serum amyloid protein A fragment-SAA25-76 on blood platelet aggregation.

Abstract：

:The effect of the major acute phase protein serum amyloid A (SAA) on collagen induced platelet aggregation was investigated. A truncated version of SAA, SAA25-76 was tested for inhibitory capacity of collagen induced platelet aggregation in platelet-rich plasma (PRP) and whole blood (WB). The tetrapeptide RGDV, a known inhibitor of platelet aggregation, was included as a reference compound. SAA25-76 at a concentration of 390 micrograms/ml inhibited platelet aggregation induced by 1 microgram/ml of collagen in PRP. This corresponds to the plasma concentration of SAA during an acute phase response. However, the inhibitory effect of the SAA25-76 fragment was lost at higher collagen concentrations (> or = 2.0 micrograms/ml). The SAA fragment at 390 micrograms/ml had no significant effect on platelet aggregation in WB. In contrast, RGDV blocked collagen induced platelet aggregation in both PRP and WB.

journal_name

Thromb Res

journal_title

Thrombosis research

authors

Syversen PV,Saeter U,Cunha-Ribeiro L,Orvim U,Sletten K,Husby G,Sakariassen KS

doi

10.1016/0049-3848(94)90201-1

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

299-305

issue

3

eissn

0049-3848

issn

1879-2472

pii

0049-3848(94)90201-1

journal_volume

76

pub_type

杂志文章

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